Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (ΔiglB) induces protective immunity against homotypic and heterotypic challenge

Vaccine

Volumn 27, Issue 41, 2009, Pages 5554-5561

  Cong, Yu ^a   Yu, Jieh Juen ^a   Guentzel, M Neal ^a   Berton, Michael T ^b   Seshu, Janakiram ^a   Klose, Karl E ^a   Arulanandam, Bernard P ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Defined attenuated vaccines; Francisella tularensis; Mouse model; Oral vaccination; Pulmonary tularemia; Respiratory immunity

Indexed keywords

ANTIBODY; BACTERIAL VACCINE; GAMMA INTERFERON; KKF235 VACCINE; LIVE VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FRANCISELLA TULARENSIS; IMMUNITY; IMMUNIZATION; LD 50; MACROPHAGE; MOUSE; MUTANT; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; TULAREMIA; VACCINATION; VIRUS REPLICATION; WILD TYPE;

ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL VACCINES; CELL LINE; COLONY COUNT, MICROBIAL; FEMALE; FRANCISELLA TULARENSIS; GENE DELETION; GENES, BACTERIAL; GENOMIC ISLANDS; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROBIAL VIABILITY; SPLEEN; SURVIVAL ANALYSIS; TULAREMIA; VACCINES, ATTENUATED;

EID: 68949170679     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.07.034     Document Type: Article

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