Effect of nicotinamide on experimental induced diabetes

Iranian Journal of Allergy, Asthma and Immunology

Volumn 8, Issue 1, 2009, Pages 11-18

  Alenzi, Faris Q ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Apoptosis; Insulin dependent diabetes mellitus; Nicotinamide; Nitric oxide; Streptozotocin

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN; NICOTINAMIDE; NITRIC OXIDE; NITRITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; STREPTOZOCIN DIABETES; ANIMAL; BLOOD; BODY WEIGHT; DRUG EFFECT; METABOLISM; PANCREAS ISLET; PATHOLOGY; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; BODY WEIGHT; C-PEPTIDE; DIABETES MELLITUS, EXPERIMENTAL; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; NIACINAMIDE; NITRITES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 69249221540     PISSN: 17351502     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 1996; 39(9):1005-29.
2. Welsh N, Eizirik DL, Bendtzen K, Sandler S. Interleukin-1 β-induced nitricoxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 1991; 129(6):3167-73.
3. Yang J, Klaidman LK, Nalbandian A, Oliver J, Chang ML, Chan PH, et al. The effects of nicotinamide on energy metabolism following transient focal cerebral ischemia in Wistar rats. Neurosci Lett 2002; 333(2):91-4.
4. Melo SS, Arantes MR, Meirelles MS, Jordão AA Jr, Vannucchi H. Lipid peroxidation in nicotinamide-deficient and nicotinamide-supplemented rats with streptozotocin-induced diabetes. Acta Diabetol 2000; 37(1):33-9.
5. Kuchmerovska T, Shymanskyy I, Bondarenko L, Klimenko A. Effects of nicotinamide supplementation on liver and serum contents of amino acids in diabetic rats Eur J Med Res 2008; 13(6):275-80.
6. Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C. Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med 2008; in press.
7. O'Brien BA Harmon BV, Cameron DP, Allan DJ. Apoptosis is the mode of β-cell death responsible for the development of IDDM in the non-obese diabetic (NOD) mouse. Diabetes 1997; 46(5):750-7.
8. Kolb H, Burkart V. Nicotinamide in type 1 diabetes. Mechanism of action revisited. Diabetes Care 1999; 22(suppl 2):B16-20.
9. Novelli M, D'Aleo V, Lupi R, Paolini M, Soleti A, Marchetti P, ET AL. Reduction of oxidative stress by a new low-molecular-weight antioxidant improves metabolic alterations in a nonobese mouse diabetes model. Pancreas 2007; 35(4):e10-7.
10. Pipeleers D, Van de Winkel M. Pancreatic B cells possess defense mechanisms against cell-specific toxicity. Proc Natl Acad Sci U S A 1986; 83(14):5267-71.
11. Mukherjee SK, Klaidman LK, Yasharel R, Adams JD Jr. Increased brain NAD prevents neuronal apoptosis in vivo. Eur J Pharmacol 1997; 330(1):27-34.
12. Klaidman LK, Mukherjee SK, Adams JD Jr. Oxidative changes in brain pyridine nucleotides and neuroprotection using nicotinamide.Biochim Biophys Acta 2001; 1525(1-2):136-48.
13. Lin SH, Chong ZZ, Maiese K. Nicotinamide: A Nutritional Supplement that Provides Protection Against Neuronal and Vascular Injury. J Med Food 2001; 4(1):27-38.
14. Ayoub IA, Lee EJ, Ogilvy CS, Beal MF, Maynard KI. Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats. Neurosci Lett 1999; 259(1):21-4.
15. Masiello P, Broca C, Gross R, Roye M, Manteghetti M, Hillaire BD, et al. Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes 1998; 47(2):224-9.
16. Lacy PE, Kostianovsky M. Method for the isolation of intact islets of Language from the rat pancreas. Diabetes 1967; 16(1):35-9.
17. Gotoh M, Maki T, Kiyoizumi T, Satomi S, Monaco AP. An improved method for isolation of mouse pancreatic islets. Transplantation 1985; 40(4):437-8.
18. Drury RAB, Wallington EA. Carleton's Histological Techniques. Oxford University Press, New York- Toronto, 1980:pp 174-5, 188-9
19. Harris JR. Electron Microscopy in Biology. A Practical Approach, Oxford, UK, 1991: pp 17-37
20. Wu TJ, Lin CL, Taylor RL, Kao PC. Proinsulin level in diabetes mellitus measured by a new immunochemiluminometric assay. Ann Clin Lab Sci 1995; 25(6):467-74.
21. Kumar MS, Schumacher OP, Deobdar SD. Measurement of serum C-peptide immunoreactivity by radioimmunoassay in insulin-dependent diabetics. Am J Clin Pathol 1980; 74(1):78-82.
22. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite and [15N] nitrite in biological fluids. Anal Biochem 1982; 126(1):131-8
23. Corbett JA, Wang JL, Sweetland MA, Lancaster JR, McDaniel ML. Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide. J clin Invest 1992; 90(6):2384-92.
24. Heller B, Wang ZQ, Wagner EF, Radons J, Burkle J, Fehsel K, et al. Inactivation of the poly (ADP- ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J Biol Chem 1995; 270(19):11176-80.
25. O'Brien BA, Harmon BV, Cameron DP, Allan DJ. Beta cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model. J Pathol 1996; 178(2):176-81.
26. Shimabukuro M, Ohneda M, Lee Y, Unger RH. Role of nitric oxide in obesity-induced beta cell disease. J Clin Invest 1997; 100(2):290-5.
27. Moncada S, Palmcr RM, Higgs Ea. Nitrie oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43(2):109-42.
28. Tanaka Y, Shimizu H, Sato N, Mori M, Shimomura Y. Involvement of spontaneous nitric oxide production in the diabetogenic action of streptozotocin. Pharmacology 1995; 50(2):69-73.
29. Turk J, Corbett JA, Romanadham S, Bohrer A, McDaniel ML. Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets. Biochem Biophys Res Commun 1993; 197(3):1458-64.
30. Tsuji A, Sakurai H. Genration of nitric oxide from streptozotocin (STZ) in the presence of copper (II) plus ascorbate: implication for the development of STZ-induced diabetes. Biochem Biophys Res Commun 1998; 245(1):11-6.
31. Bedoya FJ, Solano F, Lucas M. N-monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets. Experientia 1996; 52(4):344-7.
32. Kim JY, chi JK, Kim EJ, Park SY, Kim YW, Lee SK. Inhibition of diabetes in non-obese diabetic mice by nicotinamide treatment for 5 weeks at the early age. J Korean Med Sci 1997; 12:293-7.
33. Suarez-Pinzon WL, Mabley JG, Power R, Szabó C, Rabinovitch A. Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes. Diabetes 2003; 52(7):1683-8.
34. Virág L. Structure and function of poly (ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. Curr Vasc Pharmacol 2005; 3(3):209-14.
35. Kretowski A, Szelachowska M, Gorska M, Zendzian-Piotrowska M, Wysocka-Solowie B, Kinalska I. Orally given nicotinamide inhibits the decreasing of glutathione content in the pancreas of streptozotocin diabetic rats Horm Metab Res 1996; 28(1):35-6.