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Volumn 47, Issue 7, 2009, Pages 617-631

Dimercaptosuccinic acid (succimer; DMSA) in inorganic lead poisoning

Author keywords

Adverse effects; DMSA; Efficacy; Lead poisoning; Pharmacodynamics; Pharmacokinetics; Succimer

Indexed keywords

AMINOTRANSFERASE; ANION; ANTIDOTE; CHELATE; CHELATING AGENT; COPPER; CYSTEINE; DISULFIDE; EDETATE CALCIUM DISODIUM; LEAD; SUCCIMER;

EID: 69149087793     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650903174828     Document Type: Review
Times cited : (91)

References (95)
  • 1
    • 0004152005 scopus 로고
    • IPCS Environmental Health Criteria 165 Geneva: World Health Organization
    • IPCS. Environmental Health Criteria 165. Inorganic Lead. Geneva: World Health Organization; 1995.
    • (1995) Inorganic Lead
  • 4
    • 0021128234 scopus 로고
    • A follow-up study of the academic attainment and classroom behavior of children with elevated dentine lead levels
    • Bellinger D, Needleman HL, Bromfield R, Mintz M. A follow-up study of the academic attainment and classroom behavior of children with elevated dentine lead levels. Biol Trace Elem Res 1984; 6:207-233.
    • (1984) Biol Trace Elem Res , vol.6 , pp. 207-233
    • Bellinger, D.1    Needleman, H.L.2    Bromfield, R.3    Mintz, M.4
  • 5
    • 0025129330 scopus 로고
    • The longterm effects of exposure to low doses of lead in childhood. An 11-year follow-up report
    • Needleman HL, Schell A, Bellinger D, Leviton A, Allred EN. The longterm effects of exposure to low doses of lead in childhood. An 11-year follow-up report. N Engl J Med 1990; 322:83-88.
    • (1990) N Engl J Med , vol.322 , pp. 83-88
    • Needleman, H.L.1    Schell, A.2    Bellinger, D.3    Leviton, A.4    Allred, E.N.5
  • 8
    • 33646962588 scopus 로고
    • The treatment of lead encephalopathy - A method for the removal of lead during the acute stage
    • Bessman SP, Rubin M, Leikin S. The treatment of lead encephalopathy - a method for the removal of lead during the acute stage. Pediatrics 1954; 14:201-208.
    • (1954) Pediatrics , vol.14 , pp. 201-208
    • Bessman, S.P.1    Rubin, M.2    Leikin, S.3
  • 9
    • 34248567201 scopus 로고
    • Edathamil calcium-disodium (versenate) in treatment of lead poisoning in children
    • Byers RK, Maloof C. Edathamil calcium-disodium (versenate) in treatment of lead poisoning in children. Am J Dis Child 1954; 87:559-569.
    • (1954) Am J Dis Child , vol.87 , pp. 559-569
    • Byers, R.K.1    Maloof, C.2
  • 10
    • 58149435105 scopus 로고
    • Calcium disodium versenate in the therapy of lead encephalopathy
    • Karpinski FE Jr., Rieders F, Girsh LS. Calcium disodium versenate in the therapy of lead encephalopathy. J Pediatr 1953; 42:687-699.
    • (1953) J Pediatr , vol.42 , pp. 687-699
    • Karpinski, Jr.F.E.1    Rieders, F.2    Girsh, L.S.3
  • 11
    • 70349719480 scopus 로고
    • Treatment of chronic lead-poisoning with calcium disodium versenate
    • Markus AC, Spencer AG. Treatment of chronic lead-poisoning with calcium disodium versenate. BMJ 1955; 2:883-885.
    • (1955) BMJ , vol.2 , pp. 883-885
    • Markus, A.C.1    Spencer, A.G.2
  • 12
    • 0000042891 scopus 로고
    • Treatment of acute and chronic lead poisoning with disodium calcium versenate
    • Wade JF Jr., Burnum JF. Treatment of acute and chronic lead poisoning with disodium calcium versenate. Ann Intern Med 1955; 42:251-259.
    • (1955) Ann Intern Med , vol.42 , pp. 251-259
    • Wade Jr., J.F.1    Burnum, J.F.2
  • 14
    • 0011018741 scopus 로고
    • Clinical manifestations and therapy of acute lead intoxication due to the ingestion of illicitly distilled alcohol
    • Crutcher JC. Clinical manifestations and therapy of acute lead intoxication due to the ingestion of illicitly distilled alcohol. Ann Intern Med 1963; 59:707-715.
    • (1963) Ann Intern Med , vol.59 , pp. 707-715
    • Crutcher, J.C.1
  • 15
    • 0024524631 scopus 로고
    • Lead encephalopathy from an imported Toby mug
    • Zuckerman MA, Savory D, Rayman G. Lead encephalopathy from an imported Toby mug. Postgrad Med J 1989; 65:307-309.
    • (1989) Postgrad Med J , vol.65 , pp. 307-309
    • Zuckerman, M.A.1    Savory, D.2    Rayman, G.3
  • 16
    • 70349720896 scopus 로고
    • Lead encephalopathy simulating subdural hematoma in an adult. Report of a case
    • Hess JW. Lead encephalopathy simulating subdural hematoma in an adult. Report of a case. N Engl J Med 1961; 264:382-384.
    • (1961) N Engl J Med , vol.264 , pp. 382-384
    • Hess, J.W.1
  • 17
    • 0026734361 scopus 로고
    • Neuropsychologic and postural sway improvement after Ca++-EDTA chelation for mild lead intoxication
    • Linz DH, Barrett ET Jr., Pflaumer JE, Keith RE. Neuropsychologic and postural sway improvement after Ca++-EDTA chelation for mild lead intoxication. J Occup Med 1992; 34:638-642.
    • (1992) J Occup Med , vol.34 , pp. 638-642
    • Linz, D.H.1    Barrett Jr., E.T.2    Pflaumer, J.E.3    Keith, R.E.4
  • 18
  • 21
    • 0013788050 scopus 로고
    • Chelating therapy with Na-DMS in occupational lead and mercury intoxications
    • Wang S-C, Ting K-S, Wu C-C. Chelating therapy with Na-DMS in occupational lead and mercury intoxications. Chin Med J (Engl ) 1965; 84:437-439.
    • (1965) Chin Med J (Engl ) , vol.84 , pp. 437-439
    • Wang, S.-C.1    Ting, K.-S.2    Wu, C.-C.3
  • 22
    • 0023742921 scopus 로고
    • Dose-response study of oral 2,3- dimercaptosuccinic acid in children with elevated blood lead concentrations
    • Graziano JH, Lolacono NJ, Meyer P. Dose-response study of oral 2,3- dimercaptosuccinic acid in children with elevated blood lead concentrations. J Pediatr 1988; 113:751-757.
    • (1988) J Pediatr , vol.113 , pp. 751-757
    • Graziano, J.H.1    Lolacono, N.J.2    Meyer, P.3
  • 23
    • 0000643464 scopus 로고
    • Treatment of Schistosomiasis mansonii with antimony-a,a'-dimercapto- potassium succinate (TWSb)
    • Friedheim EAH, Da Silva JR, Martins AV. Treatment of Schistosomiasis mansonii with antimony-a,a'-dimercapto-potassium succinate (TWSb). Am J Trop Med Hyg 1954; 3:714-727.
    • (1954) Am J Trop Med Hyg , vol.3 , pp. 714-727
    • Friedheim, E.A.H.1    Da Silva, J.R.2    Martins, A.V.3
  • 24
    • 0020644951 scopus 로고
    • DMSA and DMPS - Water soluble antidotes for heavy metal poisoning
    • Aposhian HV. DMSA and DMPS - water soluble antidotes for heavy metal poisoning. Annu Rev Pharmacol Toxicol 1983; 23:193-215.
    • (1983) Annu Rev Pharmacol Toxicol , vol.23 , pp. 193-215
    • Aposhian, H.V.1
  • 25
    • 0024789271 scopus 로고
    • Lead chelates of meso- and racemicdimercaptosuccinic acid
    • Rivera M, Aposhian HV, Fernando Q. Lead chelates of meso- and racemicdimercaptosuccinic acid. J Inorg Biochem 1989; 37:283-293.
    • (1989) J Inorg Biochem , vol.37 , pp. 283-293
    • Rivera, M.1    Aposhian, H.V.2    Fernando, Q.3
  • 26
    • 0026543079 scopus 로고
    • Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication
    • Graziano JH, LoIacono NJ, Moulton T, Mitchell ME, Slavkovich V, Zarate C. Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication. J Pediatr 1992; 120:133-139.
    • (1992) J Pediatr , vol.120 , pp. 133-139
    • Graziano, J.H.1    Loiacono, N.J.2    Moulton, T.3    Mitchell, M.E.4    Slavkovich, V.5    Zarate, C.6
  • 27
    • 0036868273 scopus 로고    scopus 로고
    • Effect of meso- 2,3-dimercaptosuccinic acid on urinary lead excretion in exposed men
    • Torres-Alanís O, Garza-Ocañas L, Piñeyro-López A. Effect of meso- 2,3-dimercaptosuccinic acid on urinary lead excretion in exposed men. Hum Exp Toxicol 2002; 21:573-577.
    • (2002) Hum Exp Toxicol , vol.21 , pp. 573-577
    • Torres-Alanís, O.1    Garza-Ocañas, L.2    Piñeyro-López, A.3
  • 28
    • 0042285713 scopus 로고    scopus 로고
    • Succimer (meso- 2,3-dimercaptosuccinic acid (DMSA)) treatment of Andean children with environmental lead exposure
    • Counter SA, Ortega F, Shannon MW, Buchanan LH. Succimer (meso- 2,3-dimercaptosuccinic acid (DMSA)) treatment of Andean children with environmental lead exposure. Int J Occup Environ Health 2003; 9:164-168.
    • (2003) Int J Occup Environ Health , vol.9 , pp. 164-168
    • Counter, S.A.1    Ortega, F.2    Shannon, M.W.3    Buchanan, L.H.4
  • 29
    • 1642407914 scopus 로고    scopus 로고
    • Therapeutics and toxicology issues associated with the agitated, violent, or psychotic pediatric patient
    • Liebelt EL. Therapeutics and toxicology issues associated with the agitated, violent, or psychotic pediatric patient. Curr Opin Pediatr 2004; 16:199-200.
    • (2004) Curr Opin Pediatr , vol.16 , pp. 199-200
    • Liebelt, E.L.1
  • 30
    • 0029129076 scopus 로고
    • Short-term efficacy of oral dimercaptosuccinic acid in children with low to moderate lead intoxication
    • Besunder JB, Anderson RL, Super DM. Short-term efficacy of oral dimercaptosuccinic acid in children with low to moderate lead intoxication. Pediatrics 1995; 96:683-687.
    • (1995) Pediatrics , vol.96 , pp. 683-687
    • Besunder, J.B.1    Anderson, R.L.2    Super, D.M.3
  • 31
    • 0026439970 scopus 로고
    • BAL, EDTA, DMSA and DMPS in the treatment of lead poisoning in children
    • Chisolm JJ. BAL, EDTA, DMSA and DMPS in the treatment of lead poisoning in children. J Toxicol Clin Toxicol 1992; 30:493-504.
    • (1992) J Toxicol Clin Toxicol , vol.30 , pp. 493-504
    • Chisolm, J.J.1
  • 32
    • 0031033114 scopus 로고    scopus 로고
    • The effect of 2,3 dimercaptosuccinic acid in the treatment of lead poisoning in adults
    • Lifshitz M, Hashkanazi R, Phillip M. The effect of 2,3 dimercaptosuccinic acid in the treatment of lead poisoning in adults. Ann Med 1997; 29:83-85.
    • (1997) Ann Med , vol.29 , pp. 83-85
    • Lifshitz, M.1    Hashkanazi, R.2    Phillip, M.3
  • 35
    • 0025121257 scopus 로고
    • Determination and metabolism of dithiol chelating agents: X in humans, meso-2,3-dimercaptosuccinic acid is bound to plasma proteins via mixed disulfide formation
    • Maiorino RM, Akins JM, Blaha K, Carter DE, Aposhian HV. Determination and metabolism of dithiol chelating agents: X. In humans, meso-2,3- dimercaptosuccinic acid is bound to plasma proteins via mixed disulfide formation. J Pharmacol Exp Ther 1990; 254:570-577.
    • (1990) J Pharmacol Exp Ther , vol.254 , pp. 570-577
    • Maiorino, R.M.1    Akins, J.M.2    Blaha, K.3    Carter, D.E.4    Aposhian, H.V.5
  • 36
    • 0024472687 scopus 로고
    • The biological fate of 14C-dimercaptosuccinic acid in monkeys and rabbits
    • Tillotson JA, Boswell G, Kincannon L, Speckman CL. The biological fate of 14C-dimercaptosuccinic acid in monkeys and rabbits. Mil Med 1989; 154:444-449.
    • (1989) Mil Med , vol.154 , pp. 444-449
    • Tillotson, J.A.1    Boswell, G.2    Kincannon, L.3    Speckman, C.L.4
  • 38
    • 0038728565 scopus 로고    scopus 로고
    • Transport of organic anions across the basolateral membrane of proximal tubule cells
    • Burckhardt BC, Burckhardt G. Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol 2003; 146:95-158.
    • (2003) Rev Physiol Biochem Pharmacol , vol.146 , pp. 95-158
    • Burckhardt, B.C.1    Burckhardt, G.2
  • 41
    • 0003447678 scopus 로고
    • Castellino N, Castellino P, Sannolo N, eds. Boca Raton, Florida, Lewis Publishers
    • Castellino N, Castellino P, Sannolo N, eds. Inorganic Lead Exposure: Metabolism and Intoxication. Boca Raton, Florida, Lewis Publishers, 1995.
    • (1995) Inorganic Lead Exposure: Metabolism and Intoxication
  • 42
    • 84907135018 scopus 로고
    • The effect of DMSA loading on the renal handling of technetium-99m in rats
    • Provoost AP, Van Aken M. The effect of DMSA loading on the renal handling of technetium-99m in rats. Uremia Invest 1985; 9:147-150. (Pubitemid 16039458)
    • (1985) Uremia Investigation , vol.9 , Issue.2 , pp. 147-150
    • Provoost, A.P.1    Van Aken, M.2
  • 45
    • 0036841390 scopus 로고    scopus 로고
    • The renal Na+-dependent dicarboxylate transporter, NaDC-3, translocates dimethyl- and disulfhydryl-compounds and contributes to renal heavy metal detoxification
    • Burckhardt BC, Drinkuth B, Menzel C, König A, Steffgen J, Wright SH, Burckhardt G. The renal Na+-dependent dicarboxylate transporter, NaDC-3, translocates dimethyl- and disulfhydryl-compounds and contributes to renal heavy metal detoxification. J Am Soc Nephrol 2002; 13:2628-2638.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2628-2638
    • Burckhardt, B.C.1    Drinkuth, B.2    Menzel, C.3    König, A.4    Steffgen, J.5    Wright, S.H.6    Burckhardt, G.7
  • 46
    • 0024508017 scopus 로고
    • Determination and metabolism of dithiol chelating agents. VI. Isolation and identification of the mixed disulfides of meso-2,3-dimercaptosuccinic acid with L-cysteine in human urine
    • Maiorino RM, Bruce DC, Aposhian HV. Determination and metabolism of dithiol chelating agents. VI. Isolation and identification of the mixed disulfides of meso-2,3-dimercaptosuccinic acid with L-cysteine in human urine. Toxicol Appl Pharmacol 1989; 97:338-349.
    • (1989) Toxicol Appl Pharmacol , vol.97 , pp. 338-349
    • Maiorino, R.M.1    Bruce, D.C.2    Aposhian, H.V.3
  • 47
  • 48
    • 0027963574 scopus 로고
    • Pharmacokinetics of meso-2,3-dimercaptosuccinic acid in patients with lead poisoning and in healthy adults
    • Dart RC, Hurlbut KM, Maiorino RM, Mayersohn M, Aposhian HV, Hassen LVB. Pharmacokinetics of meso-2,3-dimercaptosuccinic acid in patients with lead poisoning and in healthy adults. J Pediatr 1994; 125:309-316.
    • (1994) J Pediatr , vol.125 , pp. 309-316
    • Dart, R.C.1    Hurlbut, K.M.2    Maiorino, R.M.3    Mayersohn, M.4    Aposhian, H.V.5    Hassen, L.V.B.6
  • 49
    • 0027716910 scopus 로고
    • Determination and metabolism of dithiol chelating agents. XV. the meso-2,3-dimercaptosuccinic acid-cysteine (1:2) mixed disulfide, a major urinary metabolite of DMSA in the human, increases the urinary excretion of lead in the rat
    • Maiorino RM, Aposhian MM, Xu Z-F, Li Y, Polt RL, Aposhian HV. Determination and metabolism of dithiol chelating agents. XV. The meso-2,3-dimercaptosuccinic acid-cysteine (1:2) mixed disulfide, a major urinary metabolite of DMSA in the human, increases the urinary excretion of lead in the rat. J Pharmacol Exp Ther 1993; 267:1221-1226.
    • (1993) J Pharmacol Exp Ther , vol.267 , pp. 1221-1226
    • Maiorino, R.M.1    Aposhian, M.M.2    Xu, Z.-F.3    Li, Y.4    Polt, R.L.5    Aposhian, H.V.6
  • 50
    • 0026768867 scopus 로고
    • Stable isotopic tracers of lead mobilized by DMSA chelation in low lead-exposed rats
    • Smith DR, Flegal AR. Stable isotopic tracers of lead mobilized by DMSA chelation in low lead-exposed rats. Toxicol Appl Pharmacol 1992; 116:85-91.
    • (1992) Toxicol Appl Pharmacol , vol.116 , pp. 85-91
    • Smith, D.R.1    Flegal, A.R.2
  • 51
    • 7344227920 scopus 로고
    • Interrelationships of urinary lead after DMSA challenge: Bone lead burden and blood lead in lead exposed workers
    • Kosnett MJ, Regan LS, Kelly TJ, Osterloh JD. Interrelationships of urinary lead after DMSA challenge: bone lead burden and blood lead in lead exposed workers. Vet Hum Toxicol 1994; 36:363.
    • (1994) Vet Hum Toxicol , vol.36 , pp. 363
    • Kosnett, M.J.1    Regan, L.S.2    Kelly, T.J.3    Osterloh, J.D.4
  • 52
    • 0028012648 scopus 로고
    • Efficacy of oral meso-2,3-dimercaptosuccinic acid therapy for low-level childhood plumbism
    • Liebelt EL, Shannon M, Graef JW. Efficacy of oral meso-2,3- dimercaptosuccinic acid therapy for low-level childhood plumbism. J Pediatr 1994; 124:313-317.
    • (1994) J Pediatr , vol.124 , pp. 313-317
    • Liebelt, E.L.1    Shannon, M.2    Graef, J.W.3
  • 54
    • 0032957375 scopus 로고    scopus 로고
    • A comparison of two dosing regimens of succimer in children with chronic lead poisoning
    • Farrar HC, McLeane LR, Wallace M, White K, Watson J. A comparison of two dosing regimens of succimer in children with chronic lead poisoning. J Clin Pharmacol 1999; 39:180-183.
    • (1999) J Clin Pharmacol , vol.39 , pp. 180-183
    • Farrar, H.C.1    McLeane, L.R.2    Wallace, M.3    White, K.4    Watson, J.5
  • 55
    • 70349682356 scopus 로고    scopus 로고
    • Use of oral dimercaptosuccinic acid (succimer; DMSA) in adult patients with inorganic lead poisoning
    • doi:10.1093/qjmed/hep114
    • Bradberry SM, Sheehan TMT, Vale JA. Use of oral dimercaptosuccinic acid (succimer; DMSA) in adult patients with inorganic lead poisoning. QJM 2009; doi:10.1093/qjmed/hep114.
    • (2009) QJM
    • Bradberry, S.M.1    Sheehan, T.M.T.2    Vale, J.A.3
  • 56
    • 0033929832 scopus 로고    scopus 로고
    • Safety and efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) in children with elevated blood lead concentrations
    • Chisolm JJ. Safety and efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) in children with elevated blood lead concentrations. J Toxicol Clin Toxicol 2000; 38:365-375.
    • (2000) J Toxicol Clin Toxicol , vol.38 , pp. 365-375
    • Chisolm, J.J.1
  • 60
    • 19044379741 scopus 로고    scopus 로고
    • IQ and blood lead from 2 to 7 years of age: Are the effects in older children the residual of high blood lead concentrations in 2-year-olds?
    • Chen A, Dietrich KN, Ware JH, Radcliffe J, Rogan WJ. IQ and blood lead from 2 to 7 years of age: are the effects in older children the residual of high blood lead concentrations in 2-year-olds? Environ Health Perspect 2005; 113:597-601.
    • (2005) Environ Health Perspect , vol.113 , pp. 597-601
    • Chen, A.1    Dietrich, K.N.2    Ware, J.H.3    Radcliffe, J.4    Rogan, W.J.5
  • 61
    • 33645639946 scopus 로고    scopus 로고
    • The effect of chelation on blood pressure in lead-exposed children: A randomized study
    • Chen A, Rhoads GG, Cai B, Salganik M, Rogan WJ. The effect of chelation on blood pressure in lead-exposed children: a randomized study. Environ Health Perspect 2006; 114:579-583.
    • (2006) Environ Health Perspect , vol.114 , pp. 579-583
    • Chen, A.1    Rhoads, G.G.2    Cai, B.3    Salganik, M.4    Rogan, W.J.5
  • 65
    • 34249729940 scopus 로고    scopus 로고
    • Effect of succimer chelation therapy on postural balance and gait outcomes in children with early exposure to environmental lead
    • Bhattacharya A, Shukla R, Auyang ED, Dietrich KN, Bornschein R. Effect of succimer chelation therapy on postural balance and gait outcomes in children with early exposure to environmental lead. Neurotoxicology 2007; 28:686-695.
    • (2007) Neurotoxicology , vol.28 , pp. 686-695
    • Bhattacharya, A.1    Shukla, R.2    Auyang, E.D.3    Dietrich, K.N.4    Bornschein, R.5
  • 66
    • 0027451265 scopus 로고
    • Dimercaptosuccinic acid in the treatment of depression following lead exposure
    • Frumkin H, Gerr F. Dimercaptosuccinic acid in the treatment of depression following lead exposure. Am J Ind Med 1993; 24:701-706.
    • (1993) Am J Ind Med , vol.24 , pp. 701-706
    • Frumkin, H.1    Gerr, F.2
  • 70
    • 0033869809 scopus 로고    scopus 로고
    • The evidence that lead increases the risk for spontaneous abortion
    • Hertz-Picciotto I. The evidence that lead increases the risk for spontaneous abortion. Am J Ind Med 2000; 38:300-309.
    • (2000) Am J Ind Med , vol.38 , pp. 300-309
    • Hertz-Picciotto, I.1
  • 71
    • 0037436520 scopus 로고    scopus 로고
    • Placental lead and outcome of pregnancy
    • Falcón M, Viñas P, Luna A. Placental lead and outcome of pregnancy. Toxicology 2003; 185:59-66.
    • (2003) Toxicology , vol.185 , pp. 59-66
    • Falcón, M.1    Viñas, P.2    Luna, A.3
  • 72
    • 0037259375 scopus 로고    scopus 로고
    • Severe lead poisoning in pregnancy
    • Shannon M. Severe lead poisoning in pregnancy. Ambul Pediatr 2003; 3:37-39.
    • (2003) Ambul Pediatr , vol.3 , pp. 37-39
    • Shannon, M.1
  • 73
    • 0035663540 scopus 로고    scopus 로고
    • Lead poisoning and chelation in a motherneonate pair
    • Horowitz BZ, Mirkin DB. Lead poisoning and chelation in a motherneonate pair. J Toxicol Clin Toxicol 2001; 39:727-731.
    • (2001) J Toxicol Clin Toxicol , vol.39 , pp. 727-731
    • Horowitz, B.Z.1    Mirkin, D.B.2
  • 79
    • 0025284824 scopus 로고
    • Oral meso-2,3-dimercaptosuccinic acid in pregnant Sprague-Dawley rats: Teratogenicity and alterations in mineral metabolism. I. Teratological evaluation
    • Domingo JL, Ortega A, Paternain JL, Llobet JM, Corbella J. Oral meso- 2,3-dimercaptosuccinic acid in pregnant Sprague-Dawley rats: teratogenicity and alterations in mineral metabolism. I. Teratological evaluation. J Toxicol Environ Health 1990; 30:181-190. (Pubitemid 20227245)
    • (1990) Journal of Toxicology and Environmental Health , vol.30 , Issue.3 , pp. 181-190
    • Domingo, J.L.1    Ortega, A.2    Paternain, J.L.3    Llobet, J.M.4    Corbella, J.5
  • 81
    • 31744435013 scopus 로고    scopus 로고
    • Succimer therapy for congenital lead poisoning from maternal petrol sniffing
    • Powell ST, Bolisetty S, Wheaton GR. Succimer therapy for congenital lead poisoning from maternal petrol sniffing. Med J Aust 2006; 184:84-85.
    • (2006) Med J Aust , vol.184 , pp. 84-85
    • Powell, S.T.1    Bolisetty, S.2    Wheaton, G.R.3
  • 84
    • 0037135912 scopus 로고    scopus 로고
    • Severe congenital lead poisoning in a preterm infant due to a herbal remedy
    • Tait PA, Vora A, James S, Fitzgerald DJ, Pester BA. Severe congenital lead poisoning in a preterm infant due to a herbal remedy. Med J Aust 2002; 177:193-195.
    • (2002) Med J Aust , vol.177 , pp. 193-195
    • Tait, P.A.1    Vora, A.2    James, S.3    Fitzgerald, D.J.4    Pester, B.A.5
  • 86
    • 34848834224 scopus 로고    scopus 로고
    • Contribution to the data on copper concentration in blood and urine in patients with Wilson's disease and in normal subjects
    • Lech T, Sadlik JK. Contribution to the data on copper concentration in blood and urine in patients with Wilson's disease and in normal subjects. Biol Trace Elem Res 2007; 118:16-20.
    • (2007) Biol Trace Elem Res , vol.118 , pp. 16-20
    • Lech, T.1    Sadlik, J.K.2
  • 87
    • 0023268019 scopus 로고
    • Meso-2,3-dimercaptosuccinic acid in the diagnosis and treatment of lead poisoning
    • Bentur Y, Brook JG, Behar R, Taitelman U. Meso-2,3-dimercaptosuccinic acid in the diagnosis and treatment of lead poisoning. J Toxicol Clin Toxicol 1987; 25:39-51.
    • (1987) J Toxicol Clin Toxicol , vol.25 , pp. 39-51
    • Bentur, Y.1    Brook, J.G.2    Behar, R.3    Taitelman, U.4
  • 88
    • 70350392890 scopus 로고
    • Abnormal liver function in childhood lead poisoning unaffected by DMSA
    • Kuntzelman DR, Angle CR. Abnormal liver function in childhood lead poisoning unaffected by DMSA. Vet Hum Toxicol 1992; 34:355.
    • (1992) Vet Hum Toxicol , vol.34 , pp. 355
    • Kuntzelman, D.R.1    Angle, C.R.2
  • 89
    • 0027989762 scopus 로고
    • Blood aminotransferase values during treatment with meso- 2,3-dimercaptosuccinic acid
    • Angle CR. Blood aminotransferase values during treatment with meso- 2,3-dimercaptosuccinic acid. J Pediatr 1994; 125:333-334.
    • (1994) J Pediatr , vol.125 , pp. 333-334
    • Angle, C.R.1
  • 91
  • 92
    • 0009754171 scopus 로고    scopus 로고
    • Lee A, ed. 2nd ed. London: Pharmaceutical Press
    • Lee A, ed. Adverse Drug Reactions. 2nd ed. London: Pharmaceutical Press; 2006.
    • (2006) Adverse Drug Reactions
  • 93
    • 0027985248 scopus 로고
    • Hemolytic anemia following succimer administration in a glucose-6-phosphate dehydrogenase deficient patient
    • Gerr F, Frumkin H, Hodgins P. Hemolytic anemia following succimer administration in a glucose-6-phosphate dehydrogenase deficient patient. J Toxicol Clin Toxicol 1994; 32:569-575.
    • (1994) J Toxicol Clin Toxicol , vol.32 , pp. 569-575
    • Gerr, F.1    Frumkin, H.2    Hodgins, P.3


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