Assessing cost effectiveness of empirical and prophylactic therapy for managing leptospirosis outbreaks

Epidemiology and Infection

Volumn 137, Issue 9, 2009, Pages 1323-1332

  Galloway, R L ^a,c   Levett, P N ^b   Tumeh, J W ^a   Flowers, C R ^a  

^a EMORY UNIVERSITY   (United States)

^b Saskatchewan Disease Control Laboratory   (Canada)

^c NONE   (United States)

Author keywords

Antibiotic treatment; Cost effectiveness; Leptospirosis

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN; DOXYCYCLINE; PLACEBO;

ARTICLE; CLINICAL TRIAL; COST EFFECTIVENESS ANALYSIS; COST UTILITY ANALYSIS; DECISION TREE; EPIDEMIC; HIGH RISK PATIENT; HOSPITALIZATION; HUMAN; KIDNEY FAILURE; LEPTOSPIROSIS; MEDICAL FEE; MULTIPLE ORGAN FAILURE; RESPIRATORY FAILURE; RISK FACTOR; SURVIVAL RATE; SYMPTOMATOLOGY;

ANTIBIOTIC PROPHYLAXIS; BARBADOS; COST-BENEFIT ANALYSIS; DECISION SUPPORT TECHNIQUES; DISEASE OUTBREAKS; HUMANS; LEPTOSPIROSIS; UNITED STATES;

EID: 68949146767     PISSN: 09502688     EISSN: 14694409     Source Type: Journal    
DOI: 10.1017/S0950268808001751     Document Type: Article

References (59)

1. Anon. Leptospirosis worldwide, 1999. Weekly Epidemiological Record 1999; 74: 237-244.
2. Faine S. Leptospira and Leptospirosis. Boca Raton: CRC Press, Inc, 1994, p. 353.
3. Bharti AR, et al. Leptospirosis: A zoonotic disease of global importance. Lancet Infectious Diseases 2003; 3: 757-771.
4. Levett PN. Leptospirosis. Clinical Microbiology Reviews 2001; 14: 296-326.
5. Abdulkader RC, et al. Leptospirosis severity may be associated with the intensity of humoral immune response. Revista do Instituto de Medicina Tropical de São Paulo 2002; 44: 79-83.
6. Weir E. The challenge posed by leptospirosis. Canadian Medical Association Journal 2000; 163: 1501-1503.
7. Guidugli F, Castro AA, Atallah AN. Antibiotics for treating leptospirosis. Cochrane Database of Systematic Reviews 2000. Issue no. 2. Article no. CD001306.
8. Costa E, et al. Penicillin at the late stage of leptospirosis: A randomized controlled trial. Revista do Instituto de Medicina Tropical de São Paulo 2003; 45: 141-145.
9. Edwards CN, et al. Penicillin therapy in icteric leptospirosis. American Journal of Tropical Medicine & Hygiene 1988; 39: 388-390.
10. Watt G, et al. Placebo-controlled trial of intravenous penicillin for severe and late leptospirosis. Lancet 1988; 1 433-435.
11. Phimda K, et al. Doxycycline versus azithromycin for treatment of leptospirosis and scrub typhus. Antimicrobial Agents and Chemotherapy 2007; 51: 3259-3263.
12. Ghouse M, et al. A two-year study of the efficacy of azithromycin in the treatment of leptospirosis in humans. Indian Journal of Medical Microbiology 2006; 24: 345-346.
13. Moon JE, et al. Efficacy of macrolides and telithromycin against leptospirosis in a hamster model. Antimicrobial Agents and Chemotherapy 2006; 50: 1989-1992.
14. Moon JE, et al. Effect of timing and duration of azithromycin therapy of leptospirosis in a hamster model. Journal of Antimicrobial Chemotherapy 2007; 59: 148-151.
15. Guidugli F, Castro AA, Atallah AN. Antibiotics for preventing leptospirosis. Cochrane Database of Systematic Reviews 2000. Issue no. 4. Article no.
16. Sehgal SC, et al. Randomized controlled trial of doxycycline prophylaxis against leptospirosis in an endemic area. International Journal of Antimicrobial Agents 2000; 13: 249-255.
17. Gonsalez CR, et al. Use of doxycycline for leptospirosis after high-risk exposure in Sao Paulo, Brazil. Revista do Instituto de Medicina Tropical de São Paulo 1998; 40: 59-61.
18. Gilks CF, et al. Failure of penicillin prophylaxis in laboratory acquired leptospirosis. Postgraduate Medical Journal 1988; 64: 236-238.
19. Griffith ME, Hospenthal DR, Murray CK. Antimicrobial therapy of leptospirosis. Current Opinion in Infectious Diseases 2006; 19 533-537.
20. Guidugli F, Castro AA, Atallah AN. Systematic reviews on leptospirosis. Revista do Instituto de Medicina Tropical de São Paulo 2000; 42: 47-49.
21. Vinetz JM. A mountain out of a molehill: Do we treat acute leptospirosis, and if so, with what? Clinical Infectious Diseases 2003; 36: 1514-1515.
22. Pappas G, Cascio A. Optimal treatment of leptospirosis: Queries and projections. International Journal of Antimicrobial Agents 2006; 28: 491-496.
23. John TJ. The prevention and control of human leptospirosis. Journal of Postgraduate Medicine 2005; 51: 205-209.
24. Gaynor K, et al. Leptospirosis on Oahu: An outbreak associated with flooding of a university campus. American Journal of Tropical Medicine and Hygiene 2007; 76: 882-885.
25. Hadad E, et al. An outbreak of leptospirosis among Israeli troops near the Jordan River. American Journal of Tropical Medicine and Hygiene 2006; 74: 127-131.
26. Raptis L, Pappas G, Akritidis N. Use of ceftriaxone in patients with severe leptospirosis. International Journal of Antimicrobial Agents 2006; 28: 259-261.
27. Kaya E, et al. Acute pancreatitis caused by leptospirosis: report of two cases. World Journal of Gastroenterology 2005; 11 4447-4449.
28. Erdinc F, et al. Three cases of anicteric leptospirosis from Turkey: Mild to severe complications. Journal of Infection 2005; 52: E45-48.
29. Stefos A, et al. Leptospirosis and pancytopenia: Two case reports and a review. Journal of Infection 2005; 51: e277-280.
30. Boland M, et al. A cluster of leptospirosis cases in canoeists following a competition on the River Liffey. Epidemiology and Infection 2004; 132: 195-200.
31. Basu D, et al. Leptospirosis and Weil's disease in eastern India. Journal of the Indian Medical Association 2003; 101: 532, 534, 536.
32. Gerke P, Rump LC. Leptospirosis - 3 cases and a review. Clinical Nephrology 2003; 60: 42-48.
33. Sejvar J, et al. Leptospirosis in 'Eco-Challenge' athletes, Malaysian Borneo, 2000. Emerging Infectious Diseases 2003; 9 702-707.
34. Panaphut T, et al. Ceftriaxone compared with sodium penicillin G for treatment of severe leptospirosis. Clinical Infectious Diseases 2003; 36: 1507-1513.
35. Verma B, Daga SR, Sawant D. Leptospirosis in children. Indian Pediatrics 2003; 40: 1081-1083.
36. Morgan J, et al. Outbreak of leptospirosis among triathlon participants and community residents in Springfield, Illinois, 1998. Clinical Infectious Diseases 2002; 34: 1593-1599.
37. Chung KJ, et al. Case reports of leptospirosis in southern Taiwan. Journal of the Formosan Medical Association 2002; 101 514-518.
38. Haddock RL, Gilmore JW, Pimentel F. A leptospirosis outbreak on Guam associated with an athletic event. Pacific Health Dialog 2002; 9: 186-189.
39. Flannery B, et al. Referral pattern of leptospirosis cases during a large urban epidemic of dengue. American Journal of Tropical Medicine and Hygiene 2001; 65: 657-663.
40. Yersin C, et al. Pulmonary haemorrhage as a predominant cause of death in leptospirosis in Seychelles. Transactions of the Royal Society of Tropical Medicine and Hygiene 2000; 94: 71-76.
41. Daher EF, Nogueira CB. Evaluation of penicillin therapy in patients with leptospirosis and acute renal failure. Revista do Instituto de Medicina Tropical de São Paulo 2000; 42: 327-332.
42. Singh SS, et al. Clinico-epidemiological study of hospitalized cases of severe leptospirosis. Indian Journal of Medical Research 1999; 109: 94-99.
43. No authors listed. Outbreak of leptospirosis among white-water rafters - Costa Rica, 1996. Morbidity and Mortality Weekly Report 1997; 46: 577-579.
44. Katz AR, et al. Leptospirosis on Oahu: An outbreak among military personnel associated with recreational exposure. Military Medicine 1997; 162: 101-104.
45. Jackson LA, et al. Outbreak of leptospirosis associated with swimming. Pediatric Disease Journal 1993; 12: 48-54.
46. Jevon TR, et al. A point-source epidemic of leptospirosis. Description of cases, cause, and prevention. Postgraduate Medicine 1986; 80: 121-122, 127-129.
47. McClain JB, et al. Doxycycline therapy for leptospirosis. Annals of Internal Medicine 1984; 100: 696-698.
48. Cucinell SA. Early diagnosis and treatment of leptospirosis. Military Medicine 1980; 145: 495-497.
49. Anderson DC, et al. Leptospirosis: A common-source outbreak due to leptospires of the grippotyphosa serogroup. American Journal of Epidemiology 1978; 107: 538-544.
50. Takafuji ET, et al. An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. New England Journal of Medicine 1984: 31: 497-500.
51. Torrance GW. Preferences for health outcomes and cost-utility analysis. American Journal of Managed Care 1997; 3 (Suppl.): S8-20.
52. Daher Ede F, Zanetta DM, Abdulkader RC. Pattern of renal function recovery after leptospirosis acute renal failure. Nephron Clinical Practice 2004; 98: C8-14.
53. Centers for Medicare and Medicaid Services. Acute inpatient files for download, 2008 (http://www.cms.hhs.gov/AcuteInpatientPPS/FFD/ list.asp).
54. Stat!Ref Online Electronic Medical Library. ICD-9-CM, volumes 1, 2, 3. 2008.
55. AHFS Drug Information 2008. In: STAT!Ref Online Electronic Medical Library (SROEM). American Society of Health System Pharmacists, 2008.
56. Hanley JA, Lippman-Hand A. If nothing goes wrong, is everything all right ? Interpreting zero numerators. Journal of the American Medical Association 1983; 249: 1743-1745.
57. Doubilet P, et al. Probabilistic sensitivity analysis using Monte Carlo simulation. A practical approach. Medical Decision Making 1985; 5: 157-177.
58. Smythe LD, et al. A quantitative PCR (TaqMan) assay for pathogenic Leptospira spp. BMC Infectious Diseases 2002; 2: 13.
59. Levett PN, et al. Detection of pathogenic leptospires by real-time quantitative PCR. Journal of Medical Microbiology 2005; 54: 45-49.