Levosimendan, a new inotropic drug: experience in children with acute heart failure;Levosimendán, un nuevo agente inotrópico: Experiencia en niños con fallo cardíaco agudo

Archivos Argentinos de Pediatria

Volumn 107, Issue 2, 2009, Pages 139-145

  Magliola, Ricardo ^a   Moreno, Guillermo ^a   Vassallo, Juan C ^a   Landry, Luis M ^a   Althabe, María ^a   Balestrini, María ^a   Charroqui, Alberto ^a   Salgado, Gladys ^a   Lataza, Evangelina ^a   Chang, Anthony C ^b  

^a HOSPITAL DE PEDIATRÍA PROF DR JUAN P GARRAHAN   (Argentina)

^b CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

Author keywords

Congenital heart disease; Intensive care; Levosimendan; Low cardiac output; Pediatrics

Indexed keywords

ADRENALIN; DOBUTAMINE; DOPAMINE; LEVOSIMENDAN; MILRINONE; CARDIOTONIC AGENT; HYDRAZONE DERIVATIVE; PYRIDAZINE DERIVATIVE; SIMENDAN;

ACUTE HEART FAILURE; ARTICLE; CHILD; CLINICAL ARTICLE; CONTINUOUS INFUSION; DRUG EFFICACY; DRUG SAFETY; ELECTROCARDIOGRAM; FEMALE; HEART HEMODYNAMICS; HEART OUTPUT; HUMAN; HYPOTENSION; INFANT; LABORATORY TEST; MALE; PRESCHOOL CHILD; PROSPECTIVE STUDY; ACUTE DISEASE; ADOLESCENT; CLINICAL TRIAL; FORWARD HEART FAILURE;

ACUTE DISEASE; ADOLESCENT; CARDIAC OUTPUT, LOW; CARDIOTONIC AGENTS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; HYDRAZONES; INFANT; MALE; PROSPECTIVE STUDIES; PYRIDAZINES;

EID: 68949218359     PISSN: 03250075     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Wernovsky G, Wypij D, Jonas R, et al. Posoperative course and hemodynamic profile after the arterial switch operation in neonates and infants: a comparison of low flow cardiopulmonary by-pass and circulatory arrest. Circulation 1995; 92:2226-2235.
2. 2. Caspi J, Coles J, Benson L, et al. Heart rate independence of catecholamine induced myocardial damage in the newborn pig. Pediatr Res 1994; 36:49-54. (Pubitemid 24185187)
3. Caspi J, Coles J, Benson L, et al. Age-related response to epinephrine-induced myocardial stress: a functional and ultrastructural study. Circulation 1991; 84(Suppl. III):394-399.
4. Lang P, Wessel D, Wernovsky G, et al. Hemodynamic effects of amrinone in infants after cardiac surgery. En: Crupi G, Parenzan L, Anderson RH (Eds). Perspectives in Pediatric Cardiology. Vol.2. Pediatric Cardiology, part II. Mount Kisco, New York: Futura publishing Company, 1989; Págs. 292-295.
5. Chang A, Atz A, Wernovsky G, et al. Milrinone systemic and pulmonary hemodynamic effects in neonates after cardiac surgery. Crit Care Med 1995; 23:1907-1914.
6. 6. Hoffman T, Wernovsky G, Atz A, et al. Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation 2003; 107: 996-1002. (Pubitemid 36258723)
7. 7. Caspi J, Coles J, Benson L et al. Effects of high plasma epinephrine and Ca concentrations on neonatal myocardial function after isquemia. J Thorac Cardiovasc Surg 1993; 105:59-67. (Pubitemid 23033761)
8. Ferrans B, Hibbs R, Black W, et al. A histochemical and microscopic study of epinephrine-induced myocardial necrosis. L Mol Cell Cardiol 1970; 1:11-22.
9. Macbride B and White M. Levosimendan: implication for clinicians. J Clin Pharmacol 2003; 43:1071-1081.
10. Paraskevaidis IA, Partissis JT, Th Kremestinos D. Antiinflamatory and anti apoptotic effects of levosimendan in descompensated heart failure: a novel mechanism of druginduce improvement in contractile performance on the failing heart. Curr Med Chem Cardiovasc Hematol Agents 2005; 3(3):243-247.
11. 11. Avgeropoulou C, Andreadou I, Markantosis-Kyroudis S. The Ca sensitizer levosimendan improves oxidative damage, BNP and pre-inflamatory cytokine levels in patients with advanced descompensated heart failure in comparison to dobutamine. Eur ] Heart Fail 2005; 7(5):882-887. (Pubitemid 41125911)
12. 12. Lilleberg J, Nieminen M, Akkila J, et al. Effects of a new calcium sensitizer, levosimendan, onhemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery by-pass grafting. Eur Heart J 1998; 19 (4): 660-668. (Pubitemid 28224690)
13. 13. Ukkonen H, Sarasste M, Akkila J, et al. Myocardial efficiency during levosimendan infusion in congestive heart failure. Clin Pharmacol Ther 2000; 68(5):522-531. (Pubitemid 30953872)
14. 14. Nieminen M, Akkila J, Hasenfuss G, et al. Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure. J Am Coll Cardiol 2000; 36:1903-1912. (Pubitemid 30844104)
15. 15. Slawsky M, Colucci W, Gottlieb S, et al. Acute hemodynamic and clinical effects in patients with severe heart failure. Circulation 2000; 102:2222-2227. (Pubitemid 30808010)
16. 16. Follath F, Cleland J, Just H, et al. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (The LIDO Study): A randomized double-blind trial. Lancet 2002; 360:196-202. (Pubitemid 34804646)
17. 17. Nijhawan N, Nicolosi A, Montgomery M, et al. Levosimendan enhances cardiac performance after cardiopulmonary by-pass: A prospective randomized placebo-controlled trial. J Cardiovasc Pharmacol 1999; 34(2):219-228. (Pubitemid 29350503)
18. 18. Labriola C, Siro-Brigiani M, Carrata F, et al. Hemodynamic effects on levosimendan in patients with low- output heart failure after cardiac failure. Int J Clin Pharmacol Ther 2004; 42(4):204-211. (Pubitemid 38477436)
19. Siirila-Waris K, Suojaranta-Ylinen R, Harjola V. Levosimendan in cardiac surgery. J Cardiothorac Vasc Anesth 2005; 19(3):345-349.
20. 20. Braun J, Schneider M, Kastrup M, et al. Treatment of acute heart failure in an infant after cardiac surgery using levosimendan. Eur J Cardiothorac Surg 2004; 26(1):228-230. (Pubitemid 38759957)
21. 21. Braun J, Schneider M. Successful treatment of dilated cardiomyopathy in a 12-year-old girl using the calcium sensitizer levosimendan after weaning from mechanical viventricular assits support. J Cardiothorac Vasc Anesth 2004;18:772-774. (Pubitemid 40093658)
22. Broberg CS, Pantely GA, Barber BJ, et al. Validation of the myocardial performance index by echocardiography in mice: a noninvasive measure of left ventricular function. J Am Soc Echocardiogr 2003; 16:841-1823
23. Tei C, Dujardian KS, Hodge DO, et al. Doppler echocardiographic index for assesment of global right ventricular function. J Am Soc Echocardiogr 1996; 9:838-847.
24. Wernovsky G, Wypij D, Jonas R, et al. Postoperative course and thermodynamics profile after the arterial switch operation in neonates and infants. A comparison of low-flow cardiopulmonary by-pass and circulatory arrest. Circulation 1995; 92:2226-2235.
25. Turanlahti M, Boldt T, Palkama T, et al. Pharmacokinetics of levosimendan in pediatric patients evaluated for cardiac surgery. Pediatr Crit Care Med 2004; 5:457-462.
26. 26. Namachivayam P, Crossland D, Butt W, Shekerdemian L. Early experience with levosimendan in children with ventricular dysfunction. Pediatr Crit Care Med 2006; 7:445-448. (Pubitemid 44386070)
27. Egan J, Clarke A, Williams S, et al. Levosimendan for low cardiac output: a pediatric experience. J Intensive Care Med 2006; 21(3):183-187.