Anti-inflammatory and anti-apoptotic effects of levosimendan in decompensated heart failure: A novel mechanism of drug-induced improvement in contractile performance of the failing heart

Current Medicinal Chemistry: Cardiovascular and Hematological Agents

Volumn 3, Issue 3, 2005, Pages 243-247

  Paraskevaidis, Ioannis A ^a,b   Parissis, John T ^a   Kremastinos, Dimitios Th ^a,b  

^a NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^b ONASSIS CARDIAC SURGERY CENTER   (Greece)

Author keywords

Apoptosis; Calcium sensitizers; Cytokines; Decompensated heart failure; Inotropes; Novel pathophysiologic machanisms

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM SENSITIZER; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOBUTAMINE; ETANERCEPT; FAS ANTIGEN; FAS LIGAND; GROWTH HORMONE; INFLIXIMAB; INTERLEUKIN 6; LEVOSIMENDAN; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITOR; PLACEBO; POTASSIUM CHANNEL; TROPONIN C; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; CELL FUNCTION; CLINICAL OBSERVATION; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CYTOTOXICITY; DIASTOLE; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFECT; DRUG MECHANISM; HEART ARRHYTHMIA; HEART FAILURE; HEART HEMODYNAMICS; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE RELAXATION; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; INOTROPISM; MORBIDITY; MORTALITY; MYOFILAMENT; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN STABILITY; REVIEW; RISK REDUCTION; SIGNAL TRANSDUCTION; SUDDEN DEATH; SYMPTOMATOLOGY; SYSTOLE; VASODILATATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; HEART FAILURE, CONGESTIVE; HUMANS; HYDRAZONES; PYRIDAZINES;

EID: 22144498863     PISSN: 15680169     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568016054368232     Document Type: Review

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