Expression of thymidine phosphorylase in malignant ovarian tumors: Correlation with microvessel density and an ultrasound-derived index of angiogenesis

Ultrasound in Obstetrics and Gynecology

Volumn 12, Issue 3, 1998, Pages 201-206

  Hata, K ^a   Nagami, H ^a   Iida, K ^a   Miyazaki, K ^a   Collins, W P ^b  

^a SHIMANE UNIVERSITY   (Japan)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Angiogenesis; Microvessel density; Ovarian cancer; Platelet derived endothelial cell growth factor; Thymidine phosphorylase

Indexed keywords

MONOCLONAL ANTIBODY; THYMIDINE PHOSPHORYLASE; VON WILLEBRAND FACTOR;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER CELL; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; COLOR ULTRASOUND FLOWMETRY; CORRELATION FUNCTION; DISEASE COURSE; ECHOGRAPHY; EPITHELIUM; FEMALE; GRANULOSA CELL TUMOR; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LAPAROTOMY; METASTASIS; MICROVASCULATURE; OVARY CANCER; PRIORITY JOURNAL; SPECTROSCOPY; SYSTOLIC BLOOD PRESSURE; TUMOR BLOOD FLOW; VAGINA;

ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; CARCINOMA; CHILD; CULTURE TECHNIQUES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MICROCIRCULATION; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; OVARIAN NEOPLASMS; OVARY; REGRESSION ANALYSIS; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC; THYMIDINE PHOSPHORYLASE; TUMOR MARKERS, BIOLOGICAL; ULTRASONOGRAPHY, DOPPLER, PULSED;

EID: 0031690528     PISSN: 09607692     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1469-0705.1998.12030201.x     Document Type: Article

References (28)

1. Blood CH, Zetter BR. Tumor interactions with the vasculature: angiogenesis and tumor metastasis. Biochim Biophys Acta 1990;1032:89-118
2. Bicknell R, Harris AL. Novel growth regulatory factors and tumour angiogenesis. Eur J Cancer 1991;27:781-5
3. Moghaddam A, Zhang H-T, Fan T-P, Hu D-E, Lees V, Turley H, Fox SB, Gatter KC, Harris AL, Bicknell R. Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc Natl Acad Sci USA 1995;92:988-1002
4. Furukawa T, Yoshimura A, Sumizawa T, Haraguchi M, Akiyama S, Fukui K, Ishizawa M, Yamada Y. Angiogenic factor. Nature (London) 1992;356:668
5. Morris PB, Ellis MN, Swain JL. Angiogenic potency of nucleotide metabolites: potential role in ischemia-induced vascular growth. J Mol Cell Cardiol 1989;21:351-8
6. Moghaddam A, Bicknell R. Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity. Biochemistry 1992;31:12141-6
7. Haraguchi M, Kazutaka M, Uemura K, Sumizawa T, Furukawa T, Yamada K, Akiyama S, Yamada Y. Angiogenic activity of enzymes. Nature (London) 1994;368:198
8. Bourne T, Campbell S, Steer C, Whitehead MI, Collins WP. Transvaginal colour imaging: a possible new screening technique for ovarian cancer. Br Med J 1989;299:1367-70
9. Hata K, Hata T, Manabe A, Sugimura K, Kitao M. A critical evaluation of transvaginal Doppler studies, transvaginal sonography, magnetic resonance imaging, and CA 125 in detecting ovarian cancer. Obstet Gynecol 1992;80:922-6
10. Hata K, Hata T, Kitao M. Intratumoral peak systolic velocity as a new possible predictor for detection of adnexal malignancy. Am J Obstet Gynecol 1995;172:1496-500
11. Tailor A, Jurkovic D, Bourne TH, Natucci M, Collins WP, Campbell S. A comparison of intratumoral indices of blood flow velocity and impedance for the diagnosis of ovarian cancer. Ultrasound Med Biol 1996;22:837-43
12. Reynolds K, Farzaneh F, Collins WP, Campbell S, Bourne TH, Lawton F, Moghaddam A, Harris AL, Bicknell R. Association of ovarian malignancy with expression of platelet-derived endothelial cell growth factor. J Natl Cancer Inst 1994;86: 1234-8
13. Hata K, Hata T, Collins WP. Association between the concentration of thymidine phosphorylase and ultrasound derived indices of blood flow in ovarian masses. Cancer 1997;80: 1079-84
14. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis -correlation in invasive breast carcinoma. N Engl J Med 1991;324:1-8
15. Serov SF, Scully RK, Sobin LH. International histological classification of tumors No. 9. Histological Typing of Ovarian Tumors. Geneva: World Health Organization, 1973
16. Nishida M, Hino A, Mori K, Matsumoto T, Tanaka Y, Ishitsuka H. Cloning of hyhridomas producing anti-human thymidine phosphorylase (dThdPase) and establishment ELISA tor measuring dThdPase. J Jpn Soc Cancer Ther 1994; 29:1192
17. Maeda K, Chung Y-S, Ogawa S, Takatsuka S, Kang S-M, Sawada T, Onoda N, Kato Y, Sowa M. Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma. Br J Cancer 1996;7.3:884-8
18. Fox SB, Moghaddam A, Westwood M, Turley H, Bicknell R, Gatter KC, Harris AL. Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissue: an immunohistochemical study. J Pathol 1995;176:180-90
19. Weidner N, Carrol PR, Flax J, Blumenfeld W, Folkman J. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol 1993;143:401-9
20. Folkman J. What is the evidence that the tumors are angiogenesis dependent? J Natl Cancer Inst 1990;82:4-6
21. Folkman J. Tumor angiogenesis. Adv Cancer Res 1985;43: 174-203
22. Folkman J, Merler K, Agernathy C, Williams G. Isolation of a tumor factor responsible for angiogenesis. J Exp Med 1971; 33:275-88
23. Toi M, Hoshina S, Taniguchi T, Yamamoto Y, Ishitsuka H, Tominaga T. Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer. Int J Cancer 1995;64:79-82
24. Fan T-PD. Angiosuppressive therapy for cancer. TIPS 1994; 15:33-5
25. Patterson AV, Zhang H, Moghaddam A, Bicknell R, Talbot DC, Stratford IJ, Harris AL. Increased sensitivity to the drug 5′-deoxy-5-fluorouridine and modulation of 5-fluoro-2′-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase. Br J Cancer 1995;72:669-75
26. Zimmerman M, Seidenberg J. Deoxyribosyl transfer. Thymidine phosphorylase and nucleoside deoxyribosyltransferase in normal and malignant tissue. J Biol Chem 1964;230:2618-21
27. Szepeshazi K, Lapis K, Schally V. Effect of combination treatment with analogs of luteinizing hormone-releasing hormone (LH-RH) or somatostatin and 5-fluorouracil on pancreatic cancer in hamsters. Int J Cancer 1991;49:260-6
28. Pickard M, Dive C, Kinsella AR. Differences in resistance to 5-fluorouracil as a function of cell cycle delay and not apoptosis. Br J Cancer 1995;72:1389-96