Characterization of a phosphodiesterase capable of hydrolyzing EA 2192, the most toxic degradation product of the nerve agent VX

Biochemistry

Volumn 46, Issue 31, 2007, Pages 9032-9040

  Ghanem, Eman ^a   Li, Yingchun ^a   Xu, Chengfu ^a   Raushel, Frank M ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHODIESTERASE; PHOSPHONATE MONOESTERS;

CATALYST ACTIVITY; DEGRADATION; ESCHERICHIA COLI; HYDROLYSIS; SUBSTRATES; TOXIC MATERIALS;

ENZYMES;

ALKYL GROUP; BIS(4 NITROPHENYL) PHOSPHATE; CYCLOSARIN; EA 2192; ESTER DERIVATIVE; ESTERASE; GLYCEROPHOSPHODIESTERASE; ISOBUTYL METHYL PHOSPHONATE; METHYL DEMETON S; METHYL GROUP; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; NERVE GAS; PHOSPHATE; PHOSPHODIESTERASE; PHOSPHONIC ACID DERIVATIVE; PHOSPHOTRIESTERASE; SARIN; SOMAN; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; DEGRADATION; ENTEROBACTER AEROGENES; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL;

CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; DISULFOTON; ENTEROBACTER AEROGENES; KINETICS; MICROBIAL VIABILITY; MOLECULAR STRUCTURE; MUTATION; NITROPHENOLS; ORGANOTHIOPHOSPHORUS COMPOUNDS; PARAOXON; PHENOLS; PHOSPHONIC ACIDS; PHOSPHORIC ACID ESTERS; PHOSPHORIC DIESTER HYDROLASES; PHOSPHORIC TRIESTER HYDROLASES; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ENTEROBACTER AEROGENES; ESCHERICHIA COLI;

EID: 34547742504     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700561k     Document Type: Article

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