The effects of unsaturated fatty acids on lipid metabolism in HepG2 cells

In Vitro Cellular and Developmental Biology - Animal

Volumn 45, Issue 1-2, 2009, Pages 6-9

  Kohjima, Motoyuki ^b   Enjoji, Munechika ^a,b   Higuchi, Nobito ^b   Kato, Masaki ^b   Kotoh, Kazuhiro ^b   Nakashima, Manabu ^a   Nakamuta, Makoto ^c  

^a FUKUOKA UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c NATIONAL HOSPITAL ORGANIZATION KYUSHU MEDICAL CENTER   (Japan)

Author keywords

Linolenic acid; HepG2; Linoleic acid; Oleic acid

Indexed keywords

LINOLEIC ACID; LINOLENIC ACID; OLEIC ACID; REACTIVE OXYGEN METABOLITE; STEARIC ACID;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME INDUCTION; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FATTY LIVER; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIPID METABOLISM; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; REAL TIME POLYMERASE CHAIN REACTION; STEATOSIS;

CELL LINE; FATTY ACIDS, UNSATURATED; HEPATOCYTES; HUMANS; LINOLEIC ACIDS; LIPID METABOLISM; OLEIC ACID; TUMOR CELLS, CULTURED;

EID: 69049093006     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-008-9144-7     Document Type: Article

References (19)

1. H. C. Bucher P. Hengstler C. Schindler G. Meier 2002 N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled study Am J Med. 112 298 304 doi:10.1016/S0002-9343(01)01114-7
2. Burdge G. C. Metabolism of α-linolenic acid in humans. Prostaglandins Leukotrienes Essential Fatty Acids. 161-168; 2006. doi: 10.1016/j.plefa.2006.05.013.
3. A. M. El-Badry R. Graf P.-A. Clavien 2007 Omega 3-omega 6: what is right for the liver J Hepatol. 47 718 725 doi:10.1016/j.jhep.2007.08.005
4. Y. Fujimoto J. Onoduka K. J. Homma et al. 2006 Long-chain fatty acids induce lipid droplet formation in a cultured human hepatocyte in a manner dependent of Acyl-CoA synthetase Biol Pharm Bull. 29 2174 2180 doi:10.1248/bpb.29.2174
5. I. A. Ghafoorunissa L. Rajkumar V. Acharya 2005 Dietary (n-3) long chain polyunsaturated fatty acids prevent sucrose-induced insulin resistance in rats J Nutr. 135 2634 2638
6. M. Javadi M. J. Geelen A. G. Lemmens et al. 2007 The influence of dietary linoleic and alpha-linolenic acid on body composition and the activities of key enzymes of hepatic lipogenesis and fatty acid oxidation in mice. J Anim Physiol Anim Nutr. 91 11 18 doi:10.1111/j.1439-0396.2006.00636.x
7. M. Kohjima M. Enjoji N. Higuchi et al. 2007 Re-evaluation of fatty acid metabolism-related gene expression in non-alcoholic fatty liver disease Int J Mol Med. 20 351 358
8. J. R. Levy J. N. Clore W. Stevens 2004 Dietary n-3 poly unsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats Hepatology. 39 608 616 doi:10.1002/hep.20093
9. T. Murase M. Aoki I. Tokimitsu 2005 Supplementation with α-linolenic acid-rich diacylglycerol suppresses fatty liver formation accompanied by an up-regulation of oxidation in Zucker fatty rats Biochim Biophys Acta. 1733 224 231
10. A. J. Sanyal C. Campbell-Sargent F. Mirshahi et al. 2001 Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities Gastroenterology. 120 1183 1192 doi:10.1053/gast.2001.23256
11. C. Schmocker K. H. Weylandt L. Kahlke et al. 2007 Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines Hepatology. 45 864 869 doi:10.1002/hep.21626
12. M. Sekiya N. Yahagi T. Matsuzaka et al. 2003 Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression Hepatology. 39 608 616
13. T. M. Stulnig 2003 Immunomodulation by polyunsaturated fatty acids; mechanisms and effects Int Arch Allergy immunol. 132 310 321 doi:10.1159/000074898
14. G. Svegliati-Baroni C. Candelaresi S. Saccomanno et al. 2006 A model of insulin resistance and nonalcoholic steatohepatitis in rats. Role of peroxisome proliferators-activated receptor-α and n-3 polyunsaturated fatty acid treatment on liver injury Am J Pathol. 169 846 860 doi:10.2353/ajpath.2006. 050953
15. M. Teran-Garcia A. W. Adamson G. Yu et al. 2007 Polyunsaturated fatty acids suppression by fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c Biochem J. 402 591 600 doi:10.1042/BJ20061722
16. M. Vinciguerra C. Veyrat-Durebex M. A. Moukil et al. 2008 PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NFκBp65/mTOR-dependent mechanism Gastroenterology. 134 268 280 doi:10.1053/j.gastro.2007.10.010
17. E. Wendland A. Farmer P. Glasziou A. Neil 2006 Effect of linolenic acid on cardiovascular risk markers: a systematic review Heart. 92 166 169 doi:10.1136/hrt.2004.053538
18. N. Yahagi H. Shimano A. H. Hasty et al. 2002 Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice J Biol Chem. 277 19353 19357 doi:10.1074/jbc.M201584200
19. S. Yu-Poth D. Yin P. M. Kris-Etherton et al. 2005 Long-chain polyunsaturated fatty acids upregulate LDL receptor protein expression in fibroblasts and HepG2 cells J Nutr. 135 2541 2545