Partial rescue of growth failure in Growth Hormone (GH)-deficient mice by a single injection of a double-stranded adeno-associated viral vector expressing the GH gene driven by a muscle-specific regulatory cassette

Human Gene Therapy

Volumn 20, Issue 7, 2009, Pages 759-766

  Martari, Marco ^a   Sagazio, Alessia ^a,b   Mohamadi, Ali ^a   Nguyen, Quynh ^c   Hauschka, Stephen D ^c   Kim, Eun ^d   Salvatori, Roberto ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; CREATINE KINASE MM; GREEN FLUORESCENT PROTEIN; GROWTH HORMONE; PARVOVIRUS VECTOR; PLACEBO;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY HEIGHT; BODY WEIGHT; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG EFFICACY; DRUG MEGADOSE; FLUORESCENCE ANALYSIS; GENE DELIVERY SYSTEM; GENE EXPRESSION; GROWTH DISORDER; GROWTH HORMONE DEFICIENCY; INTRAABDOMINAL FAT; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; TRANSGENE; VIRUS;

ANIMALS; BODY COMPOSITION; BODY WEIGHT; DEPENDOVIRUS; FEMUR; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC VECTORS; GROWTH DISORDERS; GROWTH HORMONE; INJECTIONS, SUBCUTANEOUS; INSULIN-LIKE GROWTH FACTOR I; MICE; MICROSCOPY, FLUORESCENCE; MUSCLES; ORGAN SPECIFICITY; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; TIBIA;

ANIMALIA; MUS;

EID: 68949200880     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2008.197     Document Type: Article

References (31)

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