Molecular imaging using contrast-enhanced ultrasound: Evaluation of angiogenesis and cell therapy

Cardiovascular Research

Volumn 84, Issue 2, 2009, Pages 190-200

  Leong Poi, Howard ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Angiogenesis; Cell therapy; Contrast agents; Molecular imaging; Ultrasound

Indexed keywords

CADENCE; CONTRAST MEDIUM; COPPER 64; FLUORODEOXYGLUCOSE F 18; GADOLINIUM; GROWTH FACTOR; INDIUM 111; IODINE; IODINE 123; IODINE 124; LIPID; LUCIFERASE; NITROGEN; PERFLUTREN; POLYMER; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TECHNETIUM 99M; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ARTERY DISEASE; BIOLUMINESCENCE; BREAST CANCER; CARDIOVASCULAR DISEASE; CELL THERAPY; CLINICAL TRIAL; COMPARATIVE STUDY; CONTRAST ENHANCEMENT; ECHOCARDIOGRAPHY; FLUORESCENCE; GENE THERAPY; HUMAN; ISCHEMIC HEART DISEASE; MICROBUBBLE; MOLECULAR IMAGING; NEOVASCULARIZATION (PATHOLOGY); NON INVASIVE PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OVARY CANCER; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVASCULARIZATION; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SQUAMOUS CELL CARCINOMA; STEM CELL; STEM CELL TRANSPLANTATION; ULTRASOUND;

ANIMALS; CARDIOVASCULAR DISEASES; CELL TRANSPLANTATION; CONTRAST MEDIA; ECHOCARDIOGRAPHY; GENE THERAPY; HUMANS; MICROBUBBLES; MOLECULAR IMAGING; NEOVASCULARIZATION, PHYSIOLOGIC; PREDICTIVE VALUE OF TESTS; TREATMENT OUTCOME;

EID: 68949145639     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp248     Document Type: Review

References (48)

1. Schaper W, Scholz D. Factors regulating arteriogenesis. Arterioscler Thromb Vasc Biol 2003;23:1143-1151.
2. Drake CJ. Embryonic and adult vasculogenesis. Birth Defects Res C Embryo Today 2003;69:73-82.
3. Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999;85:221-228.
4. Risau W. Mechanisms of angiogenesis. Nature 1997;386:671-674.
5. Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005; 438:932-936.
6. Tirziu D, Simons M. Angiogenesis in the human heart: gene and cell therapy. Angiogenesis 2005;8:241-251.
7. Simons M, Ware JA. Therapeutic angiogenesis in cardiovascular disease. Nat Rev Drug Discov 2003;2:863-871.
8. Grines CL, Watkins MW, Helmer G, Penny W, Brinker J, Marmur JD et al. Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris. Circulation 2002;105:1291-1297.
9. Simons M, Bonow RO, Chronos NA, Cohen DJ, Giordano FJ, Hammond HK et al. Clinical trials in coronary angiogenesis: issues, problems, consensus: an expert panel summary. Circulation 2000;102:E73-E86.
10. Schachinger V, Erbs S, Elsasser A, Haberbosch W, Hambrecht R, Holschermann H et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006;355:1210-1221. (Pubitemid 44427445)
11. Abdel-Latif A, Bolli R, Tleyjeh IM, Montori VM, Perin EC, Hornung CA et al. Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med 2007;167:989-997.
12. Ly HQ, Frangioni JV, Hajjar RJ. Imaging in cardiac cell-based therapy: in vivo tracking of the biological fate of therapeutic cells. Nat Clin Pract Cardiovasc Med 2008;5(Suppl. 2):S96-S102.
13. Frangioni JV, Hajjar RJ. In vivo tracking of stem cells for clinical trials in cardiovascular disease. Circulation 2004;110:3378-3383.
14. Brack SS, Dinkelborg LM, Neri D. Molecular targeting of angiogenesis for imaging and therapy. Eur J Nucl Med Mol Imaging 2004;31:1327-1341.
15. Morawski AM, Lanza GA, Wickline SA. Targeted contrast agents for magnetic resonance imaging and ultrasound. Curr Opin Biotechnol 2005;16: 89-92.
16. Mulder WJ, Castermans K, van Beijnum JR, Oude Egbrink MG, Chin PT, Fayad ZA et al. Molecular imaging of tumor angiogenesis using alphavbeta3-integrin targeted multimodal quantum dots. Angiogenesis 2009;12:17-24.
17. Hua J, Dobrucki LW, Sadeghi MM, Zhang J, Bourke BN, Cavaliere P et al. Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia. Circulation 2005;111:3255-3260.
18. Haubner R. Noninvasive tracer techniques to characterize angiogenesis. Handb Exp Pharmacol 2008;185:323-339.
19. Klibanov AL, Rasche PT, Hughes MS, Wojdyla JK, Galen KP, Wible JH Jr et al. Detection of individual microbubbles of ultrasound contrast agents: imaging of free-floating and targeted bubbles. Invest Radiol 2004;39:187-195.
20. Kaufmann BA, Lindner JR. Molecular imaging with targeted contrast ultrasound. Curr Opin Biotechnol 2007;18:11-16.
21. Villanueva FS, Wagner WR. Ultrasound molecular imaging of cardiovascular disease. Nat Clin Pract Cardiovasc Med 2008;5(Suppl. 2):S26-S32.
22. Lindner JR. Molecular imaging with contrast ultrasound and targeted microbubbles. J Nucl Cardiol 2004;11:215-221.
23. Lindner JR, Dayton PA, Coggins MP, Ley K, Song J, Ferrara K et al. Nonin-vasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles. Circulation 2000;102:531-538. (Pubitemid 30639971)
24. Buysschaert I, Carmeliet P, Dewerchin M. Clinical and fundamental aspects of angiogenesis and anti-angiogenesis. Acta Clin Belg 2007;62: 162-169.
25. Eliceiri BP, Cheresh DA. Role of alpha v integrins during angiogenesis. Cancer J 2000;6(Suppl. 3):S245-S249.
26. Sipkins DA, Cheresh DA, Kazemi MR, Nevin LM, Bednarski MD, Li KC. Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat Med 1998;4:623-626.
27. Wu Z, Li ZB, Chen K, Cai W, He L, Chin FTet al. microPETof tumor integ-rin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4). J Nucl Med 2007;48:1536-1544.
28. Hantgan RR, Stahle MC, Connor JH, Lyles DS, Horita DA, Rocco M et al. The disintegrin echistatin stabilizes integrin alphaIIbbeta3's open conformation and promotes its oligomerization. J Mol Biol 2004;342: 1625-1636.
29. Leong-Poi H, Christiansen J, Klibanov AL, Kaul S, Lindner JR. Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins. Circulation 2003;107:455-460. (Pubitemid 36158049)
30. Stieger SM, Dayton PA, Borden MA, Caskey CF, Griffey SM, Wisner ER et al. Imaging of angiogenesis using Cadence contrast pulse sequencing and targeted contrast agents. Contrast Media Mol Imaging 2008;3:9-18.
31. Leong-Poi H, Christiansen J, Heppner P, Lewis CW, Klibanov AL, Kaul S et al. Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression. Circulation 2005;111:3248-3254.
32. Behm CZ, Kaufmann BA, Carr C, Lankford M, Sanders JM, Rose CE et al. Molecular imaging of endothelial vascular cell adhesion molecule-1 expression and inflammatory cell recruitment during vasculogenesis and ischemia-mediated arteriogenesis. Circulation 2008;117:2902-2911.
33. Ellegala DB, Leong-Poi H, Carpenter JE, Klibanov AL, Kaul S, Shaffrey ME et al. Imaging tumor angiogenesis with contrast ultrasound and micro-bubbles targeted to alpha(v)beta3. Circulation 2003;108:336-341.
34. Weller GE, Wong MK, Modzelewski RA, Lu E, Klibanov AL, Wagner WR et al. Ultrasonic imaging of tumor angiogenesis using contrast micro-bubbles targeted via the tumor-binding peptide arginine-arginine-leucine. Cancer Res 2005;65:533-539.
35. Lyshchik A, Fleischer AC, Huamani J, Hallahan DE, Brissova M, Gore JC. Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced high-frequency ultrasono-graphy. J Ultrasound Med 2007;26:1575-1586.
36. Rychak JJ, Graba J, Cheung AM, Mystry BS, Lindner JR, Kerbel RS et al. Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis. Mol Imaging 2007;6:289-296.
37. Willmann JK, Lutz AM, Paulmurugan R, Patel MR, Chu P, Rosenberg J et al. Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo. Radiology 2008;248:936-944.
38. Palmowski M, Huppert J, Ladewig G, Hauff P, Reinhardt M, Mueller MM et al. Molecular profiling of angiogenesis with targeted ultrasound imaging: early assessment of antiangiogenic therapy effects. Mol Cancer Ther 2008;7:101-109.
39. Korpanty G, Carbon JG, Grayburn PA, Fleming JB, Brekken RA. Monitoring response to anticancer therapy by targeting microbubbles to tumor vas-culature. Clin Cancer Res 2007;13:323-330.
40. Wilson K, Yu J, Lee A, Wu JC. In vitro and in vivo bioluminescence reporter gene imaging of human embryonic stem cells. J Vis Exp 2008; doi:10.3791/740.
41. Wu JC, Chen IY, Sundaresan G, Min JJ, De A, Qiao JH et al. Molecular imaging of cardiac cell transplantation in living animals using optical bio-luminescence and positron emission tomography. Circulation 2003;108: 1302-1305.
42. Napoli C, William-Ignarro S, Byrns R, Balestrieri ML, Crimi E, Farzati B et al. Therapeutic targeting of the stem cell niche in experimental hind-limb ischemia. Nat Clin Pract Cardiovasc Med 2008;5:571-579.
43. Aicher A, Brenner W, Zuhayra M, Badorff C, Massoudi S, Assmus B et al. Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation 2003;107: 2134-2139.
44. Hill JM, Dick AJ, Raman VK, Thompson RB, Yu ZX, Hinds KA et al. Serial cardiac magnetic resonance imaging of injected mesenchymal stem cells. Circulation 2003;108:1009-1014.
45. Foltz WD, Cunningham CH, Mutsaers AJ, Conolly SM, Stewart DJ, Dick AJ. Positive-contrast imaging in the rabbit hind-limb of transplanted cells bearing endocytosed superparamagnetic beads. J Cardiovasc Magn Reson 2006;8:817-823.
46. Kuliszewski MA, Fujii H, Liao C, Smith AH, Xie A, Lindner JR et al. Molecular imaging of endothelial progenitor cell engraftment using contrast-enhanced ultrasound and targeted microbubbles. Cardiovasc Res 2009;83:653-662.
47. Cui W, Chen X, Wang J, Fisher A, Kim K, Carson A et al. A new method for stem cell imaging using contrast ultrasound. Circulation 2008;118: S642.
48. Dayton PA, Pearson D, Clark J, Simon S, Schumann PA, Zutshi R et al. Ultrasonic analysis of peptide-and antibody-targeted microbubble contrast agents for molecular imaging of alphavbeta3-expressing cells. Mol Imaging 2004;3:125-134.