Evidence for phosphorylation of human parainfluenza virus type 3 C protein: Mutant C proteins exhibit variable inhibitory activities in vitro

Virus Research

Volumn 144, Issue 1-2, 2009, Pages 180-187

  Malur, Achut G ^a   Wells, Greg ^a   McCoy, Almedia ^a   Banerjee, Amiya K ^b  

^a EAST CAROLINA UNIVERSITY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

C protein; Human parainfluenza virus type 3; Minigenome replication; Phosphorylation

Indexed keywords

MUTANT PROTEIN; PROTEIN C;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; MUTATION; NONHUMAN; PARAINFLUENZA VIRUS 3; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA SYNTHESIS; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; DNA MUTATIONAL ANALYSIS; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PARAINFLUENZA VIRUS 3, HUMAN; PHOSPHORYLATION; RNA, VIRAL; SERINE; VERO CELLS; VIRAL PROTEINS; VIRUS REPLICATION;

HUMAN PARAINFLUENZA VIRUS 3; PARAMYXOVIRINAE;

EID: 69349101835     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virusres.2009.04.022     Document Type: Article

References (51)

1. Asenjo A., Rodriguez L., and Villanueva N. Determination of phosphorylated residues of human respiratory syncytial virus P protein that are dynamically dephosphorylated by cellular phosphatases: a possible role for serine 54. J. Gen. Virol. 86 (2005) 1109-1120
2. Asenjo A., Calvo E., and Villanueva N. Phosphorylation of human respiratory syncytial virus P protein at threonine 108 controls its interaction with the M2-1 protein in the viral RNA polymerase complex. J. Gen. Virol. 87 (2006) 3637-3642
3. Bailojan C., and Takai A. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Biochem. J. 256 (1998) 283-290
4. Banerjee A.K., Barik S., and De B.P. Gene expression of nonsegmented negative strand RNA viruses. Pharmacol. Ther. 51 (1991) 47-70
5. Bankamp B., Wilson J., Bellini W.J., and Rota P.A. Identification of naturally occurring amino acid variations that affect the ability of measles virus C protein to regulate genome replication and transcription. Virology 336 (2005) 120-129
6. Bose S., and Banerjee A.K. Innate immune response against non-segmented negative strand RNA viruses. J. Interferon Cytokine. Res. 3 (2003) 401-412
7. Cadd T., Garcin D., Tapparel C., Itoh M., Homma M., Roux L., Curran J., and Kolakofsky D. The Sendai paramyxovirus accessory C proteins inhibit viral genome amplification in a promoter-specific fashion. J. Virol. 70 (1996) 5067-5074
8. Cevik B., Smallwood S., and Moyer S.A. The L-L oligomerization domain resides at the very N-terminus of the Sendai virus L RNA polymerase protein. Virology 313 (2003) 525-536
9. Chanock R.M., Murphy B.R., and Collins P.L. Parainfluenza viruses. In: Fields B.N., Knipe D.M., and Howley P.M. (Eds). Fields Virology. 4th ed. (2001), Lippincott Williams and Wilkins, Philadelphia 1341-1379
10. Curran J., Marq J.B., and Kolakofsky D. The Sendai virus non-structural C proteins specifically inhibit viral mRNA synthesis. Virology 189 (1992) 647-656
11. De B.P., Lesoon A., and Banerjee A.K. Human parainfluenza virus type 3 transcription in vitro: role of cellular actin in mRNA synthesis. J. Virol. 65 (1991) 3268-3275
12. De B.P., Burdsall A.L., and Banerjee A.K. Role of cellular actin in human parainfluenza virus type 3 genome transcription. J. Biol. Chem. 268 (1993) 5703-5710
13. De B.P., and Banerjee A.K. Role of host proteins in gene expression of non segmented negative strand RNA viruses. Adv. Vir. Res. 48 (1997) 169-204
14. Devaux P., and Cattaneo R. Measles virus phosphoprotein gene products: conformational flexibility of the P/V protein amino-terminal domain and C protein infectivity factor function. J. Virol. 78 (2004) 11632-11640
15. Durbin A.P., McAuliffe J.M., Collins P.L., and Murphy B.R. Mutations in the C, D and V open reading frames of human parainfluenza virus type 3 attenuate replication in rodents and primates. Virology 261 (1999) 319-330
16. Escoffier C., Manie S., Vincent S., Muller C.P., Billeter M., and Gerlier D. Nonstructural C protein is required for efficient measles virus replication in human peripheral blood cells. J. Virol. 73 (1999) 1695-1698
17. Galinski M.S., Mink M.A., Lambert D.M., Wechsler S.L., and Pons M.W. Molecular cloning and sequence analysis of the human parainfluenza 3 virus mRNA encoding the P and C proteins. Virology 154 (1986) 46-60
18. Galinski M.S., Troy R.M., and Banerjee A.K. RNA editing in the phosphoprotein gene of the human parainfluenza virus type 3. Virology 186 (1992) 543-555
19. Garcia A., Cayla X., and Sontag E. Protein phosphatase 2A: a definitive player in viral and parasitic regulation. Microbes Infect. 2 (2000) 401-407
20. Garcin D., Itoh M., and Kolakofsky D. A point mutation in the Sendai virus accessory C proteins attenuates virulence for mice, but not growth in cell culture. Virology 238 (1997) 424-431
21. Gotoh B., Komatsu T., Takeuchi K., and Yokoo J. Paramyxovirus accessory proteins as interferon antagonists. Microbiol. Immunol. 45 (2001) 787-800
22. Gotoh B., Komatsu T., Takeuchi K., and Yokoo J. Paramyxovirus strategies for evading the interferon response. Rev. Med. Virol. 12 (2002) 337-357
23. Grogan G.C., and Moyer S.A. Sendai virus wild-type and mutant C proteins show a direct correlation between L polymerase binding and inhibition of viral RNA synthesis. Virology 288 (2001) 96-108
24. Hasan M.K., Kato A., Muranaka M., Yamaguchi R., Sakai Y., Hatano I., Tashiro M., and Nagai Y. Versatility of the accessory C proteins of Sendai virus: contribution to virus assembly as an additional role. J. Virol. 74 (2000) 5619-5628
25. Hendricks D.D., Ono E., Seyer J.M., and Gupta K.C. Phosphorylation of Sendai virus C proteins. Virology 197 (1993) 471-474
26. Hoffman M.A., and Banerjee A.K. Precise mapping of the replication and transcription promoters of human parainfluenza virus type 3. Virology 269 (2000) 201-211
27. Horikami S.M., Hector R.M., Smallwood S., and Moyer S.A. The Sendai virus C protein binds the L polymerase protein to inhibit viral RNA synthesis. Virology 235 (1997) 261-270
28. Itoh M., Hotta H., and Homma M. Increased induction of apoptosis by a Sendai virus mutant is associated with attenuation of mouse pathogenicity. J. Virol. 72 (1998) 2927-2934
29. Kato A., Cortese-Grogan C., Moyer S.A., Sugahara F., Sakaguchi T., Kubota T., Otsuki N., Kohase M., Tashiro M., and Nagai Y. Characterization of the amino acid residues of Sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation. J. Virol. 78 (2004) 7443-7454
30. Kato A., Kiyotani K., Kubota T., Yoshida T., Tashiro M., and Nagai Y. Importance of the anti-interferon capacity of Sendai virus C protein for pathogenicity in mice. J. Virol. 81 (2007) 3264-3271
31. Koyama Hajime A., Irie H., Kato A., Nagai Y., and Adachi A. Virus multiplication and induction of apoptosis by Sendai virus: role of the C proteins. Microbes Infect. 5 (2003) 373-378
32. Kurotani A., Kiyotani A., Kato A., Shioda T., Sakai Y., Mizumoto K., Yoshida T., and Nagai Y. Sendai virus C proteins are categorically non-essential gene products but silencing their expression severely impairs viral replication and pathogenesis. Gene Cells 3 (1998) 111-124
33. Lamb R.A., and Kolakofsky D. Paramyxoviridae: the viruses and their replication. In: Fields B.N., Knipe D.M., and Howley P.M. (Eds). Fields Virology. 4th ed. (2001), Lippincott Williams and Wilkins, Philadelphia 1305-1340
34. Luk D., Sanchez A., and Banerjee A.K. Messenger RNA encoding the phosphoprotein (P) gene of human parainfluenza virus 3 is bicistronic. Virology 153 (1986) 318-325
35. 2-terminal domain of the human parainfluenza virus type 3 RNA polymerase. J. Virol. 76 (2002) 8101-8109
36. Malur A.G., Hoffman M.A., and Banerjee A.K. The human parainfluenza virus type 3 (HPIV 3) C protein inhibits viral transcription. Virus Res. 99 (2004) 199-204
37. Malur A.G., Chattopadhyay S., Maitra R.K., and Banerjee A.K. Inhibition of STAT 1 phosphorylation by human parainfluenza virus type 3 C protein. J. Virol. 79 (2005) 7877-7882
38. Millward T., Zolnierowicz S., and Hemmings B.A. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem. Sci. 5 (1999) 186-191
39. Neumann G., Whitt M.A., and Kawaoka Y. A decade after the generation of a negative-sense RNA virus from cloned cDNA-what have we learned?. J. Gen. Virol. 83 (2002) 2635-2662
40. Onorato J.J., Palczewski K., Regan J.W., Caron M.G., Lefkowitz R.J., and Benovic J.L. Role of amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. Biochemistry 30 (1991) 5118-5125
41. Patterson J.B., Thomas D., Lewicki H., Billeter M.A., and Oldstone M.B. V and C proteins of measles virus function as virulence factors in vivo. Virology 267 (2000) 80-89
42. Reutter G.L., Grogan-Cortese C., Wilson J., and Moyer S.A. Mutations in the measles virus C protein that up regulate viral RNA synthesis. Virology 285 (2001) 100-109
43. Sakaguchi T., Kato A., Sugahara F., Shimazu Y., Inoue M., Kiyotani K., Nagai Y., and Yoshida T. AIP1/Alix is a binding partner of Sendai virus C protein and facilitates virus budding. J. Virol. 79 (2005) 8933-8941
44. Smallwood S., and Moyer S.A. The L polymerase of parainfluenza virus 3 forms an oligomer and can interact with the heterologous Sendai virus L, P and C proteins. Virology 318 (2004) 439-450
45. Spriggs M.K., and Collins P.L. Sequence analysis of the P and C protein genes of human parainfluenza virus type 3: patterns of amino acid sequence homology among paramyxovirus proteins. J. Gen. Virol. 67 (1986) 2705-2719
46. Sweetman D.A., Miskin J., and Baron M.D. Rinderpest virus C and V proteins interact with the major (L) component of the viral polymerase. Virology 281 (2001) 193-204
47. Sugahara F., Uchiyama T., Watanabe H., Shimazu Y., Kuwayama M., Fujii Y., Kiyotani K., Adachi A., Kohno N., Yoshida T., and Sakaguchi T. Paramyxovirus Sendai virus-like particle formation by expression of multiple viral proteins and acceleration of its release by C protein. Virology 325 (2004) 1-10
48. Tapparel C., Hausmann S., Pelet T., Curran J., Kolakofsky D., and Roux L. Inhibition of Sendai virus genome replication due to promoter-increased selectivity: a possible role for the accessory C proteins. J. Virol. 71 (1997) 9588-9599
49. Wells G., and Malur A.G. Expression of human parainfluenza virus type 3 PD protein and intracellular localization in virus infected cells. Virus Genes 37 (2008) 358-367
50. Whitmarsh A.J., and Davis R.J. Regulation of transcription factor function by phosphorylation. Cell. Mol. Life Sci. 57 (2000) 1172-1183
51. Yang S.-H., Sharrocks A.D., and Whitmarsh A.J. Transcriptional regulation by the MAP kinase signaling cascades. Gene 320 (2003) 3-21