The insulin-like growth factor-I (IGF-I) generation test as an indicator of growth hormone status

Hormones

Volumn 8, Issue 2, 2009, Pages 117-128

  Spiliotis, Bessie E ^a   Alexandrides, Theodore K ^a   Karystianos, Christoforos ^a   Vassilakos, Pavlos ^a   Zadik, Zvi ^b   Nikolakopoulou, Nikoleta M ^a   Nikiforidis, George ^a   Beratis, Nicholas G ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b KAPLAN MEDICAL CENTER   (Israel)

Author keywords

GH deficiency; Growth delay; IGF I; IGF I generation test; Short stature

Indexed keywords

CLONIDINE; HUMAN GROWTH HORMONE; LEVODOPA; SOMATOMEDIN C; DIAGNOSTIC AGENT;

ADOLESCENT; ARTICLE; CHILD; CONTROLLED STUDY; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; GROWTH RATE; HORMONE DETERMINATION; HUMAN; INSULIN LIKE GROWTH FACTOR I GENERATION TEST; MAJOR CLINICAL STUDY; MALE; PREPUBERTY; PROVOCATION TEST; PUBERTY; SCHOOL CHILD; SHORT STATURE; ANALYSIS OF VARIANCE; BIOLOGICAL MODEL; BLOOD; CASE CONTROL STUDY; ENDOCRINE SYSTEM EXAMINATION; EVALUATION; GROWTH DISORDER; NONPARAMETRIC TEST; REFERENCE VALUE; SECRETION; STATISTICAL ANALYSIS; STIMULATION;

ADOLESCENT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CHILD; DIAGNOSTIC TECHNIQUES, ENDOCRINE; FEMALE; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MATCHED-PAIR ANALYSIS; MODELS, BIOLOGICAL; PUBERTY; REFERENCE VALUES; STATISTICS, NONPARAMETRIC; STIMULATION, CHEMICAL;

EID: 69149106391     PISSN: 11093099     EISSN: None     Source Type: Journal    
DOI: 10.14310/horm.2002.1228     Document Type: Article

References (43)

1. Carter-Su C, Schwartz J, Smit LS, 1996 Molecular mechanism of growth hormone action. Annu Rev Physiol 58: 187-207. (Pubitemid 26106718)
2. Spiliotis BE, August GP, Hung W, et al, 1984 Growth hormone neurosecretory dysfunction. A treatable cause of short stature. JAMA 251: 2223-2230.
3. Bercu BB, Shulman D, Root AW, et al, 1986 Growth hormone (GH) provocative testing frequently does not reflect endogenous GH secretion. J Clin Endocrinol Metab 63: 709-716. (Pubitemid 16050573)
4. Zadik Z, Chalew SA, Raiti S, et al, 1985 Do short children secrete insufficient growth hormone? Pediatrics 76: 355-360.
5. Hindmarsh P, Smith PJ, Brook CG, et al, 1987 The relationship between height velocity and growth hormone secretion in short pre-pubertal children. Clin Endocrinol (Oxf) 27: 581-591. (Pubitemid 17161171)
6. Saggese G, Meossi C, Cesaretti G, et al, 1987 Physiological assessment of growth hormone secretion in the diagnosis of children with short stature. Pediatrician 14: 121-137. (Pubitemid 18131207)
7. Zadik A, Zung A, Sarel R, et al, 1997 Evolving growth hormone deficiency in children with subnormal secretion of growth hormone. J Pediatr 130: 481-484. (Pubitemid 27492699)
8. Martha PM Jr, Gorman KM, Blizzard RM, et al, 1992 Endogenous Growth Hormone Secretion and Clearance Rates in Normal Boys, as Determined by Deconvolution Analysis: Relationship to Age, Pubertal Status, and Body Mass J Clin Endocrinol Metab 74: 336-344.
9. Veldhuis JD, Iranmanesh A, Ho KKY, et al, 1991 Dual defects in growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab 72: 51-59. (Pubitemid 21921655)
10. Ballerini MG, Ropelato MG, Domené HM, et al, 2004 Differential impact of simple childhood obesity on the components of the growth hormone-insulin-like growth factor (IGF)-IGF binding proteins axis. J Pediatr Endocrinol Metab 17: 749-757.
11. Di Somma C, Savastano S, Rota F, et al, 2008 Appropriate use of stimulation tests and insulin-like growth factor-I in obesity. J Endocrinol Invest 31: Suppl 9: 21-26.
12. Ferber R, Kryger MH 1995 Principles and practice of sleep medicine in the child. Philadelphia; London: Saunders, pp, 20-25.
13. Costin G, Kaufman FR, 1987 Growth hormone secretory patterns in children with short stature. J Pediatr 110: 362-368. (Pubitemid 17028041)
14. Albertsson-Wikland K, Rosberg S, 1988 Analyses of 24-hour growth hormone profiles in children: relation to growth. J Clin Endocrinol Metab 67: 493-500. (Pubitemid 18226464)
15. Rose RS, Ross JL, Uriarte M, et al, 1988 The advantage of measuring stimulated as compared with spontaneous growth hormone levels in the diagnosis of growth hormone deficiency. N Engl J Med 319: 201-207. (Pubitemid 18185059)
16. Albertsson-Wikland K, Rosberg S, Libre E, et al, 1989 Growth hormone secretory rates in children as estimated by deconvolution analysis of 24-hour plasma concentration profiles. Am J Physiol 257: E809-E814. (Pubitemid 20027842)
17. Zadik Z, Chalew SA, Kowarski A, 1990 Assessment of growth hormone secretion in normal stature children using 24-hour integrated concentration of GH and pharmacological stimulation. J Clin Endocrinol Metab 71: 932-936. (Pubitemid 20312104)
18. Laron Z, Pertzelan A, Karp M, et al, 1971 Administration of growth hormone to patients with familial dwarfism with high plasma immunoreactive growth hormone: measurement of sulfation factor, metabolic and linear growth responses. J Clin Endocrinol Metab 33: 332-342.
19. Hayek A, Peake GT, 1981 Growth and somatomedin-C responses to growth hormone in dwarfed children. J Pediatr 99: 868-872. (Pubitemid 12240106)
20. Savage MO, Blum WF, Ranke MB, et al, 1993 Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome). J Clin Endocrinol Metab 77: 1465-1471. (Pubitemid 24000897)
21. Blum WF, Cotterill AM, Postel-Vinay MC, et al, 1994 Improvement of diagnostic criteria in growth hormone insensitivity syndrome: solutions and pitfalls. Pharmacia Study Group on Insulin-like Growth Factor I Treatment in Growth Hormone Insensitivity Syndromes. Acta Paediatr Suppl 399: 117-124.
22. Cotterill AM, Camacho-Hubner C, Woods K, et al, 1994 The insulin-like growth factor I generation test in the investigation of short stature. Acta Paediatr Suppl 399: 128-130. (Pubitemid 24261897)
23. Thalange NK, Price DA, Gill MS, et al, 1996 Insulin-like growth factor binding protein-3 generation: an index of growth hormone insensitivity. Pediatr Res 39: 849-855. (Pubitemid 26130026)
24. Rosenfeld RG, Buckway C, Selva K, et al, 2004 Insulin-like growth factor (IGF) parameters and tools for efficacy: The IGF-I generation test in children. Horm Res 62: Suppl 1: 37-43. (Pubitemid 40529149)
25. Selva KA, Buckway CK, Sexton G, et al 2003 Reproducibility in patterns of IGF generation with special reference to idiopathic short stature. Horm Res 60: 237-246. (Pubitemid 37465086)
26. Rudman D, Kutner MH, Blackston RD, et al, 1981 Children with normal-variant short stature: treatment with human growth hormone for six months. N Engl J Med 305: 123-131. (Pubitemid 11073078)
27. Rosenfeld RG, Kemp SF, Hintz RL, 1981 Constancy of somatomedin response to growth hormone treatment of hypopituitary dwarfism, and lack of correlation with growth rate. J Clin Endocrinol Metab 53: 611-617.
28. Van Vliet G, Styne DM, Kaplan SL, et al, 1983 Growth hormone treatment for short stature. N Engl J Med 309: 1016-1022.
29. Ranke MB, Blum WF, Bierich JR, 1988 Clinical relevance of serum measurements of insulin-like growth factors and somatomedin binding proteins. Acta Paediatr Scand Suppl 347: 114-126. (Pubitemid 19080309)
30. Buckway CK, Guevara-Aguirre J, Pratt KL, et al, 2001 The IGF-I generation test revisited: a marker of GH sensitivity. J Clin Endocrinol Metab 86: 5176-5183. (Pubitemid 33070233)
31. Chrysis DC, Alexandrides TK, Koromantzou E, et al, 2001 Novel application of IGF-I and IGFBP-3 generation tests in the diagnosis of growth hormone axis disturbances in children with beta-thalassaemia. Clin Endocrinol (Oxf) 54: 253-259. (Pubitemid 32193528)
32. Darendeliler F, Ocal C, Bas F, 2005 Evaluation of insulin-like growth factor (IGF)-I and IGF binding protein-3 generation test in short stature. J Pediatr Endocrinol Metab 18: 443-452. (Pubitemid 40645578)
33. Schwarze CP, Wollmann HA, Binder G, et al, 1999 Short-term increments of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 predict the growth response to growth hormone (GH) therapy in GH-sensitive children. Acta Paediatr Suppl 88: 200-208. (Pubitemid 29108433)
34. Schalch DS, Tollefsen SE, Klingensmith GJ, et al, 1982 Effects of human growth hormone administration on serum somatomedins, somatomedin carrier proteins, and growth rates in children with growth hormone deficiency. J Clin Endocrinol Metab 55: 49-55.
35. Veldhuis JD, Carlson ML, Johnson ML, 1987 The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA 84: 7686-7690.
36. Veldhuis JD, Johnson ML, 1988 A novel general biophysical model for simulating episodic endocrine gland signaling. Am J Physiol 255: E749-759.
37. Johnson ML, Veldhuis JD, 1995 Evolution of deconvolution analysis as a hormone pulse detection method. Methods in Neuroscience 28: 1-24.
38. Johnson ML, Veldhuis JD, 1995 Specific Methodological Approaches to Selected Contemporary Issues in Deconvolution Analysis of Pulsatile Neuroendocrine Data. Methods in Neuroscience 28: 25-92.
39. Mauras N, Blizzard RM, Link K, et al, 1987 Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenon. J Clin Endocrinol Metab 64: 596-601. (Pubitemid 17020930)
40. Blair JC, Camacho-Hubner C, Miraki Moud F, et al, 2004 Standard and low-dose IGF-I generation tests and spontaneous growth hormone secretion in children with idiopathic short stature. Clin Endocrinol (Oxf) 60: 163-168; discussion 161-162. (Pubitemid 38200896)
41. Gertner JM, Genel M, Gianfredi SP, et al, 1984 Prospective clinical trial of human growth hormone in short children without growth hormone deficiency. J Pediatr 104: 172-176. (Pubitemid 14188919)
42. Albertsson-Wikland K, Hall K, 1987 Growth hormone treatment in short children: relationship between growth and serum insulin-like growth factor I and II levels. J Clin Endocrinol Metab 65: 671-678. (Pubitemid 17157383)
43. Bouhours-Nouet N, Gatelais F, Boux de Casson F, et al 2007 The Insulin-like Growth Factor-I response to growth hormone is increased in prepubertal children with obesity and tall stature. J Clin Endocrinol Metab 92: 629-635. (Pubitemid 46255307)