Effect of overexpression of constitutively active PKCα on rat lacrimal gland protein secretion

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 11, 2004, Pages 3974-3981

  Hodges, Robin R ^a   Raddassi, Isabelle ^a   Zoukbri, Driss ^c   Toker, Alex ^b   Kazlauskas, Andrius ^a   Dartt, Darlene A ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c TUFTS UNIVERSITY SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE C ALPHA;

ACINAR CELL; ALPHA ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL TYPE; CHOLINERGIC STIMULATION; DRY EYE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; LACRIMAL GLAND; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; TEAR FILM; WESTERN BLOTTING;

ADENOVIRIDAE; ADRENERGIC ALPHA-AGONISTS; ANIMALS; BLOTTING, WESTERN; CALCIUM; CARBACHOL; CHOLINERGIC AGONISTS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GREEN FLUORESCENT PROTEINS; ISOENZYMES; LACRIMAL APPARATUS; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; PHENYLEPHRINE; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; RATS; RATS, SPRAGUE-DAWLEY; TRANSDUCTION, GENETIC;

EID: 6944233583     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0508     Document Type: Article

References (41)

1. Dartt DA. Regulation of lacrimal gland secretion by neurotransmitters and the EGF family of growth factors. Exp Eye Res. 2001;73:741-752.
2. Schaumberg DA, Sullivan DA, Buring JE, Dana MR. Prevalence of dry eye syndrome among US women. Am J Ophthalmol. 2003;136:318-326.
3. Ding C, Walcott B, Keyser KT. Neuronal nitric oxide synthase and the autonomic innervation of the mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2001;42:2789-2794.
4. Botelho SY, Hisada M, Fuenmayor N. Functional innervation of the lacrimal gland in the cat: origin of secretomotor fibers in the lacrimal nerve. Arch Ophthalmol. 1966;76:581-588.
5. Ehinger B. Distribution of adrenergic nerves in the eye and some related structures in the cat. Acta Physiol Scand. 1966;66:123-128.
6. Powell CC, Martin CL. Distribution of cholinergic and adrenergic nerve fibers in the lacrimal glands of dogs. Am J Vet Res. 1989;50:2084-2088.
7. 3 muscarinic acetylcholine receptor coupling to PLC in rat exorbital lacrimal acinar cells. Am J Physiol. 1993;264:C1550-C1560.
8. Meneray MA, Fields TY, Bennett DJ. Gs and Gq/11 couple vasoactive intestinal peptide and cholinergic stimulation to lacrimal secretion. Invest Ophthalmol Vis Sci. 1997;38:1261-1270.
9. Godfrey PP, Putney JW Jr. Receptor-mediated metabolism of the phosphoinositides and phosphatidic acid in rat lacrimal acinar cells. Biochem J. 1984;218:187-195.
10. Dartt DA, Dicker DM, Ronco LV, Kjeldsen IM, Hodges RR, Murphy SA. Lacrimal gland inositol trisphosphate isomer and inositol tetrakisphosphate production. Am J Physiol. 1990;259:G274-281.
11. Sundermeier T, Matthews G, Brink PR, Walcott B. Calcium dependence of exocytosis in lacrimal gland acinar cells. Am J Physiol. 2002;282:C360-C365.
12. Satoh Y, Sano K, Habara Y, Kanno T. Effects of carbachol and catecholamines on ultrastructure and intracellular calcium-ion dynamics of acinar and myoepithelial cells of lacrimal glands. Cell Tissue Res. 1997;289:473-485.
13. Mauduit P, Herman G, Rossignol B. Effect of trifluoperazine on SH-labeled protein secretion induced by pentoxifylline, cholinergic or adrenergic agonists in rat lacrimal gland: a possible role of calmodulin? FEBS Lett. 1983;152:207-211.
14. Dartt DA, Ronco LV, Murphy SA, Unser MF. Effect of phorbol esters on rat lacrimal gland protein secretion. Invest Ophthalmol Vis Sci. 1988;29:1726-1731.
15. Zoukhri D, Hodges RR, Sergherraert C, Toker A, Dartt DA. Lacrimal gland PKC isoforms are differentially involved in agonist-induced protein secretion. Am J Physiol. 1997;272C263-C269.
16. 1-Adrenergic and cholinergic agonists use separate signal transduction pathways in lacrimal gland. Am J Physiol. 1992;262G1087-G1096.
17. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 1992;258:607-614.
18. Newton AC. Protein kinase C: structure, function, and regulation. J Biol Chem. 1995;270:28495-28498.
19. Mackay K, Mochly-Rosen D. Localization, anchoring, and functions of protein kinase C isozymes in the heart. J Mol Cell Cardiol. 2001;33:1301-1307.
20. Zoukhri D Hodges RR, Willert S, Dartt DA. Immunolocalization of lacrimal gland PKC isoforms: effect of phorbol esters and cholinergic agonists on their cellular distribution. J Membr Biol. 1997;157:169-175.
21. Tan YP, Marty A. Protein kinase C-mediated desensitization of the muscarinic response in rat lacrimal gland cells. J Physiol. 1991;43:357-371.
22. Zoukhri D, Hodges RR, Sergheraert C, Dartt DA. Cholinergic-induced Ca2+ elevation in rat lacrimal gland acini is negatively modulated by PKCdelta and PKCepsilon. Invest Ophthalmol Vis Sci. 2000;41:386-392.
23. Berne CP, Elliott AC. Activation of protein kinase C does not cause desensitization in rat and rabbit mandibular acinar cells. Pflugers Arch. 1994;428:163-172.
24. Gromada J, Jorgensen TD, Dissing S. The release of intracellular Ca2+ in lacrimal acinar cells by alpha-, beta-adrenergic and muscarinic cholinergic stimulation: the roles of inositol triphosphate and cyclic ADP-ribose. Pflugers Arch. 1995;429:751-761.
25. Lee-Kwon W, Johns DC, Cha B, et al. Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3. J Biol Chem. 2001;276:31296-31304.
26. Althoefer H, Eversole-Cire P, Simon MI. Constitutively Active Galpha q and Galpha 13 trigger apoptosis through different pathways. J Biol Chem. 1997;272:24380-24386.
27. Kim HH, Chung WJ, Lee SW, et al. Association of sustained ERK activity with integrin beta3 induction during receptor activator of nuclear factor kappaB ligand (RANKL)-directed osteoclast differentiation. Exp Cell Res. 2003;289:368-377.
28. Scapoli L, Ramos-Nino ME, Martinelli M, Mossman BT. Src-dependent ERK5 and Src/EGFR-dependent ERK1/2 activation is required for cell proliferation by asbestos. Oncogene. 2004;23:805-813.
29. Holstein DM, Berg KA, Leeb-Lundberg LMF, Olson MS, Saunders C. Calcium-sensing receptor-mediated ERK1/2 activation requires Galpha i2-coupling and dynamin-independent receptor internalization. J Biol Chem. 2004;279:10060-10069.
30. Zhao J, Renner O, Wightman L, et al. The expression of constitutively active isotypes of protein kinase C to investigate preconditioning. J Biol Chem. 1998;273:23072-23079.
31. Rabinovitz I Toker A, Mercurio AM. Protein kinase C-dependent mobilization of the a6b4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. J Cell Biol. 1999;146:1147-1159.
32. 2+ indicators with greatly improved fluorescence properties. J Biol Chem. 1985;260:3440-3450.
33. Keranen LM, Dutil EM, Newton AC. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol. 1995;5:1394-1403.
34. Zoukhri D, Hodges RR, Dartt DA. Lacrimal gland innervation is not altered with the onset and progression of disease in a murine model of Sjogren's syndrome. Clin Immunol Immunopathol. 1998;89:126-133.
35. Zoukhri D, Kublin, CL. Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjogren's syndrome. Invest Ophthalmol Vis Sci. 2001;42:925-932.
36. Jaken S, Parker PJ. Protein kinase C binding partners. Bioessays. 2000;22:245-254.
37. Dempsey EC, Newton AC, Mochly-Rosen D, et al. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol. 2000;279:L429-L438.
38. Akita Y, Ohno S, Yajima Y, et al. Overproduction of a Ca(2+)-independent protein kinase C isozyme, nPKC epsilon, increases the secretion of prolactin from thyrotropin-releasing hormone-stimulated rat pituitary GH4C1 cells. J Biol Chem. 1994;269:4653-4660.
39. Hamm-Alvarez SF, Xie J, Wang Y, Medina-Kauwe LK. Modulation of secretory functions in epithelia by adenovirus capsid proteins. J Control Release. 2003;93:129-140.
40. Chen X, Edwards JA, Logsdon CD, Ernst SA, Williams JA. Dominant negative Rab3D inhibits amylase release from mouse pancreatic acini. J Biol Chem. 2002;277:18002-18009.
41. Wang Y, Xie J, Yarber FA, et al. Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland. Gene Ther. 2004;11:970-981.