Desensitization of the inhibitory effect of norepinephrine on insulin secretion from pancreatic islets of exercise-trained rats

Metabolism: Clinical and Experimental

Volumn 53, Issue 11, 2004, Pages 1424-1432

  Urano, Yuriko ^a   Sakurai, Tomonobu ^a   Ueda, Hiroshi ^a   Ogasawara, Junetsu ^a   Sakurai, Takuya ^a   Takei, Megumi ^a   Izawa, Tetsuya ^a  

^a TOKYO METROPOLITAN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE ACTIVATOR; ADENYLATE CYCLASE INHIBITOR; ALPHA 2 ADRENERGIC RECEPTOR; CALCIUM ION; CLONIDINE; CYCLIC AMP; ENZYME INHIBITOR; GLUCOSE; INSULIN; MESSENGER RNA; NORADRENALIN; PROTEIN KINASE C ACTIVATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DOSE RESPONSE; DRUG EFFECT; EXERCISE; INSULIN RELEASE; MALE; MEMBRANE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING; RECEPTOR DENSITY; TRAINING;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; CLONIDINE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; INSULIN; ISLETS OF LANGERHANS; MALE; NOREPINEPHRINE; PHYSICAL CONDITIONING, ANIMAL; PROTO-ONCOGENE PROTEINS; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; YOHIMBINE;

EID: 6944237771     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2004.06.008     Document Type: Article

References (54)

1. Hoelzer D.R., Dalsky G.P., Schwartz N.S., et al. Epinephrine is not critical to the prevention of hypoglycemia during exercise in humans. Am J Physiol. 251:1986;E104-110
2. Jarhult J., Holst J. The role of the adrenergic innervation to the pancreatic islets in the control of insulin release during exercise in man. Pflugers Arch. 383:1979;41-45
3. 2-receptor blockade. Diabetes. 50:2001;1834-1843
4. 2-blockade on insulin action and secretion in humans. Am J Physiol. 274:1988;E57-64
5. Engdahl J.H., Veldhuis J.D., Farrell P.A. Altered pulsatile insulin secretion associated with endurance training. J Appl Physiol. 79:1995;1977-1985
6. Coggan A.R., Kohrt W.M., Spina R.J., et al. Endurance training decreases plasma glucose turnover and oxidation during moderate-intensity exercise in men. J Appl Physiol. 68:1990;990-996
7. Kjaer M., Farrell P.A., Christensen N.J., et al. Increased epinephrine response and inaccurate glucoregulation in exercising athletes. J Appl Physiol. 61:1986;1693-1700
8. Gyntelberg F., Rennie M.J., Hickson R.C., et al. Effect of training on the response of plasma glucagon to exercise. J Appl Physiol. 43:1977;302-305
9. Winder W.W., Hickson R.C., Hagberg J.M., et al. Training-induced changes in hormonal and metabolic responses to submaximal exercise. J Appl Physiol. 46:1979;766-771
10. Hartley L.H., Mason J.W., Hogan R.P., et al. Multiple hormonal responses to prolonged exercise in relation to physical training. J Appl Physiol. 33:1972;607-610
11. Hartley L.H., Mason J.W., Hogan R.P., et al. Multiple hormonal responses to graded exercise in relation to physical training. J Appl Physiol. 33:1972;602-606
12. LeBlanc J., Boulay M., Dulac S., et al. Metabolic and cardiovascular responses to norepinephrine in trained and nontrained human subjects. J Appl Physiol. 42:1977;166-173
13. Coker R.H., Koyama Y., Lacy D.B., et al. Pancreatic innervation is not essential for exercise-induced changes in glucagon and insulin or glucose kinetics. Am J Physiol. 277:1999;E1122-1129
14. Arnall D.A., Marker J.C., Conlee R.K., et al. Effect of infusing epinephrine on liver and muscle glycogenolysis during exercise in rats. Am J Physiol. 250:1986;E641-649
15. Benthem L., van der Leest J., Steffens A.B., et al. Metabolic and hormonal responses to adrenoceptor antagonists in exercising rats. Metabolism. 44:1995;245-253
16. Benthem L., van der Leest J., Steffens A.B., et al. Metabolic and hormonal responses to adrenoceptor antagonists in 48-hour-starved exercising rats. Metabolism. 44:1995;1332-1339
17. Scheurink A.J., Steffens A.B., Benthem L. Central and peripheral adrenoceptors affect glucose, free fatty acids, and insulin in exercising rats. Am J Physiol. 255:1988;R547-R556
18. 3-adrenoceptor agonist BRL 35135 in obese Zucker rats by exercise. Br J Pharmacol. 113:1994;1231-1236
19. Ullrich S., Wollheim C.B. GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells Lack of correlation between insulin secretion and cyclic AMP levels. J Biol Chem. 263:1988;8615-8620
20. 2+-induced insulin secretion from electrically permeabilized islets of Langerhans. FEBS Lett. 219:1987;139-144
21. 2+, cyclic AMP, a phorbol ester, and noradrenaline. Biochem J. 254:1988;397-403
22. 2-adrenergic inhibition of insulin secretion via interference with cyclic AMP generation in rat pancreatic islets. Mol Pharmacol. 21:1982;648-653
23. 2+-independent insulin release independently from its action on adenylyl cyclase. Endocr J. 48:2001;647-654
24. Sharp G.W. Mechanisms of inhibition of insulin release. Am J Physiol. 271:1996;C1781-1799
25. Lang J. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem. 259:1999;3-17
26. Dela F., Mikines K.J., Tronier B., et al. Diminished arginine-stimulated insulin secretion in trained men. J Appl Physiol. 69:1990;261-267
27. Galbo H., Hedeskov C.J., Capito K., et al. The effect of physical training on insulin secretion of rat pancreatic islets. Acta Physiol Scand. 111:1981;75-79
28. Farrell P.A., Caston A.L., Rodd D., et al. Effect of training on insulin secretion from single pancreatic beta cells. Med Sci Sports Exerc. 24:1992;426-433
29. Greiwe J.S., Hickner R.C., Shah S.D., et al. Norepinephrine response to exercise at the same relative intensity before and after endurance exercise training. J Appl Physiol. 86:1999;531-535
30. Izawa T., Komabayashi T., Shinoda S., et al. Possible mechanism of regulating adenylate cyclase activity in adipocyte membranes from exercise-trained male rats. Biochem Biophys Res Commun. 151:1988;1262-1268
31. Gotoh M., Maki T., Kiyoizumi T., et al. An improved method for isolation of mouse pancreatic islets. Transplantation. 40:1985;437-438
32. 2-adrenergic receptor subtypes to distinct G-proteins. J Biol Chem. 267:1992;9844-9851
33. 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go. J Biol Chem. 267:1992;9852-9857
34. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685
35. 2+ in rat pancreatic islets. Proc Natl Acad Sci USA. 92:1995;10728-10732
36. Straub S.G., Sharp G.W. A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide. J Biol Chem. 271:1996;1660-1668
37. 2-adrenergic receptors by epinephrine during exercise in human adipose tissue. Am J Physiol. 277:1999;R1076-R1083
38. Mikines K.J., Dela F., Sonne B., et al. Insulin action and insulin secretion Effects of different levels of physical activity. Can J Sport Sci. 12:1987;113-116
39. Yada T., Sakurada M., Ihida K., et al. Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells. J Biol Chem. 269:1994;1290-1293
40. Renstrom E., Eliasson L., Rorsman P. Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells. J Physiol (Lond). 502:1997;105-118
41. 2+-dependent exocytosis in pancreatic beta cells. Proc Natl Acad Sci USA. 96:1999;760-765
42. 2+/calmodulin and cyclic 3,5′ adenosine monophosphate control movement of secretory granules through protein phosphorylation/dephosphorylation in the pancreatic beta-cell. Endocrinology. 137:1996;4644-4649
43. Persaud S.J., Jones P.M., Howell S.L. Glucose-stimulated insulin secretion is not dependent on activation of protein kinase A. Biochem Biophys Res Commun. 173:1990;833-839
44. Bode H.P., Moormann B., Dabew R., et al. Glucagon-like peptide 1 elevates cytosolic calcium in pancreatic β-cells independently of protein kinase A. Endocrinology. 140:1990;3919-3927
45. Gromada J., Bokvist K., Ding W.G., et al. Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic β-cells by both proximal and distal regulatory steps in stimulus-secretion coupling. Diabetes. 47:1998;57-65
46. 2+-independent pathways in stimulus-coupling to insulin secretion can be distinguished by their guanosine triphosphate requirements Studies on rat pancreatic islets. Endocrinology. 139:1998;1172-1183
47. Botion L.M., Braiser A.R., Tian B., et al. Inhibition of proteasome activity blocks the ability of TNFα to down-regulate Gi proteins and stimulate lipolysis. Endocrinology. 142:2001;5069-5075
48. 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation. Biochemistry. 37:1998;15720-15725
49. Busconi L., Guan J., Denker B.M. Degradation of heterotrimeric Gαo subunits via the proteosome pathway is induced by the hsp90-specific compound geldanamycin. J Biol Chem. 275:2000;1565-1569
50. Madura K., Varshavsky A. Degradation of G alpha by the N-end rule pathway. Science. 265:1994;1454-1458
51. Marotti L.A. Jr, Newitt R., Wang Y., et al. Direct identification of a G protein ubiquitination site by mass spectrometry. Biochemistry. 241:2002;5067-5074
52. Radak Z., Kaneko T., Tahara S., et al. The effect of exercise training on oxidative damage of lipids, proteins, and DNA in rat skeletal muscle Evidence for beneficial outcomes. Free Radic Biol Med. 27:1999;69-74
53. Kraus-Friedmann N. Hormonal regulation of hepatic gluconeogenesis. Physiol Rev. 64:1984;170-259
54. Fitts R.H., Booth F.W., Winder W.W., et al. Skeletal muscle respiratory capacity, endurance, and glycogen utilization. Am J Physiol. 228:1975;1029-1033