24-hour variation in gene expression of redox pathway enzymes in rat hypothalamus: Effect of melatonin treatment

Redox Report

Volumn 14, Issue 3, 2009, Pages 132-138

  Jiménez Ortega, Vanesa ^a   Cano, Pilar ^a   Cardinali, Daniel P ^b   Esquifino, Ana I ^a  

^a SCHOOL OF MEDICINE   (Spain)

^b PONTIFICIA UNIVERSIDAD CATÓLICA ARGENTINA   (Argentina)

Author keywords

Catalase; Circadian rhythms; Gene expression; Heme oxygenase; Medial basal hypothalamus; Melatonin; Nitric oxide synthase; Superoxide dismutase

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; DRINKING WATER; HEME OXYGENASE 1; HEME OXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; MANGANESE SUPEROXIDE DISMUTASE; MELATONIN; MESSENGER RNA; NEURONAL NITRIC OXIDE SYNTHASE; ANTIOXIDANT; HEME OXYGENASE; HEME OXYGENASE-2; NITRIC OXIDE SYNTHASE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ANALYSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HYPOTHALAMUS; LIGHT DARK CYCLE; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REACTION TIME; REAL TIME POLYMERASE CHAIN REACTION; WISTAR RAT; ANIMAL; DRUG EFFECT; GENETICS; METABOLISM; POLYMERASE CHAIN REACTION;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

ANIMALS; ANTIOXIDANTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HYPOTHALAMUS; MALE; MELATONIN; NITRIC OXIDE SYNTHASE; OXIDATION-REDUCTION; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

EID: 68949105902     PISSN: 13510002     EISSN: None     Source Type: Journal    
DOI: 10.1179/135100009X392548     Document Type: Article

References (39)

1. Mancuso C, Scapagini G, Curro D et al. Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders. Front Biosci 2007; 12: 1107-1123.
2. Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ. One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007; 42: 28-42.
3. Pandi-Perumal SR, Srinivasan V, Maestroni GJM, Cardinali DP, Poeggeler B, Hardeland R. Melatonin: Nature's most versatile biological signal? FEBS J 2006; 273: 2813-2838.
4. Pozo D, Reiter RJ, Calvo JR, Guerrero JM. Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci 1994; 55: L455-L460.
5. Uz T, Longone P, Manev H. Increased hippocampal 5-lipoxygenase mRNA content in melatonin-deficient, pinealectomized rats. J Neurochem 1997; 69: 2220-2223.
6. Liu F, Ng TB. Effect of pineal indoles on activities of the antioxidant defense enzymes superoxide dismutase, catalase, and glutathione reductase, and levels of reduced and oxidized glutathione in rat tissues. Biochem Cell Biol 2000; 78: 447-453.
7. Montilla P, Tunez I, Munoz MC, Soria JV, Lopez A. Antioxidative effect of melatonin in rat brain oxidative stress induced by adriamycin. Rev Esp Fisiol 1997; 53: 301-305.
8. Barlow-Walden LR, Reiter RJ, Abe M et al. Melatonin stimulates brain glutathione peroxidase activity. Neurochem Int 1995; 26: 497-502.
9. Pablos MI, Reiter RJ, Chuang JI et al. Acutely administered melatonin reduces oxidative damage in lung and brain induced by hyperbaric oxygen. J Appl Physiol 1997; 83: 354-358.
10. Winiarska K, Fraczyk T, Malinska D, Drozak J, Bryla J. Melatonin attenuates diabetes-induced oxidative stress in rabbits. J Pineal Res 2006; 40: 168-176.
11. Merrow M, Roenneberg T. Circadian clocks: Running on redox. Cell 2001; 106: 141-143.
12. Ayers NA, Kapas L, Krueger JM. Circadian variation of nitric oxide synthase activity and cytosolic protein levels in rat brain. Brain Res 1996; 707: 127-130.
13. Rubio MF, Agostino PV, Ferreyra GA, Golombek DA. Circadian heme oxygenase activity in the hamster suprachiasmatic nuclei. Neurosci Lett 2003; 353: 9-12.
14. Martin V, Sainz RM, Mayo JC, Antolin I, Herrera F, Rodriguez C. Daily rhythm of gene expression in rat superoxide dismutases. Endocr Res 2003; 29: 83-95.
15. Sani M, Sebai H, Gadacha W, Boughattas NA, Reinberg A, Mossadok BA. Catalase activity and rhythmic patterns inmouse brain, kidney and liver. Comp Biochem Physiol B Biochem Mol Biol 2006; 145: 331-337.
16. Poliandri AH, Esquifino AI, Cano P et al. In vivo protective effect of melatonin on cadmium-induced changes in redox balance and gene expression in rat hypothalamus and anterior pituitary. J Pineal Res 2006; 41: 238-246.
17. Cardinali DP, Garcia AP, Cano P, Esquifino AI. Melatonin role in experimental arthritis. Curr Drug Targets Immune Endocr Metab Disord 2004; 4: 1-10.
18. Szentagothai B, Flerko B, Mess B, Halász B. Hypothalamic Control of the Anterior Pituitary, 3rd edn. Budapest: Akademiai Kiado, 1968.
19. Institute of Laboratory Animal Resources CoLSNRC. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press, 1996.
20. -ΔΔCt method. Methods 2001; 25: 402-8.
21. Ceccatelli S. Expression and plasticity of NO synthase in the neuroendocrine system. Brain Res Bull 1997; 44: 533-538
22. Wong ML, Rettori V, al Shekhlee A et al. Inducible nitric oxide synthase gene expression in the brain during systemic inflammation. Nat Med 1996; 2: 581-584.
23. Plano SA, Agostino PV, Golombek DA. Extracellular nitric oxide signaling in the hamster biological clock. FEBS Lett 2007; 581: 5500-5504.
24. Knauf C, Ferreira S, Hamdane M et al. Variation of endothelial nitric oxide synthase synthesis in the median eminence during the rat estrous cycle: An additional argument for the implication of vascular blood vessel in the control of GnRH release. Endocrinology 2001; 142: 4288-4294.
25. Yen SH, Pan JT. Nitric oxide plays an important role in the diurnal change of tuberoinfundibular dopaminergic neuronal activity and prolactin secretion in ovariectomized, estrogen/progesterone-treated rats. Endocrinology 1999; 140: 286-291.
26. Clemens S, Sawchuk MA, Hochman S. Reversal of the circadian expression of tyrosine-hydroxylase but not nitric oxide synthase levels in the spinal cord of dopamine D3 receptor knockout mice. Neuroscience 2005; 133: 353-357.
27. Pae HO, Kim EC, Chung HT. Integrative survival response evoked by heme oxygenase-1 and heme metabolites. J Clin Biochem Nutr 2008; 42: 197-203.
28. Ewing JF, Maines MD. Histochemical localization of heme oxygenase-2 protein and mRNA expression in rat brain. Brain Res Brain Res Protoc 1997; 1: 165-174.
29. Mancuso C, Kostoglou-Athanassiou I, Forsling ML et al. Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants. Molecular linkage between heme catabolism and neuroendocrine function. Brain Res Mol Brain Res 1997; 50: 267-276.
30. Lezoualc'h F, Sparapani M, Behl C. N-Acetyl-serotonin (normelatonin) and melatonin protect neurons against oxidative challenges and suppress the activity of the transcription factor NF-kappaB. J Pineal Res 1998; 24: 168-178.
31. Rodriguez C, Mayo JC, Sainz RM et al. Regulation of antioxidant enzymes: A significant role for melatonin. J Pineal Res 2004; 36: 1-9.
32. Beni SM, Kohen R, Reiter RJ, Tan DX, Shohami E. Melatonin-induced neuroprotection after closed head injury is associated with increased brain antioxidants and attenuated late-phase activation of NF-kappa B and AP-1. FASEB J 2004; 18: 149-151.
33. Alba G, El Bekay R, Chacon P et al. Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils. J Leukoc Biol 2008; 84: 397-405.
34. Mayo JC, Sainz RM, Antoli I, Herrera F, Martin V, Rodriguez C. Melatonin regulation of antioxidant enzyme gene expression. Cell Mol Life Sci 2002; 59: 1706-1713.
35. Subramanian P, Mirunalini S, Pandi-Perumal SR, Trakht I, Cardinali DP. Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats. Eur J Pharmacol 2007; 571: 116-119.
36. Tan DX, Manchester LC, Terron MP, Flores LJ, Tamura H, Reiter RJ. Melatonin as a naturally occurring co-substrate of quinone reductase-2, the putative MT3 melatonin membrane receptor: Hypothesis and significance. J Pineal Res 2007; 43: 317-320.
37. Acuna-Castroviejo D, Escames G, Rodriguez MI, Lopez LC. Melatonin role in the mitochondrial function. Front Biosci 2007; 12: 947-963.
38. Hardeland R, Coto-Montes A, Poeggeler B. Circadian rhythms, oxidative stress, and antioxidative defense mechanisms. Chronobiol Int 2003; 20: 921-962.
39. Subramanian P, Dakshayani K, Pandi-Perumal SR, Trakht I, Cardinali DP. 24-Hour rhythms in oxidative stress during hepatocarcinogenesis in rats: effect of melatonin or α-ketoglutarate. Redox Report 2008; 13: 78-86.