Association of MC4R gene variants with carcass and meat quality traits in Qinchuan cattle

African Journal of Biotechnology

Volumn 8, Issue 15, 2009, Pages 3666-3671

  Liu, Hongyu ^a,c   Tian, Wanqiang ^a,d   Zan, Linsen ^a,b   Wang, Hongbao ^a,b   Cui, Huan ^a  

^a NORTHWEST A F UNIVERSITY   (China)

^b National Beef Cattle Improvement Centre   (China)

^c Anhui Agriculture University   (China)

^d Yangling Vocational and Technical College   (China)

Author keywords

Carcass traits; MC4R gene; Meat quality; Polymorphism; Qinchuan cattle

Indexed keywords

FAT;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CARCASS; CATTLE; CHINA; CONTROLLED STUDY; FOOD QUALITY; GENE; GENE FREQUENCY; GENOTYPE; MC4R GENE; MEAT; NONHUMAN; POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALIA; BOS;

EID: 68949140537     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Bronner G, Sattler AM, Hinney A, Soufi M, Geller F, Schafer H, Maisch B, Hebebrand J, Schaefer JR (2006). The 103I variant of the melanocortin 4 receptor is associated with low serum triglyceride levels. J. Clin. Endocrinol. Metab. 91: 535-538.
2. De Vries AG, Sosnicki A, Garnier JP, Plastow GS (1998). The role of major genes and DNA technology in selection for meat quality in pigs. Meat Sci. 49(1): S245-S255. (Pubitemid 128471458)
3. Dempfle A, Hinney A, Heinzel-Gutenbrunner M, Raab M, Geller F, Gudermann T, Schafer H, Hebebrand J (2004). Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index. J. Med. Genet. 41: 795-800.
4. Fehm HL, Smolnik R, Kern W, McGregor GP, Bickel U, Born J (2001). The melanocortin melanocyte-stimulating hormone/adrenocorticotropin (4-10) decreases body fat in humans. J. Clin., Endocrinol. Metab. 86: 1144-1148.
5. Gan Q, Zhang L, Xu S, Li H, Li J, Gao X, Ren H, Chen J (2008). Association of LXRA gene variants with carcass and meat quality traits in beef cattle. Afr. J. Biotechnol. 7: 3546-3549.
6. Haegeman A, Coopman F, Jacobs K, Mattheeuws M, Van Zeveren A Peelman L (2001). Bovine melanocortin receptor 4: cDNA sequence, polymorphisms and mapping. Anim. Genet. 32: 189-192.
7. Heid IM, Vollmert C, Kronenberg F, Huth C, Ankerst DP, Luchner A, Hinney A, Bronner G, Wichmann HE, Illig T, Doring A, Hebebrand J (2008). Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study. Obesity 16: 369-376. (Pubitemid 351271918)
8. Hernández-Sánchez J, Visscher P, Plastow G, Haley C (2003). Candidate gene analysis for quantitative traits using the transmission disequilibrium test the example of the melanocortin four receptor in pigs. Genetics 164: 637-644. (Pubitemid 36773500)
9. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F (1997). Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88: 131-141. (Pubitemid 27180337)
10. Jokubka R, Maak S, Kerziene S, Swalve HH (2006). Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs. J. Anim. Breed. Genet. 123: 17-22.
11. Kim KS, Larsen N, Short T, Plastow G, Rothschild MF (2000). A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mamm. Genome 11: 131-135. (Pubitemid 30054415)
12. Kobayashi H, Ogawa Y, Shintani M, Ebihara K, Shimodahira M, Iwakura T, Hino M, Ishihara T, Ikekubo K, Kurahachi H, Nakao K (2002). A Novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity. Diabetes 51: 243-246. (Pubitemid 34518005)
13. Mullenbach R, Lagoda PJ, Welter C (1989). An efficient salt-chloroform extraction of DNA from blood and tissue. Trends Genet. 5: 391. (Pubitemid 20011529)
14. Obici S, Feng Z, Tan J, Liu L, Karkanias G, Rossetti L (2001). Central melanocortin receptors regulate insulin action. J. Clin. Invest. 108: 1079-1085.
15. Ovilo C, Fn A, Rodríguez MC, Nieto M, Silió L (2005). Association of MC4R gene variants with growth, fatness, carcass composition and meat and fat quality traits in heavy pigs. Meat Sci. 73. 42-47. (Pubitemid 43177743)
16. Rutanen J, Pihlajamaki J, Karhapaa P, Vauhkonen I, Kuusisto J, Moilanen Mykkanen L, Laakso M (2004). The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain. Obes. Res. 12: 1060-1066.
17. Seeley RJ, Yagaloff KA, Fisher SL, Burn P, Thiele TE, van Dijk G, Baskin DG, Schwartz MW (1997). Melanocortin receptors in leptin effects. Nature 390: 349.
18. Sina M, Hinney A, Ziegler A, Neupert T, Mayer H, Siegfried W, Blum WF, Remschmidt H, Hebebrand J (1999). Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene. Am. J. Hum. Genet. 65: 1501-1507.
19. Ste Marie L, Miura GI, Marsh DJ, Yagaloff K, Palmiter RD (2000). A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc. Natl. Acad. Sci. U S A. 97: 12339-12344.
20. Sun HS, Anderson LL, Yua TP, Kima KS, Klindt J, Tuggle CK (2002). Neonatal Meishan pigs show POU1F1 genotype effects on plasma GH and PRL concentration. Anim. Reprod. Sci. 69: 223-237.
21. Thue TD, Schmutz SM, Buchanan FC (2001). A SNP in the cattle MC4R gene is used to map MC4R to BTA 24. Anim. Genet. 32: 390-391.
22. Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P (2000). Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J. Clin. Invest. 106: 253-262.
23. Valle E, Habermann FA, Moore SS, Crews DH, Benkel BF (2004). Genomic localization and SNP discovery in the bovine melanocortin receptor 4 gene (MC4R). Anim. Genet. 35: 351-352. (Pubitemid 39040182)
24. Yeo GS, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG, O'Rahilly S (1998). A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat. Genet. 20: 111-112.
25. Zhang CL, Che H, Wang YH, Lan XY, Zhang L, Zhang AL, Zhang RF (2006). Association of a missense mutation of the MC4R gene with growth traits in cattle. Archiv. Fuer. Tierzucht. 5: 515-516.
26. Zhang CL, Wang YH, Chen H, Lan XY, Lei CZ, Fang XT (2008). Association between variants in the 5'-untranslated region of the bovine MC4R gene and two growth traits in Nanyang cattle. Mol. Biol. Rep. DOI 10.1007/s11033-008-9388-z.
27. Zobel DP, Andreasen CH, Grarup N, Eiberg H, Sorensen TI, Sandbaek A, Lauritzen T, Borch-Johnsen K, Jorgensen T, Pedersen O, Hansen T (2009). Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes. Diabetes 58: 757-764.