Neuroprotective activity of Viola mandshurica extracts on hydrogen peroxide-induced DNA damage and cell death in PC12 cells

Annals of the New York Academy of Sciences

Volumn 1171, Issue , 2009, Pages 576-582

  Jeon, Gyeong Im ^a   Yoon, Mi Young ^a   Park, Hae Ryoung ^a   Lee, Seung Cheol ^a   Park, Eunju ^a  

^a Kyungnam University   (South Korea)

Author keywords

Apoptosis; Neurodegeneration; Oxidative stress; PC12 cells; Viola mandshurica

Indexed keywords

ACETONE; DNA; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; PLANT EXTRACT; UNCLASSIFIED DRUG; VIOLA MANDSHURICA EXTRACT;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; CELL ASSAY; CELL DEATH; CELL PROTECTION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; COMET ASSAY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME RELEASE; MEDICINAL PLANT; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PHEOCHROMOCYTOMA CELL; RAT; SIGNAL TRANSDUCTION; VIOLA MANDSHURICA;

VIOLA MANDSHURICA;

EID: 69149090287     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04889.x     Document Type: Conference Paper

References (20)

1. Floyd, R.A. 1999. Antioxidants, oxidative stress, and degenerative neurological disorders. Exp. Biol. Med. 222 : 236 245.
2. 2. Free Radic. Biol. Med. 33 : 691 702.
3. Krishnaswamy, K. K.J. Sushil. 2000. Oxidative stress and apoptosis. Pathophysiology 7 : 153 163.
4. Rao, A.V. B. Balachandran. 2002. Role of oxidative stress and antioxidants in neurodegenerative diseases. Nutr. Neurosci. 5 : 291 309.
5. Harris, E.D. 1992. Regulation of antioxidant enzymes. FASEB J. 6 : 2675 2683.
6. Gouaze, V., J.Y. Yu, R.J. Bleicher, et al. 2004. Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy. Mol. Cancer Ther. 3 : 633 639.
7. Kodach, L.L., C.L. Bos, N. Duran, et al. 2006. Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells. Carcinogenesis 27 : 508 516.
8. Mabberley, D.J. 1987. A portable dictionary of the higher plants. In The Plant Book. 747 p. Cambridge University Press. Cambridge.
9. Svangard, E., U. Goransson, D. Smith, et al. 2003. Primary and 3-D modeled structures of two cyclotides from Viola odorata. Phytochemistry 64 : 135 142.
10. Carnat, A.P., A. Carnat, D. Fraisse, et al. 1998. Violarvensin, a new flavone di-C-glycoside from Viola arvensis. J. Nat. Prod. 61 : 272 274.
11. Qin, B., Q.P. Chen Z.C. Lou. 1994. Active constituents of Viola prionantha Bge. Chin. Pharm. Sci. 3 : 91 96.
12. Lindholm, P., U. Göransson, S. Johansson, et al. 2002. Cyclotides: a novel type of cytotoxic agents. Mol. Cancer Ther. 6 : 365 369.
13. Vukics, V., A. Kery, G.K. Bonn A. Guttman. 2008. Major flavonoid components of heartsease (Viola tricolor L.) and their antioxidant activities. Anal. Bioanal. Chem. 1618 2642.
14. Kassie, F., W. Parzefal S. Knasmuller. 2000. Single cell gel electrophoresis assay: a new technique for human biomonitoring studies. Mutat. Res. 463 : 13 31.
15. Mullaart, E., M.E. Boerrigter, R. Ravid, et al. 1990. Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients. Neurobiol. Aging 11 : 169 173.
16. Diplock, A.T. 1991. Antioxidant nutrients and disease prevention: an overview. Am. J. Clin. Nutr. 53 : 189S 193S.
17. 2 for platelet-derived growth factor signal transduction. Science 270 : 296 299.
18. Forman, H.J. M. Torres. 2001. Redox signaling in macrophages. Mol. Asp. Med. 22 : 189 216.
19. 2 induce apoptosis through Fenton chemistry independent of the cellular thiol state. Free Radic. Biol. Med. 30 : 1008 1018.
20. Yang, Y., J.Z. Cheng, S.S. Singhal, et al. 2001. Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2- 2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation. J. Biol. Chem. 276 : 19220 19230.