In vivo assessment of lung inflammatory cell activity in patients with COPD and asthma

European Respiratory Journal

Volumn 21, Issue 4, 2003, Pages 567-573

  Jones, H A ^a   Marino, P S ^a   Shakur, B H ^a   Morrell, N W ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

18F fluorodeoxyglucose; Macrophages; Neutrophils; PK11195; Positron emission tomography

Indexed keywords

ANTIBIOTIC AGENT; CORTICOSTEROID; FLUORODEOXYGLUCOSE F 18; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; SALBUTAMOL;

ADULT; AGED; ARTICLE; ASTHMA; CELL ACTIVITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; HUMAN; IN VIVO STUDY; INFLAMMATORY CELL; MACROPHAGE; MALE; NEUTROPHIL; PARTITION COEFFICIENT; PATHOGENESIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

EID: 0037385508     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.03.00048502     Document Type: Article

References (27)

1. Lopez AD, Murray CC. The global burden of disease. 1990-2020. Nat Med 1998; 4: 1241-1243.
2. National Institute of Health. Global strategy for asthma management and prevention. NHLBI/WHO workshop report. Bethesda, MD, National Heart Lung and Blood Institute, 1995. Publication number 95-3659.
3. Barnes PJ. Chronic obstructive pulmonary disease. N Engl J Med 2000; 343: 269-280.
4. Vignola AM, Chanez P, Campbell AM, et al. Airway inflammation in mild intermittent and in persistent asthma. Am J Respir Crit Care Med 1998; 157: 403-409.
5. Saverymuttu SH, Phillips G, Peters AM, Lavender JP. Indium 111 autologous leucocyte scanning in lobar pneumonia and lung abscesses. Thorax 1985; 40: 925-930.
6. Jones HA, Sriskandan S, Peters AM, Pride NB, Boobis AR, Haslett C. Dissociation of neutrophil emigration and metabolic activity in lobar pneumonia and bronchiectasis. Eur Respir J 1997; 10: 795-803.
7. Jones HA, Clark RJ, Rhodes CG, Schofield JB, Krausz T, Haslett C. In vivo measurement of neutrophil activity in experimental lung inflammation. Am J Respir Crit Care Med 1994; 149: 1635-1639.
8. Jones HA, Schofield JB, Krausz T, Boobis AR, Haslett C. Pulmonary fibrosis correlates with duration of tissue neutrophil activation. Am J Respir Crit Care Med 1998; 158: 620-628.
9. Jones HA, Cadwallader KA, White JF, Uddin M, Peters AM, Chilvers ER. Dissociation between respiratory burst activity and deoxyglucose uptake in human neutrophil granulocytes: Implications for interpretation of 18F-FDG PET images. J Nucl Med 2002; 43: 652-657.
10. Jones HA, Valind SO, Clark IC, et al. Kinetics of lung macrophages monitored in vivo following particulate challenge in rabbits. Toxicol Appl Pharmacol 2002; 183: 46-54.
11. Pauwels RA, Buist S, Calverley PMA, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global initiative for chronic obstructive pulmonary disease (GOLD). Am J Respir Crit Care Med 2001; 163: 1256-1276.
12. Spanevello A, Migliori GB, Sharara A, et al. Induced sputum to assess airway inflammation: a study of reproducibility. Clin Exp Allergy 1997; 27: 1138-1144.
13. Pin I, Gibson PG, Kolendovicz R, et al. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 1992; 47: 25-29.
14. Robb RA, Hanson DP. A software system for interactive and quantitaive visualisation of multidimensional images. Phys End Sci Med 1991; 14: 9-30.
15. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple time uptake data. J Cereb Blood Flow Metab 1983; 3: 1-7.
16. Barnes PJ. Mechanisms in COPD: differences from asthma. Chest 2000; 117: 10S-14S.
17. Turato G, Stefano A, Maestrelli P, et al. Effect of smoking cessation on airway inflammation in chronic bronchitis. Am J Respir Crit Care Med 1995; 152: 1262-1267.
18. Keatings VM, Jatakanon A, Worsdell YM, Barnes PJ. Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am J Respir Crit Care Med 1997; 155: 542-548.
19. Burge PS, Calverley PMA, Jones PW, Spencer S, Anderson JA, Maslen TK. Randomised, double-blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease. The ISOLDE trial. BMJ 2000; 320: 1297-1303.
20. Jatakanon A, Uasuf C, Maziak W, Lim S, Chung KF, Barnes PJ. Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med 1999; 160: 1532-1539.
21. Kraft M, Djukanovic R, Wilson S, Holgate ST, Martin RJ. Alveolar tissue inflammation in asthma. Am J Respir Crit Care Med 1996; 154: 1505-1510.
22. Wenzel SE, Schwartz LB, Langmack EL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999; 160: 1001-1008.
23. Finkelstein R, Fraser RS, Ghezzo H, Cosio MG. Alveolar inflammation and its relation to emphysema in smokers. Am J Respir Crit Care Med 1995; 152: 1666-1672.
24. Zavala F, Lenfant M. Benzodiazepines and PK 11195 exert immunomodulating activities on a specific receptor on macrophages. Ann NY Acad Sci 1987; 96: 240-249.
25. Ramsay SC, Weiller C, Myers R, et al. Monitoring by PET of macrophage accumulation in brain after ischaemic stroke. Lancet 1992; 339: 1054-1055.
26. Mak JCW, Barnes PJ. Peripheral type benzodiazepine receptors in human and guinea pig lung: Characterization and autoradiographic mapping. J Pharm Exp Ther 1990; 252: 880-885.
27. Cambell DA, Poulter LW, du Bois RM. Phenotypic analysis of alveolar macrophages in normal subjects and in patients with interstitial lung disease. Thorax 1986; 41: 429-434.