-
1
-
-
0036843158
-
Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death
-
Bueno OF, Molkentin JD. Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death. Circ Res. 2002;91:776-781.
-
(2002)
Circ Res
, vol.91
, pp. 776-781
-
-
Bueno, O.F.1
Molkentin, J.D.2
-
2
-
-
34548695952
-
Mitogen-activated protein kinases in heart development and diseases
-
Wang Y. Mitogen-activated protein kinases in heart development and diseases. Circulation. 2007;116:1413-1423.
-
(2007)
Circulation
, vol.116
, pp. 1413-1423
-
-
Wang, Y.1
-
3
-
-
0032572534
-
Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists endothelin-1 and phenylephrine: A role in cardiac myocyte hypertrophy?
-
Clerk A, Michael A, Sugden PH. Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy? J Cell Biol. 1998;142:523-535.
-
(1998)
J Cell Biol
, vol.142
, pp. 523-535
-
-
Clerk, A.1
Michael, A.2
Sugden, P.H.3
-
4
-
-
0034383952
-
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
-
Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, Kitsis RN, Molkentin JD. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J. 2000;19:6341-6350.
-
(2000)
EMBO J
, vol.19
, pp. 6341-6350
-
-
Bueno, O.F.1
De Windt, L.J.2
Tymitz, K.M.3
Witt, S.A.4
Kimball, T.R.5
Klevitsky, R.6
Hewett, T.E.7
Jones, S.P.8
Lefer, D.J.9
Peng, C.F.10
Kitsis, R.N.11
Molkentin, J.D.12
-
5
-
-
0038651918
-
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling
-
Braz JC, Bueno OF, Liang Q, Wilkins BJ, Dai YS, Parsons S, Braunwart J, Glascock BJ, Klevitsky R, Kimball TF, Hewett TE, Molkentin JD. Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. J Clin Invest. 2003;111:1475-1486.
-
(2003)
J Clin Invest
, vol.111
, pp. 1475-1486
-
-
Braz, J.C.1
Bueno, O.F.2
Liang, Q.3
Wilkins, B.J.4
Dai, Y.S.5
Parsons, S.6
Braunwart, J.7
Glascock, B.J.8
Klevitsky, R.9
Kimball, T.F.10
Hewett, T.E.11
Molkentin, J.D.12
-
6
-
-
0043172403
-
Transactivation joins multiple tracks to the ERK/MAPK cascade
-
Wetzker R, Böhmer FD. Transactivation joins multiple tracks to the ERK/MAPK cascade. Nat Rev Mol Cell Biol. 2003;4:651-657.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 651-657
-
-
Wetzker, R.1
Böhmer, F.D.2
-
7
-
-
0036152858
-
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy
-
Asakura M, Kitakaze M, Takashima S, Liao Y, Ishikura F, Yoshinaka T, Ohmoto H, Node K, Yoshino K, Ishiguro H, Asanuma H, Sanada S, Matsumura Y, Takeda H, Beppu S, Tada M, Hori M, Higashiyama S. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat Med. 2002;8:35-40.
-
(2002)
Nat Med
, vol.8
, pp. 35-40
-
-
Asakura, M.1
Kitakaze, M.2
Takashima, S.3
Liao, Y.4
Ishikura, F.5
Yoshinaka, T.6
Ohmoto, H.7
Node, K.8
Yoshino, K.9
Ishiguro, H.10
Asanuma, H.11
Sanada, S.12
Matsumura, Y.13
Takeda, H.14
Beppu, S.15
Tada, M.16
Hori, M.17
Higashiyama, S.18
-
10
-
-
0038702326
-
2+ signaling in contractile regulation induced by crosstalk between endothelin-1 and norepinephrine in dog ventricular myocardium
-
2+ signaling in contractile regulation induced by crosstalk between endothelin-1 and norepinephrine in dog ventricular myocardium. Circ Res. 2003;92:1024-1032.
-
(2003)
Circ Res
, vol.92
, pp. 1024-1032
-
-
Chu, L.1
Takahashi, R.2
Norota, I.3
Miyamoto, T.4
Takeishi, Y.5
Ishii, K.6
Kubota, I.7
Endoh, M.8
-
11
-
-
12344282869
-
2+ sensitization induced by endothelin-1
-
2+ sensitization induced by endothelin-1. Eur J Pharmacol. 2004;507:135-143.
-
(2004)
Eur J Pharmacol
, vol.507
, pp. 135-143
-
-
Chu, L.1
Endoh, M.2
-
13
-
-
0037032005
-
Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility
-
Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H, Pikkarainen S, Piuhola J, Rysä J, Tóth M, Ruskoaho H. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res. 2002;91:434-440.
-
(2002)
Circ Res
, vol.91
, pp. 434-440
-
-
Szokodi, I.1
Tavi, P.2
Földes, G.3
Voutilainen-Myllylä, S.4
Ilves, M.5
Tokola, H.6
Pikkarainen, S.7
Piuhola, J.8
Rysä, J.9
Tóth, M.10
Ruskoaho, H.11
-
14
-
-
0035916879
-
Endothelin-1 has a unique oxygen-saving effect by increasing contractile efficiency in the isolated rat heart
-
Takeuchi Y, Kihara Y, Inagaki K, Yoneda T, Sasayama S. Endothelin-1 has a unique oxygen-saving effect by increasing contractile efficiency in the isolated rat heart. Circulation. 2001;103:1557-1563.
-
(2001)
Circulation
, vol.103
, pp. 1557-1563
-
-
Takeuchi, Y.1
Kihara, Y.2
Inagaki, K.3
Yoneda, T.4
Sasayama, S.5
-
16
-
-
1642402735
-
Effects of chronic endothelin-1 stimulation on cardiac myocyte contractile function
-
Zolk O, Münzel F, Eschenhagen T. Effects of chronic endothelin-1 stimulation on cardiac myocyte contractile function. Am J Physiol Heart Circ Physiol. 2004;286:H1248-H1257.
-
(2004)
Am J Physiol Heart Circ Physiol
, vol.286
-
-
Zolk, O.1
Münzel, F.2
Eschenhagen, T.3
-
17
-
-
0027528410
-
Endothelin-1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes
-
Bogoyevitch MA, Glennon PE, Sugden PH. Endothelin-1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes. FEBS Lett. 1993;317:271-275.
-
(1993)
FEBS Lett
, vol.317
, pp. 271-275
-
-
Bogoyevitch, M.A.1
Glennon, P.E.2
Sugden, P.H.3
-
18
-
-
0037962080
-
An overview of endothelin signaling in the cardiac myocyte
-
Sugden PH. An overview of endothelin signaling in the cardiac myocyte. J Mol Cell Cardiol. 2003;35:871-886.
-
(2003)
J Mol Cell Cardiol
, vol.35
, pp. 871-886
-
-
Sugden, P.H.1
-
19
-
-
0032562258
-
Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide
-
Szokodi I, Kinnunen P, Tavi P, Weckström M, Tóth M, Ruskoaho H. Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide. Circulation. 1998;97:1062-1070.
-
(1998)
Circulation
, vol.97
, pp. 1062-1070
-
-
Szokodi, I.1
Kinnunen, P.2
Tavi, P.3
Weckström, M.4
Tóth, M.5
Ruskoaho, H.6
-
20
-
-
2642568647
-
Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart
-
Tenhunen O, Sármán B, Kerkelä R, Szokodi I, Papp L, Tóth M, Ruskoaho H. Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart. J Biol Chem. 2004;279: 24852-24860.
-
(2004)
J Biol Chem
, vol.279
, pp. 24852-24860
-
-
Tenhunen, O.1
Sármán, B.2
Kerkelä, R.3
Szokodi, I.4
Papp, L.5
Tóth, M.6
Ruskoaho, H.7
-
21
-
-
0030439234
-
Role of phospholipase C and phospholipase A2 in the nitric oxide-induced vasodilator effect of bradykinin in the rat perfused heart
-
Fulton D, McGiff JC, Quilley J. Role of phospholipase C and phospholipase A2 in the nitric oxide-induced vasodilator effect of bradykinin in the rat perfused heart. J Pharmacol Exp Ther. 1996;278:518-526.
-
(1996)
J Pharmacol Exp Ther
, vol.278
, pp. 518-526
-
-
Fulton, D.1
McGiff, J.C.2
Quilley, J.3
-
22
-
-
0037040165
-
Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor
-
Thomas WG, Brandenburger Y, Autelitano DJ, Pham T, Qian H, Hannan RD. Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor. Circ Res. 2002;90:135-142.
-
(2002)
Circ Res
, vol.90
, pp. 135-142
-
-
Thomas, W.G.1
Brandenburger, Y.2
Autelitano, D.J.3
Pham, T.4
Qian, H.5
Hannan, R.D.6
-
23
-
-
0035082669
-
A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo
-
Knight DR, Smith AH, Flynn DM, MacAndrew JT, Ellery SS, Kong JX, Marala RB, Wester RT, Guzman-Perez A, Hill RJ, Magee WP, Tracey WR. A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J Pharmacol Exp Ther. 2001;297: 254-259.
-
(2001)
J Pharmacol Exp Ther
, vol.297
, pp. 254-259
-
-
Knight, D.R.1
Smith, A.H.2
Flynn, D.M.3
MacAndrew, J.T.4
Ellery, S.S.5
Kong, J.X.6
Marala, R.B.7
Wester, R.T.8
Guzman-Perez, A.9
Hill, R.J.10
Magee, W.P.11
Tracey, W.R.12
-
24
-
-
0027955166
-
Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes: The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy
-
Bogoyevitch MA, Glennon PE, Andersson MB, Clerk A, Lazou A, Marshall CJ, Parker PJ, Sugden PH. Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes: the potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy. J Biol Chem. 1994;269: 1110-1119.
-
(1994)
J Biol Chem
, vol.269
, pp. 1110-1119
-
-
Bogoyevitch, M.A.1
Glennon, P.E.2
Andersson, M.B.3
Clerk, A.4
Lazou, A.5
Marshall, C.J.6
Parker, P.J.7
Sugden, P.H.8
-
25
-
-
0033551771
-
+ exchanger in the rat myocardium by mitogen-activated protein kinase-dependent pathways
-
+ exchanger in the rat myocardium by mitogen-activated protein kinase-dependent pathways. J Biol Chem. 1999;274:22985-22992.
-
(1999)
J Biol Chem
, vol.274
, pp. 22985-22992
-
-
Moor, A.N.1
Fliegel, L.2
-
26
-
-
0038464639
-
Phospholamban: A crucial regulator of cardiac contractility
-
MacLennan DH, Kranias EG. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol. 2003;4:566-577.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 566-577
-
-
MacLennan, D.H.1
Kranias, E.G.2
-
27
-
-
1642419557
-
2+ antagonist-insensitive coronary smooth muscle contraction via activation of ε-protein kinase C
-
2+ antagonist-insensitive coronary smooth muscle contraction via activation of ε-protein kinase C. Hypertension. 2004;43:897-904.
-
(2004)
Hypertension
, vol.43
, pp. 897-904
-
-
McNair, L.L.1
Salamanca, D.A.2
Khalil, R.A.3
-
28
-
-
11144358069
-
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo
-
Lips DJ, Bueno OF, Wilkins BJ, Purcell NH, Kaiser RA, Lorenz JN, Voisin L, Saba-El-Leil MK, Meloche S, Pouyssegur J, Pages G, De Windt LJ, Doevendans PA, Molkentin JD. MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation. 2004;109:1938-1941.
-
(2004)
Circulation
, vol.109
, pp. 1938-1941
-
-
Lips, D.J.1
Bueno, O.F.2
Wilkins, B.J.3
Purcell, N.H.4
Kaiser, R.A.5
Lorenz, J.N.6
Voisin, L.7
Saba-El-Leil, M.K.8
Meloche, S.9
Pouyssegur, J.10
Pages, G.11
De Windt, L.J.12
Doevendans, P.A.13
Molkentin, J.D.14
-
29
-
-
4043076222
-
Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload
-
Harris IS, Zhang S, Treskov I, Kovacs A, Weinheimer C, Muslin AJ. Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload. Circulation. 2004;110:718-723.
-
(2004)
Circulation
, vol.110
, pp. 718-723
-
-
Harris, I.S.1
Zhang, S.2
Treskov, I.3
Kovacs, A.4
Weinheimer, C.5
Muslin, A.J.6
-
30
-
-
35348921181
-
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo
-
Purcell NH, Wilkins BJ, York A, Saba-El-Leil MK, Meloche S, Robbins J, Molkentin JD. Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proc Natl Acad Sci USA. 2007;104:14074-14079.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 14074-14079
-
-
Purcell, N.H.1
Wilkins, B.J.2
York, A.3
Saba-El-Leil, M.K.4
Meloche, S.5
Robbins, J.6
Molkentin, J.D.7
-
31
-
-
0037453001
-
Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function
-
Iwamoto R, Yamazaki S, Asakura M, Takashima S, Hasuwa H, Miyado K, Adachi S, Kitakaze M, Hashimoto K, Raab G, Nanba D, Higashiyama S, Hori M, Klagsbrun M, Mekada E Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci USA. 2003;100:3221-3226.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 3221-3226
-
-
Iwamoto, R.1
Yamazaki, S.2
Asakura, M.3
Takashima, S.4
Hasuwa, H.5
Miyado, K.6
Adachi, S.7
Kitakaze, M.8
Hashimoto, K.9
Raab, G.10
Nanba, D.11
Higashiyama, S.12
Hori, M.13
Klagsbrun, M.14
Mekada, E.15
-
32
-
-
30544449081
-
A quantitative protein interaction network for the ErbB receptors using protein microarrays
-
Jones RB, Gordus A, Krall JA, MacBeath G. A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006;439:168-174.
-
(2006)
Nature
, vol.439
, pp. 168-174
-
-
Jones, R.B.1
Gordus, A.2
Krall, J.A.3
MacBeath, G.4
-
33
-
-
0033570229
-
+ exchanger in the slow force response to myocardial stretch
-
+ exchanger in the slow force response to myocardial stretch. Circ Res. 1999;85:658-660.
-
(1999)
Circ Res
, vol.85
, pp. 658-660
-
-
Kentish, J.C.1
-
36
-
-
0034785929
-
Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1
-
Richards SA, Dreisbach VC, Murphy LO, Blenis J. Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1. Mol Cell Biol. 2001;21:7470-7480.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7470-7480
-
-
Richards, S.A.1
Dreisbach, V.C.2
Murphy, L.O.3
Blenis, J.4
-
37
-
-
33745166998
-
+ exchanger-mediated cardiac ischemia-reperfusion injury
-
+ exchanger-mediated cardiac ischemia-reperfusion injury. Circulation. 2006;113:2516-2523.
-
(2006)
Circulation
, vol.113
, pp. 2516-2523
-
-
Maekawa, N.1
Abe, J.2
Shishido, T.3
Itoh, S.4
Ding, B.5
Sharma, V.K.6
Sheu, S.S.7
Blaxall, B.C.8
Berk, B.C.9
-
40
-
-
0037040161
-
p38 mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes
-
Liao P, Wang SQ, Wang S, Zheng M, Zheng M, Zhang SJ, Cheng H, Wang Y, Xiao RP. p38 mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes. Circ Res. 2002;90:190-196.
-
(2002)
Circ Res
, vol.90
, pp. 190-196
-
-
Liao, P.1
Wang, S.Q.2
Wang, S.3
Zheng, M.4
Zheng, M.5
Zhang, S.J.6
Cheng, H.7
Wang, Y.8
Xiao, R.P.9
-
42
-
-
33746198344
-
Activation of p38 mitogen activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor
-
Bellahcene M, Jacquet S, Cao XB, Tanno M, Haworth RS, Layland J, Kabir AM, Gaestel M, Davis RJ, Fiavell RA, Shah AM, Avkiran M, Marber MS. Activation of p38 mitogen activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor. J Am Coll Cardiol. 2006;48: 545-555.
-
(2006)
J Am Coll Cardiol
, vol.48
, pp. 545-555
-
-
Bellahcene, M.1
Jacquet, S.2
Cao, X.B.3
Tanno, M.4
Haworth, R.S.5
Layland, J.6
Kabir, A.M.7
Gaestel, M.8
Davis, R.J.9
Fiavell, R.A.10
Shah, A.M.11
Avkiran, M.12
Marber, M.S.13
-
43
-
-
2542433090
-
Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes
-
Liu Q, Hofmann PA. Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes. Am J Physiol Heart Circ Physiol. 2004;286:H2204-H2212.
-
(2004)
Am J Physiol Heart Circ Physiol
, vol.286
-
-
Liu, Q.1
Hofmann, P.A.2
-
44
-
-
0038001420
-
Modulation of protein phosphatase 2a by adenosine A, receptors in cardiomyocytes: Role for p38 MAPK
-
Liu Q, Hofmann PA. Modulation of protein phosphatase 2a by adenosine A, receptors in cardiomyocytes: role for p38 MAPK. Am J Physiol Heart Circ Physiol. 2003;285:H97-H103.
-
(2003)
Am J Physiol Heart Circ Physiol
, vol.285
-
-
Liu, Q.1
Hofmann, P.A.2
-
45
-
-
0035834071
-
The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy
-
Liao P, Georgakopoulos D, Kovacs A, Zheng M, Lerner D, Pu H, Saffitz J, Chien K, Xiao RP, Kass DA, Wang Y. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc Natl Acad Sci USA. 2001;98:12283-12288.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 12283-12288
-
-
Liao, P.1
Georgakopoulos, D.2
Kovacs, A.3
Zheng, M.4
Lerner, D.5
Pu, H.6
Saffitz, J.7
Chien, K.8
Xiao, R.P.9
Kass, D.A.10
Wang, Y.11
|