Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene

PLoS ONE

Volumn 4, Issue 8, 2009, Pages

  Roe, Brian E ^a   Tilley, Michael R ^b   Gu, Howard H ^c   Beversdorf, David Q ^a   Sadee, Wolfgang ^c   Haab, Timothy C ^a   Papp, Audrey C ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b Central Methodist University   (United States)

^c University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CATECHOL METHYLTRANSFERASE; DEXTRO AMINO ACID OXIDASE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; ESTROGEN RECEPTOR ALPHA; MESSENGER RNA; NICOTINIC RECEPTOR ALPHA4; NORADRENALIN TRANSPORTER; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE 2; TYROSINE 3 MONOOXYGENASE; VESICULAR MONOAMINE TRANSPORTER 2; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA4 SUBUNIT; NICOTINIC RECEPTOR;

ADULT; ARTICLE; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC REGULATION; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; NEUROTRANSMISSION; PERSONALITY; SINGLE NUCLEOTIDE POLYMORPHISM; FINANCIAL MANAGEMENT; GENETICS; HIGH RISK BEHAVIOR;

ADULT; FEMALE; FINANCIAL MANAGEMENT; HUMANS; MALE; PERSONALITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, NICOTINIC; RISK-TAKING;

EID: 69249132597     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006704     Document Type: Article

References (66)

1. Barsky RB, Juster FT, Kimball MS, Shapiro MD (1997) Preference parameters and behavioral heterogeneity: An experimental approach in the health and retirement study. Quarterly Journal of Economics 112: 537-579.
2. Dohmen TJ, Falk A, Huffman D, Sunde U, Schupp J, et al. Individual Risk Attitudes: New Evidence from a Large, Representative, Experimentally-Validated Survey. IZA Discussion Paper. Bonn, Germany.
3. Ekelund J, Johansson E, Jarvelin MR, Lichtermann D (2005) Self-employment and risk aversion - evidence from psychological test data. Labour Economics 12: 649-659.
4. Forbush KT, Shaw M, Graeber MA, Hovick L, Meyer VJ, et al. (2008) Neuropsychological characteristics and personality traits in pathological gambling. Cns Spectrums 13: 306-315.
5. Alvarez-Moya EM, Jimenez-Murcia S, Granero R, Vallejo J, Krug I, et al. (2007) Comparison of personality risk factors in bulimia nervosa and pathological gambling. Comprehensive Psychiatry 48: 452-457.
6. Nordin C, Nylander PO (2007) Temperament and character in pathological gambling. Journal of Gambling Studies 23: 113-120.
7. Starcevic V, Uhlenhuth EH, Fallon S, Pathak D (1996) Personality dimensions in panic disorder and generalized anxiety disorder. Journal of Affective Disorders 37: 75-79.
8. Kusunoki K, Sato T, Taga C, Yoshida T, Komori K, et al. (2000) Low novelty-seeking differentiates obsessive-compulsive disorder from major depression. Acta Psychiatrica Scandinavica 101: 403-405.
9. Blairy S, Massat I, Staner L, Le Bon O, Van Gestel S, et al. (2000) 5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait. American Journal of Medical Genetics 96: 360-364.
10. Voon V, Potenza MN, Thomsen T (2007) Medication-related impulse control and repetitive behaviors in Parkinson's disease. Current Opinion in Neurology 20: 484-492.
11. Paulus MP, Rogalsky C, Simmons A, Feinstein JS, Stein MB (2003) Increased activation in the right insula during risk-taking decision making is related to harm avoidance and neuroticism. Neuroimage 19: 1439-1448.
12. Yang TT, Simmons AN, Matthews SC, Tapert SF, Frank GK, et al. (2009) Adolescent subgenual anterior cingulate activity is related to harm avoidance. Neuroreport 20: 19-23.
13. Yamasue H, Abe O, Suga M, Yamada H, Inoue H, et al. (2008) Gender-common and -specific neuroanatomical basis of human anxiety-related personality traits. Cerebral Cortex 18: 46-52.
14. Martin SB, Covell DJ, Joseph JE, Chebrolu H, Smith CD, et al. (2007) Human experience seeking correlates with hippocampus volume: Convergent evidence from manual tracing and voxel-based morphometry. Neuropsychologia 45: 2874-2881.
15. Cesarini D, Dawes CT, Johannesson M, Lichtenstein P, Wallace B (In Press) Genetic Variation in Preferences for Giving and Risk-Taking. Quarterly Journal of Economics.
16. Zhong S, Chew SH, Set E, Zhang J, Xue H, et al. (2009) The Heritability of Attitude Toward Economic Risk. Twin Research and Human Genetics 12: 5.
17. Eisen SA, Lin N, Lyons MJ, Scherrer JF, Griffith K, et al. (1998) Familial influences on gambling behavior: an analysis of 3359 twin pairs. Addiction 93: 1375-1384.
18. Cloninger CR (1987) A SYSTEMATIC METHOD FOR CLINICAL DESCRIPTION AND CLASSIFICATION OF PERSONALITY VARIANTS - A PROPOSAL. Archives of General Psychiatry 44: 573-588.
19. Cloninger CR (1986) A UNIFIED BIOSOCIAL THEORY OF PERSONALITY AND ITS ROLE IN THE DEVELOPMENT OF ANXIETY-STATES. Psychiatric Developments 4: 167-226.
20. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, et al. (1996) Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nature Genetics 12: 78-80.
21. Comings DE, Gade-Andavolu R, Gonzalez N, Wu S, Muhleman D, et al. (2000) A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. Clinical Genetics 58: 375-385.
22. Ronai Z, Szekely A, Nemoda Z, Lakatos K, Gervai J, et al. (2001) Association between Novelty Seeking and the-521 C/T polymorphism in the promoter region of the DRD4 gene. Molecular Psychiatry 6: 35-38.
23. Kazantseva AV, Gaysina DA, Faskhutdinova GG, Noskova T, Malykh SB, et al. (2008) Polymorphisms of the serotonin transporter gene (5-HTTLPR, A/ G SNP in 5-HTTLPR, and STin2 VNTR) and their relation to personality traits in healthy individuals from Russia. Psychiatric Genetics 18: 167-176.
24. Strobel A, Gutknecht L, Rothe C, Reif A, Mossner R, et al. (2003) Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits. Journal of Neural Transmission 110: 1445-1453.
25. Reuter M, Hennig J (2005) Association of the functional catechol-Omethyltransferase VALI58MET polymorphism with the personality trait of extraversion. Neuroreport 16: 1135-1138.
26. Gutknecht L, Jacob C, Strobel A, Kriegebaum C, Muller J, et al. (2007) Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. International Journal of Neuropsychopharmacology 10: 309-320.
27. Jiang XY, Xu K, Hoberman J, Tian F, Marko AJ, et al. (2005) BDNF variation and mood disorders: A novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. Neuropsychopharmacology 30: 1353-1361.
28. Roe BE, Haab TC, Beversdorf DQ, Gu HH, Tilley MR (In press) Risk-attitude Selection Bias in Subject Pools for Experiments Involving Neuroimagin and Blood Samples. Journal of Economic Psychology.
29. Weber EU, Blais AR, Betz NE (2002) A domain-specific risk-attitude scale: Measuring risk perceptions and risk behaviors. Journal of Behavioral Decision Making 15: 263-+.
30. Roussos P, Giakoumaki SG, Pavlakis S, Bitsios P (2008) Planning, decision-making and the COMT rs4818 polymorphism in healthy males. Neuropsychologia 46: 757-763.
31. Kuhnen CM, Chiao JY (2009) Genetic Determinants of Financial Risk Taking. PLoS ONE 4: 4.
32. Dreber A, Apicella CL, Eisenberg DTA, Garcia JR, Zamore RS, et al. (2009) The 7R polymorphism in the dopamine receptor D-4 gene (DRD4) is associated with financial risk taking in men. Evolution and Human Behavior 30: 85-92.
33. Goudriaan AE, Oosterlaan J, de Beurs E, van den Brink W (2006) Psychophysiological determinants and concomitants of deficient decision making in pathological gamblers. Drug and Alcohol Dependence 84: 231-239.
34. Andersen S, Harrison GW, Lau MI, Rutstroem EE (2008) Lost in state space: Are preferences stable? International Economic Review 49: 1091-1112.
35. Holt CA, Laury SK (2002) Risk aversion and incentive effects. American Economic Review 92: 1644-1655.
36. Kahneman D, Tversky A (1979) Prospect Theory - Analysis of Decision Making Under Risk. Econometrica 47: 263-291.
37. Pool IPI (2001) A scientific collaboratory for the development of advanced measures of personality traits and other individual differences.
38. Goldberg LR (1999) A broad-bandwidth, public domain, personality inventory measuring the lower-level facets of several five-factor models. In: Mervielde I, Deary I, De Fruyt F, Ostendorf F, eds (1999) Personality Psychology in Europe. Tilburg, The Netherlands: Tilburg University Press. pp 7-28.
39. Chien AJ, Dunner DL (1996) The tridimensional personality questionnaire in depression: State versus trait issues. Journal of Psychiatric Research 30: 21-27.
40. Matthews SC, Simmons AN, Lane SD, Paulus MP (2004) Selective activation of the nucleus accumbens during risk-taking decision making. Neuroreport 15: 2123-2127.
41. Martinotti G, Andreoli S, Giametta E, Poli V, Bria P, et al. (2006) The dimensional assessment of personality in pathologic and social gamblers: the role of novelty seeking and self-transcendence. Comprehensive Psychiatry 47: 350-356.
42. Dreher JC, Kohn P, Kolachana B, Weinberger DR, Berman KF (2009) Variation in dopamine genes influences responsivity of the human reward system. Proceedings of the National Academy of Sciences of the United States of America 106: 617-622.
43. Westberg L, Melke J, Landen M, Nilsson S, Baghaei F, et al. (2003) Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women. Molecular Psychiatry 8: 118-122.
44. Rosenberg S, Templeton AR, Feigin PD, Lancet D, Beckmann JS, et al. (2006) The association of DNA sequence variation at the MAOA genetic locus with quantitative behavioural traits in normal males. Human Genetics 120: 447-459.
45. Storey JD (2002) A direct approach to false discovery rates. Journal of the Royal Statistical Society Series B-Statistical Methodology 64: 479-498.
46. Benjamini Y, Hochberg Y (1995) CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING. Journal of the Royal Statistical Society Series B-Methodological 57: 289-300.
47. Voineskos S, De Luca V, Mensah A, Vincent JB, Potapova N, et al. (2007) Association of alpha 4 beta 2 nicotinic receptor and heavy smoking in schizophrenia. Journal of Psychiatry & Neuroscience 32: 412-416.
48. Laviolette SR, van der Kooy D (2004) The neurobiology of nicotine addiction: Bridging the gap from molecules to behaviour. Nature Reviews Neuroscience 5: 55-65.
49. Hutchison KE, Allen DL, Filbey FM, Jepson C, Lerman C, et al. (2007) CHRNA4 and tobacco dependence - From gene regulation to treatment outcome. Archives of General Psychiatry 64: 1078-1086.
50. Rigbi A, Kanyas K, Yakir A, Greenbaum L, Pollak Y, et al. (2008) Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. Genes Brain and Behavior 7: 164-172.
51. Hansenne M, Pinto E, Scantamburlo G, Renard B, Reggers J, et al. (2003) Harm avoidance is related to mismatch negativity (MMN) amplitude in healthy subjects. Personality and Individual Differences 34: 1039-1048.
52. Voon V, Thomsen T, Miyasaki JM, de Souza M, Shafro A, et al. (2007) Factors associated with dopaminergic drug-related pathological gambling in Parkinson disease. Archives of Neurology 64: 212-216.
53. Takeuchi H, Yanagida T, Inden M, Takata K, Kitamura Y, et al. (2009) Nicotinic Receptor Stimulation Protects Nigral Dopaminergic Neurons in Rotenone-induced Parkinson's Disease Models. Journal of Neuroscience Research 87: 576-585.
54. Ling DJ, Niu TH, Feng Y, Xing HX, Xu XP (2004) Association between polymorphism of the dopamine transporter gene and early smoking onset: an interaction risk on nicotine dependence. Journal of Human Genetics 49: 35-39.
55. Le Strat Y, Ramoz N, Pickering P, Burger V, Boni C, et al. (2008) The 3′ part of the dopamine transporter gene DAT1/SLC6A3 is associated with withdrawal seizures in patients with alcohol dependence. Alcoholism-Clinical and Experimental Research 32: 27-35.
56. Ouellet-Morin I, Wigg KG, Feng Y, Dionne G, Robaey P, et al. (2008) Association of the Dopamine Transporter Gene and ADHD Symptoms in a Canadian Population-Based Sample of Same-Age Twins. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 147B: 1442-1449.
57. Sullivan PF, Fifield WJ, Kennedy MA, Mulder RT, Sellman JD, et al. (1997) Novelty seeking and a dopamine transporter gene polymorphism (DAT1). Biological Psychiatry 42: 1070-1072.
58. Laine TPJ, Ahonen A, Rasanen P, Tiihonen J (2001) Dopamine transporter density and novelty seeking among alcoholics. Journal of Addictive Diseases 20: 91-96.
59. Schwab SG, Franke PE, Hoefgen B, Guttenthaler V, Lichtermann D, et al. (2005) Association of DNA Polymorphisms in the synaptic vesicular amine transporter gene (SLCI8A2) with alcohol and nicotine dependence. Neuropsychopharmacology 30: 2263-2268.
60. Little KY, Krolewski DM, Zhang L, Cassin BJ (2003) Loss of striatal vesicular monoamine transporter protein (VMAT2) in human cocaine users; 2003. pp 47-55.
61. Barry D, Petry NM (2008) Predictors of decision-making on the Iowa Gambling Task: Independent effects of lifetime history of substance use disorders and performance on the Trail Making Test. Brain and Cognition 66: 243-252.
62. Bechara A, Dolan S, Denburg N, Hindes A, Anderson SW, et al. (2001) Decision-malting deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers; 2001. pp 376-389.
63. Lin ZC, Walther D, Yu XY, Li SX, Drgon T, et al. (2005) SLC18A2 promoter haplotypes and identification of a novel protective factor against alcoholism. Human Molecular Genetics 14: 1393-1404.
64. Glatt CE, Wahner AD, White DJ, Ruiz-Linares A, Ritz B (2006) Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women. Human Molecular Genetics 15: 299-305.
65. Lang UE, Bajbouj M, Sander T, Gallinat J (2007) Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait. Neuropsychopharmacology 32: 1950-1955.
66. Tsai SJ, Hong CJ, Yu YWY, Chen TJ (2004) Association study of catechol-Omethyltransferase gene and dopamine D-4 receptor gene polymorphisms and personality traits in healthy young chinese females. Neuropsychobiology 50: 153-156.