Fascin overexpression is regulated by the transactivation of the promoter but not by its hypomethylation in esophageal squamous cell carcinoma

Molecular Medicine Reports

Volumn 2, Issue 5, 2009, Pages 843-849

  Hou, Jian ^a   Guo, Zhang Yan ^a   Xie, Jian Jun ^a   Li, En Min ^a   Xu, Li Yan ^a  

^a SHANTOU UNIVERSITY   (China)

Author keywords

Esophageal squamous cell carcinoma; Fascin 1 gene; Methylation; Promoter; Transactivation

Indexed keywords

BISULFITE; FASCIN; LUCIFERASE;

ARTICLE; ASSAY; BINDING SITE; CANCER CELL; CANCER CELL CULTURE; CPG ISLAND; DEMETHYLATION; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; EXON; GENE OVEREXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; METHYLATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROMOTER REGION; SILENCER GENE; TRANSACTIVATION; TUMOR CELL;

EID: 69249213580     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr_00000182     Document Type: Article

References (30)

1. Edwards RA and Bryan J: Fascins, a family of actin bundling proteins. Cell Motil Cytoskel 32: 1-9, 1995.
2. Zhang FR, Tao LH, Shen ZY, Lv Z, Xu LY and Li EM: Fascin expression in human embryonic, fetal, and normal adult tissue. J Histochem Cytochem 56: 193-199, 2008. (Pubitemid 351170971)
3. Duh FM, Latif F, Weng Y, Geil L, Modi W and Stackhouse T: cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein. DNA Cell Biol 13: 821-827, 1994. (Pubitemid 24293734)
4. Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L and Matsumura F: Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein. J Virol 68: 7320-7328, 1994. (Pubitemid 24328786)
5. Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS and Kieff E: Circulating human dendritic cells differentially express high levels of a 55-kDa actin-bundhng protein. Am J Pathol 148: 593-600, 1996. (Pubitemid 26056743)
6. Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S and Mosialos G: Fascin, a sensitive new marker for Reed-Sternberg cells of Hodgkin's disease. Evidence for a dendritic or B cell derivation? Am J Pathol 150: 543-562, 1997.
7. Hashimoto Y, Skacel M and Adams JC: Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker? Int J Biochem Cell Biol 37: 1787 - 1804, 2005.
8. Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F and Iannucci A: Independent prognostic value of fascin immunoreactivity in stage I non-small cell lung cancer. Br J Cancer 88: 537-547, 2003. (Pubitemid 36363363)
9. Hashimoto Y, Shimada Y, Kawamura J, Yamasaki S and Imamura M: The prognostic relevance of fascin expression in human gastric carcinoma. Oncology 67: 262-270, 2004. (Pubitemid 39551711)
10. Yoder BJ, Tso E, Skacel M, Pettay J, Tarr S and Budd T: The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course. Clin Cancer Res 11: 186-192, 2005. (Pubitemid 40075794)
11. Hashimoto Y, Ito T, Inoue H, Okumura T, Tanaka E and Tsunoda S: Prognostic significance of fascin overexpression in human esophageal squamous cell carcinoma. Clin Cancer Res 11: 2597-2605, 2005. (Pubitemid 40569459)
12. Thang H, Xu L, Xiao D, Xie J, Zeng H and Cal W: Fascin is a potential biomarker for early-stage oesophageal squamous cell carcinoma. J Clin Pathol 59: 958-964, 2006. (Pubitemid 44422851)
13. Xie JJ, Xu LY, Zhang HH, Cai WJ, Mai RQ and Xie YM: Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells. Biochem Biophys Res Commun 337: 355-362, 2005.
14. Bros M, Ross XL, Pautz A, Reske-Kunz AB and Ross R: The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer. J Immunol 171: 1825-1834, 2003.
15. Singal R and Ginder GD: DNA Methylation. Blood 93: 4059-4070, 1999.
16. Pan Q and Xue X: The proliferation and cell cycle of a human epitheial cell line (Eca 109) from esophageal carcinoma. J Mol Cell Biol 13: 19-27, 1890.
17. Wang X, Xiao F, Wang M, Zhou C and Wu M: Establishment of two human esophageal carcinoma cell lines and their cytogenetic analysis. Chin J Oncol 20: 3-6, 1998.
18. Shen Z, Cai W and Shen J: Human papilloma virus 18E6E7 in synergy with TPA induced malignant transformation of human embryonic esophageal epithelial cells. Chin J Virol 15: 5-10, 100-101, 1999.
19. Shen Z, Cen S and Cai W: Immortalization of human fetal esophageal epitheial cells induced by E6 and E7 genes of human papilloma virus 18. Chin J Exp Clin Virol 13: 121-124, 1999.
20. Li L, He S, Sun JM and Davie JR: Gene regulation by Sp1 and Sp3. Biochem Cell Biol 82: 460-471, 2004.
21. Kaczynski J, Cook T and Urrutia R: Sp1- and Krüppel-like transcription factors. Genome Biol 4: 206-208, 2003.
22. Bouwman P and Philipsen S: Regulation of the activity of Sp1-related transcription factors. Mol Cell Endocrinol 195: 27-38, 2002. (Pubitemid 35287159)
23. Suske G: The Sp-family of transcription factors. Gene 238: 291-300, 1999.
24. Chu S and Ferro TJ: Sp1: Regulation of gene expression by phosphorylation. Gene 348: 1-11, 2005. (Pubitemid 40410011)
25. Tokizane T, Shiina H and Igawa M: Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer. Clin Cancer Res 11: 5793-5801, 2005. (Pubitemid 41170305)
26. Paredes J, Albergaria A, Oliveira JT, Jeronimo C, Milanezi F and Schmitt FC: P-cadberin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation. Clin Cancer Res 11: 5869-5877, 2005. (Pubitemid 41170315)
27. Lin J, Lai M, Huang Q, Ma Y, Cui J and Ruan W: Methylation patterns of IGFBP7 in colon cancer cell lines are associated with levels of gene expression. J Pathol 212: 83-90, 2007. (Pubitemid 46746293)
28. Chen WD, Han ZJ, Skoletsky J, Olson J, Sah J and Myeroff L: Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene. J Natl Cancer Inst 97: 1124-1132, 2005. (Pubitemid 41511211)
29. Lu A, Gupta A, Li C, Ahlborn TE, Ma Y and Shi EY: Molecular mechanisms for aberrant expression of the human breast cancer specific gene 1 in breast cancer cells: control of transcription by DNA methylation and intronic sequences. Oncogene 20: 5173-5185, 2001. (Pubitemid 32844046)
30. Unoki M and Nakamura Y: Methylation at CpG islands in intron 1 of EGR2 confers enhancer-like activity. FEBS Lett 554: 67-72, 2003. (Pubitemid 37324816)