Hypoxia increases corneal cell expression of CFTR leading to increased Pseudomonas aeruginosa binding, internalization, and initiation of inflammation

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 11, 2004, Pages 4066-4074

  Zaidi, Tanweer ^a   Mowrey McKee, Mary ^b   Pier, Gerald B ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b CIBA Vision Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL TISSUE; ARTICLE; BACTERIUM ADHERENCE; CELL HYPOXIA; CORNEA EPITHELIUM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFECTION RISK; INFLAMMATION; INTERNALIZATION; KERATITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; RABBIT; SCANNING ELECTRON MICROSCOPY;

ANIMALS; ANOXIA; BACTERIAL ADHESION; CELL LINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIUM, CORNEAL; EYE INFECTIONS, BACTERIAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; KERATITIS; MICROSCOPY, CONFOCAL; NF-KAPPA B; ORGAN CULTURE TECHNIQUES; OXYGEN; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RABBITS; TIME FACTORS;

EID: 6944219920     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0627     Document Type: Article

References (51)

1. Bennett HG, Hay J, Kirkness CM, Seal DV, Devonshire P. Antimicrobial management of presumed microbial keratitis: guidelines for treatment of central and peripheral ulcers. Br J Ophthalmol. 1998;82:137-145.
2. Dart JK. Predisposing factors in microbial keratitis: the significance of contact lens wear. Br J Ophthalmol. 1988;72:926-930.
3. Cruz OA, Sabir SM, Capo H, Alfonso EC. Microbial keratitis in childhood. Ophthalmology. 1993;100:192-196.
4. Mela EK, Giannelou IP, John KX, Sotirios GP. Ulcerative keratitis in contact lens wearers. Eye Contact Lens. 2003;29:207-209.
5. Holden BA, Sweeney DF, Sankaridurg PR, et al. Microbial keratitis and vision loss with contact lenses. Eye Contact Lens. 2003;29: S131-S134; discussion S143-S134, S192-S134.
6. Fleiszig SM, Evans DJ. The pathogenesis of bacterial keratitis: studies with Pseudomonas aeruginosa. Clin Exp Optom. 2002; 85:271-278.
7. Erie JC, Nevitt MP, Hodge DO, Ballard DJ. Incidence of ulcerative keratitis in a defined population from 1950 through 1988. Arch Ophthalmol. 1993;111:1665-1671.
8. Koch JM, Refojo MF, Hanninen LA, Leong FL, Kenyon KR. Experimental Pseudomonas aeruginosa keratitis from extended wear of soft contact lenses. Arch Ophthalmol. 1990;108:1453-1459.
9. Pier GB, Grout M, Zaidi TS, et al. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Science. 1996;271:64-67.
10. Zaidi TS, Lyczak J, Preston M, Pier GB. Cystic fibrosis transmembrane conductance regulator-mediated corneal epithelial cell ingestion of Pseudomonas aeruginosa is a key component in the pathogenesis of experimental murine keratitis. Infect Immun. 1999;67:1481-1492.
11. Solomon OD, Loff H, Perla B, et al. Testing hypotheses for risk factors for contact lens-associated infectious keratitis in an animal model. CLAO J. 1994;20:109-113.
12. Ren DH, Petroll WM, Jester JV, Ho-Fan J, Cavanagh HD. The relationship between contact lens oxygen permeability and binding of Pseudomonas aeruginosa to human corneal epithelial cells after overnight and extended wear. CLAO J. 1999;25:80-100.
13. Nilsson SE. Seven-day extended wear and 30-day continuous wear of high oxygen transmissibility soft silicone hydrogel contact lenses: a randomized 1-year study of 504 patients. CLAO J. 2001; 27:125-136.
14. Weissman B, Mondino BJ. Why daily wear is still better than extended wear. Eye Contact Lens. 2003;29:S145-S146; discussion S166, S192-S194.
15. Syam P, Hussain B, Hutchinson C. Mixed infection (Pseudomonas and coagulase negative staphylococci) microbial keratitis associated with extended wear silicone hydrogel contact lens. Br J Ophthalmol. 2004;88:579.
16. Lee KY, Lim L. Pseudomonas keratitis associated with continuous wear silicone-hydrogel soft contact lens: a case report. Eye Contact Lens. 2003;29:255-257.
17. Zaidi TS, Fleiszig SMJ, Preston MJ, Goldberg JB, Pier GB. Lipopolysaccharide outer core is a ligand for corneal cell binding and ingestion of Pseudomonas aeruginosa. Invest Ophthalmol Vis Sci. 1996;37:976-986.
18. Pier GB, Grout M, Zaidi TS. Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung. Proc Natl Acad Sci USA. 1997;94:12088-12093.
19. Schroeder TH, Lee MM, Yacono PW, et al. CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation. Proc Natl Acad Sci USA. 2002;99:6907-6912.
20. Preston MJ, Fleiszig SMJ, Zaidi TS, et al. Rapid and sensitive method for evaluating Pseudomonas aeruginosa virulence factors during corneal infections in mice. Infect Immun. 1995;63:3497-3501.
21. Olsen JC, Johnson LG, Stutts MJ, et al. Correction of the apical membrane chloride permeability defect in polarized cystic fibrosis airway epithelia following retroviral-mediated gene transfer. Hum Gene Ther. 1992;3:253-266.
22. Fleiszig SMJ, Zaidi TS, Fletcher EL, Preston MJ, Pier GB. Pseudomonas aeruginosa invades corneal epithelial cells during experimental infection. Infect Immun. 1994;62:3485-3493.
23. Zaidi TS, Preston MJ, Pier GB. Inhibition of bacterial adherence to host tissue does not markedly affect disease in the murine model of Pseudomonas aeruginosa corneal infection. Infect Immun. 1997;65:1370-1376.
24. Fleiszig SMI, Zaidi TS, Ramphal R, Pier GB. Modulation of Pseudomonas aeruginosa adherence to the corneal surface by mucus. Infect Immun. 1994;62:1799-1804.
25. Walker J, Watson J, Holmes C, Edelman A, Banting G. Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related proteins. J Cell Sci. 1995;108:2433-2444.
26. Schroeder TH, Reiniger N, Meluleni G, Grout M, Coleman FT, Pier GB. Transgenic cystic fibrosis mice exhibit reduced early clearance of Pseudomonas aeruginosa from the respiratory tract. J Immunol. 2001;166:7410-7418.
27. Stover CK, Pham XQ, Erwin AL, et al. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000;406:959-964.
28. Lee A, Chow D, Haus B, et al. Airway epithelial tight junctions and binding and cytotoxicity of Pseudomonas aeruginosa. Am J Physiol. 1999;277:L204-L217.
29. Fleiszig SM, Evans DJ, Do N, Vallas V, Shin S, Mostov KE. Epithelial cell polarity affects susceptibility to Pseudomonas aeruginosa invasion and cytotoxicity. Infect Immun. 1997;65:2861-2867.
30. Sato S, Ward CL, Krouse ME, Wine JJ, Kopito RR. Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation. J Biol Chem. 1996;271:635-638.
31. Stapleton F. Contact lens-related microbial keratitis: what can epidemiologic studies tell us? Eye Contact Lens. 2003;29:S85-S89; discussion S115-S118.
32. Lam DS, Houang E, Fan DS, Lyon D, Seal D, Wong E. Incidence and risk factors for microbial keratitis in Hong Kong: comparison with Europe and North America. Eye. 2002;16:608-618.
33. Brennan NA. Is there a question of safety with continuous wear? Clin Exp Optom. 2002;85:127-140.
34. Cavanagh HD, Ladage PM, Li SL, et al. Effects of daily and overnight wear of a novel hyper oxygen-transmissible soft contact lens on bacterial binding and corneal epithelium: a 13-month clinical trial. Ophthalmology. 2002;109:1957-1969.
35. Ladage PM, Yamamoto K, Li L, et al. Effects of O2 transmissibility on corneal epithelium after daily and extended contact lens wear in rabbit and man. Adv Exp Med Biol. 2002;506:885-893.
36. Li SL, Ladage PM, Yamamoto T, Petroll WM, Jester JV, Cavanagh HD. Effects of contact lens care solutions on surface exfoliation and bacterial binding to corneal epithelial cells. Eye Contact Lens. 2003;29:27-30.
37. Ladage PM, Yamamoto K, Ren DH, et al. Effects of rigid and soft contact lens daily wear on corneal epithelium, tear lactate dehydrogenase, and bacterial binding to exfoliated epithelial cells. Ophthalmology. 2001;108:1279-1288.
38. Cavanagh HD, Ladage P, Yamamoto K, Li SL, Petroll WM, Jester JV. Effects of daily and overnight wear of hyper-oxygen transmissible rigid and silicone hydrogel lenses on bacterial binding to the corneal epithelium: 13-month clinical trials. Eye Contact Lens. 2003;29:S14-S16; discussion S26-S19, S192-S194.
39. Yamamoto K, Ladage PM, Ren DH, et al. Effects of low and hyper Dk rigid gas permeable contact lenses on Bcl-2 expression and apoptosis in the rabbit corneal epithelium. CLAO J. 2001;27:137-143.
40. Cavanagh HD. The effects of low- and hyper-Dk contact lenses on corneal epithelial homeostasis. Ophthalmol Clin North Am. 2003; 16:311-325.
41. Ladage PM, Yamamoto K, Ren DH, et al. Proliferation rate of rabbit corneal epithelium during overnight rigid contact lens wear. Invest Ophthalmol Vis Sci. 2001;42:2804-2812.
42. Ladage PM, Jester JV, Petroll WM, Bergmanson JP, Cavanagh HD. Vertical movement of epithelial basal cells toward the corneal surface during use of extended-wear contact lenses. Invest Ophthalmol Vis Sci. 2003;44:1056-1063.
43. Ladage PM, Yamamoto K, Ren DH, et al. Recovery time of corneal epithelial proliferation in the rabbit following rigid gas-permeable extended contact-lens wear. Eye Contact Lens. 2003;29:61-64.
44. Nilsson SE. Bacterial keratitis and inflammatory corneal reactions: possible relations to contact lens oxygen transmissibility: the Harold A. Stein Lectureship 2001. CLAO J. 2002;28:62-65.
45. Gleason W, Tanaka H, Albright RA, Cavanagh HD. A 1-year prospective clinical trial of menicon Z (tisilfocon A) rigid gas-permeable contact lenses worn on a 30-day continuous wear schedule. Eye Contact Lens. 2003;29:2-9.
46. Goldberg JB, Pier GB. The role of the CFTR in susceptibility to Pseudomonas aeruginosa infections in cystic fibrosis. Trends Microbiol. 2000;8:514-520.
47. Kernacki KA, Goebel DJ, Poosch MS, Hazlett LD. Early cytokine and chemokine gene expression during Pseudomonas aeruginosa corneal infection in mice. Infect Immun. 1998;66:376-379.
48. Hobden JA, Masinick SA, Barrett RP, Hazlett LD. Proinflammatory cytokine deficiency and pathogenesis of Pseudomonas aeruginosa keratitis in aged mice. Infect Immun. 1997;65:2754-2758.
49. Bonora M, Bernaudin JF, Guernier C, Brahimi-Horn MC. Ventilatory responses to hypercapnia and hypoxia in conscious cystic fibrosis knockout mice cftr. Pediatr Res. 2004;55:738-746.
50. Mairbaurl H, Schwobel F, Hoschele S, et al. Altered ion transporter expression in bronchial epithelium in mountaineers with high-altitude pulmonary edema. J Appl Physiol. 2003;95:1843-1850.
51. Pan J, Bear C, Farragher S, Cutz E, Yeger H. Cystic fibrosis transmembrane conductance regulator modulates neurosecretory function in pulmonary neuroendocrine cell-related tumor cell line models. Am J Respir Cell Mol Biol. 2002;27:553-560.