The effect of herpes simplex virus virion host shutoff gene - A new suicide gene- on tumor cells

Iranian Biomedical Journal

Volumn 13, Issue 3, 2009, Pages 185-189

  Baghi, Hossein Bannazadeh ^a   Bamdad, Taravat ^a   Soleimanjahi, Hoorieh ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

Herpes simplex virus (HSV); RNA degradation; Tumor; Virion host shut off (Vhs)

Indexed keywords

GENE PRODUCT; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; MESSENGER RNA; UNCLASSIFIED DRUG; VIRION HOST SHUTOFF PROTEIN;

ANIMAL CELL; ARTICLE; CANCER GENE THERAPY; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; EXPRESSION VECTOR; GENETIC TRANSFECTION; HELA CELL; HERPES SIMPLEX VIRUS; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PROTO ONCOGENE; QUANTITATIVE ANALYSIS; REGULATOR GENE; SUICIDE GENE; TUMOR CELL; UPREGULATION; VIRION; VIROTHERAPY;

ANIMALS; BETA 2-MICROGLOBULIN; CERCOPITHECUS AETHIOPS; CLONING, MOLECULAR; GENE THERAPY; GENES, TRANSGENIC, SUICIDE; HELA CELLS; HUMANS; NEOPLASMS; RNA STABILITY; SIMPLEXVIRUS; TUMOR CELLS, CULTURED; VERO CELLS; VIRAL PROTEINS;

EUKARYOTA; HERPES; SIMPLEXVIRUS;

EID: 69249159534     PISSN: 1028852X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Strelow, L.I. and Leib, D.A. (1995) Role of the virion host shutoff (Vhs) of herpes simplex virus type 1 in latency and pathogenesis. J. Virol. 69 (11): 6779-6786.
2. Everly, D.N. and Read, G.S. (2002) mRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: genetic and biochemical evidence that Vhs is a nuclease. J. Virol. 76 (17): 8560-8571.
3. Strelow, L.I. and Leib, D.A. (1996) Analysis of conserved domains of UL41 of herpes simplex virus type 1 in virion host shutoff and pathogenesis. J. Virol. 70 (8): 5665-5667.
4. Smith, T.J., Morrison, L.A. and Leib, D.A. (2002) Pathogenesis of herpes simplex virus type 2 virion host shutoff (Vhs) mutants. J. Virol. 76 (5): 2054-2061.
5. Zelus, B.D., Stewart, R.S. and Ross, J. (1996) The virion host shutoff protein of herpes simplex virus type 1: messenger ribonucleolytic activity in vitro. J. Virol. 70 (4): 2411-2419.
6. Esclatine, A., Taddeo, B., Evans, L. and Roizman, B. (2004) The herpes simplex virus 1 UL41 genedependent destabilization of cellular RNAs is selective and may be sequence-specific. Proc. Natl. Acad. Sci. 101 (10): 3603-3608. (Pubitemid 38338242)
7. Murphy, A.J., Duerst, R.J., Smith, T.J. and Morrison, L.A. (2003) Herpes simplex virus type 2 virion host shutoff protein regulates alpha/beta interferon but not adaptive immune responses during primary infection in vivo. J. Virol. 77 (17): 9337-9345.
8. Doepker, R.C., Hsu, W.L., Saffran, H.A. and Smiley, J.R. (2004) Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factor eIF4 B eIF4H. J. Virol. 78 (9): 4684-4699.
9. Taddeo, B., Weiran, Z. and Roizman, B. (2006) The UL41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins. Proc. Natl. Acad. Sci. 103 (8): 2827-2832. (Pubitemid 43306634)
10. Smiley, J.R. (2004) Herpes simplex virus virion host shutoff protein: immune evasion mediated by a viral RNase? J. Virol. 78 (3): 1063-1068.
11. L41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs. Proc. Natl. Acad. Sci. PNAS. 101(52):18165-18170.
12. Bakheet, T., Frevel, M., Williams, B.R., Greer, W. and Khabar, K.S. (2001) ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins. Nucleic Acids Res. 29 (1): 246-254. (Pubitemid 32054460)
13. Balczon, R. (2004) Overexpression of cyclin a in human HeLa cells induces detachment of kinetochores and spindle pole/centrosome overproduction. Chromosoma 110 (6): 381-392.
14. Rinehart-Kim, J., Johnston, M., Birrer, M. and Bos, T. (2000) Alterations in the gene expression profile of MCF-7 breast tumor cells in response to c-Jun. Int. J. Cancer 88 (2): 180-190. (Pubitemid 30745209)
15. Fotouhi, F., Soleimanjahi, H., Roostaee, M.H. and Dalimi Asl, A. (2008) Expression of the herpes simplex virus type 2 glycoprotein d in baculovirus expression system and evaluation of its immunogenicity in Guinea pigs. Iran. Biomed. J. 12 (2): 59-66.
16. Kermanian, M., Soleimanjahi, H., Arefian, E. and Bamdad, T. (2008) Enrichment of CSF samples on cell culture for enhancement of sensitivity of mumps and enterovirus detection by multiplex RT-PCR. Diagnostic. Microbiol. Inf. Dis. 60 (4): 375-379.
17. Read. G.S. and Patterson, M. (2007) Packaging of the virion host shutoff (Vhs) protein of herpes simplex virus: Two forms of the Vhs polypeptide are associated with intranuclear B and C capsids, but only one is associated with enveloped virions. J. Virol. 81 (3): 1148-1161.
18. Pak, AS., Everly DN., Knight, K. and Read, G.S. (1995) The virion host shutoff protein of herpes simplex virus inhibits reporter gene expression in the absence of other viral gene products. Virology 211 (2): 491-506.
19. Hamouda, T., McPhee, R., Hsia, S.C., Read, G.S., Holland, T.C. and King, S.R. (1997) Inhibition of human immunodeficiency virus replication by the herpes simplex virus virion host shutoff protein. J. Virol. 71 (7): 5521-5527. (Pubitemid 27258231)
20. Glenn, GM. and Chatterjee, S. (2001) Generation of adenovirus encoding the herpes simplex virus vhs gene: A novel strategy to generate adenoviruses expressing genes toxic to producer cells. Cancer Gene Therapy 8 (8): 566-572.