Efficacy of grass pollen sublingual immunotherapy for three consecutive seasons and after cessation of treatment: The ECRIT study

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 64, Issue 9, 2009, Pages 1394-1401

  Ott, H ^a   Sieber, J ^b   Brehler, R ^c   Folster Holst R ^d   Kapp, A ^e   Klimek, L ^f   Pfaar, O ^f   Merk, H ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b Stallergenes GmbH   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f Center of Rhinology   (Germany)

Author keywords

Allergic rhinitis; Carry over effect; Grass pollen extract; Sublingual immunotherapy; Ultra rush titration

Indexed keywords

GRASS POLLEN EXTRACT; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4; PLACEBO; STALORAL; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ALLERGIC REACTION; ARTICLE; BRONCHITIS; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG DOSE TITRATION; DRUG EFFECT; DRUG SAFETY; EYE SWELLING; FEMALE; GRASS POLLEN; HEADACHE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; INJECTION SITE EDEMA; INJECTION SITE IRRITATION; INJECTION SITE PARESTHESIA; MAJOR CLINICAL STUDY; MALE; POLLEN ALLERGY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINOCONJUNCTIVITIS; RHINOPHARYNGITIS; SCHOOL CHILD; SEASON;

ADMINISTRATION, SUBLINGUAL; ADOLESCENT; ADULT; AGED; ALLERGENS; CHILD; DESENSITIZATION, IMMUNOLOGIC; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; POLLEN; RHINITIS, ALLERGIC, SEASONAL; SEASONS; YOUNG ADULT;

EID: 69049105894     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2009.02194.x     Document Type: Article

References (29)

1. Canonica GW, Passalacqua G. Sublingual immunotherapy in the treatment of adult allergic rhinitis patients. Allergy 2006 61 (Suppl. 81 20 23.
2. Wilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 2005 60 : 4 12.
3. Malling HJ. Comparison of the clinical efficacy and safety of subcutaneous and sublingual immunotherapy: methodological approaches and experimental results. Curr Opin Allergy Clin Immunol 2004 4 : 539 542.
4. Bufe A, Ziegler-Kirbach E, Stoeckmann E, Heidemann P, Gehlhar K, Holland-Letz T et al. Efficacy of sublingual swallow immunotherapy in children with severe grass pollen allergic symptoms: a double-blind placebo-controlled study. Allergy 2004 59 : 498 504.
5. Passalacqua G, Durham SR. Allergic rhinitis and its impact on asthma update: allergen immunotherapy. J Allergy Clin Immunol 2007 119 : 881 891.
6. Purello-D'Ambrosio F, Gangemi S, Merendino RA, Isola S, Puccinelli P, Parmiani S et al. Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study. Clin Exp Allergy 2001 31 : 1295 1302.
7. Jacobsen L, Niggemann B, Dreborg S, Ferdousi HA, Halken S, Host A et al. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study. Allergy 2007 62 : 943 948.
8. Novembre E, Galli E, Landi F, Caffarelli C, Pifferi M, De Marco E et al. Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 2004 114 : 851 857.
9. Cox L. Sublingual immunotherapy in pediatric allergic rhinitis and asthma: efficacy, safety, and practical considerations. Curr Allergy Asthma Rep 2007 7 : 410 420.
10. Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001 108 : S147 S334.
11. Grosclaude M, Bouillot P, Alt R, Leynadier F, Scheinmann P, Rufin P et al. Safety of various dosage regimens during induction of sublingual immunotherapy. A preliminary study. Int Arch Allergy Immunol 2002 129 : 248 253.
12. Rossi RE, Monasterolo G. A pilot study of feasibility of ultra-rush (20-25 minutes) sublingual-swallow immunotherapy in 679 patients (699 sessions) with allergic rhinitis and/or asthma. Int J Immunopathol Pharmacol 2005 18 : 277 285.
13. Vervloet D, Birnbaum J, Laurent P, Hugues B, Fardeau MF, Massabie-Bouchat YP et al. Safety and Efficacy of Juniperus ashei Sublingual-Swallow Ultra-Rush Pollen Immunotherapy in Cypress Rhinoconjunctivitis. A Double-Blind, Placebo-Controlled Study. Int Arch Allergy Immunol 2007 142 : 239 246.
14. Global Initiative for Asthma. Global strategy for asthma management and prevention. Bethesda, MD : NIH Publication No. 02-3659 L1, 2005. 1 30.
15. Joint Council of Allergy, Asthma and Immunology. Allergen immunotherapy: a practice parameter second update. J Allergy Clin Immunol 2007 120 : S25 S85.
16. Madonini E, Agostinis F, Barra R, Berra A, Donadio D, Pappacoda A et al. Long-term and preventive effects of sublingual allergen-specific immunotherapy: a retrospective, multicentric study. Int J Immunopathol Pharmacol 2003 16 : 73 79.
17. Di Rienzo V, Marcucci F, Puccinelli P, Parmiani S, Frati F, Sensi L et al. Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study. Clin Exp Allergy 2003 33 : 206 210.
18. Malling HJ. Sublingual immunotherapy: efficacy-methodology and outcome of clinical trials. Allergy 2006 61 (Suppl. 81 24 28.
19. Penagos M, Compalati E, Tarantini F, Baena-Cagnani R, Huerta J, Passalacqua G et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials. Ann Allergy Asthma Immunol 2006 97 : 141 148.
20. Penagos M, Passalacqua G, Compalati E, Baena-Cagnani CE, Orozco S, Pedroza A et al. Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age. Chest 2008 133 : 599 609.
21. Cox LS, Linnemann DL, Nolte H, Weldon D, Finegold I, Nelson HS. Sublingual immunotherapy: a comprehensive review. J Allergy Clin Immunol 2006 117 : 1021 1035.
22. Antico A, Pagani M, Crema A. Anaphylaxis by latex sublingual immunotherapy. Allergy 2006 61 : 1236 1237.
23. Didier A, Malling HJ, Worm M, Horak F, Jager S, Montagut A et al. Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis. J Allergy Clin Immunol 2007 120 : 1338 1345.
24. Leynadier F, Banoun L, Dollois B, Terrier P, Epstein M, Guinnepain MT et al. Immunotherapy with a calcium phosphate-adsorbed five-grass-pollen extract in seasonal rhinoconjunctivitis: a double-blind, placebo-controlled study. Clin Exp Allergy 2001 31 : 988 996.
25. Till SJ, Francis JN, Nouri-Aria K, Durham SR. Mechanisms of immunotherapy. J Allergy Clin Immunol 2004 113 : 1025 1034.
26. Bousquet J, Scheinmann P, Guinnepain MT, Perrin-Fayolle M, Sauvaget J, Tonnel AB et al. Sublingual-swallow immunotherapy (SLIT) in patients with asthma due to house-dust mites: a double-blind, placebo-controlled study. Allergy 1999 54 : 249 260.
27. Moingeon P, Batard T, Fadel R, Frati F, Sieber J, Overtvelt L. Immune mechanisms of allergen-specific sublingual immunotherapy. Allergy 2006 61 : 151 165.
28. Gidaro GB, Marcucci F, Sensi L, Incorvaia C, Frati F, Ciprandi G. The safety of sublingual-swallow immunotherapy: an analysis of published studies. Clin Exp Allergy 2005 35 : 565 571.
29. Guerra L, Compalati E, Rogkakou A, Pecora S, Passalacqua G, Canonica GW. Randomized open comparison of the safety of SLIT in a no-updosing and traditional updosing schedule in patients with Parietaria allergy. Allergol Immunopathol (Madr) 2006 34 : 82 83.