Use of oral dimercaptosuccinic acid (succimer) in adult patients with inorganic lead poisoning

QJM: An International Journal of Medicine

Volumn 102, Issue 10, 2009, Pages 721-732

  Bradberry, S ^a   Sheehan, T ^a   Vale, Allister ^a,b,c  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EDETATE CALCIUM DISODIUM; SUCCIMER;

ABDOMINAL PAIN; ADOLESCENT; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANOREXIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHELATION THERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; CONFUSION; CONSTIPATION; COPPER BLOOD LEVEL; DIZZINESS; DRUG EFFICACY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ERYTHEMA; FEMALE; FEVER; HEADACHE; HUMAN; LEAD BLOOD LEVEL; LEAD POISONING; LETHARGY; MALE; MOUTH ULCER; NAUSEA AND VOMITING; NEUTROPENIA; OCCUPATIONAL EXPOSURE; PARESTHESIA; PATIENT COMPLIANCE; PRIORITY JOURNAL; SIDE EFFECT; URINARY EXCRETION; WEIGHT REDUCTION; ZINC BLOOD LEVEL;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; ANTIDOTES; CHELATING AGENTS; CHELATION THERAPY; DRUG EVALUATION; FEMALE; HUMANS; LEAD; LEAD POISONING; MALE; MIDDLE AGED; SUCCIMER; YOUNG ADULT;

EID: 70349682356     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcp114     Document Type: Article

References (46)

1. Virji MA, Woskie SR, Pepper LD. Task-based lead exposures and work site characteristics of bridge surface preparation and painting contractors. J Occup Environ Hyg 2009; 6: 99-112.
2. Araujo J, Beelen AP, Lewis LD, Robinson GG, DeLaurier C, Carbajal M, et al. Lead poisoning associated with Ayurvedic medications - five states, 2000-2003. MMWR Morb Mortal Wkly Rep 2004; 53:582-84.
3. IPCS. Environmental Health Criteria 165. Inorganic Lead Geneva, World Health Organization, 1995.
4. Borja-Aburto VH, Hertz-Picciotto I, Rojas Lopez M, Farias P, Rios C, Blanco J. Blood lead levels measured prospectively and risk of spontaneous abortion. Am J Epidemiol 1999; 150:590-7.
5. Kosnett MJ, Wedeen RP, Rothenberg SJ, Hipkins KL, Materna BL, Schwartz BS, et al. Recommendations for medical management of adult lead exposure. Environ Health Perspect 2007; 115:463-71.
6. Bellinger D, Needleman HL, Bromfield R, Mintz M. A follow-up study of the academic attainment and classroom behavior of children with elevated dentine lead levels. Biol Trace Elem Res 1984; 6:207-33.
7. Needleman HL, Schell A, Bellinger D, Leviton A, Allred EN. The long-term effects of exposure to low doses of lead in childhood. An 11-year follow-up report. N Engl J Med 1990; 322:83-8.
8. Stokes L, Letz R, Gerr F, Kolczak M, McNeill FE, Chettle DR, et al Neurotoxicity in young adults 20 years after childhood exposure to lead: The Bunker Hill experience. Occup Environ Med 1998; 55 507-16.
9. Pasternak G, Becker CE, Lash A, Bowler R, Estrin WJ, Law D. Cross-sectional neurotoxicology study of lead-exposed cohort. J Toxicol Clin Toxicol 1989; 27:37-51.
10. Bessman SP, Rubin M, Leikin S. The treatment of lead encephalopathy - a method for the removal of lead during the acute stage. Pediatrics 1954; 14:201-8.
11. Byers RK, Maloof C. Edathamil calcium-disodium (versenate) in treatment of lead poisoning in children. Am J Dis Child 1954; 87 559-69.
12. Karpinski EE Jr, Rieders F, Girsh LS. Calcium disodium versenate in the therapy of lead encephalopathy. J Pediatr 1953; 42:687-99.
13. Markus AC, Spencer AG. Treatment of chronic lead-poisoning with calcium disodium versenate. Br Med J 1955; 2:883-5.
14. Wade JE Jr, Burnum JF. Treatment of acute and chronic lead poisoning with disodium calcium versenate. Ann Intern Med 1955; 42 251-9.
15. Whitfield CL, Ch'ien LT, Whitehead JD. Lead encephalopathy in adults. Am J Med 1972; 52:289-98.
16. Crutcher JC. Clinical manifestations and therapy of acute lead intoxication due to the ingestion of illicitly distilled alcohol. Ann Intern Med 1963; 59:707-15.
17. Zuckerman MA, Savory D, Rayman G. Lead encephalopathy from an imported Toby mug. Postgrad Med J 1989; 65: 307-9.
18. Hess JW. Lead encephalopathy simulating subdural hematoma in an adult. Report of a case. N Engl J Med 1961; 264:382-4.
19. ++-EDTA chelation for mild lead intoxication. J Occup Med 1992; 34:638-42.
20. Friedheim E, Graziano J, Popovac D, Dragovic D, Kaul B. Treatment of lead poisoning by 2,3-dimercaptosuccinic acid. Lancet 1978; 2 1234-6.
21. Graziano JH, Siris ES, LoIacono N, Silverberg SJ, Turgeon L. 2,3-Dimercaptosuccinic acid as an antidote for lead intoxication. Clin Pharmacol Ther 1985; 37:431-8.
22. Fournier L, Thomas G, Garnier R, Buisine A, Houze P, Pradier F, et al 2,3-Dimercaptosuccinic acid treatment of heavy metal poisoning in humans. Med Toxicol Adverse Drug Exp 1988; 3:499-504.
23. Wang S-C, Ting K-S, Wu C-C. Chelating therapy with Na-DMS in occupational lead and mercury intoxications. Chin Med J 1965; 84:437-9.
24. Graziano JH, Lolacono NJ, Meyer P. Dose-response study of oral 2,3-dimercaptosuccinic acid in children with elevated blood lead concentrations. J Pediatr 1988; 113:751-7.
25. Besunder JB, Anderson RL, Super DM. Short-term efficacy of oral dimercaptosuccinic acid in children with low to moderate lead intoxication. Pediatrics 1995; 96:683-7.
26. Liebelt EL, Shannon M, Graef JW. Efficacy of oral meso-2,3-dimercaptosuccinic acid therapy for low-level childhood plumbism. J Pediatr 1994; 124:313-17.
27. Lifshitz M, Hashkanazi R, Phillip M. The effect of 2,3 dimer-captosuccinic acid in the treatment of lead poisoning in adults. Ann Med 1997; 29:83-5.
28. Chisolm JJ. BAL, EDTA, DMSA and DMPS in the treatment of lead poisoning in children. J Toxicol Clin Toxicol 1992; 30:493-504.
29. Meggs WJ, Gerr F, Aly MH, Kierena T, Roberts DL, Shih R, et al. The treatment of lead poisoning from gunshot wounds with succimer (DMSA). J Toxicol Clin Toxicol 1994; 32: 377-85.
30. Graziano JH, LoIacono NJ, Moulton T, Mitchell ME, Slavkovich V, Zarate C. Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication. J Pediatr 1992; 120 133-9.
31. Farrar HC, McLeane LR, Wallace M, White K, Watson J. A comparison of two dosing regimens of succimer in children with chronic lead poisoning. J Clin Pharmacol 1999; 39:180-3.
32. Restek-Samarzija N, Blanusa M, Pizent A, Samarzija M, Turk R, Corovic N, et al. Meso-2,3-dimercaptosuccinic acid in the treatment of occupationally exposed lead workers. Arh Hig Rada Toksikol 1998; 49:137-45.
33. Chisolm JJ. Safety and efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) in children with elevated blood lead concentrations. J Toxicol Clin Toxicol 2000; 38:365-75.
34. Torres-Alanís O, Garza-Ocañas L, Piñeyro-López A. Effect of meso-2,3-dimercaptosuccinic acid on urinary lead excretion in exposed men. Hum Exp Toxicol 2002; 21:573-7.
35. Bornschein RL, Chisholm JJ Jr, Jones RL, Rhoads GG, Rogan WJ, Schwarz DF, et al. The Treatment of Lead-exposed Children (TLC) trial: design and recruitment for a study of the effect of oral chelation on growth and development in toddlers. Paediatr Perinat Epidemiol 1998; 12: 313-33.
36. Rogan WJ, Dietrich KN, Ware JH, Dockery DW, Salganik M, Radcliffe J, et al. Treatment of Lead-Exposed Children Trial. The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead. N Engl J Med 2001; 344:1421-6.
37. Dietrich KN, Ware JH, Salganik M, Radcliffe J, Rogan WJ, Rhoads G, et al. Treatment of Lead-Exposed Children Trial. Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry. Pediatrics 2004; 114 19-26.
38. Su M, Barrueto E Jr, Hoffman RS. Childhood lead poisoning from paint chips: A continuing problem. J Urban Health 2002; 79:491-501.
39. Counter SA, Ortega F, Shannon MW, Buchanan LH. Succimer (meso-2,3-dimercaptosuccinic acid (DMSA)) treatment of Andean children with environmental lead exposure. Int J Occup Environ Health 2003; 9:164-8.
40. O'Connor ME, Rich D. Children with moderately elevated lead levels: Is chelation with DMSA helpful? Clin Pediatr 1999; 38:325-31.
41. Akhtar AJ, Funnye AS, Akanno J. Gunshot-induced plumbism in an adult male. J Natl Med Assoc 2003; 95:986-90.
42. Grandjean P, Jacobsen IA, Jørgensen PJ. Chronic lead poisoning treated with dimercaptosuccinic acid. Pharmacol Toxicol 1991; 68 266-9.
43. Gordon JN, Taylor A, Bennett PN. Lead poisoning: Case studies. Br J Clin Pharmacol 2002; 53:451-8.
44. Lee A, Thomson J. Drug-induced skin reaction. In: Lee A, ed. Adverse Drug Reactions, 2nd edn. London, Pharmaceutical Press, 2006.
45. Angle CR. Blood aminotransferase values during treatment with meso-2,3-dimercaptosuccinic acid. J Pediatr 1994; 125:333-4.
46. Taylor A, ed. Trace Element Analyses Provided by the Supraregional Assay Service of the National Health Service, 4th edn. Guildford, Surrey, Royal Surrey County Hospital, 2006.