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Volumn 104, Issue SUPPL. 1, 2009, Pages 122-135

Usefulness of PCR-based assays to assess drug efficacy in Chagas disease chemotherapy: Value and limitations

Author keywords

Chagas disease; Chemotherapy; Cure assessment; Molecular diagnosis; Trypanosoma cruzi

Indexed keywords

TRYPANOSOMA CRUZI;

EID: 68949203206     PISSN: 00740276     EISSN: 16788060     Source Type: Journal    
DOI: 10.1590/S0074-02762009000900018     Document Type: Article
Times cited : (92)

References (134)
  • 3
    • 0016572671 scopus 로고
    • Reaction of the Trypanosoma cruzi strains to the experimental therapeutical response to Bay 2502 (results of long term treatment)
    • Andrade SG, Figueira RM, Carvalho ML, Gorini DF 1975. Reaction of the Trypanosoma cruzi strains to the experimental therapeutical response to Bay 2502 (results of long term treatment). Rev Inst Med Trop Sao Paulo 17: 380-399.
    • (1975) Rev Inst Med Trop Sao Paulo , vol.17 , pp. 380-399
    • Andrade, S.G.1    Figueira, R.M.2    Carvalho, M.L.3    Gorini, D.F.4
  • 4
    • 0023841958 scopus 로고
    • Trypanosoma cruzi antigens detected by immunoelectron microscopy in the spleen of mice serologically positive but parasitologically cured by chemotherapy (preliminary report)
    • Andrade SG, Freitas LAR, Peyrol S, Pimentel AR, Sadigursky M 1988. Trypanosoma cruzi antigens detected by immunoelectron microscopy in the spleen of mice serologically positive but parasitologically cured by chemotherapy (preliminary report). Rev Soc Bras Med Trop 21: 41-42.
    • (1988) Rev Soc Bras Med Trop , vol.21 , pp. 41-42
    • Andrade, S.G.1    Freitas, L.A.R.2    Peyrol, S.3    Pimentel, A.R.4    Sadigursky, M.5
  • 5
    • 0025753040 scopus 로고
    • Experimental chemotherapy of Trypanosoma cruzi reveals infection persistence of parasite antigens and positive sorology in parasitologically cured mice
    • Andrade SG, Freitas LAR, Peyrol S, Pimentel AR, Sadigursky M 1991. Experimental chemotherapy of Trypanosoma cruzi reveals infection persistence of parasite antigens and positive sorology in parasitologically cured mice. Bull World Health Organ 69: 191-199.
    • (1991) Bull World Health Organ , vol.69 , pp. 191-199
    • Andrade, S.G.1    Freitas, L.A.R.2    Peyrol, S.3    Pimentel, A.R.4    Sadigursky, M.5
  • 6
    • 0029678001 scopus 로고    scopus 로고
    • Biodemes and zymodemes of Trypanosoma cruzi strains: Correlations with clinical data and experimental pathology
    • Andrade SG, Magalhães JB 1996. Biodemes and zymodemes of Trypanosoma cruzi strains: correlations with clinical data and experimental pathology. Rev Soc Bras Med Trop 30: 27-35.
    • (1996) Rev Soc Bras Med Trop , vol.30 , pp. 27-35
    • Andrade, S.G.1    Magalhães, J.B.2
  • 7
    • 0022344585 scopus 로고
    • Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types
    • Andrade SG, Magalhães JB, Pontes AL 1985. Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types. Bull World Health Organ 63: 721-726.
    • (1985) Bull World Health Organ , vol.63 , pp. 721-726
    • Andrade, S.G.1    Magalhães, J.B.2    Pontes, A.L.3
  • 8
    • 0027077951 scopus 로고
    • Specific chemotherapy of Chagas disease: A comparison between the response in patients and experimental animals inoculated with the same strains
    • Andrade SG, Rassi A, Magalhaes JB, Ferriolli Filho F, Luquetti AO 1992. Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains. Trans R Soc Trop Med Hyg 86: 624-626.
    • (1992) Trans R Soc Trop Med Hyg , vol.86 , pp. 624-626
    • Andrade, S.G.1    Rassi, A.2    Magalhaes, J.B.3    Filho, F.F.4    Luquetti, A.O.5
  • 9
    • 0023177510 scopus 로고
    • Enhancement of chronic Trypanosoma cruzi myocarditis in dogs treated with low doses of cyclophosphamide
    • Andrade ZA, Andrade SG, Sadigursky M 1987. Enhancement of chronic Trypanosoma cruzi myocarditis in dogs treated with low doses of cyclophosphamide. Am J Pathol 127: 467-473.
    • (1987) Am J Pathol , vol.127 , pp. 467-473
    • Andrade, Z.A.1    Andrade, S.G.2    Sadigursky, M.3
  • 11
    • 28144459142 scopus 로고    scopus 로고
    • Itraconazole or allopurinol in the treatment of chronic American trypanosomiasis: The results of clinical and parasitological examinations 11 years post-treatment
    • Apt W, Arribada A, Zulantay I, Solari A, Sánchez G, Mundana K, Coronado X, Rodríguez G, Gil LC, Osuna A 2005. Itraconazole or allopurinol in the treatment of chronic American trypanosomiasis: the results of clinical and parasitological examinations 11 years post-treatment. Ann Trop Med Parasitol 99: 733-741.
    • (2005) Ann Trop Med Parasitol , vol.99 , pp. 733-741
    • Apt, W.1    Arribada, A.2    Zulantay, I.3    Solari, A.4    Sánchez, G.5    Mundana, K.6    Coronado, X.7    Rodríguez, G.8    Gil, L.C.9    Osuna, A.10
  • 12
    • 0027279356 scopus 로고
    • Detection of Trypanosoma cruzi in blood specimens of chronic chagasic patients by polymerase chain reaction amplification of kinetoplast minicircle DNA: Comparison with serology and xenodiagnosis
    • Avila HA, Borges-Pereira J, Thiemann O, de Paiva E, Degrave W, Morel CM, Simpson L 1993. Detection of Trypanosoma cruzi in blood specimens of chronic chagasic patients by polymerase chain reaction amplification of kinetoplast minicircle DNA: comparison with serology and xenodiagnosis. J Clin Microbiol 31: 2421-2426.
    • (1993) J Clin Microbiol , vol.31 , pp. 2421-2426
    • Avila, H.A.1    Borges-Pereira, J.2    Thiemann, O.3    de Paiva, E.4    Degrave, W.5    Morel, C.M.6    Simpson, L.7
  • 13
    • 0025769803 scopus 로고
    • Polymerase chain reaction amplification of Trypanosoma cruzi kinetoplast minicircle DNA isolated from whole blood lysates: Diagnosis of chronic Chagas disease
    • Avila HA, Sigman DS, Cohen LM, Millikan RC, Simpson L 1991. Polymerase chain reaction amplification of Trypanosoma cruzi kinetoplast minicircle DNA isolated from whole blood lysates: diagnosis of chronic Chagas disease. Mol Biochem Parasitol 48: 211-222.
    • (1991) Mol Biochem Parasitol , vol.48 , pp. 211-222
    • Avila, H.A.1    Sigman, D.S.2    Cohen, L.M.3    Millikan, R.C.4    Simpson, L.5
  • 15
    • 0036000310 scopus 로고    scopus 로고
    • Viral genome quantification as a tool for improving patient management: The example of HIV, HBV, HCV and CMV
    • Berger A, Preiser W 2000. Viral genome quantification as a tool for improving patient management: the example of HIV, HBV, HCV and CMV. J Antimicrob Chemother 49: 713-721.
    • (2000) J Antimicrob Chemother , vol.49 , pp. 713-721
    • Berger, A.1    Preiser, W.2
  • 16
    • 0026911344 scopus 로고
    • Possible risk factors for vertical transmission of Chagas' disease
    • Bittencourt AL 1992. Possible risk factors for vertical transmission of Chagas' disease. Rev Inst Med Trop São Paulo 34: 403-408.
    • (1992) Rev Inst Med Trop São Paulo , vol.34 , pp. 403-408
    • Bittencourt, A.L.1
  • 18
    • 0033253888 scopus 로고    scopus 로고
    • El control de la transmisión congénita de T. cruzi en la Argentina
    • Blanco SB, Segura EL, Gürtler RE 1999. El control de la transmisión congénita de T. cruzi en la Argentina. Medicina (B Aires) 59 (Suppl. 2): 138-142.
    • (1999) Medicina (B Aires) , vol.59 , Issue.2 , pp. 138-142
    • Blanco, S.B.1    Segura, E.L.2    Gürtler, R.E.3
  • 19
    • 0034991748 scopus 로고    scopus 로고
    • First Guideline Group for Heart Transplantation of the Brazilian Society of Cardiology. The Brazilian experience with heart transplantation: A multicenter report
    • Bocchi EA, Fiorelli A 2001. First Guideline Group for Heart Transplantation of the Brazilian Society of Cardiology. The Brazilian experience with heart transplantation: a multicenter report. J Heart Lung Transplant 20: 637-645.
    • (2001) J Heart Lung Transplant , vol.20 , pp. 637-645
    • Bocchi, E.A.1    Fiorelli, A.2
  • 20
    • 0034267378 scopus 로고    scopus 로고
    • Selection of Trypanosoma cruzi clonal genotypes (clones 20 and 39) isolated from Bolivian triatomines following subculture in liquid medium
    • Bosseno MF, Yacsik N, Vargas F, Brenière SF 2000. Selection of Trypanosoma cruzi clonal genotypes (clones 20 and 39) isolated from Bolivian triatomines following subculture in liquid medium. Mem Inst Oswaldo Cruz 95: 601-607.
    • (2000) Mem Inst Oswaldo Cruz , vol.95 , pp. 601-607
    • Bosseno, M.F.1    Yacsik, N.2    Vargas, F.3    Brenière, S.F.4
  • 22
    • 73649161135 scopus 로고
    • Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi
    • Brener Z 1962. Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi. Rev Inst Med Trop São Paulo 4: 389-396.
    • (1962) Rev Inst Med Trop São Paulo , vol.4 , pp. 389-396
    • Brener, Z.1
  • 25
    • 0028926829 scopus 로고
    • Polymerase chain reaction detection of Trypanosoma cruzi in human blood samples as a tool for diagnosis and treatment evaluation
    • Britto C, Cardoso MA, Vanni CMM, Haslocher-Moreno A, Xavier SS, Wincker P 1995. Polymerase chain reaction detection of Trypanosoma cruzi in human blood samples as a tool for diagnosis and treatment evaluation. Parasitology 110: 241-247.
    • (1995) Parasitology , vol.110 , pp. 241-247
    • Britto, C.1    Cardoso, M.A.2    Vanni, C.M.M.3    Haslocher-Moreno, A.4    Xavier, S.S.5    Wincker, P.6
  • 26
    • 0027428255 scopus 로고
    • A simple protocol for the physical cleavage of Trypanosoma cruzi kinetoplast DNA present in blood samples and its use in polymerase chain reaction (PCR)-based diagnosis of chronic Chagas disease
    • Britto C, Cardoso MA, Wincker P, Morel CM 1993. A simple protocol for the physical cleavage of Trypanosoma cruzi kinetoplast DNA present in blood samples and its use in polymerase chain reaction (PCR)-based diagnosis of chronic Chagas disease. Mem Inst Oswaldo Cruz 88: 171-172.
    • (1993) Mem Inst Oswaldo Cruz , vol.88 , pp. 171-172
    • Britto, C.1    Cardoso, M.A.2    Wincker, P.3    Morel, C.M.4
  • 29
    • 11244259934 scopus 로고
    • Aspectos clínicos na padronização dos métodos de avaliação terapêutica na doença de Chagas
    • Cançado JR 1963. Aspectos clínicos na padronização dos métodos de avaliação terapêutica na doença de Chagas. Rev Goiana Med 9 (Suppl.): 212-232.
    • (1963) Rev Goiana Med , vol.9 , pp. 212-232
    • Cançado, J.R.1
  • 30
    • 0042676635 scopus 로고
    • In JR Cançado, M Chuster, Cardiopatia chagásica, Imprensa Oficial de Minas Gerais, Minas Gerais
    • Cançado JR 1985. Tratamento específico. In JR Cançado, M Chuster, Cardiopatia chagásica, Imprensa Oficial de Minas Gerais, Minas Gerais, p. 327-355.
    • (1985) Tratamento específico , pp. 327-355
    • Cançado, J.R.1
  • 31
    • 0002030732 scopus 로고    scopus 로고
    • In JCP Dias, JR Coura, Clínica e terapêutica da doença de Chagas. Uma abordagem prática para o clínico geral, Fiocruz, Rio de Janeiro
    • Cançado JR 1997. Terapêutica específica. In JCP Dias, JR Coura, Clínica e terapêutica da doença de Chagas. Uma abordagem prática para o clínico geral, Fiocruz, Rio de Janeiro, p. 323-351.
    • (1997) Terapêutica específica , pp. 323-351
    • Cançado, J.R.1
  • 32
    • 0033253710 scopus 로고    scopus 로고
    • Criteria of Chagas disease cure
    • Cançado JR 1999. Criteria of Chagas disease cure. Mem Inst Oswaldo Cruz 94 (Suppl. I): 331-335.
    • (1999) Mem Inst Oswaldo Cruz , vol.94 , Issue.I , pp. 331-335
    • Cançado, J.R.1
  • 33
    • 17544400692 scopus 로고    scopus 로고
    • Long term evaluation of etiological treatment of Chagas disease with benznidazole
    • Cançado JR 2002. Long term evaluation of etiological treatment of Chagas disease with benznidazole. Rev Inst Med Trop Sao Paulo 44: 29-37.
    • (2002) Rev Inst Med Trop Sao Paulo , vol.44 , pp. 29-37
    • Cançado, J.R.1
  • 34
    • 0036038280 scopus 로고    scopus 로고
    • Blood culture and polymerase chain reaction for the diagnosis of the chronic phase of human infection with Trypanosoma cruzi
    • Castro AM, Luquetti AO, Rassi A, Rassi GG, Chiari E, Galvão LMC 2002. Blood culture and polymerase chain reaction for the diagnosis of the chronic phase of human infection with Trypanosoma cruzi. Parasitol Res 88: 894-900.
    • (2002) Parasitol Res , vol.88 , pp. 894-900
    • Castro, A.M.1    Luquetti, A.O.2    Rassi, A.3    Rassi, G.G.4    Chiari, E.5    Galvão, L.M.C.6
  • 35
    • 0024828846 scopus 로고
    • Hemocultures for the parasitological diagnosis of human chronic Chagas disease
    • Chiari E, Dias JCP, Lana M, Chiari CA 1989. Hemocultures for the parasitological diagnosis of human chronic Chagas disease. Rev Soc Bras Med Trop 22: 19-23.
    • (1989) Rev Soc Bras Med Trop , vol.22 , pp. 19-23
    • Chiari, E.1    Dias, J.C.P.2    Lana, M.3    Chiari, C.A.4
  • 37
    • 36348992108 scopus 로고    scopus 로고
    • Chagas disease: What is known and what is needed - A background article
    • Coura JR 2007. Chagas disease: what is known and what is needed - A background article. Mem Inst Oswaldo Cruz 102 (Suppl. I): 113-122.
    • (2007) Mem Inst Oswaldo Cruz , vol.102 , Issue.I , pp. 113-122
    • Coura, J.R.1
  • 38
    • 0036359943 scopus 로고    scopus 로고
    • A critical review on Chagas disease chemotherapy
    • Coura JR, de Castro SL 2002. A critical review on Chagas disease chemotherapy. Mem Inst Oswaldo Cruz 97: 3-24.
    • (2002) Mem Inst Oswaldo Cruz , vol.97 , pp. 3-24
    • Coura, J.R.1    de Castro, S.L.2
  • 40
    • 0038512547 scopus 로고    scopus 로고
    • Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR
    • Cummings KL, Tarleton RL 2003. Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR. Mol Biochem Parasitol 129: 53-59.
    • (2003) Mol Biochem Parasitol , vol.129 , pp. 53-59
    • Cummings, K.L.1    Tarleton, R.L.2
  • 42
    • 0029861783 scopus 로고    scopus 로고
    • Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient
    • Cunha-Neto E, Coelho V, Guilherme L, Fiorelli A, Stolf N, Kalil J 1996. Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient. J Clin Invest 98: 1709-1712
    • (1996) J Clin Invest , vol.98 , pp. 1709-1712
    • Cunha-Neto, E.1    Coelho, V.2    Guilherme, L.3    Fiorelli, A.4    Stolf, N.5    Kalil, J.6
  • 43
    • 0031977217 scopus 로고    scopus 로고
    • Compared vectorial transmissibility of pure and mixed clonal genotypes of Trypanosoma cruzi in Triatoma infestans
    • da Pinto A.S., de Lana M, Bastrenta B, Barnabé C, Quesney V, Noel S, Tibayrenc M 1998. Compared vectorial transmissibility of pure and mixed clonal genotypes of Trypanosoma cruzi in Triatoma infestans. Parasitol Res 84: 348-353.
    • (1998) Parasitol Res , vol.84 , pp. 348-353
    • da Pinto, A.S.1    de Lana, M.2    Bastrenta, B.3    Barnabé, C.4    Quesney, V.5    Noel, S.6    Tibayrenc, M.7
  • 44
    • 0034210707 scopus 로고    scopus 로고
    • Experimental Trypanosoma cruzi biclonal infection in Triatoma infestans: Detection of distinct clonal genotypes using kinetoplast DNA probes
    • da Silveira Pinto A, de Lana M, Britto C, Bastrenta B, Tibayrenc M 2000. Experimental Trypanosoma cruzi biclonal infection in Triatoma infestans: detection of distinct clonal genotypes using kinetoplast DNA probes. Int J Parasitol 30: 843-848.
    • (2000) Int J Parasitol , vol.30 , pp. 843-848
    • da Pinto, A.S.1    de Lana, M.2    Britto, C.3    Bastrenta, B.4    Tibayrenc, M.5
  • 46
    • 33748907725 scopus 로고    scopus 로고
    • Detection of parasitemia profiles by blood culture after treatment of chronic Trypanosoma cruzi infection
    • de Castro AM, Luquetti AO, Rassi A, Chiari E, Galvao LM 2006. Detection of parasitemia profiles by blood culture after treatment of chronic Trypanosoma cruzi infection. Parasitol Res 99: 379-383.
    • (2006) Parasitol Res , vol.99 , pp. 379-383
    • de Castro, A.M.1    Luquetti, A.O.2    Rassi, A.3    Chiari, E.4    Galvao, L.M.5
  • 50
    • 0023609713 scopus 로고
    • Susceptibility and natural-resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease
    • Filardi LS, Brener Z 1987. Susceptibility and natural-resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease. Trans R Soc Trop Med Hyg 5: 755-759.
    • (1987) Trans R Soc Trop Med Hyg , vol.5 , pp. 755-759
    • Filardi, L.S.1    Brener, Z.2
  • 52
    • 0029094286 scopus 로고
    • Congenital Chagas' disease. Diagnostic and clinical aspects
    • Freilij H, Altcheh J 1995. Congenital Chagas' disease. Diagnostic and clinical aspects. Clin Infect Dis 21: 551-555.
    • (1995) Clin Infect Dis , vol.21 , pp. 551-555
    • Freilij, H.1    Altcheh, J.2
  • 53
    • 0020583946 scopus 로고
    • Direct micromethod for diagnosis of acute and congenital Chagas disease
    • Freilij H, Muller L, Gonzalez-Cappa EM 1983. Direct micromethod for diagnosis of acute and congenital Chagas disease. J Clin Microbiol 18: 327-330.
    • (1983) J Clin Microbiol , vol.18 , pp. 327-330
    • Freilij, H.1    Muller, L.2    Gonzalez-Cappa, E.M.3
  • 54
    • 15044361524 scopus 로고    scopus 로고
    • Real time PCR strategy for the identification of major lineages of Trypanosoma cruzi directly in chronically infected human tissues
    • Freitas JM, Lages-Silva E, Crema E, Pena SD, Macedo AM 2005. Real time PCR strategy for the identification of major lineages of Trypanosoma cruzi directly in chronically infected human tissues. Int J Parasitol 35: 411-417.
    • (2005) Int J Parasitol , vol.35 , pp. 411-417
    • Freitas, J.M.1    Lages-Silva, E.2    Crema, E.3    Pena, S.D.4    Macedo, A.M.5
  • 55
    • 0025108051 scopus 로고
    • Therapeutic efficacy of allopurinol in patients with chronic Chagas disease
    • Galleano RH, Marr JJ, Sosa RR 1990. Therapeutic efficacy of allopurinol in patients with chronic Chagas disease. Am J Trop Med Hyg 43: 159-166.
    • (1990) Am J Trop Med Hyg , vol.43 , pp. 159-166
    • Galleano, R.H.1    Marr, J.J.2    Sosa, R.R.3
  • 57
    • 0027299618 scopus 로고
    • Lytic antibody titre as a means of assessing cure after treatment of Chagas disease: A 10 years follow-up study
    • Galvão LMC, Nines RMB, Cançado JR, Brener Z, Krettli AU 1993. Lytic antibody titre as a means of assessing cure after treatment of Chagas disease: a 10 years follow-up study. Trans R Soc Trop Med Hyg 87: 220-223.
    • (1993) Trans R Soc Trop Med Hyg , vol.87 , pp. 220-223
    • Galvão, L.M.C.1    Nines, R.M.B.2    Cançado, J.R.3    Brener, Z.4    Krettli, A.U.5
  • 58
    • 27944483595 scopus 로고    scopus 로고
    • Trypanosoma cruzi-induced molecular mimicry and Chagas disease
    • Girones N, Cuervo H, Fresno M 2005. Trypanosoma cruzi-induced molecular mimicry and Chagas disease. Curr Trop Microbiol Immunol 296: 89-123.
    • (2005) Curr Trop Microbiol Immunol , vol.296 , pp. 89-123
    • Girones, N.1    Cuervo, H.2    Fresno, M.3
  • 59
    • 0032972844 scopus 로고    scopus 로고
    • Chagas disease diagnosis: Comparative analysis of parasitologic, molecular and serologic methods
    • Gomes ML, Galvão LM, Macedo AM, Pena SD, Chiari E 1999. Chagas disease diagnosis: comparative analysis of parasitologic, molecular and serologic methods. Am J Trop Med Hyg 60: 205-210.
    • (1999) Am J Trop Med Hyg , vol.60 , pp. 205-210
    • Gomes, M.L.1    Galvão, L.M.2    Macedo, A.M.3    Pena, S.D.4    Chiari, E.5
  • 60
    • 0031902238 scopus 로고    scopus 로고
    • Trypanosoma cruzi: Optimization of polymerase chain reaction for detection in human blood
    • Gomes ML, Macedo AM, Vago AR, Pena SD, Galvão LM, Chiari E 1998. Trypanosoma cruzi: optimization of polymerase chain reaction for detection in human blood. Exp Parasitol 88: 28-33.
    • (1998) Exp Parasitol , vol.88 , pp. 28-33
    • Gomes, M.L.1    Macedo, A.M.2    Vago, A.R.3    Pena, S.D.4    Galvão, L.M.5    Chiari, E.6
  • 62
    • 0035414219 scopus 로고    scopus 로고
    • Epidemiology of Chagas disease in Mexico: An update
    • Guzmán-Brancho C 2001. Epidemiology of Chagas disease in Mexico: an update. Trends Parasitol 17: 372-377.
    • (2001) Trends Parasitol , vol.17 , pp. 372-377
    • Guzmán-Brancho, C.1
  • 63
    • 0000496002 scopus 로고
    • Correlation between Trypanosoma cruzi parasitism and myocardial inflammation in human chronic chagasic myocardits. Light microscopy and immunohistochemical findings
    • Higuchi ML, Brito T, Reis M, Bellotti G, Pereira-Barreto AC, Pileggi F 1993. Correlation between Trypanosoma cruzi parasitism and myocardial inflammation in human chronic chagasic myocardits. Light microscopy and immunohistochemical findings. Cardiovasc Pathol 2: 101-106.
    • (1993) Cardiovasc Pathol , vol.2 , pp. 101-106
    • Higuchi, M.L.1    Brito, T.2    Reis, M.3    Bellotti, G.4    Pereira-Barreto, A.C.5    Pileggi, F.6
  • 64
    • 17044411262 scopus 로고    scopus 로고
    • T-cell molecular mimicry in Chagas disease: Identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain
    • Iwai LK, Juliano MA, Juliano L, Kalil J, Cunha-Neto E 2005. T-cell molecular mimicry in Chagas disease: identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain. J Autoimmun 24: 111-117.
    • (2005) J Autoimmun , vol.24 , pp. 111-117
    • Iwai, L.K.1    Juliano, M.A.2    Juliano, L.3    Kalil, J.4    Cunha-Neto, E.5
  • 65
    • 0027447284 scopus 로고
    • Amplification of Trypanosoma cruzi DNA sequence from inflammatory lesions in human chagasic cardiomyopathy
    • Jones EM, Colley DG, Tostes S, Lopes ER, Venencak-Jones C, Mc Curley TL 1993. Amplification of Trypanosoma cruzi DNA sequence from inflammatory lesions in human chagasic cardiomyopathy. Am J Trop Med Hyg 48: 348-357.
    • (1993) Am J Trop Med Hyg , vol.48 , pp. 348-357
    • Jones, E.M.1    Colley, D.G.2    Tostes, S.3    Lopes, E.R.4    Venencak-Jones, C.5    Curley, T.L.6
  • 66
    • 0029874959 scopus 로고    scopus 로고
    • Comparison of the polymerase chain reaction with two classical parasitological methods for the diagnosis of Chagas disease in endemic region of North-Eastern Brazil
    • Junqueira ACV, Chiari E, Wincker P 1996. Comparison of the polymerase chain reaction with two classical parasitological methods for the diagnosis of Chagas disease in endemic region of North-Eastern Brazil. Trans R Soc Trop Med Hyg 90: 129-132.
    • (1996) Trans R Soc Trop Med Hyg , vol.90 , pp. 129-132
    • Junqueira, A.C.V.1    Chiari, E.2    Wincker, P.3
  • 67
    • 0030271981 scopus 로고    scopus 로고
    • Autoimmunity in Chagas disease cardiomyopathy: Fulfilling the criteria at last?
    • Kalil J, Cunha-Neto E 1996. Autoimmunity in Chagas disease cardiomyopathy: fulfilling the criteria at last? Parasitol Today 12: 396-399.
    • (1996) Parasitol Today , vol.12 , pp. 396-399
    • Kalil, J.1    Cunha-Neto, E.2
  • 68
    • 0032890779 scopus 로고    scopus 로고
    • Chagas' disease and the autoimmunity hypothesis
    • Kierszenbaum F 1999. Chagas' disease and the autoimmunity hypothesis. Clin Microbiol Rev 12: 210-223.
    • (1999) Clin Microbiol Rev , vol.12 , pp. 210-223
    • Kierszenbaum, F.1
  • 69
    • 0019972544 scopus 로고
    • Resistance against Trypanosoma cruzi associate to anti-living trypomastigote antibodies
    • Krettli AU, Brener Z 1982. Resistance against Trypanosoma cruzi associate to anti-living trypomastigote antibodies. J Immunol 128: 2009-2012.
    • (1982) J Immunol , vol.128 , pp. 2009-2012
    • Krettli, A.U.1    Brener, Z.2
  • 70
    • 0019938534 scopus 로고
    • Effect of specific chemotherapy on the levels of lytic antibodies in Chagas' disease
    • Krettli AU, Cançado JR, Brener Z 1982. Effect of specific chemotherapy on the levels of lytic antibodies in Chagas' disease. Trans R Soc Trop Med Hyg 76: 334-340.
    • (1982) Trans R Soc Trop Med Hyg , vol.76 , pp. 334-340
    • Krettli, A.U.1    Cançado, J.R.2    Brener, Z.3
  • 71
    • 0000207802 scopus 로고
    • Criterion of cure of human Chagas disease after specific chemotherapy: Recent advances
    • Krettli AU, Cançado R, Brener Z 1984. Criterion of cure of human Chagas disease after specific chemotherapy: recent advances. Mem Inst Oswaldo Cruz 79: 157-164.
    • (1984) Mem Inst Oswaldo Cruz , vol.79 , pp. 157-164
    • Krettli, A.U.1    Cançado, R.2    Brener, Z.3
  • 72
    • 0036133704 scopus 로고    scopus 로고
    • Chagasic meningoencephalitis in a patient with acquired immunodeficiency syndrome: Diagnosis, follow-up and genetic characterization of Trypanosoma cruzi
    • Lages-Silva E, Ramirez LE, Silva-Vergara ML, Chiari E 2002. Chagasic meningoencephalitis in a patient with acquired immunodeficiency syndrome: diagnosis, follow-up and genetic characterization of Trypanosoma cruzi. Clin Infect Dis 34: 118-123.
    • (2002) Clin Infect Dis , vol.34 , pp. 118-123
    • Lages-Silva, E.1    Ramirez, L.E.2    Silva-Vergara, M.L.3    Chiari, E.4
  • 73
    • 0030742008 scopus 로고    scopus 로고
    • Detection of Trypanosoma cruzi with the polymerase chain reaction and in situ hybridization in infected murine cardiac tissue
    • Lane JE, Olivares-Villagomez D, Vnencak-Jones CL, McCurley TL, Carter CE 1997. Detection of Trypanosoma cruzi with the polymerase chain reaction and in situ hybridization in infected murine cardiac tissue. Am J Trop Med Hyg 56: 588-595.
    • (1997) Am J Trop Med Hyg , vol.56 , pp. 588-595
    • Lane, J.E.1    Olivares-Villagomez, D.2    Vnencak-Jones, C.L.3    Curley, T.L.4    Carter, C.E.5
  • 76
    • 0001697870 scopus 로고    scopus 로고
    • In chronic Chagas heart disease, don't forget the parasite
    • Levin MJ 1996. In chronic Chagas heart disease, don't forget the parasite. Parasitol Today 12: 415-416.
    • (1996) Parasitol Today , vol.12 , pp. 415-416
    • Levin, M.J.1
  • 77
    • 0030988004 scopus 로고    scopus 로고
    • The National Health Foundation of Brazil, etiological treatment for Chagas disease
    • Luquetti A 1997. The National Health Foundation of Brazil, etiological treatment for Chagas disease. Parasitol Today 13: 127-128.
    • (1997) Parasitol Today , vol.13 , pp. 127-128
    • Luquetti, A.1
  • 78
    • 0033984242 scopus 로고    scopus 로고
    • Cardiac autonomic denervation in congestive heart failure: Comparison of Chagas' heart disease with other dilated cardiomyopathy
    • Machado CR, Camargos ER, Guerra LB, Moreira MC 2000. Cardiac autonomic denervation in congestive heart failure: comparison of Chagas' heart disease with other dilated cardiomyopathy. Hum Pathol 31: 3-10.
    • (2000) Hum Pathol , vol.31 , pp. 3-10
    • Machado, C.R.1    Camargos, E.R.2    Guerra, L.B.3    Moreira, M.C.4
  • 80
    • 0033256629 scopus 로고    scopus 로고
    • Risk of death due to chronic chagasic cardiopathy
    • Manzullo EC, Chuit R 1999. Risk of death due to chronic chagasic cardiopathy. Mem Inst Oswaldo Cruz 94 (Suppl. I): 317-320.
    • (1999) Mem Inst Oswaldo Cruz , vol.94 , Issue.I , pp. 317-320
    • Manzullo, E.C.1    Chuit, R.2
  • 82
    • 45549100534 scopus 로고    scopus 로고
    • Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: The BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT)
    • BENEFIT Investigators
    • Marin-Neto JA, Rassi A Jr, Morillo CA, Avezum A, Connolly SJ, Sosa-Estani S, Rosas F, Yusuf S, BENEFIT Investigators 2008. Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT). Am Heart J 156: 37-43.
    • (2008) Am Heart J , vol.156 , pp. 37-43
    • Marin-Neto, J.A.1    Rassi Jr, A.2    Morillo, C.A.3    Avezum, A.4    Connolly, S.J.5    Sosa-Estani, S.6    Rosas, F.7    Yusuf, S.8
  • 85
    • 0029863641 scopus 로고    scopus 로고
    • Acute Chagas disease: Plasma levels of alpha-2-macroglobulin and C-reactive protein in children under 13 years in a high endemic area of Bolivia
    • Medrano NM, Luz MRMP, Cabello P, Tapia GT, Van Leuven F, Araújo-Jorge TC 1996. Acute Chagas disease: plasma levels of alpha-2-macroglobulin and C-reactive protein in children under 13 years in a high endemic area of Bolivia. J Trop Pediatr 42: 68-74.
    • (1996) J Trop Pediatr , vol.42 , pp. 68-74
    • Medrano, N.M.1    Luz, M.R.M.P.2    Cabello, P.3    Tapia, G.T.4    van Leuven, F.5    Araújo-Jorge, T.C.6
  • 86
    • 32544458510 scopus 로고    scopus 로고
    • Early diagnosis of congenital Trypanosoma cruzi infection using PCR, hemoculture and capillary concentration as compared with delayed serology
    • Mora MC, Sánchez Negrette O, Marco D, Barrio A, Ciaccio M, Segura MA, Basombrio MA 2005. Early diagnosis of congenital Trypanosoma cruzi infection using PCR, hemoculture and capillary concentration as compared with delayed serology. J Parasitol 91: 1468-1473.
    • (2005) J Parasitol , vol.91 , pp. 1468-1473
    • Mora, M.C.1    Negrette, O.S.2    Marco, D.3    Barrio, A.4    Ciaccio, M.5    Segura, M.A.6    Basombrio, M.A.7
  • 87
    • 0024315776 scopus 로고
    • Detection of Trypanosoma cruzi by DNA amplification using the polymerase chain reaction
    • Moser DR, Kirchoff LV, Donelson JE 1989. Detection of Trypanosoma cruzi by DNA amplification using the polymerase chain reaction. J Clin Microbiol 27: 1477-1482.
    • (1989) J Clin Microbiol , vol.27 , pp. 1477-1482
    • Moser, D.R.1    Kirchoff, L.V.2    Donelson, J.E.3
  • 89
    • 33746767655 scopus 로고    scopus 로고
    • Consenso Brasileiro em Doença de Chagas
    • MS - Ministério da Saúde
    • MS - Ministério da Saúde 2005. Consenso Brasileiro em Doença de Chagas. Rev Soc Bras Med Trop 38 (Suppl. III): 1-29.
    • (2005) Rev Soc Bras Med Trop , vol.38 , Issue.III , pp. 1-29
  • 92
    • 11244321119 scopus 로고    scopus 로고
    • Tratamiento Etiológico de la Enfermedad de Chagas. Conclusiones de una consulta técnica
    • OPAS/OMS
    • OPAS/OMS 1998. Tratamiento Etiológico de la Enfermedad de Chagas. Conclusiones de una consulta técnica. Rev Patol Trop 28: 247-279, 1999.
    • (1998) Rev Patol Trop , vol.28 , pp. 247-279
  • 93
    • 0027518417 scopus 로고
    • Quantitative competitive polymerase chain reaction for accurate quantitation of HIV DNA and RNA species
    • Piatak M Jr, Luk KC, Williams B, Lifson JD 1993. Quantitative competitive polymerase chain reaction for accurate quantitation of HIV DNA and RNA species. Biotechniques 14: 70-81.
    • (1993) Biotechniques , vol.14 , pp. 70-81
    • Piatak Jr, M.1    Luk, K.C.2    Williams, B.3    Lifson, J.D.4
  • 95
    • 0036525519 scopus 로고    scopus 로고
    • Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens
    • Pontes-de-Carvalho L, Santana CC, Soares MB, Oliveira GG, Cunha-Neto E, Ribeiro-dos-Santos R 2002. Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens. J Autoimmun 18: 131-138.
    • (2002) J Autoimmun , vol.18 , pp. 131-138
    • Pontes-de-Carvalho, L.1    Santana, C.C.2    Soares, M.B.3    Oliveira, G.G.4    Cunha-Neto, E.5    Ribeiro-dos-Santos, R.6
  • 97
    • 0242454037 scopus 로고    scopus 로고
    • Specific treatment for Trypanosoma cruzi infection (Chagas disease)
    • In KM Tyler, Miles MA, Kluwer Academic Publishers, Boston
    • Rassi A, Luquetti AO 2003. Specific treatment for Trypanosoma cruzi infection (Chagas disease). In KM Tyler, Miles MA, American trypanosomiasis, Kluwer Academic Publishers, Boston, p. 117-125.
    • (2003) American trypanosomiasis , pp. 117-125
    • Rassi, A.1    Luquetti, A.O.2
  • 102
    • 29144536153 scopus 로고    scopus 로고
    • Monitoring the efficacy of specific treatment in chronic Chagas disease by polymerase chain reaction and flow cytometry analysis
    • Sánchez G, Coronado X, Zulantay I, Apt W, Gajardo M, Solari S, Venegas J 2005. Monitoring the efficacy of specific treatment in chronic Chagas disease by polymerase chain reaction and flow cytometry analysis. Parasite 12: 353-357.
    • (2005) Parasite , vol.12 , pp. 353-357
    • Sánchez, G.1    Coronado, X.2    Zulantay, I.3    Apt, W.4    Gajardo, M.5    Solari, S.6    Venegas, J.7
  • 104
    • 0033764508 scopus 로고    scopus 로고
    • Early diagnosis of recurrence of Trypanosoma cruzi infection by polymerase chain reaction after heart transplantation of a chronic Chagas' heart disease patient
    • Schijman AG, Vigliano C, Burgos J, Favaloro R, Perrone S, Laguens R, Levin MJ 2000. Early diagnosis of recurrence of Trypanosoma cruzi infection by polymerase chain reaction after heart transplantation of a chronic Chagas' heart disease patient. J Heart Lung Transplant 19: 1114-1117.
    • (2000) J Heart Lung Transplant , vol.19 , pp. 1114-1117
    • Schijman, A.G.1    Vigliano, C.2    Burgos, J.3    Favaloro, R.4    Perrone, S.5    Laguens, R.6    Levin, M.J.7
  • 105
    • 0032463396 scopus 로고    scopus 로고
    • The Southern Cone Initiative against Chagas disease
    • Schofield CJ, Dias JCP 1999. The Southern Cone Initiative against Chagas disease. Adv Parasitol 42: 1-27.
    • (1999) Adv Parasitol , vol.42 , pp. 1-27
    • Schofield, C.J.1    Dias, J.C.P.2
  • 106
    • 0025215476 scopus 로고
    • Intensification of acute Trypanosoma cruzi myocarditis in BALB/c mice pretreated with low doses of cyclophosphamide or gamma irradiation
    • Silva JS, Rossi MA 1990. Intensification of acute Trypanosoma cruzi myocarditis in BALB/c mice pretreated with low doses of cyclophosphamide or gamma irradiation. J Exp Pathol 71: 33-39.
    • (1990) J Exp Pathol , vol.71 , pp. 33-39
    • Silva, J.S.1    Rossi, M.A.2
  • 108
    • 0033252802 scopus 로고    scopus 로고
    • Treatment of Trypanosoma cruzi infection in the undetermined phase. Experience and current guidelines of treatment in Argentina
    • Sosa-Estani S, Segura EL 1999. Treatment of Trypanosoma cruzi infection in the undetermined phase. Experience and current guidelines of treatment in Argentina. Mem Inst Oswaldo Cruz 94 (Suppl. I): 363-365.
    • (1999) Mem Inst Oswaldo Cruz , vol.94 , Issue.I , pp. 363-365
    • Sosa-Estani, S.1    Segura, E.L.2
  • 109
    • 33750503607 scopus 로고    scopus 로고
    • Etiological treatment in patients infected by Trypanosoma cruzi: Experiences in Argentina
    • Sosa-Estani S, Segura EL 2006. Etiological treatment in patients infected by Trypanosoma cruzi: experiences in Argentina. Curr Opin Infect Dis 19: 583-587.
    • (2006) Curr Opin Infect Dis , vol.19 , pp. 583-587
    • Sosa-Estani, S.1    Segura, E.L.2
  • 111
    • 0024511436 scopus 로고
    • Sensitive detection by amplification of kinetoplast minicircle DNA sequences: Use in diagnosis of Chagas disease
    • Sturm NR, Degrave W, Morel CM, Simpson L 1989. Sensitive detection by amplification of kinetoplast minicircle DNA sequences: use in diagnosis of Chagas disease. Mol Biochem Parasitol 33: 205-214.
    • (1989) Mol Biochem Parasitol , vol.33 , pp. 205-214
    • Sturm, N.R.1    Degrave, W.2    Morel, C.M.3    Simpson, L.4
  • 112
    • 0035340666 scopus 로고    scopus 로고
    • Parasite persistence in the aetiology of Chagas disease
    • Tarleton RL 2001. Parasite persistence in the aetiology of Chagas disease. Int J Parasitol 31: 550-554.
    • (2001) Int J Parasitol , vol.31 , pp. 550-554
    • Tarleton, R.L.1
  • 114
    • 0033102525 scopus 로고    scopus 로고
    • Chagas' disease etiology: Autoimmunity or parasite persistence?
    • Tarleton RL, Zhang L 1999. Chagas' disease etiology: autoimmunity or parasite persistence? Parasitol Today 15: 94-99.
    • (1999) Parasitol Today , vol.15 , pp. 94-99
    • Tarleton, R.L.1    Zhang, L.2
  • 115
    • 0342636508 scopus 로고
    • Natural populations of Trypanosoma cruzi, the agent of Chagas disease, have a complex multiclonal structure
    • Tibayrenc M, Ward P, Moya A, Ayala FJ 1986. Natural populations of Trypanosoma cruzi, the agent of Chagas disease, have a complex multiclonal structure. Proc Natl Acad Sci USA 83: 115-119.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 115-119
    • Tibayrenc, M.1    Ward, P.2    Moya, A.3    Ayala, F.J.4
  • 118
    • 0035211508 scopus 로고    scopus 로고
    • Specific treatment of Chagas disease: Current status and new developments
    • Urbina JA 2001. Specific treatment of Chagas disease: current status and new developments. Curr Opin in Infect Dis 14: 733-741.
    • (2001) Curr Opin in Infect Dis , vol.14 , pp. 733-741
    • Urbina, J.A.1
  • 119
    • 0142227145 scopus 로고    scopus 로고
    • Specific chemotherapy of Chagas disease: Controversies and advances
    • Urbina JA, Docampo R 2003. Specific chemotherapy of Chagas disease: controversies and advances. Trends Parasitol 19: 495-501.
    • (2003) Trends Parasitol , vol.19 , pp. 495-501
    • Urbina, J.A.1    Docampo, R.2
  • 120
    • 0029742234 scopus 로고    scopus 로고
    • PCR detection of Trypanosoma cruzi DNA in oesophageal tissues of patients with chronic digestive Chagas' disease
    • Vago AR, Macedo AM, Adad SJ, Reis DD, Corrêa-Oliveira R 1996. PCR detection of Trypanosoma cruzi DNA in oesophageal tissues of patients with chronic digestive Chagas' disease. Lancet 348: 891-892.
    • (1996) Lancet , vol.348 , pp. 891-892
    • Vago, A.R.1    Macedo, A.M.2    Adad, S.J.3    Reis, D.D.4    Corrêa-Oliveira, R.5
  • 121
    • 36348953310 scopus 로고    scopus 로고
    • Access to diagnosis and treatment of Chagas disease/infection in endemic and non-endemic countries in the XXI century
    • Villa L, Morote S, Bernal O, Bulla D, Albajar-Vinas P 2007. Access to diagnosis and treatment of Chagas disease/infection in endemic and non-endemic countries in the XXI century. Mem Inst Oswaldo Cruz 102 (Suppl. I): 87-93.
    • (2007) Mem Inst Oswaldo Cruz , vol.102 , Issue.I , pp. 87-93
    • Villa, L.1    Morote, S.2    Bernal, O.3    Bulla, D.4    Albajar-Vinas, P.5
  • 122
    • 0027955005 scopus 로고
    • Treatment of chronic Chagas disease with benznidazole: Clinical and serologic evolution of patients with long-term follow-up
    • Viotti R, Vigliano C, Armenti H, Segura E 1994. Treatment of chronic Chagas disease with benznidazole: clinical and serologic evolution of patients with long-term follow-up. Am Heart J 127: 151-162.
    • (1994) Am Heart J , vol.127 , pp. 151-162
    • Viotti, R.1    Vigliano, C.2    Armenti, H.3    Segura, E.4
  • 123
    • 33646847271 scopus 로고    scopus 로고
    • Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: A nonrandomized trial
    • Viotti R, Vigliano C, Lococo B, Bertocchi G, Petti M, Alvarez MG, Postan M, Armenti A 2006. Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial. Ann Intern Med 144: 724-734.
    • (2006) Ann Intern Med , vol.144 , pp. 724-734
    • Viotti, R.1    Vigliano, C.2    Lococo, B.3    Bertocchi, G.4    Petti, M.5    Alvarez, M.G.6    Postan, M.7    Armenti, A.8
  • 125
    • 0038131757 scopus 로고    scopus 로고
    • Comparison of polymerase chain reaction methods for reliable and easy detection of congenital Trypanosoma cruzi infection
    • Virreira M, Torrico F, Truyens C, Alonso-Vega C, Solano M, Carlier Y, Svoboda M 2003. Comparison of polymerase chain reaction methods for reliable and easy detection of congenital Trypanosoma cruzi infection. Am J Trop Med Hyg 68: 574-582.
    • (2003) Am J Trop Med Hyg , vol.68 , pp. 574-582
    • Virreira, M.1    Torrico, F.2    Truyens, C.3    Alonso-Vega, C.4    Solano, M.5    Carlier, Y.6    Svoboda, M.7
  • 128
    • 0026000473 scopus 로고
    • Control of Chagas disease
    • WHO - World Health Organization
    • WHO - World Health Organization 1991. Control of Chagas disease. WHO Techn Rep Sers 811: 2-11.
    • (1991) WHO Techn Rep Sers , vol.811 , pp. 2-11
  • 129
    • 0346971251 scopus 로고    scopus 로고
    • WHO - World Health Organization, Seventeenth Programme Report UNDP/TDR, Geneva
    • WHO - World Health Organization 2005. Chagas disease. Seventeenth Programme Report UNDP/TDR, Geneva.
    • (2005) Chagas disease
  • 130
    • 0028173009 scopus 로고
    • High correlation between Chagas' disease serology and PCR-based detection of Trypanosoma cruzi kinetoplast DNA in Bolivian children living in an endemic area
    • Winker P, Bosseno MF, Britto C, Yaksic N, Cardoso MA, Morel CM, Brenière SF 1994a. High correlation between Chagas' disease serology and PCR-based detection of Trypanosoma cruzi kinetoplast DNA in Bolivian children living in an endemic area. FEMS Microbiol Lett 124: 419-423.
    • (1994) FEMS Microbiol Lett , vol.124 , pp. 419-423
    • Winker, P.1    Bosseno, M.F.2    Britto, C.3    Yaksic, N.4    Cardoso, M.A.5    Morel, C.M.6    Brenière, S.F.7
  • 131
    • 0028582022 scopus 로고
    • Use of simplified polymerase chain reaction procedure to detect Trypanosoma cruzi in blood samples from chronic chagasic patients in a rural endemic area
    • Winker P, Britto C, Borges Pereira J, Cardoso MA, Oelemann W, Morel CM 1994b. Use of simplified polymerase chain reaction procedure to detect Trypanosoma cruzi in blood samples from chronic chagasic patients in a rural endemic area. Am J Trop Med Hyg 51: 771-777.
    • (1994) Am J Trop Med Hyg , vol.51 , pp. 771-777
    • Winker, P.1    Britto, C.2    Pereira, J.B.3    Cardoso, M.A.4    Oelemann, W.5    Morel, C.M.6
  • 134
    • 1942424753 scopus 로고    scopus 로고
    • Use of polymerase chain reaction (PCR) and hybridization assays to detect Trypanosoma cruzi in chronic chagasic patients treated with itraconazole or allopurinol
    • Zulantay I, Honores P, Solari A, Apt W, Ortiz S, Osuna A, Rojas A, López B, Sánchez G 2004. Use of polymerase chain reaction (PCR) and hybridization assays to detect Trypanosoma cruzi in chronic chagasic patients treated with itraconazole or allopurinol. Diag Microbiol Infect Dis 48: 253-257.
    • (2004) Diag Microbiol Infect Dis , vol.48 , pp. 253-257
    • Zulantay, I.1    Honores, P.2    Solari, A.3    Apt, W.4    Ortiz, S.5    Osuna, A.6    Rojas, A.7    López, B.8    Sánchez, G.9


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