Short-term increments of insulin-like growth factor I (IGF-I) and IGF- binding protein-3 predict the growth response to growth hormone (GH) therapy in GH-sensitive children

Acta Paediatrica, International Journal of Paediatrics, Supplement

Volumn 88, Issue 428, 1999, Pages 200-208

  Schwarze, C P ^a   Wollmann, H A ^a   Binder, G ^a   Ranke, M B ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Growth hormone treatment; Insulin like growth factor binding protein 3; Insulin like growth factor generation test; Insulin like growth factor I

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADOLESCENT; BODY HEIGHT; CHILD; CLINICAL ARTICLE; CONFERENCE PAPER; DIAGNOSTIC APPROACH ROUTE; FEMALE; GROWTH DISORDER; GROWTH RATE; HORMONAL THERAPY; HORMONE BLOOD LEVEL; HORMONE RESISTANCE; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SHORT STATURE;

ADOLESCENT; BODY HEIGHT; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; LINEAR MODELS; MALE; PREDICTIVE VALUE OF TESTS; RECEPTORS, SOMATOTROPIN; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SYNDROME;

EID: 0032975356     PISSN: 08035326     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (21)

1. Rudman D, Moffitt SD, Fernhoff PM, McKenzie WJ, Kenny JM, Bain RP. The relation between growth velocity and serum somatomedin C concentration. J Clin Endocrinol Metab 1981;52:622-7
2. Rudman D, Kutner MH, Blackston RD, Cushman RA, Bain RP, Patterson JH. Children with normal-variant short stature: treatment with human growth hormone for six months. N Engl J Med 1981;305:123-31
3. Rosenfeld RG, Kemp SF, Hintz RL. Constancy of somatomedin response to growth hormone treatment of hypopituitary dwarfism, and lack of correlation with growth rate. J Clin Endocrinol Metab 1981;53:611-17
4. Hayek A, Peake GT. Growth and somatomedin-C responses to growth hormone in dwarfed children. J Pediatr 1981; 99:868-72
5. Blethen SL, Daughaday WH, Weldon W. Kinetics of the somatomedin C/insulin-like growth factor I: response to exogenous growth hormone (GH) in GH-deficient children. J Clin Endocrinol Metab 1982;54:986-90
6. Schalch DS, Tollefsen SE, Klingensmith GJ, Gotlin RW, Diehl MJ. Effects of human growth hormone administration on serum somatomedins, somatomedin carrier proteins, and growth rates in children with growth hormone deficiency. J Clin Endocrinol Metab 1982;55:49-55
7. Dean HJ, Kellett JG, Bala RM Guyda HJ, Bhaumick B, Posner BI, et al. The effect of growth hormone treatment on somatomedin levels in growth hormone-deficient children. J Clin Endocrinol Metab 1982;55:1167-73
8. Jorgensen JOL, Blum WF, Moller N, Ranke MB, Christiansen JS. Short-term changes in serum insulin-like growth factors (IGF) and IGF binding protein 3 after different modes of intravenous growth hormone (GH) exposure in GH-deficient patients. J Clin Endocrinol Metab 1991;72:582-7
9. Plotnick LP, Quentin CDR, Meter LV, Kowarski AA. Human growth hormone treatment of children with growth failure and normal growth hormone levels by immunoassay: lack of correlation with somatomedin generation. Pediatrics 1983; 71:324-7
10. Van Vliet G, Styne DM, Kaplan SL, Grumbach MM. Growth hormone treatment for short stature. N Engl J Med 1983; 309:1016-22
11. Gertner JM, Genel M, Gianfredi SP, Hintz RL, Rosenfeld RG, Tamborlane WV, et al. Prospective clinical trial of human growth hormone in short children without growth hormone deficiency. J Pediatr 1984;104:172-6
12. Albertsson-Wikland K, Hall K. Growth hormone treatment in short children: relationship between growth and serum insulinlike growth factor I and II levels. J Clin Endocrinol Metab 1987;65:671-8
13. Cotterill AM, Camacho-Hübner C, Woods K, Martinelli C, Duquesnoy P, Savage MO. The insulin-like growth factor I generation test in the investigation of short stature. Acta Paediatr Suppl 1994;399:128-30
14. Savage MO, Blum WF, Ranke MB, Postel-Vinay MC, Cotterill AM, Hall K, et al. Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome). J Clin Endocrinol Metab 1993;77:1465-71
15. Blum WF, Ranke MB, Savage MO, Hall K, Kabi Pharmacia Study Group. Insulin-like growth factors and their binding proteins in patients with growth hormone receptor deficiency: suggestions for new diagnostic criteria. Acta Paediatr Suppl 1992;383:125-6
16. Blum WF, Cotterill AM, Postel-Vinay MC, Ranke MB, Savage MO, Wilton P. Improvement of diagnostic criteria in growth hormone insensitivity syndrome: solutions and pitfalls. Acta Paediatr Suppl 1994;399:117-24
17. Thalange NKS, Price DA, Gill MS, Whatmore AJ, Addison GM, Clayton PE. Insulin-like growth factor binding protein-3 generation: an index of growth hormone insensitivity. Pediatr Res 1996;39:849-55
18. Rosenbloom AL, Rosenfeld RG, Guevara-Aguirre J. Growth hormone insensitivity. Pediatr Clin North Am 1997;2:423-42
19. Laron Z, Pertzelan A, Mannheimer S. Genetic pituitary dwarfism with high serum concentration of growth hormone. A new inborn error of metabolism? Isr J Med Sci 1966; 2:152-5
20. Laron Z, Blum WF, Chatelain P, Ranke MB, Rosenfeld R, -Savage M, et al. Classification of growth hormone insensitivity syndrome. J Pediatr 1993;122:241
21. Woods KA, Dastot F, Preece MA, Clark AJL, Postel-Vinay MC, Chatelain PG, et al. Phenotype: genotype relationships in growth hormone insensitivity syndrome. J Clin Endocrinol Metab 1997;82:3529-35