TCD8 response in diverse outcomes of recurrent exposure to hepatitis C virus

Immunology and Cell Biology

Volumn 87, Issue 6, 2009, Pages 464-472

  Bharadwaj, Mandvi ^a   Thammanichanond, Duangtawan ^a   Aitken, Campbell Kynoch ^b   Moneer, Sarah ^a   Drummer, Heidi E ^b,e   Tracy, Samantha ^c   Holdsworth, Rhonda ^d   Bowden, Scott ^c   Jackson, David ^a   Hellard, Margaret ^b   Torresi, Joseph ^a   McCluskey, James ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH   (Australia)

^c VICTORIAN INFECTIOUS DISEASES REFERENCE LABORATORY   (Australia)

^d AUSTRALIAN RED CROSS BLOOD SERVICE   (Australia)

^e MONASH UNIVERSITY   (Australia)

Author keywords

Hepatitis C virus; Injecting drug users; T cell response

Indexed keywords

GAMMA INTERFERON; HUMAN LYMPHOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; HLA ANTIGEN;

ADULT; ARTICLE; CD8+ T LYMPHOCYTE; DRUG ABUSE; ENZYME LINKED IMMUNOSPOT ASSAY; HEPATITIS C; HUMAN; IMMUNOREACTIVITY; INFECTION RISK; ADOLESCENT; CELL PROLIFERATION; DISEASE TRANSMISSION; DRUG USE; ENVIRONMENTAL EXPOSURE; FEMALE; HEPATITIS C VIRUS; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; PATHOGENICITY; PATHOLOGY; RECURRENT DISEASE; REMISSION; SECRETION;

HEPATITIS C VIRUS;

ADOLESCENT; ADULT; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DRUG USERS; ENVIRONMENTAL EXPOSURE; FEMALE; HEPACIVIRUS; HEPATITIS C; HLA ANTIGENS; HUMANS; INTERFERON-GAMMA; MALE; MIDDLE AGED; RECURRENCE; REMISSION, SPONTANEOUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 69049097042     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2009.24     Document Type: Article

References (21)

1. Shepard CW, Finelli L, Alter MJ. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 2005; 5: 558-567. (Pubitemid 41196755)
2. Lechner F, Wong DK, Dunbar PR, Chapman R, Chung RT, Dohrenwend P et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 2000; 191: 1499-1512. (Pubitemid 30257347)
3. Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 2001; 194: 1395-1406. (Pubitemid 33081515)
4. Shoukry NH, Grakoui A, Houghton M, Chien DY, Ghrayeb J, Reimann KA et al. Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J Exp Med 2003; 197: 1645-1655. (Pubitemid 36745340)
5. Ward S, Lauer G, Isba R, Walker B, Klenerman P. Cellular immune responses against hepatitis C virus: the evidence base 2002. Clin Exp Immunol 2002; 128: 195-203.
6. Lauer GM, Barnes E, Lucas M, Timm J, Ouchi K, Kim AY et al. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology 2004; 127: 924-936. (Pubitemid 39208424)
7. Takaki A, Wiese M, Maertens G, Depla E, Seifert U, Liebetrau A et al. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat Med 2000; 6: 578-582. (Pubitemid 30305910)
8. Wedemeyer H, He XS, Nascimbeni M, Davis AR, Greenberg HB, Hoofnagle JH et al. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J Immunol 2002; 169: 3447-3458. (Pubitemid 35013196)
9. Chang KM, Thimme R, Melpolder JJ, Oldach D, Pemberton J, Moorhead-Loudis J et al. Differential CD4(+) and CD8(+) T-cell responsiveness in hepatitis C virus infection. Hepatology 2002; 33: 267-276.
10. Timm J, Lauer GM, Kavanagh DG, Sheridan I, Kim AY, Lucas M et al. CD8 epitope escape and reversion in acute HCV infection. J Exp Med 2004; 200: 1593-1604. (Pubitemid 40094183)
11. Neumann-Haefelin C, McKiernan S, Ward S, Ward S, Viazov S, Spangenberg HC et al. Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution. Hepatology 2006; 43: 563-572.
12. Mizukoshi E, Eisenbach C, Edlin BR, Newton KP, Raghuraman S, Weiler-Normann C et al. Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV. J Infect Dis 2008; 198: 203-212. (Pubitemid 352019285)
13. Kaplan DE, Sugimoto K, Newton K, Valiga ME, Ikeda F, Aytaman A et al. Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 2007; 132: 654-666. (Pubitemid 46274664)
14. Folgori A, Spada E, Pezzanera M, Ruggeri L, Mele A, Garbuglia AR, et al., Acute Hepatitis C Italian Study Group. Early impairment of hepatitis C virus specific T cell proliferation during acute infection leads to failure of viral clearance. Gut 2006; 55: 1012-1019.
15. Bowen DG, Walker CM. Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man. J Exp Med 2005; 201: 1709-1714.
16. Smyk-Pearson S, Tester IA, Klarquist J, Palmer BE, Pawlotsky JM, Golden-Mason L et al. Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help. J Virol 2008; 82: 1827-1837. (Pubitemid 351206931)
17. Spangenberg HC, Viazov S, Kersting N, Neumann-Haefelin C, McKinney D, Roggendorf M et al. Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection. Hepatology 2005; 42: 828-837. (Pubitemid 41401120)
18. Penna A, Pilli M, Zerbini A, Orlandini A, Mezzadri S, Sacchelli L et al. Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection. Hepatology 2007; 45: 588-601. (Pubitemid 46450610)
19. McCaw R, Moaven L, Locarnini S, Bowden S. Hepatitis C virus genotypes in Australia. J Viral Hepat 1997; 4: 351-357.
20. Rickinson AB, Moss DJ. Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection. Annu Rev Immunol 1997; 15: 405-431. (Pubitemid 27169287)
21. Thammanichanond D, Moneer S, Yotnda P, Aitken C, Earnest-Silveira L, Jackson D et al. Fiber-modified recombinant adenoviral constructs encoding hepatitis C virus proteins induce potent HCV-specific T cell response. Clin Immunol 2008; 128: 329-339.