Sonographic depiction of microvessel perfusion: Principles and potential

Journal of Ultrasound in Medicine

Volumn 23, Issue 11, 2004, Pages 1499-1506

  Fleischer, Arthur C ^a   Niermann, Kenneth J ^a   Donnelly, Edwin F ^a   Yankeelov, Thomas E ^a   Canniff, Kathryn M ^b   Hallahan, Dennis E ^a   Rothenberg, Mace E ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Microbubble enhanced sonography; Microvessel perfusion; Tumor neovascularity

Indexed keywords

BLOOD; DIAGNOSTIC RADIOGRAPHY; MAGNETIC RESONANCE; PATIENT MONITORING; PATIENT TREATMENT; SONOCHEMISTRY; TUMORS; ULTRASONICS;

FLUORODEOXYGLUCOSE AUTORADIOGRAPHY; IN VIVO MURINE TUMORS; MICROBUBBLE-ENHANCED SONOGRAPHY; MICROVESSEL PERFUSION;

MEDICAL IMAGING;

FLUORODEOXYGLUCOSE;

AUTORADIOGRAPHY; COLOR ULTRASOUND FLOWMETRY; CONTRAST ENHANCEMENT; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; ECHOGRAPHY; IMAGE ENHANCEMENT; MICROBUBBLE ENHANCED SONOGRAPHY; MICROVASCULATURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PERFUSION; REPRODUCIBILITY; REVIEW; TUMOR; TUMOR DIAGNOSIS; TUMOR VASCULARIZATION;

EID: 6944227670     PISSN: 02784297     EISSN: None     Source Type: Journal    
DOI: 10.7863/jum.2004.23.11.1499     Document Type: Review

References (28)

1. Fleischer AC. Sonographic depiction of tumor vascularity and flow: from in vivo models to clinical applications. J Ultrasound Med 2000; 19:55-61.
2. Fleischer AC, Donnelly EF, Grippo RJ, Black AS, Hallahan DE. Quantification of tumor vascularity with contrast-enhanced sonography: correlation with magnetic resonance imaging and fluorodeoxyglucose autoradiography in an implanted tumor. J Ultrasound Med 2004; 23:37-41.
3. Kiessling F, Krix M, Heilmann M, et al. Comparing dynamic parameters of tumor vascularization in nude mice revealed by magnetic resonance imaging and contrast-enhanced intermittent power Doppler sonography. Invest Radiol 2003; 38:516-524.
4. Krix M, Kiessling F, Vosseler S, et al. Comparison of intermittent-bolus contrast imaging with conventional power Doppler sonography: quantification of tumor perfusion in small animals. Ultrasound Med Biol 2003; 29:1093-1103.
5. Foster FS, Burns PN, Simpson DH, Wilson SR, Christopher DA, Goertz DE. Ultrasound for the visualization and quantification of tumor microcirculation. Cancer Metastasis Rev 2000; 19:131-138.
6. Hallahan D, Geng L, Qu S, et al. Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels. Cancer Cell 2003; 3:63-74.
7. Iordanescu I, Becker C, Zetter B, Dunning R Taylor GA. Tumor vascularity: evaluation in a murine model with contrast-enhanced color Doppler US-effect of angiogenesis inhibitors. Radiology 2002; 222:460-467.
8. Denis F, Bougnoux P, Paon L, le Floch O, Tranquart F. Radiosensitivity of rat mammary tumors correlates with early vessel changes assessed by power Doppler sonography. J Ultrasound Med 2003; 22: 921-929.
9. Lassau N, Kosdelny S, Opolon P, et al. Evaluation of contrast-enhanced color Doppler ultrasound for the quantification of angiogenesis in vivo. Invest Radiol 2001; 36:50-55.
10. Donnelly EF, Geng L, Wojcicki WE, Fleischer AC, Hallahan DE. Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels. Radiology 2001; 219:166-170.
11. Cosgrove D, Eckersley R, Blomley M, Harvey C. Quantification of blood flow. Eur Radiol 2001; 11: 1338-1344.
12. Yang WT, Tse GM, Lam PK, Metreweli C, Chang J. Correlation between color power Doppler sonographic measurement of breast tumor vasculature and immunohistochemical analysis of microvessel density for the quantitation of angiogenesis. J Ultrasound Med 2002; 21:1227-1235.
13. Kamotani Y, Lee WM, Arger PH, Cary TW, Sehgal CM. Multigated contrast-enhanced power Doppler to measure blood flow in mice tumors. Ultrasound Med Biol 2003; 29:977-984.
14. Averkiou M, Powers J, Skyba D, Bruce M, Jensen S. Ultrasound contrast imaging research. Ultrasound Q 2003; 19:27-37.
15. Su MY, Mühler A, Lao X, Nalcioglu O. Tumor characterization with dynamic contrast-enhanced MRI using MR contrast agents of various molecular weights. Magn Reson Med 1998; 39:259-269.
16. Vaupel P. Tumor blood flow: In: Molls M, Vaupel P (eds). Blood Perfusion and Microenvironment of Human Tumors: Implications for Clinical Radio-oncology. New York, NY: Springer-Verlag; 1998: 41-46.
17. Folkman J, Merler E, Abernathy C, Williams G. Isolation of a tumor factor responsible for angiogenesis. J Exp Med 1971; 33:275-288.
18. Wilson SR, Burns PN, Muradali D, Wilson JA, Lai X. Harmonic hepatic US with microbubble contrast agent: initial experience showing improved characterization of hemangioma, hepatocellular carcinoma, and metastasis. Radiology 2000; 215:153-161.
19. Albrecht T, Blomley MJK, Burns PN, et al. Improved detection of hepatic metastases with pulse-inversion US during the liver-specific phase of SHU 508A: multicenter study. Radiology 2003; 227:361-370.
20. Moon WK, Im JG, Noh DY, Han MC. Nonpalpable breast lesions: evaluation with power Doppler US and a microbubble contrast agent-initial experience. Radiology 2002; 217:240-246.
21. Ordén MR, Jurvelin JS, Kirkinen PP. Kinetics of a US contrast agent in benign and malignant adnexal tumors. Radiology 2003; 226:405-411.
22. Kupesic S, Kurjak A. Contrast-enhanced, three-dimensional power Doppler sonography for differentiation of adnexal masses. Obstet Gynecol 2000; 96:452-458.
23. Hata K, Nagami H, lida K, Miyazaki K, Collins WP. Expression of thymidine phosphorylase in malignant ovarian tumors: correlation with microvessel density and an ultrasound-derived index of angiogenesis. Ultrasound Obstet Gynecol 1998; 12:201-206.
24. Halpern EJ, Rosenberg M, Gomella LG. Prostate cancer: contrast-enhanced US for detection. Radiology 2001; 219:219-225.
25. Lindner JR. Detection of inflamed plaques with contrast ultrasound. Am J Cardiol 2002; 90:32L-35L
26. Unger EC, McCreery TP, Sweitzer RH, Caldwell VE, Wu Y. Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent. Invest Radiol 1998; 33:886-892.
27. Leong-Poi H, Christiansen J, Klibanov AL, Kaul S, Lindner JR. Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins. Circulation 2003; 107:455-460.
28. Kuszyk BS, Corl FM, Franano FN. Tumor transport physiology: implications for imaging and imaging-guided therapy. AJR Am J Roentgenol 2001; 177: 747-753.