Both DNA damage and mitochondrial dysfunction are involved in novel oxadiazolo[3,4-d]pyrimidine nucleoside derivatives-induced cancer cell death

Journal of Applied Toxicology

Volumn 29, Issue 6, 2009, Pages 489-495

  Liu, Hai Liang ^a   Xu, Jing Jing ^a   Dai, Xiao Min ^a   Shi, Jing Bo ^b   Xu, Song ^b   Gao, Jing ^a   Yao, Qi Zheng ^b   Liu, Feng ^c  

^a JIANGSU UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antitumor; Calcium ion; DNA damage; Mitochondrion; Nitric oxide; Oxadiazolo 3,4 d pyrimidine nucleoside

Indexed keywords

CALCIUM ION; NITRIC OXIDE; OXADIAZOLO[3,4-D]PYRIMIDINE NUCLEOSIDE DERIVATIVE; PYRIMIDINE NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL PROLIFERATION; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL;

APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMAZANS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MOLECULAR STRUCTURE; OXADIAZOLES; PYRIMIDINE NUCLEOSIDES; TETRAZOLIUM SALTS; TIME FACTORS;

EID: 68949108158     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1433     Document Type: Article

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