Urocortin induces positive inotropic effect in rat heart

Cardiovascular Research

Volumn 83, Issue 4, 2009, Pages 717-725

  Calderón Sanchez, Eva ^a   Delgado, Carmen ^b   Ruiz Hurtado, Gema ^c   Domínguez Rodríguez, Alejandro ^a   Cachofeiro, Victoria ^b   Rodríguez Moyano, María ^a   Gomez, Ana María ^c   Ordóñez, Antonio ^a   Smani, Tarik ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c UNIV MONTPELLIER   (France)

Author keywords

Ca2+; Epac; ERK1 2; Inotropic; PKC; Urocortin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ASTRESSIN; BREFELDIN A; CALCIUM ION; CHELERYTHRINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; UROCORTIN;

ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HEART CELL CULTURE; HEART MUSCLE CONTRACTILITY; INOTROPISM; ISOLATED HEART; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT;

ANIMALS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELECTROPHYSIOLOGICAL PHENOMENA; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MALE; MAP KINASE SIGNALING SYSTEM; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR; SARCOPLASMIC RETICULUM; STIMULATION, CHEMICAL; UROCORTINS;

EID: 68949150965     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp161     Document Type: Article

References (42)

1. Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S et al. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 1995;378:287-292.
2. Boorse GC, Denver RJ. Widespread tissue distribution and diverse functions of corticotropin-releasing factor and related peptides. Gen Comp Endocrinol 2006;146:9-18.
3. Shi M, Yan X, Ryan DH, Harris RB. Identification of urocortin mRNA anti-sense transcripts in rat tissue. Brain Res Bull 2000;53:317- 324.
4. Vale W, Spiess J, Rivier C, Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 1981;213:1394-1397.
5. Koob GF, Heinrichs SC. A role for corticotropin releasing factor and urocortin in behavioral responses to stressors. Brain Res 1999;848:141-152.
6. Rademaker MT, Charles CJ, Espiner EA, Fisher S, Frampton CM, Kirkpatrick CM et al. Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: comparison with normal sheep. J Am Coll Cardiol 2002;40:1495-1505.
7. Rademaker MT, Cameron AC, Charles CJ, Richards AM. Integrated hemodynamic, hormonal and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure. Circulation 2005;112:3624-3632.
8. Bale TL, Hoshijima M, Gu Y, Dalton N, Anderson KR, Lee KF et al. The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. Proc Natl Acad Sci USA 2004;101:3697-3702.
9. Parkes DG, Weisinger RS, May CN. Cardiovascular actions of CRH and urocortin: an update. Peptides 2001;22:821-827.
10. Brar BK, Stephanou A, Okosi A, Lawrence KM, Knight RA, Marber MS et al. CRH-like peptides protect cardiac myocytes from lethal ischaemic injury. Mol Cell Endocrinol 1999;158:55-63.
11. Brar BK, Jonassen AK, Stephanou A, Santilli G, Railson J, Knight RA et al. Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway. J Biol Chem 2000;275:8508-8514.
12. Bers DM. Cardiac excitation-contraction coupling. Nature 2002;415:198-205.
13. Fabiato A. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol Cell Physiol 1983;245:C1-C14.
14. Tao J, Xu H, Yang C, Liu CN, Li S. Effect of urocortin on L-type calcium currents in adult rat ventricular myocytes. Pharmacol Res 2004;50:471-476.
15. Yang LZ, Kockskämper J, Heinzel FR, Hauber M, Walther S, Spiess J et al. Urocortin II enhances contractility in rabbit ventricular myocytes via CRF(2) receptor-mediated stimulation of protein kinase A. Cardiovasc Res 2006;69:402-411.
16. Reyes TM, Lewis K, Perrin MH, Kunitake KS, Vaughan J, Arias CA et al. Urocortin II: a member of the corticotropin-releasing factor (CRF) neuro-peptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci USA 2001;98:2843-2848.
17. Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci USA 2001;98:7570-7575.
18. Wiley KE, Davenport AP. CRF2 receptors are highly expressed in the human cardiovascular system and their cognate ligands urocortins 2 and 3 are potent vasodilators. Br J Pharmacol 2004;143:508-514.
19. Smani T, Domínguez-Rodríguez A, Hmadcha A, Calderón-Sánchez E, Horrillo-Ledesma A, Ordóñez A. Role of Ca2+-independent phospholipase A2 and store-operated pathway in urocortin-induced vasodilatation of rat coronary artery. Circ Res 2007;101:1194-1203.
20. de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A et al. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 1998;396:474-477.
21. Fukuhara S, Sakurai A, Sano H, Yamagishi A, Somekawa S, Takakura N et al. Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol 2005;25:136-146.
22. Morel E, Marcantoni A, Gastineau M, Birkedal R, Rochais F, Garnier A et al. cAMP-binding protein Epac induces cardiomyocyte hypertrophy. Circ Res 2005;97:1296-1304.
23. Pereira L, Métrich M, Fernández-Velasco M, Lucas A, Leroy J, Perrier R et al. The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes. J Physiol 2007;583:685-694.
24. Lawrence KM, Kabir AM, Bellahcene M, Davidson S, Cao XB, McCormick J et al. Cardioprotection mediated by urocortin is dependent on PKCepsilon activation. FASEB J 2005;19:831-833.
25. Calderón-Sanchez E, Domínguez-Rodríguez A, Rodríguez-Moyano M, Ordóñez A, Smani T. Urocortin induces heart protection against ischemia-reperfusion injury. In XXVIII European Section Meeting of the International Society for Heart Research, Bologna, Italy, Medimond S.r.l, 2008, Vol. K528C0126, 15-20.
26. Fernández-Velasco M, Rueda A, Rizzi N, Benitah JP, Colombi B, Napolitano C et al. Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia. Circ Res 2009;104:201-209.
27. 2+ channels in ventricular cells from hypertrophied rat hearts. J Mol Cell Cardiol 1999;31:1617-1625.
28. Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res 2002;91:434-440.
29. Rivier J, Gulyas J, Kirby D, Low W, Perrin MH, Kunitake K et al. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem 2002;45:4737-4747.
30. Huang CC, Hsu KS. Presynaptic mechanism underlying cAMP-induced synaptic potentiation in medial prefrontal cortex pyramidal neurons. Mol Pharmacol 2006;69:846-856.
31. Zhong N, Zucker RS. cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction. J Neurosci 2005;25:208-214.
32. Vinogradova TM, Lyashkov AE, Zhu W, Ruknudin AM, Sirenko S, Yang D et al. High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res 2006;98:505-514.
33. Chardin P, McCormick F. Brefeldin A: the advantage of being uncompetitive. Cell 1999;97:153-155.
34. Smrcka AV, Oestreich EA, Blaxall BC, Dirksen RT. EPAC regulation of cardiac EC coupling. J Physiol 2007;584:1029-1031.
35. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 1995;9:484-496.
36. Gordon JM, Dusting GJ, Woodman OL, Ritchie RH. Cardioprotective action of CRF peptide urocortin against simulated ischemia in adult rat cardiomyocytes. Am J Physiol Heart Circ Physiol 2003;284:H330-H336.
37. Chiloeches A, Paterson HF, Marais R, Clerk A, Marshall CJ, Sugden PH. Regulation of Ras. GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras. J Biol Chem 1999;274:19762-19770.
38. Mohammadi K, Kometiani P, Xie Z, Askari A. Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. J Biol Chem 2001;276:42050-42056.
39. Takahashi E, Fukuda K, Miyoshi S, Murata M, Kato T, Ita M et al. Leukemia inhibitory factor activates cardiac L-type Ca2+ channels via phosphorylation of serine 1829 in the rabbit Cav1.2 subunit. Circ Res 2004;94:1242-1248.
40. Szokodi I, Kerkelä R, Kubin AM, Sármán B, Pikkarainen S, Kónyi A et al. Functionally opposing roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the regulation of cardiac contractility. Circulation 2008;118:1651- 1658.
41. Trafford AW, Díaz ME, Eisner DA. Coordinated control of cell Ca2+ loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca2+ current. Circ Res 2001;88:195-220.
42. Boonprasert P, Lailerd N, Chattipakorn N. Urocortins in heart failure and ischemic heart disease. Int J Cardiol 2008;127:307-312.