AP-2 (activating protein 2) and Sp1 (selective promoter factor 1) regulatory elements play distinct roles in the control of basal activity and cyclic adenosine 3',5'- monophosphate responsiveness of the human chorionic gonadotropin-β promoter

Molecular Endocrinology

Volumn 13, Issue 11, 1999, Pages 1963-1975

  Johnson, Wade ^a   Jameson, J Larry ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; CYCLIC AMP; LUTEINIZING HORMONE; SELECTIVE PROMOTER FACTOR 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 2; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARCINOMA CELL; CHORIOCARCINOMA; CONTROLLED STUDY; GENE DUPLICATION; GENE EXPRESSION REGULATION; GENE STRUCTURE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 0033305360     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.11.0386     Document Type: Article

References (42)

1. Regulation of chorionic gonadotropin gene expression
2. Human chorionic gonadotropin b-subunit is encoded by at least eight genes arranged in tandem and inverted pairs
3. The human genome contains seven genes for the b-subunit of chorionic gonadotropin but only one gene for the β-subunit of luteinizing hormone
4. Isolation and characterization of the human chorionic gonadotropin β subunit (CGβ) gene cluster: Regulation of a transcriptionally active CGβ gene by cyclic AMP
5. Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin β-subunit genes
6. Mutiple promoter elements in the human chorionic gonadotropin β subunit genes distinguish their expression from the luteinizing hormone β gene
7. Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone β-subunit gene expression
8. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation
9. The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis
10. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGF I-A (Egr-1)
11. Novel cyclic adenosine 3',5'-monophosphate response element in the human chorionic gonadotropin β-subunit gene
12. Coordinate control of the α- and β-subunit genes of human chorionic gonadotropin by trophoblast-specific element-binding protein
13. c-Jun represses transcription of the human chorionic gonadotropin α and β genes through distinct types of CREs
14. Silencing of the gene for the β subunit of human chorionic gonadotropin by the embryonic transcription factor Oct3/4
15. Regulation of the human chorionic gonadotropin α and β-subunit promoters by AP-2
16. The gonadotropin α-gene contains multiple protein binding domains that interact to modulate basal and cAMP-responsive transcription
17. GATA-binding proteins regulate the human gonadotropin α-subunit gene in the placenta and pituitary gland
18. Functional analysis of the placenta-specific enhancer of the human glycoprotein hormone α subunit gene. Emergence of a new element
19. Transcription factor AP-2 g regulates murine adenosine deaminase gene expression during placental development
20. Regulation of gene expression in the mouse oocyte and early preimplantation embryo: Developmental changes in Sp1 and TATA box-binding protein, TBP
21. Regulation of gene expression in the preimplantation mouse embryo: Temporal and spatial patterns of expression of the transcription factor Sp1
22. Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2
23. Transcription factor AP-2 essential for cranial closure and craniofacial development
24. AP-2-Null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice
25. Comparative analysis of AP-2α and AP-2β gene expression during murine embryogenesis
26. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation
27. Modulation of transcription factor Sp1 by cAMP-dependent protein kinase
28. Sp1 is phosphorylated and its DNA binding activity down-regulated upon terminal differentiation of the liver
29. Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression
30. Interaction of AP-1-, AP-2-, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol 12-myristate 13-acetate response
31. The proximal promoter region of the gene encoding human 17β-hedroxysteroid dehydrognease type 1 contains GATA, AP-2, and Sp1 response elements: Analysis of promoter function in choriocarcinoma cells
32. Regulation of K3 keratin gene transcription by Sp1 and AP-2 in differentiating rabbit corneal epithelial cells
33. Transcriptional regulation of lysosomal acid lipase in differentiating monocytes is mediated by transcription factors Sp1 and AP-2
34. Cloning by recognition site screening of two novel GT box binding proteins: A family of Sp1 related genes
35. Sp1-Mediated transcriptional activation is repressed by Sp3
36. Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference
37. The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator
38. Association of p107 with Sp1: Genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription
39. YY 1 and Sp1 transcription factors bind the human transferrin gene in an age-related manner
40. Cyclic AMP (cAMP) effects on chorionic gonadotropin gene transcription and mRNA stability: Labile proteins mediate basal expression whereas stable proteins mediate cAMP stimulation
41. Purification and biochemical characterization of the promoter-specific transcription factor, Sp 1
42. Luciferase reporter gene vectors for analysis of promoters and enhancers