Pharmacokinetic-pharmacodynamic modeling in anesthesia, intensive care and pain medicine

Current Opinion in Anaesthesiology

Volumn 22, Issue 4, 2009, Pages 463-468

  Sadean, Mihai R ^a   Glass, Peter S A ^a  

^a STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Pharmacodynamics; Pharmacokinetic pharmacodynamic modeling; Pharmacokinetics

Indexed keywords

ANESTHETIC AGENT; BUPRENORPHINE; ESMOLOL; FENTANYL; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE; PROPOFOL; REMIFENTANIL; SEVOFLURANE;

BAYES THEOREM; BISPECTRAL INDEX; DRUG DOSE TITRATION; DRUG EXCRETION; DRUG HALF LIFE; ENTROPY; GENERAL ANESTHESIA; GERIATRIC ANESTHESIA; HUMAN; HYPNOSIS; IMMOBILIZATION; INTENSIVE CARE; MUSCLE TETANIC CONTRACTION; NERVE CELL NETWORK; NOCICEPTION; NONHUMAN; PEDIATRIC ANESTHESIA; PHYSIOLOGY; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RESPIRATION DEPRESSION; RESPONSE SURFACE METHOD; REVIEW; SKIN CONDUCTANCE; SURGICAL STRESS; WITHDRAWAL REFLEX;

AGE FACTORS; ANESTHESIA; ANIMALS; BAYES THEOREM; BODY WEIGHT; DRUG INTERACTIONS; ELECTRIC CONDUCTIVITY; ELECTROENCEPHALOGRAPHY; ENTROPY; HUMANS; INTENSIVE CARE; MODELS, BIOLOGICAL; ODDS RATIO; PHARMACOKINETICS; REFLEX; STRESS, PHYSIOLOGICAL;

EID: 68949119647     PISSN: 09527907     EISSN: None     Source Type: Journal    
DOI: 10.1097/ACO.0b013e32832c3c6c     Document Type: Review

References (29)

1. Minto CF, Schnider TW. Contributions of PK/PD modeling to intravenous anesthesia. Clin Pharmacol Ther 2008; 84:27-38.
2. Albertin A, Poli D, La Col la L, etal. Predictive performance of'Servin's formula' during BIS-guided propofol-remifentanil target-controlled infusion in morbidly obese patients. Br J Anaesth 2007; 98:66-75.
3. Mazoit JX, Butscher K, Samii K. Morphine in postoperative patients: pharma-cokinetics and pharmacodynamics of metabolites. Anesth Analg 2007; 105:70-78.
4. Struys MMRF, Coppens MJ, De Neve N, etal. Influence of administration rate on propofol plasma-effect site equilibration. Anesthesiology 2007; 107:386-396.
5. Lerou JGC, Mourisse J. Applying a physiological model to quantify the delay between changes in end-expired concentrations of sevoflurane and bispectral index. Br J Anaesth 2007; 99:226-236.
6. Fuentes R, Cortnez LI, Struys MMRF, et al. The dynamic relationship between end-tidal sevoflurane concentrations, bispectral index, and cerebral state index in children. Anesth Analg 2008; 107:1573-1578.
7. Cortnez LI, Troconiz IF, Fuentes R, et al. The influence of age on the dynamic relationship between end-tidal sevoflurane concentrations and bispectral index. Anesth Analg 2008; 107:1566-1572.
8. Johnson KB, Syroid ND, Gupta DK, etal. An evaluation of remifentanil propofol response surfaces for loss of responsiveness, loss of response to surrogates of painful stimuli and laryngoscopy in patients undergoing elective surgery. Anesth Analg 2008; 106:471-479.
9. Zanderigo E, Sartori V, Sveticic MSC, et al. The well being model. A new drug interaction model for positive and negative effects. Anesthesiology 2006; 104:742-753.
10. Yassen A, Olofsen E, Kan J, et al. Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats. Pharm Res 2008; 25:183-193.
11. Copeland SE, Ladd LA, Gu XQ, et al. The effects of general anesthesia on whole body and regional pharmacokinetics of local anesthetics at toxic doses. Anesth Analg 2008; 106:1440-1449.
12. Kreuer S, Bruhn J, Walter E, et al. Comparative pharmacodynamic modeling using bispectral and narcotrend-index with and without a pharmacodynamic plateau during sevoflurane anesthesia. Anesth Analg 2008; 106:1171-1181.
13. Jeleazcov C, Schmidt J, Schmitz B, et al. EEG variables as measures of arousal during propofol anaesthesia for general surgery in children: rational selection and age dependence. Br J Anaesth 2007; 99:845-854.
14. Jeleazcov C, Ihmsen H, Schmid J, et al. Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children. Br J Anaesth 2008; 100:509-516.
15. Li X, Cui S, Voss LJ. Using permutation entropy to measure the electro-encephalographic effects of sevoflurane. Anesthesiology 2008; 109:448-456.
16. McKay IDH, Voss LJ, Sleigh JW, et al. Pharmacokinetic-pharmacodynamic modeling the hypnotic effect of sevoflurane using the spectral entropy of the electroencephalogram. Anesth Analg 2006; 102:91-97.
17. Mourisse J, Lerou J, Struys M, et al. Multilevel approach to anaesthetic effects produced by sevoflurane or propofol in humans: 1. BIS and blink reflex. Br J Anaesth 2007; 98:737-745.
18. Mourisse J, Lerou J, Struys M, et al. Multilevel approach to anaesthetic effects produced by sevoflurane or propofol in humans: 2. BIS and tetanic stimulus-induced withdrawal reflex. Br J Anaesth 2007; 98:746-755.
19. Huiku M, Uutela K, van Gils M, et al. Assessment of surgical stress during general anaesthesia. Br J Anaesth 2007; 98:447-455.
20. Ahonen J, Jokela R, Uutela K, et al. Surgical stress index reflects surgical stress in gynaecological laparoscopic day-case surgery. Br J Anaesth 2007; 98:456-461.
21. Struys MMRF, Vanpeteghem C, Huiku M, et al. Changes in a surgical stress index in response to standardized pain stimuli during propofol-remifentanil infusion. Br J Anaesth 2007; 99:359-367.
22. Wennervirta J, Hynynen M, Koivusalo AM, et al. Surgical stress index as a measure of nociception/antinociception balance during general anesthesia. Acta Anaesthesiol Scand 2008; 52:1038-1045.
23. Storm H. Changes in skin conductance as a tool to monitor nociceptive stimulation and pain. Curr Opin Anaesthesiol 2008; 21:796-804.
24. Gjerstad A, Storm C, Hagen HR, et al. Skin conductance or entropy for detection of non noxious stimulation during different clinical levels of sedation. Acta Anaesthesiol Scand 2007; 51:1-7.
25. Ledowski T, Bromilow J, Wu J, et al. The assessment of postoperative pain by monitoring skin conductance: results of a prospective study. Anaesthesia 2007; 62:989-993.
26. De Smet T, Struys MM, Greenwald S, et al. Estimation of optimal modeling weights for a Bayesian-based closed-loop system for propofol administration using the bispectral index as a controlled variable: a simulation study. Anesth Analg 2007; 105:1629-1638.
27. De Smet T, Struys MM, Neckebroek MM, et al. The accuracy and clinical feasibility of a new Bayesian-based closed-loop control system for propofol administration using the bispectral index as a controlled variable. Anesth Analg 2008; 107:1200-1210.
28. Zanderigo E, Caruso A, Bouillon T, et al. Pharmacodynamic modelling of drug-induced ventilatory depression and automatic drug dosing in conscious sedation. Proceedings of the 28th IEEE EMBS Annual International Conference; 30 August-3 September 2006; New York City, NY.
29. Caruso A, Bouillon T, Peter M, etal. Drug-induced respiratory depression: an integrated model of drug effects on the hypercapnic and hypoxic drive. Proceedings of the 29th Annual International Conference of the IEEE EMBS Cite Internationale; 23-26 August 2007; Lyon, France.