Lacrimal gland PKC isoforms are differentially involved in agonist- induced protein secretion

American Journal of Physiology - Cell Physiology

Volumn 272, Issue 1 41-1, 1997, Pages

  Zoukhri, Driss ^a,d   Hodges, Robin R ^a   Sergheraert, Christian ^b   Toker, Alex ^c   Dartt, Darlene A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INSTITUT PASTEUR DE LILLE   (France)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

cholinergic; protein kinase A; protein kinase C; vasoactive intestinal peptide; 1 adrenergic

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; PROTEIN KINASE C;

ACINAR CELL; ALPHA ADRENERGIC STIMULATION; ANIMAL TISSUE; ARTICLE; CHOLINERGIC STIMULATION; CONTROLLED STUDY; LACRIMAL GLAND; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; TRANSPORT KINETICS;

EID: 0031032192     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1997.272.1.c263     Document Type: Article

References (36)

1. 1 cells. J. Biol. Chem. 269: 4653-4660, 1994.
2. Ashendel, C. L. The phorbol ester receptor: a phospholipid-regulated protein kinase. Biochim. Biophys. Acta 822: 219-242, 1985.
3. Baker, P. F. Calcium channels and other devices for effecting stimulus-exocytosis coupling. In: Structure and Physiology of the Slow Inward Calcium Channel. New York: Liss, 1987, p. 247-265.
4. Berridge, M. J. Inositol trisphosphate and diacylglycerol: two interacting second messengers. Annu. Rev. Biochem. 56: 159-193, 1987.
5. Castagna, M., Y. Takai, K. Kaibuchi, K. Sano, U. Kikkawa, and Y. Nishizuka. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumour-promoting phorbol esters. J. Biol. Chem. 257: 7847-7851, 1982.
6. Dartt, D. A. Regulation of inositol phosphates, calcium and protein kinase C in the lacrimal gland. Prog. Retina Eye Res. 13: 443-478, 1994.
7. Dartt, D. A., A. K. Baker, C. Vaillant, and P. E. Rose. Vasoactive intestinal polypeptide stimulation of protein secretion from rat lacrimal gland acini. Am. J. Physiol. 247 (Gastrointest. Liver Physiol. 10): G502-G509, 1984.
8. Dartt, D. A., L. V. Ronco, S. A. Murphy, and M. F. Unser. Effect of phorbol esters on rat lacrimal gland protein secretion. Invest. Ophthalmol. Vis. Sci. 29: 1726-1731, 1988.
9. Dekker, L. V., and P. J. Parker. Protein kinase C - a question of specificity. Trends Biochem. Sci. 19: 73-77, 1994.
10. Eichholtz, T., B. A. de Bons, J. de Widt, M. J. Liskamp, and H. L. Ploegh. A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor. J. Biol. Chem. 268: 1982-1986, 1993.
11. Herman, G., S. Busson, L. Ovtracht, C. Maurs, and B. Rossignol. Regualtion of protein discharge in two exocrine glands: rat parotid and exorbital lacrimal glands. Biol. Cell 31: 255-264, 1978.
12. 1-Adrenergic and cholinergic agonists use separate signal transduction pathways in lacrimal gland. Am. J. Physiol. 262 (Gastrointest. Liver Physiol. 25): G1087-G1096, 1992.
13. House, C., and B. E. Kemp. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science Wash. DC 238: 1726-1728, 1987.
14. Housey, G. M., M. D. Johnson, W. L. W. Hsiao, C. A. O'Brian, J. P. Murphy, P. Kirschmeier, and I. B. Weinstein. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell 52: 343-354, 1988.
15. Hug, H., and T. F. Sarre. Protein kinase C isoenzymes: divergence in signal transaction? Biochem. J. 291: 329-343, 1993.
16. Jaken, S. Protein kinase C isozymes and substrates. Curr. Biol. 8: 168-173, 1996.
17. Klauck, T. M., M. C. Faux, K. Labudda, L. K. Langeberg, S. Jaken, and J. D. Scott. Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science Wash. DC 271: 1589-1592, 1996.
18. Lehel, C., Z. Oláh, G. Jkab, Z. Szállási, G. Petrovics, G. Harta, P. M. Blumberg, and W. B. Anderson. Protein kinase C ε subcellular localization domains and proteolytic degradation sites. A model for protein kinase C conformational changes. J. Biol. Chem. 270: 19651-19658, 1995.
19. 3 muscarinic acetylcholine receptor coupling to PLC in rat exorbital lacrimal acinar cells. Am. J. Physiol. 264 (Cell Physiol 33): C1550-C1560, 1993.
20. Mochly-Rosen, D. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science Wash. DC 268: 247-251, 1995.
21. Mochly-Rosen, D., H. Khaner, and J. Lopez. Identification of intracellular receptor proteins for activated protein kinase C. Proc. Natl. Acad. Sci. USA 88: 3997-4000, 1991.
22. Newton, A. C. Interaction of proteins with lipid headgroups: lessons from protein kinase C. Annu. Rev. Biophys. Biomol. Struct. 22: 1-25, 1993.
23. Newton, A. C. Protein kinase C: structure, function, and regulation. J. Biol. Chem. 270: 28495-28498, 1995.
24. Nishizuka, Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature Lond. 334: 661-665, 1988.
25. Nishizuka, Y. Protein kinase C and lipid signaling for sustained responses. FASEB J. 9: 484-496, 1995.
26. Rüegg, U. T., and G. M. Burgess. Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. Trends Pharmacol. Sci. 10: 218-220, 1989.
27. Singer, W. D., H. A. Brown, X. Jiang, and P. C. Sternweis. Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and indepenedent of protein kinase activity. J. Biol. Chem. 271: 4504-4510, 1996.
28. Smith, B. L., and D. Mochly-Rosen. Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme. Biochem. Biophys. Res. Commun. 188: 1235-1240, 1992.
29. Staudinger, J., J. Zhou, R. Burgess, S. J. Elledge, and E. N. Olson. PICK1: a perinuclear binding protein and substrate of protein kinase C isolated by the yeast two-hybrid system. J. Cell Biol. 128: 263-271, 1995.
30. 3. J. Biol. Chem. 269: 32358-32367, 1994.
31. Verhoeven, A. J., J. H. Leucen, G. C. Kessels, P. M. Hilarius, D. B. de Bont, and R. M. Liskamp. Inhibition of neutrophils NADPH oxidase assembly by a myristoylated pseudosubstrate of protein kinase C. J. Biol. Chem. 268: 18593-18598, 1993.
32. Zhou, G., M. W. Wooten, and E. S. Coleman. Regulation of atypical ζ-protein kinase C in cellular signaling. Exp. Cell Res. 214: 1-11, 1994.
33. Zoukhri, D., and D. A. Dartt. Cholinergic activation of phospholipase D in lacrimal gland acini is independent of protein kinase C and calcium. Am. J. Physiol. 268 (Cell Physiol. 37): C713-C720, 1995.
34. Zoukhri, D., R. R. Hodges, D. M. Dicker, and D. A. Dartt. Role of protein kinase C in cholinergic stimulation of lacrimal gland protein secretion. FEBS Lett. 351: 67-72, 1994.
35. Zoukhri, D., J. M. Pelosin, P. Mauduit, E. Chambaz, C. Sergheraert, and B. Rossignol. The rat lacrimal gland expresses the α isoform of PKC: further evidence for the PMA-activated and phospholipid-independent protein kinase activity. Cell. Signal. 4: 111-119, 1992.
36. Zoukhri, D., C. Sergheraert, and B. Rossignol. Phorbol ester-stimulated exocytosis in lacrimal gland: PKC might not be the sole effector. Am. J. Physiol. 264 (Cell Physiol. 33): C1045-C1050, 1993.