Terahertz technology in biology and medicine

IEEE Transactions on Microwave Theory and Techniques

Volumn 52, Issue 10, 2004, Pages 2438-2447

  Siegel, Peter H ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Applications; Biology; Medicine; Technology; Terahertz

Indexed keywords

BIOMEDICAL ENGINEERING; DATA ACQUISITION; INFRARED RADIATION; MOLECULAR SPECTROSCOPY; OPTICAL RESOLVING POWER; PLASMA DIAGNOSTICS; SUBMILLIMETER WAVES;

DISEASE DIAGNOSTICS; DNA SEQUENCING; MICROWAVE TECHNIQUES; TERAHERTZ;

REMOTE SENSING;

EID: 6944229531     PISSN: 00189480     EISSN: None     Source Type: Journal    
DOI: 10.1109/TMTT.2004.835916     Document Type: Article

References (99)

1. R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, "Terahertz pulse imaging of ex vivo basal cell carcinoma," J. Investigative Dermatol., vol. 120, no. 1, pp. 72-78, Jan. 2003.
2. A. Markelz, S. Whitmore, J. Hillebrecht, and R. Birge, "THz time domain spectroscopy of bimolecular conformational modes," Phys. Med. Biol., vol. 47, no. 21, pp. 3797-3805. Nov. 2002.
3. S. P. Mickan, A. Menikhu, H. Liu, C. A. Mannella, R. MacColl, D. Abbott, J. Munch, and X.-C. Zhang, "Label-free bioaffinity detection using terahertz technology," Phys. Med. Biol., vol. 47, no. 21, pp. 3789-3795, Nov. 2002.
4. P. H. Bolivar, M. Brucherseifer, M. Nagel, H. Kurz, A. Bosserhoff, and R. Buttner, "Label-free probing of genes by time domain terahertz sensing," Phys. Med. Biol., vol. 47, no. 21, pp. 3815-3821, Nov. 2002.
5. K. J. Seibert, T. Loffler, H. Quast, M, Thomson, T. Bauer, R. Leonhardt, S. Czasch, and H. G. Roskos, "All-optoelectronic continuous wave THz imaging for biomedical applications," Phys. Med. Biol., vol. 47, no. 21, pp. 3743-3748, Nov. 2002.
6. A. J. Fitzgerald, E. Berry, N. N. Zinov'ev, S. Homer-Vanniasinkam, R. E. Miles, J. M. Chamberlain, and M. A. Smith, "Catalogue of human tissue optical properties at terahertz frequencies," J. Biol. Phys., vol. 29, no. 2/3, pp. 123-128, 2003.
7. M. R. Scarfi, M. Romano, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, and M. D'Arienzo, "THz exposure of whole blood for the study of biological effects on human lymphocytes," J. Biol. Phys., vol. 29, no. 2/3, pp. 171-176, 2003.
8. V. P. Wallace, private communication, 2003.
9. P. H. Siegel and R. J. Dengler, "Terahertz heterodyne imager for biomedical applications," presented at the NASA/NCI Fundamental Technologies for Biomolecular Sensors, Chicago, IL, July 28-29, 2003.
10. O. V. Betskii and N. N. Lebedeva, "Current concepts on the mechanisms of action of low-intensity millimeter waves on biological objects" (in Russian), Online Journal of United Phys. Soc. Russian Federation, vol. 4, 2001.
11. B. B. Hu and M. C. Nuss, "Imaging with terahertz waves," Opt. Lett., vol. 20, no. 16, pp. 1716-1718, Aug. 1995.
12. S. P. Mickan and X.-C. Zhang, "T-ray sensing and imaging," in Terahertz Sensing Technology: Electronic Devices and Advanced Systems Technology, D. L. Woolard, W. R. Loerop, and M. S. Shur, Eds, Singapore: World Sci., July 2003, pp. 251-326.
13. D. Mittleman, Ed., Sensing With Terahertz Radiation. ser. Opt. Sci.. Berlin, Germany: Springer-Verlag, 2003.
14. D. L. Woolard, W. R. Loerop, and M. S. Shur, Eds., Terahertz Sensing Technology: Electronic Devices and Advanced Systems Technology, Singapore: World Sci., 2003.
15. J. Biol. Phys., vol. 29, no. 2/3, 2002.
16. Phys. Med. Biol., vol. 47, no. 21, Nov. 2002.
17. S. W. Smye, J. M. Chamberlain, A. J. Fitzgerald, and E. Berry, "The interaction between terahertz radiation and biological tissue," Phys. Med. Biol., vol. 46, no. 9, pp. R101-R112, Sept. 2001.
18. A. J. Fitzgerald, E. Berry, N. N. Zinovev, G. C. Walker, M. A. Smith, and J. M. Chamberlain, "An introduction to medical imaging with coherent terahertz radiation," Phys. Med. Biol., vol. 47, no. 21, pp. R67-R84, Nov. 2002.
19. A. F. Lawrence, J. C. McDaniel, D. B. Chang, and R. Birge, "The nature of phonons and solitary waves in α-helical proteins," Biophys. J., vol. 51, pp. 785-793, May 1987.
20. L. Young, V. V. Prabhu, E. W. Prohofsky, and G. S. Edwards, "Prediction of modes with dominant base roll and propeller twist in B-DNA poly(dA)-poly(dT)," Phys. Rev. A, Gen. Phys., vol. 41, no. 12, pp. 7020-7023, June 1990.
21. 2O)," in Handbook of Optical Constants of Solids II, E. D. Palik, Ed. Boston, MA: Academic, 1991, pp. 1067-1077.
22. M. C. Nuss and J. Orenstein, "Terahertz time domain spectroscopy (THz-TDS)," in Millimeter-Wave Spectroscopy of Solids, G. Gruener, Ed. Heidelberg, Germany: Springer-Verlag, 1997.
23. -1," Appl. Spectrosc., vol. 50, no. 8, pp. 1047-1057, Aug. 1996.
24. J. T. Kindt and C. A. Schmuttenmaer, "Far-infrared dielectric properties of polar liquids probed by femtosecond terahertz pulse spectroscopy," J. Phys. Chem., vol. 100, no. 24, pp. 10373-10379, June 1996.
25. Y. Ulgen and M. Sezdi, "Electrical parameters of human blood," in Proc. 20th Annu. Int. IEEE EMBS Conf., vol. 6, Oct. 29-Nov. 1, 1998, pp. 2983-2986.
26. M. J. Peters, J. G. Stinstra, and M. Hendricks, "Estimation of the electrical conductivity of human tissue," Electromagnetics, vol. 21, no. 7/8, pp. 545-557, Oct.-Dec. 2001.
27. E. Giovenale, M. D'Arienzo, A. Doria, G. P. Gallerano, A. Lai, G. Mesina, and D. Piccinelli, "Absorption and diffusion measurements of biological samples using a THz free electron, laser," J. Biol. Phys., vol. 29, no. 2/3, pp. 159-170, 2003.
28. A. R. von Hippel, Tables of Dielectric Materials. Norwood, MA: Artech House, 1995.
29. S. Hadjiloucas, L. S. Karatzas, and J. W. Bowen, "Measurements of leaf water content using terahertz radiation," IEEE Trans. Microwave Theory Tech., vol. 47, pp. 142-149, Feb. 1999.
30. D. M. Mittleman, M. Gupta, R. Neelamani, R. G. Baraniuk, J. V. Rudd, and M. Koch, "Recent advances in terahertz imaging," Appl. Phys. B, Photophys. Laser Chem., vol. B68, no. 6, pp. 1085-1094, June 1999.
31. R. M. Woodward, V. P. Wallace, D. D. Arnone, E. H. Linfield, and M. Pepper, "Terahertz pulsed imaging of skin cancer in the time and frequency domain," J. Biol. Phys., vol. 29, no. 2/3, pp. 257-259, 2003.
32. S. Hadjiloucas and J. W. Bowen, "Precision of quasioptical null-balanced bridge techniques for transmission and reflection coefficient measurements," Rev. Sci. Instrum., vol. 70, no. 1, pp. 213-219, Jan. 1999.
33. D. M. Mittleman, R. H. Jacobsen, and M. C. Nuss, "T-ray imaging," IEEE J. Select. Topics Quantum Electron., vol. 2, pp. 679-692, Sept. 1996.
34. P. H. Siegel and R. J. Dengler, "Terahertz heterodyne imager for biomedical applications," presented at the SPIE Terahertz and Gigahertz Electronics and Photonics III Conf., vol. 5354, San Jose, CA, Jan. 25-26, 2004.
35. _, "Applications & early results from THz heterodyne imaging at 119 μm," presented at the Joint 29th Int. Infrared and Millimeter Waves and 12th Int. Conf. on Terahertz Electronics Conf., Karlsruhe, Germany, Sept. 27-Oct. 1, 2004.
36. F. N. Keutsch, M. G. Brown, P. B. Petrersen, R. J. Saykally, M. Geleljins, and A. van der Avoird, "Terahertz vibration-rotation-tunneling spectroscopy of water clusters in the translational band region of liquid water," J. Chem. Phys., vol. 114, no. 9, pp. 3993-4004, Mar. 2001.
37. C. Ronne, L. Thrane, P.-O. Astrand, A. Wallqvist, K. V. Mikkelsen, and S. Keiding, "Investigation of the temperature dependence of dielectric relaxation in liquid water by THz reflection spectroscopy and molecular dynamics simulation," J. Chem. Phys., vol. 107, no. 14, pp. 5319-5331, Oct. 1997.
38. F. De Lucia, "Spectroscopy in the terahertz spectral region," in Sensing With Terahertz Radiation, D. Mittleman, Ed. Berlin, Germany: Springer-Verlag, 2003, pp. 39-115.
39. P. H. Siegel, "Terahertz technology," IEEE Trans. Microwave Theory Tech., vol. 50, pp. 910-928, Mar. 2002.
40. A. G. Markelz, A. Roitberg, and E. J. Heilweil, "Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz," Chem. Phys. Lett., vol. 320, pp. 42-48, Mar. 31, 2000.
41. M. Walther, B. Fischer, M. Schall, H. Helm, and P. Uhd Jepsen, "Far-infrared vibrational spectra of all-trans, 9-cis and 13-cis retinal measured by THz time-domain spectroscopy," Chem. Phys. Lett., vol. 332, pp. 389-395, Dec. 22, 2000.
42. P. Martel, P. Calmettes, and B. Hennion, "Vibrational modes of hemoglobin in red blood cells," Biophys. J., vol. 59, pp. 363-377, Feb. 1991.
43. T. S. Hartwick, D. T. Hodges, D. H. Barker, and F. B. Foote, "Far infrared imagery," Appl. Opt., vol. 15, no. 8, pp. 1919-1922, Aug. 1976.
44. S. C. Shen, L. Santo, and L. Genzel, "Far infrared spectroscopy of amino acids, polypeptides and proteins," Can. J. Spectrosc., vol. 26, no. 3, pp. 126-133, Mar. 1981.
45. F. L. Gervasio, G. C. Cardini, P. R. Salvi, and V. Schettino, "Low-frequency vibrations of all-trans-retinal: Far infrared ad Raman spectra and density functional calculations," J. Phys. Chem. A, vol. 102, no. 12, pp. 2131-2136, Mar. 1998.
46. D. Grischkowsky, S. R. Keiding, M. Van Exter, and C. Fattinger, "Far-infrared time-domain spectroscopy with terahertz beams of dielectrics and semiconductors," J. Opt. Soc. Amer. B, Opt. Image Sci., vol. 7, no. 10, pp. 2006-2015, Oct. 1990.
47. E. R. Brown, "Fundamentals of terrestrial millimeter-wave and THz remote sensing," in Terahertz Sensing Technology Volume II: Emerging Scientific Applications and Novel Device Concepts, D. L. Woolard, W. R. Loerop, and M. S. Shur, Eds, Singapore: World Sci., 2003.
48. X. Y. Liu, Q. Yang, C. Nakamura, and J. Miyake, "Avidin-biotin-immobilized liposome column for chromatographic fluorescence on-line analysis of solute-membrane interactions," J. Chromatography B, vol. 750, no. 1, pp. 51-60, Jan. 2001.
49. K. Hoya, L. R. Guterman, L. Miskolczi, and L. N. Hopkins, "A novel intravascular drug delivery method using endothelial biotinylation and avidin-biotin binding," Drug Delivery, vol. 8, no. 4, pp. 215-222, Oct.-Dec. 2001.
50. N. Emans, J. Biwersi, and A. Verkman, "Imaging of endosome fusion in Bhk fibroblasts based on a novel fluorometric avidin-biotin binding assay," Biophys. J., vol. 69, no. 2, pp. 716-728, Aug. 1995.
51. M. Nagel, P. H. Bolivar, M. Brucherseifer, H. Kurz, A. Bosserhoff, and R. Büttner, "Integrated THz technology for label-free genetic diagnostics," Appl. Phys. Lett., vol. 80, no. 1, pp. 154-156, Jan. 2002.
52. H. Frohlich, "Long range coherence and energy storage in biological systems," Int. J. Quantum Chem., vol. II, pp. 641-649, Feb. 1968.
53. G. W. Chantry and H. A. Gibbie, "Submillimeter wave spectra of polar liquids," Nature, vol. 208, p. 378, Oct. 1965.
54. C. P. Beetz and G. Ascarelli, "Far-infrared absorption of nucleotides and Poly(I).Poly(C) RNA," Biopolymers, vol. 21, no. 8, pp. 1569-1586, Aug. 1982.
55. L. Young, V. V. Prabhu, E. W. Prohofsky, and G. S. Edwards, "Prediction of modes with dominant base roll and propeller twist in B-DNA and poly(dA)-poly(dT)," Phys. Rev. A, Gen. Phys., vol. 41, no. 12, pp. 7010-7023, June 1990.
56. V. K. Saxena, B. H. Dorfman, and L. L. Van Zandt, "Identifying and interpreting spectral features of dissolved poly(dA)-poly(dT) DNA polymer in the high-microwave range," Phys. Rev. A, Gen. Phys., vol. 43, no. 8, pp. 4510-4516, Apr. 1991.
57. B. M. Fischer, M. Walther, and P. Jepsen, "Far-infrared vibrational modes of DNA components studied by terahertz time domain spectroscopy," Phys. Med. Biol., vol. 47, no. 21, pp. 3807-3814, Nov. 2002.
58. T. R. Globus, D. L. Woolard, T. Khromova, T. W. Crowe, M. Bykhovskaia, B. L. Gelmont, J. Hesler, and A. C. Samuels, "THz-spectroscopy of biological molecules," J. Biol. Phys., vol. 29, no. 2/3, pp. 89-100, 2003.
59. M. K. Choi, K. Taylor, A. Bettermann, and D. W. van der Weide, "Broadband 10-300 GHz stimulus-response sensing for chemical and biological entities," Phys. Med. Biol., vol. 47, no. 21, pp. 3777-3789, Nov. 2002.
60. P. F. Taday, "Applications of terahertz spectroscopy to medical and pharmaceutical sciences," presented at the Discussion Meeting on the THz Gap: The Generation of Far-Infrared Radiation and Its Applications, London, U.K., June 2003.
61. P. F. Taday, I. V. Bradley, D. D. Arnone, and M. Pepper, "Using terahertz pulse spectroscopy to study the crystalline structure of a drug: A case study of the polymorphs of ranitidine hydrochloride," J. Pharmaceutical Sci., vol. 92, no. 4, pp. 831-838, Apr. 2003.
62. G. P. Gallerano, private communication, June 2004.
63. K. Kawase, J. Shikata, and H. Ito, "Terahertz wave parametric source," J. Phys. D, Appl. Phys., vol. 35, pp. R1-R14, Jan. 2002.
64. K. Kawase, private communication, Nov. 2003.
65. Y. Watanabe, K. Kawase, T. Ikari, H. Ito, Y. Ishikawa, and H. Minamide, "Spatial pattern separation of chemicals and frequency-independent components by terahertz spectroscopic imaging," Appl. Opt., vol. 42, no. 28, pp. 5744-5748, Oct. 2003.
66. P. H. Siegel, R. J. Dengler, E. Mueller, C. Readhead, and S. E. Fraser, "Scanned pixel heterodyne terahertz imaging," presented at the British Royal Soc. Terahertz Gap Meeting, June 3, 2003.
67. T. Loffler, K. Siebert, S. Czasch, T. Bauer, and H. G. Roskos, "Visualization and classification in biomedical terahertz pulsed imaging," Phys. Med. Biol., vol. 47, no. 21, pp. 3847-3852, Nov. 2002.
68. T. Loffler, T. Bauer, K. J. Siebert, H. G. Roskos, A. Fitzgerald, and S. Czasch, "Terahertz dark field imaging of biomedical tissue," Opt. Express, vol. 9, no. 12, pp. 616-621, Dec. 2001.
69. P. Knobloch, K. Schmalstieg, M. Koch, E. Rehberg, F. Vauti, and K. Donhuijsen, "THz imaging of histo-pathological samples," Proc. SPIE-Int. Soc. Opt. Eng., vol. 4434, pp. 239-245, Oct. 2001.
70. V. P. Wallace, D. Arnone, R. M. Woodward, and R. J. Pye, "Biomedical applications of terahertz pulsed imaging," in Proc. 2nd Joint EMBS/BMES Conf., Houston, TX, Oct. 23-28, 2002, pp. 2333-2334.
71. B. E. Cole, R. Woodward, D. Crawley, V. P. Wallace, D. D. Arnone, and M. Pepper, "Terahertz imaging and spectroscopy of human skin, in-vivo," Proc. SPIE-Int. Soc. Opt. Eng., vol. 4276, pp. 1-10, 2001.
72. R. M. Woodward, V. P. Wallace, B. E. Cole, R. J. Pyle, D. D. Arnone, E. H. Linfield, and M. Pepper, "Terahertz pulse imaging in reflection geometry of skin tissue using time domain analysis techniques," Proc. SPIE-Int. Soc. Opt. Eng., vol. 4625, pp. 160-169, 2002.
73. B. B. Hu and M. C. Nuss, "Imaging with terahertz waves," Opt. Lett., vol. 20, no. 16, pp. 1716-1718, Aug. 15, 1995.
74. B. Ferguson, S. Wang, D. Gray, D. Abbott, and X.-C. Zhang, "Toward functional 3D T-ray imaging," Phys. Med. Biol., vol. 47, no. 21, pp. 3735-3742, Nov. 2002.
75. D. A. Crawley, C. Longbottom, B. Cole, C. M. Ciesla, D. Arnone, V. Wallace, and M. Pepper, "Terahertz pulse imaging: A pilot study of potential applications in dentistry," Caries Res., vol. 37, no. 5, pp. 352-359, Sept.-Oct. 2003.
76. D. Mittleman, "Terahertz imaging," in Sensing With Terahertz Radiation, D. Mittleman, Ed. Berlin, Germany: Springer-Verlag, 2003, pp. 117-153.
77. P. Plassmann and T. D. Jones, "MAVIS: A noninvasive instrument to measure area and volume of wounds," Med. Eng. Phys., vol. 20, no. 5, pp. 332-338, July 1998.
78. B. F. Jones, "A reappraisal of the use of infrared thermal image analysis in medicine," IEEE Trans. Med. Imag., vol. 17, pp. 1019-1027, Dec. 1998.
79. J. Steketee, "Spectral emissivity of the skin and pericardium, " Phys. Med. Biol., vol. 18, no. 5, pp. 686-694, May 1973.
80. P. H. Siegel, R. P. Smith, S. Martin, and M. Gaidis, "2.5 THz GaAs monolithic membrane-diode mixer," IEEE Trans. Microwave Theory Tech., vol. 47, pp. 596-604, May 1999.
81. P. H. Siegel, "Flexible ribbon guide for in-vivo and hand-held THz imaging," NIH, Bethesda, MD, Grant applicat. PAR-03-075, Aug. 2003.
82. A. G. Pakhomov, Y. Akyel, O. N. Pakhomova, B. E. Stuck, and M. R. Murphy, "Current state and implications of research on biological effects of millimeter waves: A review of the literature," Bioelectromagnetics, vol. 19, no. 7, pp. 393-413, July 1998.
83. B. Veyret, "Biological effects in the microwave, THz and infrared regions," presented at the Terahertz Bridge Workshop, Capri, Italy, Sept. 29-Oct. 2, 2002.
84. P. Dumas and L. Miller, "Biological and biomedical applications of synchrotron infrared microspectroscopy," J. Biol. Phys., vol. 29, no. 2, pp. 201-218, Jan. 2003.
85. L. M. Miller, G. D. Smith, and G. L. Carr, "Synchrotron-based biological microspectroscopy: From the mid-infrared through the far-infrared regimes," J. Biol. Phys., vol. 29, no. 2, pp. 219-230, Jan. 2003.
86. R. H. Clothier and N. Bourne, "Effects of THz exposure on human primary keratinocyte differentiation and viability," J. Biol. Phys., vol. 29, no. 2, pp. 179-185, Jan. 2003.
87. A. Matei and M. Dressel, "Experimental determination of the far-infrared optical properties of biological matter in aqueous solution," J. Biol. Phys., vol. 29, no. 2, pp. 101-108, Jan. 2003.
88. A. Korenstein-Ilan, A. Gover, and R. Korenstien, "Genomic stability following exposure of human lymphocytes to THz radiation," presented at the Terahertz Bridge Workshop, Capri, Italy, Sept. 29-Oct. 2, 2002.
89. R. A. Freitas, Jr., Nanomedicine Volume I. Austin, TX: Landes Bioscience, 1999, p. 164.
90. E. Berry, G. C. Walker, A. J. Fitzgerald, N. N. Zinov'ev, M. Chamberlain, S. W. Smye, R. E. Miles, and M. A. Smith, "Do in-vivo terahertz imaging systems comply with safety guidelines," J. Laser Phys., vol. 13, no. 3, pp. 192-198, Aug. 2003.
91. J. Pokorny, A. Jandova, J. Kobilkova, K. Heyberger, and T. Hraba, "Frohlich electromagnetic radiation from human leukocytes: Implications for leukocyte adherence inhibition test," J. Theoretical Biol., vol. 102, pp. 295-305, 1983.
92. P. Goldsmith, Quasioptical Systems: Gaussian Beam Quasioptical Propagation and Applications. Piscataway, NJ: IEEE Press, 1998.
93. J. F. Federici, O. Mitrofanov, M. Lee, J. W. P. Hsu, I. Brener, R. Harel, J. D. Wynn, L. N. Pfeiffer, and K. W. West, "THz near field imaging, " Phys. Med. Biol., vol. 47, no. 21, pp. 3727-3734, Nov. 2002.
94. S. Hunsche, Y. Cai, I. Brener, M. C. Nuss, and J. Wynn, "Near field time resolved imaging with far-infrared dipole sources," in Lasers and Electro-Optics Conf., 1998, pp. 64-65.
95. N. J. C. Van der Valk and P. Planken, "Measurement of THz spot sizes with a lambda/200 diameter in the near-field of a metal tip," J. Biol. Phys., vol. 29, no. 2-3, pp. 239-245, 2003.
96. J. L. Johnson, T. D. Dorney, and D. M. Mittleman, "Interferometric imaging with terahertz pulses," IEEE J. Select. Topics Quantum Electron., vol. 7, pp. 592-599, July/Aug. 2001.
97. A. M. Chekalyuk, F. E. Hoge, C. W. Wright, R. N. Swift, and J. K. Yungel, "Airborne test of laser pump-and-probe technique for assessment of phytoplankton photochemical characteristics," Photosynthesis Res., vol. 66, no. 1, pp. 45-56, Jan. 2000.
98. A. Barkan, F. K. Tittel, D. M. Mittleman, R. Dengler, P. H. Siegel, G. Scalari, L. Ajili, J. Faist, H. E. Beere, E. H. Linfield, A. G. Davies, and D. A. Ritchie, "Linewidth and tuning characteristics of terahertz quantum cascade lasers," Opt. Lett., vol. 29, no. 6, pp. 575-577, Mar. 2004.
99. H. Roskos, "Opto-electronic continuous-wave terahertz systems and their application for imaging," presented at the Royal Soc. Discussion Meeting on the THz Gap: The Generation of Far-Infrared Radiation and Its Applications, London, U.K., June 4-5, 2003.