Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line

Endocrinology

Volumn 150, Issue 9, 2009, Pages 4376-4385

  Kotani, Tomomi ^a   Iwase, Akira ^a   Ino, Kazuhiko ^a   Sumigama, Seiji ^a   Yamamoto, Eiko ^a   Hayakawa, Hiromi ^a   Nagasaka, Tetsuo ^b   Itakura, Atsuo ^c   Nomura, Seiji ^d   Kikkawa, Fumitaka ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

^d Seven Bell Clinic   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX METALLOPROTEINASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEINASE ACTIVATED RECEPTOR 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR AP 2 ALPHA; TRANSCRIPTION FACTOR AP 2 GAMMA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; PREECLAMPSIA; PRIORITY JOURNAL; TROPHOBLAST;

ANOXIA; CELL LINE; CELL MOVEMENT; FEMALE; HUMANS; PLACENTA; PLASMINOGEN ACTIVATOR INHIBITOR 1; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY TRIMESTER, FIRST; RECEPTOR, PAR-1; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSCRIPTION FACTOR AP-2; TROPHOBLASTS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 69249121723     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1645     Document Type: Article

References (42)

1. Sibai B, Dekker G, Kupferminc M 2005 Pre-eclampsia. Lancet 365:785-799
2. Zhou Y, Damsky CH, Fisher SJ 1997 Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? J Clin Invest 99:2152-2164
3. Soleymanlou N, Jurisica I, Nevo O, Ietta F, Zhang X, Zamudio S, Post M, Caniggia I 2005 Molecular evidence of placental hypoxia in preeclampsia. J Clin Endocrinol Metab 90:4299-4308
4. Hung TH, Charnock-Jones DS, Skepper JN, Burton GJ 2004 Secretion of tumor necrosis factor-α from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia. Am J Pathol 164:1049-1061
5. Conrad KP, Benyo DF 1997 Placental cytokines and the pathogenesis of preeclampsia. Am J Reprod Immunol 37:240-249
6. Benyo DF, Smarason A, Redman CW, Sims C, Conrad KP 2001 Expression of inflammatory cytokines in placentas from women with preeclampsia. J Clin Endocrinol Metab 86:2505-2512
7. Bauer S, Pollheimer J, Hartmann J, Husslein P, Aplin JD, KnöflerM 2004 Tumor necrosis factor-α inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures. J Clin Endocrinol Metab 89:812-822
8. Eckert D, Buhl S, Weber S, Jäger R, Schorle H 2005 The AP-2 family of transcription factors. Genome Biol 6:246
9. Williams T, Admon A, Luscher B, Tjian R 1988 Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev 2:1557-1569
10. Ito T, Nomura S, Okada M, Katsumata Y, Kikkawa F, Rogi T, Tsujimoto M, Mizutani S 2002 Ap-2 and Ikaros regulate transcription of human placental leucine aminopeptidase/oxytocinase gene. Biochem Biophys Res Commun 290:1048-1053
11. Richardson BD, Langland RA, Bachurski CJ, Richards RG, Kessler CA, Cheng YH, Handwerger S 2000 Activator protein-2 regulates human placental lactogen gene expression. Mol Cell Endocrinol 160:183-192
12. Schwartz B, Melnikova VO, Tellez C, Mourad-Zeidan A, Blehm K, Zhao YJ, McCarty M, Adam L, Bar-Eli M 2007 Loss of AP-2α results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo. Oncogene 26:4049-4058
13. Sumigama S, Ito T, Kajiyama H, Shibata K, Tamakoshi K, Kikkawa F, Williams T, Tainsky MA, Nomura S, Mizutani S 2004 Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2α. Oncogene 23:5496-5504
14. Tellez C, McCarty M, Ruiz M, Bar-Eli M 2003 Loss of activator protein-2α results in overexpression of protease-activated receptor-1 and correlates with the malignant phenotype of human melanoma. J Biol Chem 278:46632-46642
15. Huppertz B, Kertschanska S, Demir AY, Frank HG, Kaufmann P 1998 Immunohistochemistry of matrix metalloproteinases (MMP), their substrates, and their inhibitors (TIMP) during trophoblast invasion in the human placenta. Cell Tissue Res 291:133-148
16. Graham CH, Lala PK 1991 Mechanism of control of trophoblast invasion in situ. J Cell Physiol 148:228-234
17. Grisaru-Granovsky S, Maoz M, Barzilay O, Yin YJ, Prus D, Bar-Shavit R 2009 Protease activated receptor-1, PAR1, promotes placenta trophoblast invasion and β-catenin stabilization. J Cell Physiol 218:512-521
18. Graham CH, Hawley TS, Hawley RG, MacDougall JR, Kerbel RS, Khoo N, Lala PK 1993 Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Exp Cell Res 206:204-211
19. Yamamoto E, Ito T, Abe A, Sido F, Ino K, Itakura A, Mizutani S, Dovat S, Nomura S, Kikkawa F 2005 Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion. Mol Hum Reprod 11:825-831
20. Lockwood CJ, Oner C, Uz YH, Kayisli UA, Huang SJ, Buchwalder LF, Murk W, Funai EF, Schatz F 2008 Matrix metalloproteinase 9 (MMP9) expression in preeclamptic decidua and MMP9 induction by tumor necrosis factor α and interleukin 1β in human first trimester decidual cells. Biol Reprod 78:1064-1072
21. Lockwood CJ, Yen CF, Basar M, Kayisli UA, Martel M, Buhimschi I, Buhimschi C, Huang SJ, Krikun G, Schatz F 2008 Preeclampsia-related inflammatory cytokines regulate interleukin-6 expression in human decidual cells. Am J Pathol 172:1571-1579
22. Sato Y, Higuchi T, Yoshioka S, Tatsumi K, Fujiwara H, Fujii S 2003 Trophoblasts acquire a chemokine receptor, CCR1, as they differentiate towards invasive phenotype. Development 130:5519-5532
23. Beger M, Butz K, Denk C, Williams T, Hurst HC, Hoppe-Seyler F 2001 Expression pattern of AP-2 transcription factors in cervical cancer cells and analysis of their influence on human papillomavirus oncogene transcription. J Mol Med 79:314-320
24. Williams T, Tjian R 1991 Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev 5:670-682
25. Huber AV, Saleh L, Bauer S, Husslein P, Knöfler M 2006 TNFα-mediated induction of PAI-1 restricts invasion of HTR-8/SVneo trophoblast cells. Placenta 27:127-136
26. Orso F, Penna E, Cimino D, Astanina E, Maione F, Valdembri D, Giraudo E, Serini G, Sismondi P, De Bortoli M, Taverna D 2008 AP-2α and AP-2γ regulate tumor progression via specific genetic programs. FASEB J 22:2702-2714
27. Enquobahrie DA, Meller M, Rice K, Psaty BM, Siscovick DS, Williams MA 2008 Differential placental gene expression in preeclampsia. Am J Obstet Gynecol 199:566.e1-566.e11
28. Cindrova-Davies T, Yung HW, Johns J, Spasic-Boskovic O, Korolchuk S, Jauniaux E, Burton GJ, Charnock-Jones DS 2007 Oxidative stress, gene expression, and protein changes induced in the human placenta during labor. Am J Pathol 171:1168-1179
29. Walton DL, Norem CT, Schoen EJ, Ray GT, Colby CJ 1999 Second-trimester serum chorionic gonadotropin concentrations and complications and outcome of pregnancy. N Engl J Med 341:2033-2038
30. Johnson W, Jameson JL 1999 AP-2 (activating protein 2) and Sp1 (selective promoter factor 1) regulatory elements play distinct roles in the control of basal activity and cyclic adenosine 3′,5′-monophosphate responsiveness of the human chorionic gonadotropin-β promoter. Mol Endocrinol 13:1963-1975
31. Baldi A, Santini D, Battista T, Dragonetti E, Ferranti G, Petitti T, Groeger AM, Angelini A, Rossiello R, Baldi F, Natali PG, Paggi MG 2001 Expression of AP-2 transcription factor and of its downstream target genes c-kit, E-cadherin and p21 in human cutaneous melanoma. J Cell Biochem 83:364-372
32. Gershenwald JE, Sumner W, Calderone T, Wang Z, Huang S, Bar-Eli M 2001 Dominant-negative transcription factor AP-2 augments SB-2 melanoma tumor growth in vivo. Oncogene 20:3363-3375
33. Tellez C, Bar-Eli M 2003 Role and regulation of the thrombin receptor (PAR-1) in human melanoma. Oncogene 22:3130-3137
34. Clark IM, Rowan AD, Edwards DR, Bech-Hansen T, Mann DA, Bahr MJ, Cawston TE 1997 Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1. Biochem J 324(Pt 2):611-617
35. Descheemaeker KA, Wyns S, Nelles L, Auwerx J, Ny T, Collen D 1992 Interaction of AP-1-, AP-2-, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol 12-myristate 13-acetate response. J Biol Chem 267:15086-15091
36. O'Brien PJ, Koi H, Parry S, Brass LF, Strauss 3rd JF, Wang LP, Tomaszewski JE, Christenson LK 2003 Thrombin receptors and protease-activated receptor-2 in human placentation: receptor activation mediates extravillous trophoblast invasion in vitro. Am J Pathol 163:1245-1254
37. Lash GE, Otun HA, Innes BA, Kirkley M, De Oliveira L, Searle RF, Robson SC, Bulmer JN 2006 Interferon-γ inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels. FASEB J 20:2512-2518
38. Chou CS, Zhu H, MacCalman CD, Leung PC 2003 Regulatory effects of gonadotropin-releasing hormone (GnRH) I and GnRH II on the levels of matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of metalloproteinases-1 in primary cultures of human extravillous cytotrophoblasts. J Clin Endocrinol Metab 88:4781-4790
39. Koklanaris N, Nwachukwu JC, Huang SJ, Guller S, Karpisheva K, Garabedian M, Lee MJ 2006 First-trimester trophoblast cell model gene response to hypoxia. Am J Obstet Gynecol 194:687-693
40. Benyo DF, Miles TM, Conrad KP 1997 Hypoxia stimulates cytokine production by villous explants from the human placenta. J Clin Endocrinol Metab 82:1582-1588
41. Hou B, Eren M, Painter CA, Covington JW, Dixon JD, Schoenhard JA, Vaughan DE 2004 Tumor necrosis factor α activates the human plasminogen activator inhibitor-1 gene through a distal nuclear factor κB site. J Biol Chem 279:18127-18136
42. Cohen M, Meisser A, Haenggeli L, Bischof P 2006 Involvement of MAPK pathway in TNF-α-induced MMP-9 expression in human trophoblastic cells. Mol Hum Reprod 12:225-232