Hypoxia inhibits maturation and trafficking of hERG K+ channel protein: Role of Hsp90 and ROS

Biochemical and Biophysical Research Communications

Volumn 388, Issue 2, 2009, Pages 212-216

  Nanduri, Jayasri ^a   Bergson, Pamela ^a   Wang, Ning ^a   Ficker, Eckhard ^b   Prabhakar, Nanduri R ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b METROHEALTH MEDICAL CENTER   (United States)

Author keywords

Chaperones; hERG; Hsp90; Hypoxia; Low temperatures; ROS

Indexed keywords

ANTIARRHYTHMIC AGENT; CHAPERONE; HEAT SHOCK PROTEIN 90; POTASSIUM CHANNEL HERG; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL CULTURE; CELL HYPOXIA; CELL MATURATION; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LOW TEMPERATURE; MEMBRANE CURRENT; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION;

CELL HYPOXIA; CELL LINE; ETHER-A-GO-GO POTASSIUM CHANNELS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES;

EID: 69249206520     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.07.149     Document Type: Article

References (23)

1. Kemp P.J., and Peers C. Oxygen sensing by ion channels. Essays Biochem. 43 (2007) 77-90 (Review)
2. Wang J., Weigand L., Wang W., Sylvester J.T., and Shimoda L.A. Chronic hypoxia inhibits Kv channel gene expression in rat distal pulmonary artery. Am. J. Physiol. Lung Cell. Mol. Physiol. 288 (2005) L1049-L1058
3. Sanguinetti M.C., Jiang C., Curran M.E., and Keating M.Y. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr. Cell 81 (1995) 299-307
4. Curran M.E., Splawski I., Timothy K.W., Vincent G.M., Green E.D., and Keating M.T. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80 (1995) 795-803
5. +-channel dysfunction in an inherited cardiac arrhythmia. Proc. Natl. Acad. Sci. USA 93 (1996) 2208-2212
6. Zhou Z., Gong Q., Epstein M.L., and January C.T. HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects. J. Biol. Chem. 273 (1998) 21061-21066
7. Anderson C.L., Delisle B.P., Anson J.A., Kilby M.L., Will D.J., Tester Q., Gong Z., Zhou Z., Ackerman M.J., and January C.T. Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. Circulation 113 (2006) 365-373
8. Ficker E., Dennis A.T., Obejero-Paz C.A., Castaldo P., Taglialatela M., and Brown A.M. Retention in the endoplasmic reticulum as a mechanism of dominant-negative current suppression in human long QT syndrome. J. Mol. Cell. Cardiol. 32 (2000) 2327-2337
9. + channels by cultivation at reduced temperature. BMC Biotechnol. 7 (2007) 93-103
10. Zhou Z., Gong Q., and January C.T. Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects. J. Biol. Chem. 274 (1999) 31123-31126
11. Robertson G.A., and January C.T. HERG trafficking and pharmacological rescue of LQTS-2 mutant channels. Handb. Exp. Pharmacol. 171 (2006) 349-355 (Review)
12. Gong Q., Jones M.A., and Zhou Z. Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome. J. Biol. Chem. 281 (2006) 4069-4074
13. Thomas D., Kiehn J., Katus H.A., and Karle C.A. Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing. Cardiovasc. Res. 60 (2003) 235-241 (Review)
14. Ficker E., Dennis A.T., Wang L., and Brown A.M. Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG. Circ. Res. 92 (2003) 87-100
15. Nanduri J., Wang N., Bergson P., Yuan G., Ficker E., and Prabhakar N.R. Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein. Biochem. Biophys. Res. Commun. 373 (2008) 309-314
16. Walker V.E., Atanasiu R., Lam H., and Shrier A. Co-chaperone FKBP38 promotes HERG trafficking. J. Biol. Chem. 282 (2007) 23509-23516
17. Heistad D.D., Wakisaka Y., Miller J., Chu Y., and Pena-Silva R. Novel aspects of oxidative stress in cardiovascular diseases. Circ. J. 73 (2009) 201-207
18. Berube J., Caouette D., and Daleau P. Hydrogen peroxide modifies the kinetics of HERG channel expressed in a mammalian cell line. J. Pharmacol. Exp. Ther. 297 (2001) 96-102
19. + channels by reactive oxygen species. Proc. Natl. Acad. Sci. USA 94 (1997) 11698-11703
20. Ficker E., Kuryshev Y.A., Dennis A.T., Obejero-Paz O., Wang L., Hawryluk P., Wible B.A., and Brown A.M. Mechanisms of arsenic-induced prolongation of cardiac repolarization. Mol. Pharmacol. 66 (2004) 33-44
21. Wang J., Wang H., Zhang Y., Gao H., Nattel S., and Wang Z. Impairment of HERG K(+) channel function by tumor necrosis factor-alpha: role of reactive oxygen species as a mediator. J. Biol. Chem. 279 (2004) 13289-13292
22. Morais Cabral J.H., Lee A., Cohen S.L., Chait B.T., Li M., and Mackinnon R. Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell 95 (1998) 649-655
23. Katschinski D.M., Le L., Schindler S.G., Thomas T., Voss A.K., and Wenger R.H. Interaction of the PAS B domain with HSP90 accelerates hypoxia-inducible factor-1alpha stabilization. Cell. Physiol. Biochem. 14 (2004) 351-360