The HSP72 stress response of monocytes from patients on haemodialysis is impaired

Nephrology Dialysis Transplantation

Volumn 24, Issue 9, 2009, Pages 2838-2846

  Reuter, Stefan ^a   Bangen, Philip ^a   Edemir, Bayram ^a   Hillebrand, Uta ^a   Pavenstädt, Hermann ^a   Heidenreich, Stefan ^b   Lang, Detlef ^a,c  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b KfH Dialysis Center   (Germany)

^c Dialysis Center   (Germany)

Author keywords

Apoptosis; Haemodialysis; HSP72; Human monocytes

Indexed keywords

CD14 ANTIGEN; HEAT SHOCK PROTEIN 72; HEAT SHOCK TRANSCRIPTION FACTOR 1; LIPOCORTIN 5; MESSENGER RNA;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CELL CULTURE; CELL ISOLATION; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HEMODIALYSIS; HISTOPATHOLOGY; HUMAN; MALE; MONOCYTE; MONONUCLEAR CELL; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STRESS; TEMPERATURE DEPENDENCE;

ADOLESCENT; ADULT; AGED; ANIMALS; APOPTOSIS; BASE SEQUENCE; CASE-CONTROL STUDIES; DISEASE MODELS, ANIMAL; DNA PRIMERS; DNA-BINDING PROTEINS; FEMALE; HEAT-SHOCK RESPONSE; HSP72 HEAT-SHOCK PROTEINS; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; MONOCYTES; RATS; RATS, SPRAGUE-DAWLEY; RENAL DIALYSIS; RNA, MESSENGER; TRANSCRIPTION FACTORS; UREA; YOUNG ADULT;

EID: 69249135406     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp142     Document Type: Article

References (58)

1. Mandayam S, Shahinian VB.Are chronic dialysis patients at increased risk for cancer? J Nephrol 2008; 21: 166-174
2. Powe NR, Jaar B, Furth SL et al. Septicemia in dialysis patients: incidence, risk factors, and prognosis. Kidney Int 1999; 55: 1081- 1090
3. Vajdic CM, McDonald SP, McCredie MR et al. Cancer incidence before and after kidney transplantation. JAMA 2006; 296: 2823-2831
4. Cheung AH, Wong LM. Surgical infections in patients with chronic renal failure. Infect Dis Clin North Am 2001; 15: 775-796
5. Goldblum SE, Reed WP. Host defenses and immunologic alterations associated with chronic hemodialysis. Ann InternMed 1980; 93: 597- 613
6. Schmidt S, Westhoff TH, Krauser P et al. The uraemic toxin phenylacetic acid impairs macrophage function. Nephrol Dial Transplant2008; 23: 3485-3493
7. Athlin L, Domellof L. The phagocytic process of human peritoneal macrophages in cancer or uremia. Acta Pathol Microbiol Immunol Scand [C] 1986; 94: 63-68
8. Heidenreich S, SchmidtM, Bachmann J et al.Apoptosis of monocytes cultured from long-term hemodialysis patients. Kidney Int 1996; 49: 792-799
9. Galli F. Protein damage and inflammation in uraemia and dialysis patients. Nephrol Dial Transplant 2007; 22(Suppl 5): v20-v36
10. Locatelli F, Canaud B, Eckardt KU et al. Oxidative stress in endstage renal disease: an emerging threat to patient outcome. Nephrol Dial Transplant 2003; 18: 1272-1280
11. Carracedo J, Ramirez R, Madueno JA et al. Cell apoptosis and hemodialysis-induced inflammation. Kidney Int Suppl 2002; 80: 89- 93
12. Himmelfarb J. Oxidative stress in hemodialysis. Contrib Nephrol2008; 161: 132-137
13. Vanholder R, Schepers E, Meert N et al. What is uremia? Retention versus oxidation. Blood Purif 2006; 24: 33-38
14. Pupim LB, Himmelfarb J, McMonagle E et al. Influence of initiation of maintenance hemodialysis on biomarkers of inflammation and oxidative stress. Kidney Int 2004; 65: 2371-2379
15. Gupta RS, Singh B. Phylogenetic analysis of 70 kD heat shock protein sequences suggests a chimeric origin for the eukaryotic cell nucleus. Curr Biol 1994; 4: 1104-1114
16. Hunt C, Morimoto RI. Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. Proc Natl Acad Sci USA 1985; 82: 6455-6459
17. Lindquist S, Craig EA. The heat-shock proteins. Annu Rev Genet1988; 22: 631-677
18. Aufricht C. Heat-shock protein 70: molecular supertool? Pediatr Nephrol 2005; 20: 707-713
19. Hartl FU, Hayer-Hartl M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 2002; 295: 1852-1858
20. Hartl FU. Molecular chaperones in cellular protein folding. Nature1996; 381: 571-579
21. Jaattela M. Heat shock proteins as cellular lifeguards. Ann Med 1999; 31: 261-271
22. DaugaardM, Rohde M, Jaattela M. The heat shock protein 70 family: highly homologous proteins with overlapping and distinct functions. FEBS Lett 2007; 581: 3702-3710
23. Lang D, Hubrich A, Dohle F et al. Differential expression of heat shock protein 70 (hsp70) in human monocytes rendered apoptotic by IL-4 or serum deprivation. J Leukoc Biol 2000; 68: 729-736
24. Li CY, Lee JS, Ko YG et al. Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation. J Biol Chem 2000; 275: 25665-25671
25. Wieland A, Denzel M, Schmidt E et al. Recombinant complexes of antigen with stress proteins are potent CD8 T-cell-stimulating immunogens. J MolMed 2008; 86: 1067-1079
26. Wang R, Town T, Gokarn V et al. HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways. J Surg Res 2006; 136: 58-69
27. Anderson KM, Srivastava PK. Heat, heat shock, heat shock proteins and death: a central link in innate and adaptive immune responses. Immunol Lett 2000; 74: 35-39
28. Moseley PL. Heat shock proteins and the inflammatory response. Ann N Y Acad Sci 1998; 856: 206-213
29. Nishimura H, Emoto M, Kimura K et al. Hsp70 protects macrophages infected with Salmonella choleraesuis against TNF-alpha-induced cell death. Cell Stress Chaperones 1997; 2: 50-59
30. van EW, Van Der ZR, Prakken B. Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat Rev Immunol 2005; 5: 318- 330
31. Lai CC, Jou MJ, Huang SY et al. Proteomic analysis of up-regulated proteins in human promonocyte cells expressing severe acute respiratory syndrome coronavirus 3C-like protease. Proteomics 2007; 7: 1446-1460
32. Melcher A, Todryk S, Hardwick N et al. Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression. Nat Med 1998; 4: 581-587
33. Schmitt E, Gehrmann M, BrunetMet al. Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy. J Leukoc Biol 2007; 81: 15-27
34. Horl WH. Hemodialysis membranes: interleukins, biocompatibility, andmiddlemolecules. J Am Soc Nephrol 2002; 13(Suppl 1): S62-S71
35. Memoli B. Cytokine production in haemodialysis. Blood Purif 1999; 17: 149-158
36. Lang D, Reuter S, Buzescu T et al. Heme-induced heme oxygenase- 1 (HO-1) in human monocytes inhibits apoptosis despite caspase-3 up-regulation. Int Immunol 2005; 17: 155-165
37. Heidenreich S, Schmidt M, August C et al. Regulation of human monocyte apoptosis by the CD14 molecule. J Immunol 1997; 159: 3178-3188
38. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitativePCRand the 2(-Delta Delta C(T))Method. Methods 2001; 25: 402-408
39. Ponce P, Cruz J, Ferreira A et al. A prospective study on incidence of bacterial infections in Portuguese dialysis units. Nephron Clin Pract2007; 107: c133-c138
40. Trinklein ND, Chen WC,KingstonRE et al. Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation. Cell Stress Chaperones 2004; 9: 21-28
41. Samali A, Cotter TG. Heat shock proteins increase resistance to apoptosis. Exp Cell Res 1996; 223: 163-170
42. Degrossoli A, Colhone MC, Arrais-Silva WW et al. Hypoxia modulates expression of the 70-kD heat shock protein and reduces Leishmania infection in macrophages. J Biomed Sci 2004; 11: 847-854
43. Kantengwa S, Polla BS. Phagocytosis of Staphylococcus aureus induces a selective stress response in human monocytes-macrophages (M phi): modulation byMphi differentiation and by iron. Infect Immun1993; 61: 1281-1287
44. Calabrese V, Mancuso C, Sapienza M et al. Oxidative stress and cellular stress response in diabetic nephropathy. Cell Stress Chaperones2007; 12: 299-306
45. Marzec L, Liberek T, Chmielewski M et al. Expression of heat shock protein 72 in peritoneal leukocytes is induced by peritoneal dialysis. Perit Dial Int 2007; 27: 288-295
46. Bangen JM, Schade FU, Flohe SB. Diverse regulatory activity of human heat shock proteins 60 and 70 on endotoxin-induced inflammation. Biochem Biophys Res Commun 2007; 359: 709-715
47. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388: 394-397
48. Visintin A, Mazzoni A, Spitzer JH et al. Regulation of Toll-like receptors in human monocytes and dendritic cells. J Immunol 2001; 166: 249-255
49. Ando M, Shibuya A, TsuchiyaKet al.Reduced expression of Toll-like receptor 4 contributes to impaired cytokine response of monocytes in uremic patients. Kidney Int 2006; 70: 358-362
50. Maddock AL, Westenfelder C. Urea induces the heat shock response in human neuroblastoma cells. J Am Soc Nephrol 1996; 7: 275-282
51. Crowe AV, McArdle A, McArdle F et al. Markers of oxidative stress in the skeletal muscle of patients on haemodialysis. Nephrol Dial Transplant 2007; 22: 1177-1183
52. Beckmann RP, Lovett M, Welch WJ. Examining the function and regulation of hsp 70 in cells subjected to metabolic stress. J Cell Biol1992; 117: 1137-1150
53. Raj DS, Welbourne T, Dominic EA et al. Glutamine kinetics and protein turnover in end-stage renal disease. Am J Physiol Endocrinol Metab 2005; 288: E37-E46
54. Pollheimer J, Zellner M, Eliasen MM et al. Increased susceptibility of glutamine-depleted monocytes to fever-range hyperthermia: the role of 70-kDa heat shock protein. Ann Surg 2005; 241: 349- 355
55. Eliasen MM, Brabec M, Gerner C et al. Reduced stress tolerance of glutamine-deprived human monocytic cells is associated with selective down-regulation of Hsp70 by decreased mRNA stability. J Mol Med 2006; 84: 147-158
56. Xu B, Dong GH, Liu H et al. Recombinant human erythropoietin pretreatment attenuates myocardial infarct size: a possible mechanism involves heat shock Protein 70 and attenuation of nuclear factorkappaB. Ann Clin Lab Sci 2005; 35: 161-168
57. Yang CW, Li C, Jung JY et al. Preconditioning with erythropoietin protects against subsequent ischemia-reperfusion injury in rat kidney. FASEB J 2003; 17: 1754-1755
58. Ribeil JA, Zermati Y, Vandekerckhove J et al. Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature 2007; 445: 102-105