Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents

Arzneimittel-Forschung/Drug Research

Volumn 59, Issue 8, 2009, Pages 415-421

  Abadi, Ashraf H ^a   Abouel Ella, Dalal A ^a   Ahmed, Nermin S ^a   Gary, Bernard D ^b   Thaiparambil, Jose T ^b   Tinsley, Heather N ^b   Keeton, Adam B ^b   Piazza, Gary A ^b  

^a German University in Cairo   (Egypt)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

Antitumor agents; CAS 171596 29 5; Tadalafil; Carboline derivatives, anticancer activity, phosphodiesterase 5 inhibition

Indexed keywords

2 ETHYL 1 OXO 5 (2,5 DIMETHOXYPHE5,6,11,11A TETRAHYDRO 1H IMIDAZO[1',5':1,6]PYRIDO[3,4 B]INDOLE 3(2H) THIONE; 2 ETHYL 5 (2,5 DIMETHOXYPHENYL) 5,6,11,11A TETRAHYDRO 1H IMIDAZO[1',5':1,6]PYRIDO[3,4 B]INDOLE 1,3(2H) DIONE; ANTINEOPLASTIC AGENT; BETA CARBOLINE DERIVATIVE; METHYL 1 (2,5 DIMETHOXYPHENYL) 2.3.4.9 TETRAHYDRO 1H BETA CARBOLINE 3 CARBOXYLATE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V; SPLEEN EXONUCLEASE; SULINDAC SULFONE; TADALAFIL; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; TUMOR CELL; TUMOR GROWTH;

EID: 69249115673     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296417     Document Type: Article

References (16)

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