Effects of 5-Aza-CdR on the proliferation of human breast cancer cell line MCF-7 and on the expression of Apaf-1 gene

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 29, Issue 4, 2009, Pages 498-502

  Xiong, Huihua ^a   Qiu, Hong ^a   Zhuang, Liang ^a   Xiong, Hua ^a   Jiang, Rui ^b   Chen, Yuan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Apaf 1 gene; Breast cancer; DNA methyltransferase

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; APAF1 PROTEIN, HUMAN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; AZACITIDINE; DNA (CYTOSINE 5) METHYLTRANSFERASE; DRUG DERIVATIVE; MESSENGER RNA;

APOPTOSIS; ARTICLE; BREAST TUMOR; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENETICS; HUMAN; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; AZACITIDINE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; FEMALE; HUMANS; RNA, MESSENGER;

EID: 68949136456     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-009-0421-9     Document Type: Article

References (25)

1. M.M. Reinholz A.K. Bruzek D.W. Visscher 2009 Breast cancer and aneusomy 17: implications for carcinogenesis and therapeutic response Lancet Oncol 10 3 267 277
2. B.J. Metge A.R. Frost J.A. King 2008 Epigenetic silencing contributes to the loss of BRMS1 expression in breast cancer Clin Exp Metastasis 25 7 753 763
3. A. Potapova A.M. Hoffman A.K. Godwin 2008 Promoter hypermethylation of the PALB2 susceptibility gene in inherited and sporadic breast and ovarian cancer Cancer Res 68 4 998 1002
4. L. Mondragón M. Orzáez G. Sanclimens 2008 Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors J Med Chem 51 3 521 529
5. F. Christoph C. Kempkensteffen S. Weikert 2006 Methylation of tumor suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer Br J Cancer 95 12 1701 1707
6. F. Christoph S. Hinz C. Kempkensteffen 2007 mRNA expression profiles of methylated APAF-1 and DAPK-1 tumor suppressor genes uncover clear cell renal cell carcinomas with aggressive phenotype J Urol 178 6 2655 2659
7. G. Del Poeta A. Bruno M.I. Del Principe 2008 Deregulation of the mitochondrial apoptotic machinery and development of molecular targeted drugs in acute myeloid leukemia Curr Cancer Drug Targets 8 3 207 222
8. S. Zuo Y. Chen L. Xu 2007 Re-expression of RASSF1A by 5-Aza-CdR induced demethylation of the promoter region in human biliary tract carcinoma cells J Huazhong Univ Sci Technol [Med Sci] 27 3 281 284
9. F.J. Lai S.S. Huang M.C. Hsieh 2005 Upregulation of neuronal nitric oxide synthase mRNA and protein in adrenal medulla of water-deprived rats J Histochem Cytochem 53 1 45 53
10. B. Zhang T. Huang K. Liu 2007 Effects of 5-Aza-CdR on cell proliferation of breast cancer cell line MDA-MB-435S and expression of maspin gene J Huazhong Univ Sci Technolog [Med Sci] 27 5 543 546
11. B.P. Shelton N.L. Misso O.M. Shaw 2008 Epigenetic regulation of human epithelial cell cancers Curr Opin Mol Ther 10 6 568 578
12. Y. Wu L. Meng H. Wang 2006 Regulation of DNA methylation on the expression of the FHIT gene contributes to cervical carcinoma cell tumorigenesis Oncol Rep 16 3 625 629
13. E. Ko Y. Kim S.J. Kim 2008 Promoter hypermethylation of the p16 gene is associated with poor prognosis in recurrent early-stage hepatocellular carcinoma Cancer Epidemiol Biomarkers Prev 17 9 2260 2267
14. D.H. Jeong M.Y. Youm Y.N. Kim 2006 Promoter methylation of p16, DAPK, CDH1, and TIMP-3 genes in cervical cancer: correlation with clinicopathologic characteristics Int J Gynecol Cancer 16 3 1234 1240
15. Y. Jung J. Park T.Y. Kim 2007 Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy J Mol Med 85 10 1137 1148
16. X. Cheng R.M. Blumenthal 2008 Mammalian DNA methyltransferases: a structural perspective Structure 16 3 341 350
17. F. Shafiei F. Rahnama L. Pawella 2008 DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells Oncogene 27 18 2602 2612
18. S. Cheetham M.J. Tang F. Mesak 2008 SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2′-deoxycytidine to increase SPARC expression and improve therapy response Br J Cancer 98 11 1810 1819
19. N. Jain A. Rossi G. Garcia-Manero 2009 Epigenetic therapy of leukemia: An update Int J Biochem Cell Biol 41 1 72 80
20. Y. Wu L. Meng H. Wang 2006 Regulation of DNA methylation on the expression of the FHIT gene contributes to cervical carcinoma cell tumorigenesis Oncol Rep 16 3 625 629
21. C.E. Johnson Y.Y. Huang A.B. Parrish 2007 Differential Apaf-1 levels allow cytochrome C to induce apoptosis in brain tumors but not in normal neural tissues Proc Natl Acad Sci USA 104 52 20 820 20 825
22. L. Mondragón M. Orzáez G. Sanclimens 2008 Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors J Med Chem 51 3 521 529
23. S. Hinz C. Kempkensteffen S. Weikert 2007 EZH2 polycomb transcriptional repressor expression correlates with methylation of the APAF-1 gene in superficial transitional cell carcinoma of the bladder Tumour Biol 28 3 151 157
24. L. Benbrahim-Tallaa R.A. Waterland A.L. Dill 2007 Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase Environ Health Perspect 115 10 1454 1459
25. T. Deng Y. Zhang 2009 Possible involvement of activation of P53/P21 and demethylation of RUNX 3 in the cytotoxicity against Lovo cells induced by 5-Aza-2′-deoxycytidine Life Sci 84 9-10 311 320