Cardiolipin biosynthesis and remodeling enzymes are altered during development of heart failure

Journal of Lipid Research

Volumn 50, Issue 8, 2009, Pages 1600-1608

  Saini Chohan, Harjot K ^a   Holmes, Michael G ^a,b   Chicco, Adam J ^c   Taylor, William A ^a   Moore, Russell L ^d   McCune, Sylvia A ^d   Hickson Bick, Diane L ^b   Hatch, Grant M ^b   Sparagna, Genevieve C ^d  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c Department of Environmental and Radiological Health Sciences   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

Acyl Coenzyme A:lysocardiolipin acyltransferase 1; Cardiolipin synthase; Cytidinediphosphate diacylglycerol synthetase; Human heart failure; Monolysocardiolipin acyltransferase; Phosphatidylglycerol phosphate synthase; Phospholipid enzyme; Spontaneously hypertensive heart failure rat; Tafazzin

Indexed keywords

ACYL COENZYME A; CARDIOLIPIN; MESSENGER RNA; MITOCHONDRIAL ENZYME; ACYLTRANSFERASE; CARDIOLIPIN SYNTHASE; CDP DIACYLGLYCEROL GLYCEROL 3 PHOSPHATE 3 PHOSPHATIDYLTRANSFERASE; CDP-DIACYLGLYCEROL-GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE; CHOLINEPHOSPHOTRANSFERASE; CYTIDINE DIPHOSPHATE DIGLYCERIDE; LYSOPHOSPHOLIPID; MEMBRANE PROTEIN; MONOLYSOCARDIOLIPIN; PHOSPHATIDIC ACID; PHOSPHOTRANSFERASE; TAZ PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME REGULATION; EXPLANT; FEMALE; GENE EXPRESSION REGULATION; HEART FAILURE; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE HEART FAILURE RAT; SPRAGUE DAWLEY RAT; AGING; ANIMAL; BIOSYNTHESIS; BODY WEIGHT; CHEMISTRY; CONGESTIVE CARDIOMYOPATHY; ENZYMOLOGY; GENE EXPRESSION; GENETICS; HEART LEFT VENTRICLE HYPERTROPHY; HEART MITOCHONDRION; HEART MUSCLE; HEART VENTRICLE; HYPERTENSION; METABOLISM; PATHOLOGY; RAT STRAIN;

ACYLTRANSFERASES; AGING; ANIMALS; BODY WEIGHT; CARDIOLIPINS; CARDIOMYOPATHY, DILATED; CYTIDINE DIPHOSPHATE DIGLYCERIDES; DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE; FEMALE; GENE EXPRESSION; HEART FAILURE; HEART VENTRICLES; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; LYSOPHOSPHOLIPIDS; MALE; MEMBRANE PROTEINS; MITOCHONDRIA, HEART; MYOCARDIUM; PHOSPHATIDIC ACIDS; RATS; RATS, INBRED STRAINS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTORS; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 69449084720     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M800561-JLR200     Document Type: Article

References (47)

1. Massie, B. M., and N. B. Shah. 1997. Evolving trends in the epidemiologic factors of heart failure: rationale for preventive strategies and comprehensive disease management. Am. Heart J. 133: 703-712.
2. Rosamond, W., K. Flegal, K. Furie, A. Go, K. Greenlund, N. Haase, S. M. Hailpern, M. Ho, V. Howard, B. Kissela, et al. 2008. Heart disease and stroke statistics-2008 update. (Report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.) Circulation. 117: e25-e146.
3. Burt, C. W., and S. M. Schappert. 2004. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 1999-2000. Vital Health Stat. 13, 157: 1-70.
4. Chicco, A. J., and G. C. Sparagna. 2007. Role of cardiolipin alterations in mitochondrial dysfunction and disease. Am. J. Physiol. Cell Physiol. 292: C33-C44.
5. Ventura-Clapier, R., A. Garnier, and V. Veksler. 2004. Energy metabolism in heart failure. J. Physiol. 555: 1-13
6. Ingwall, J. S., and R. G. Weiss. 2004. Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ. Res. 95: 135-145.
7. Neubauer, S. 2007. The failing heart-an engine out of fuel. N. Engl. J. Med. 356: 1140-1151.
8. Sparagna, G. C., A. J. Chicco, R. C. Murphy, M. R. Bristow, C. A. Johnson, M. L. Rees, M. L. Maxey, S. A. McCune, and R. L. Moore. 2007. Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure. J. Lipid Res. 48: 1559-1570.
9. Sparagna, G. C., C. A. Johnson, S. A. McCune, R. L. Moore, and R. C. Murphy. 2005. Quantitation of cardiolipin molecular species in spontaneously hypertensive heart failure rats using electrospray ionization mass spectrometry. J. Lipid Res. 46: 1196-1204.
10. Schlame, M., M. Ren, Y. Xu, M. L. Greenberg, and I. Haller. 2005. Molecular symmetry in mitochondrial cardiolipins. Chem. Phys. Lipids. 138: 38-49.
11. cp rat model: a genetic model of congestive heart failure. In Mechanisms of Heart Failure. P. K. Singal, I. M. C. Dixon, R. E. Beamish, and N. S. Dhalla, editors. Kluwer Acad, Norwell, MA. 91-106.
12. Heyen, J. R., E. R. Blasi, K. Nikula, R. Rocha, H. A. Daust, G. Frierdich, J. F. Van Vleet, P. De Ciechi, E. G. McMahon, and A. E. Rudolph. 2002. Structural, functional, and molecular characterization of the SHHF model of heart failure. Am. J. Physiol. Heart Circ. Physiol. 283: H1775-H1784.
13. Chicco, A. J., G. C. Sparagna, S. A. McCune, C. A. Johnson, R. C. Murphy, D. A. Bolden, M. L. Rees, R. T. Gardner, and R. L. Moore. 2008. Linoleate-rich high-fat diet decreases mortality in hypertensive heart failure rats compared with lard and low-fat diets. Hypertension. 52: 549-555.
14. Emter, C. A., S. A. McCune, G. C. Sparagna, M. J. Radin, and R. L. Moore. 2005. Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats. Am. J. Physiol. Heart Circ. Physiol. 289: H2030-H2038.
15. Hatch, G. M., and G. McClarty. 1996. Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5′-triphosphate. J. Biol. Chem. 271: 25810-25816.
16. Palmer, J. W., B. Tandler, and C. L. Hoppel. 1977. Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle. J. Biol. Chem. 252: 8731-8739.
17. Hatch, G. M., S. G. Cao, and A. Angel. 1995. Decrease in cardiac phosphatidylglycerol in streptozotocin-induced diabetic rats does not affect cardiolipin biosynthesis: evidence for distinct pools of phosphatidylglycerol in the heart. Biochem. J. 306: 759-764.
18. Rusnak, A., R. Mangat, F. Xu, G. McClarty, and G. M. Hatch. 1997. Cardiolipin remodeling in a Chinese hamster lung fibroblast cell line deficient in oxidative energy production. J. Bioenerg. Biomembr. 29: 291-298.
19. Hatch, G. M. 1994. Cardiolipin biosynthesis in the isolated heart. Biochem. J. 297: 201-208.
20. Ma, B. J., W. A. Taylor, V. W. Dolinsky, and G. M. Hatch. 1999. Acylation of monolysocardiolipin in rat heart. J. Lipid Res. 40: 1837-1845.
21. Taylor, W. A., and G. M. Hatch. 2003. Purification and characterization of monolysocardiolipin acyltransferase from pig liver mitochondria. J. Biol. Chem. 278: 12716-12721.
22. Xu, Y., R. I. Kelley, T. J. Blanck, and M. Schlame. 2003. Remodeling of cardiolipin by phospholipid transacylation. J. Biol. Chem. 278: 51380-51385.
23. Young, M. E., S. Patil, J. Ying, C. Depre, H. S. Ahuja, G. L. Shipley, S. M. Stepkowski, P. J. Davies, and H. Taegtmeyer. 2001. Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart. FASEB J. 15: 833-845.
24. Gibson, U. E., C. A. Heid, and P. M. Williams. 1996. A novel method for real time quantitative RT-PCR. Genome Res. 6: 995-1001.
25. Heid, C. A., J. Stevens, K. J. Livak, and P. M. Williams. 1996. Real time quantitative PCR. Genome Res. 6: 986-994.
26. Zhang, F., T. Pan, L. D. Nielsen, and R. J. Mason. 2004. Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase. Am. J. Respir. Cell Mol. Biol. 30: 174-183.
27. Lekanne Deprez, R. H., A. C. Fijnvandraat, J. M. Ruijter, and A. F. Moorman. 2002. Sensitivity and accuracy of quantitative real-time polymerase chain reaction using SYBR green I depend on cDNA synthesis conditions. Anal. Biochem. 307: 63-69.
28. Janssen, P. M., L. B. Stull, M. K. Leppo, R. A. Altschuld, and E. Marbán. 2003. Selective contractile dysfunction of left, not right, ventricular myocardium in the SHHF rat. Am. J. Physiol. Heart Circ. Physiol. 284: H772-H778.
29. Hatch, G. M. 1998. Cardiolipin: biosynthesis, remodeling and trafficking in the heart and mammalian cells. Int. J. Mol. Med. 1: 33-41.
30. Lykidis, A., P. D. Jackson, C. O. Rock, and S. Jackowski. 1997. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. J. Biol. Chem. 272: 33402-33409.
31. Heacock, A. M., M. D. Uhler, and B. W. Agranoff. 1996. Cloning of CDP-diacylglycerol synthase from a human neuronal cell line. J. Neurochem. 67: 2200-2203.
32. Mercade, A., A. Sanchez, and J. M. Folch. 2007. Characterization and physical mapping of the porcine CDS1 and CDS2 genes. Anim. Biotechnol. 18: 23-35.
33. Cao, J., Y. Liu, J. Lockwood, P. Burn, and Y. Shi. 2004. A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse. J. Biol. Chem. 279: 31727-31734.
34. Hauff, K. D., and G. M. Hatch. 2006. Cardiolipin metabolism and Barth Syndrome. Prog. Lipid Res. 45: 91-101.
35. Mok, A. Y., G. E. McDougall, and W. C. McMurray. 1993. Comparative studies of CDP-diacylglycerol synthase in rat liver mitochondria and microsomes. Biochem. Cell Biol. 71: 183-189.
36. Weeks, R., W. Dowhan, H. Shen, N. Balantac, B. Meengs, E. Nudelman, and D. W. Leung. 1997. Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA. DNA Cell Biol. 16: 281-289.
37. Mayer, B., S. R. Holmer, C. Hengstenberg, W. Lieb, M. Pfeifer, and H. Schunkert. 2005. Functional improvement in heart failure patients treated with beta-blockers is associated with a decline of cytokine levels. Int. J. Cardiol. 103: 182-186.
38. Hatch, G. M. 2004. Cell biology of cardiac mitochondrial phospholipids. Biochem. Cell Biol. 82: 99-112.
39. He, Q., and M. L. Greenberg. 2004. Post-translational regulation of phosphatidylglycerolphosphate synthase in response to inositol. Mol. Microbiol. 53: 1243-1249.
40. Cheng, P., and G. M. Hatch. 1995. Inhibition of cardiolipin biosyntheis in the hypoxic rat heart. Lipids. 30: 513-519.
41. Schlame, M., and M. Ren. 2006. Barth syndrome, a human disorder of cardiolipin metabolism. FEBS Lett. 580: 5450-5455.
42. Vreken, P., F. Valianpour, L. G. Nijtmans, L. A. Grivell, B. Plecko, R. J. Wanders, and P. G. Barth. 2000. Defective remodeling of cardiolipin and phosphatidylglycerol in Barth syndrome. Biochem. Biophys. Res. Commun. 279: 378-382.
43. McKenzie, M., M. Lazarou, D. R. Thorburn, and M. T. Ryan. 2006. Mitochondrial respiratory chain supercomplexes are destabilized in Barth Syndrome patients. J. Mol. Biol. 361: 462-469.
44. Ma, L., F. M. Vaz, Z. Gu, R. J. Wanders, and M. L. Greenberg. 2004. The human TAZ gene complements mitochondrial dysfunction in the yeast taz1Delta mutant. Implications for Barth syndrome. J. Biol. Chem. 279: 44394-44399.
45. Schlame, M., and B. Rustow. 1990. Lysocardiolipin formation and reacylation in isolated rat liver mitochondria. Biochem. J. 272: 589-595.
46. McHowat, J., P. S. Tappia, S. Liu, R. McCrory, and V. Panagia. 2001. Redistribution and abnormal activity of phospholipase A(2) isoenzymes in postinfarct congestive heart failure. Am. J. Physiol. Cell Physiol. 280: C573-C580.
47. Mancuso, D. J., H. F. Sims, X. Han, C. M. Jenkins, S. P. Guan, K. Yang, S. H. Moon, T. Pietka, N. A. Abumrad, P. H. Schlesinger, et al. 2007. Genetic ablation of calcium-independent phospholipase A2 gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype. J. Biol. Chem. 282: 34611-34622.