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Volumn 9, Issue 4, 2009, Pages 689-698

Quasispecies of hepatitis C virus genotype 1 and treatment outcome with Peginterferon and Ribavirin

Author keywords

Genotype 1; Hepatitis C virus; Nonstructural 5A region; Pegylated interferon; Quasispecies; Ribavirin; Sequence analysis

Indexed keywords

AMINO ACID; NONSTRUCTURAL PROTEIN 5A; PEGINTERFERON; RIBAVIRIN;

EID: 68949085550     PISSN: 15671348     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.meegid.2008.11.001     Document Type: Article
Times cited : (22)

References (65)
  • 1
    • 0032814384 scopus 로고    scopus 로고
    • Efficacy and changes of the nonstructural 5A GENE by prolonged interferon therapy for patients with hepatitis C virus genotype 1b and a high level of serum HCV-RNA
    • Arase Y., Ikeda K., Chayama K., Murashima N., Tsubota A., Suzuki Y., Saitoh S., Kobayashi M., Kobayashi M., Kobayashi M., and Kumada H. Efficacy and changes of the nonstructural 5A GENE by prolonged interferon therapy for patients with hepatitis C virus genotype 1b and a high level of serum HCV-RNA. Intern. Med. 38 (1999) 461-466
    • (1999) Intern. Med. , vol.38 , pp. 461-466
    • Arase, Y.1    Ikeda, K.2    Chayama, K.3    Murashima, N.4    Tsubota, A.5    Suzuki, Y.6    Saitoh, S.7    Kobayashi, M.8    Kobayashi, M.9    Kobayashi, M.10    Kumada, H.11
  • 2
    • 0033653568 scopus 로고    scopus 로고
    • Mutations in the E2-PePHD and NS5A region of hepatitis C virus type 1 and the dynamics of hepatitis C viremia decline during interferon alfa treatment
    • Berg T., Mas Marques A., Hohne M., Wiedenmann B., Hopf U., and Schreier E. Mutations in the E2-PePHD and NS5A region of hepatitis C virus type 1 and the dynamics of hepatitis C viremia decline during interferon alfa treatment. Hepatology 32 (2000) 1386-1395
    • (2000) Hepatology , vol.32 , pp. 1386-1395
    • Berg, T.1    Mas Marques, A.2    Hohne, M.3    Wiedenmann, B.4    Hopf, U.5    Schreier, E.6
  • 3
    • 0031050892 scopus 로고    scopus 로고
    • Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype 1b hepatitis C virus infection
    • Chayama K., Tsubota A., Kobayashi M., Okamoto K., Hashimoto M., Miyano Y., Koike H., Kobayashi M., Koida I., Arase Y., Saitoh S., Suzuki Y., Murashima N., Ikeda K., and Kumada H. Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype 1b hepatitis C virus infection. Hepatology 25 (1997) 745-749
    • (1997) Hepatology , vol.25 , pp. 745-749
    • Chayama, K.1    Tsubota, A.2    Kobayashi, M.3    Okamoto, K.4    Hashimoto, M.5    Miyano, Y.6    Koike, H.7    Kobayashi, M.8    Koida, I.9    Arase, Y.10    Saitoh, S.11    Suzuki, Y.12    Murashima, N.13    Ikeda, K.14    Kumada, H.15
  • 4
    • 34250621773 scopus 로고    scopus 로고
    • Hepatitis C virus: virology, diagnosis and management of antiviral therapy
    • Chevaliez S., and Pawlotsky J.M. Hepatitis C virus: virology, diagnosis and management of antiviral therapy. World J. Gastroenterol. 13 (2007) 2461-2466
    • (2007) World J. Gastroenterol. , vol.13 , pp. 2461-2466
    • Chevaliez, S.1    Pawlotsky, J.M.2
  • 5
    • 0032791543 scopus 로고    scopus 로고
    • Mutations in the NS5A region do not predict interferon-responsiveness in american patients infected with genotype 1b hepatitis C virus
    • Chung R.T., Monto A., Dienstag J.L., and Kaplan L.M. Mutations in the NS5A region do not predict interferon-responsiveness in american patients infected with genotype 1b hepatitis C virus. J. Med. Virol. 58 (1999) 353-358
    • (1999) J. Med. Virol. , vol.58 , pp. 353-358
    • Chung, R.T.1    Monto, A.2    Dienstag, J.L.3    Kaplan, L.M.4
  • 7
    • 0031836249 scopus 로고    scopus 로고
    • Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity
    • Duverlie G., Khorsi H., Castelain S., Jaillon O., Izopet J., Lunel F., Eb F., Penin F., and Wychowski C. Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity. J. Gen. Virol. 79 Pt 6 (1998) 1373-1381
    • (1998) J. Gen. Virol. , vol.79 , Issue.PART 6 , pp. 1373-1381
    • Duverlie, G.1    Khorsi, H.2    Castelain, S.3    Jaillon, O.4    Izopet, J.5    Lunel, F.6    Eb, F.7    Penin, F.8    Wychowski, C.9
  • 8
    • 34247395820 scopus 로고    scopus 로고
    • Prediction of efficient virological response to pegylated interferon/ribavirin combination therapy by NS5A sequences of hepatitis C virus and anti-NS5A antibodies in pre-treatment sera
    • El-Shamy A., Sasayama M., Nagano-Fujii M., Sasase N., Imoto S., Kim S.R., and Hotta H. Prediction of efficient virological response to pegylated interferon/ribavirin combination therapy by NS5A sequences of hepatitis C virus and anti-NS5A antibodies in pre-treatment sera. Microbiol. Immunol. 51 (2007) 471-482
    • (2007) Microbiol. Immunol. , vol.51 , pp. 471-482
    • El-Shamy, A.1    Sasayama, M.2    Nagano-Fujii, M.3    Sasase, N.4    Imoto, S.5    Kim, S.R.6    Hotta, H.7
  • 9
    • 0029161576 scopus 로고
    • Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region
    • Enomoto N., Sakuma I., Asahina Y., Kurosaki M., Murakami T., Yamamoto C., Izumi N., Marumo F., and Sato C. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J. Clin. Invest. 96 (1995) 224-230
    • (1995) J. Clin. Invest. , vol.96 , pp. 224-230
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3    Kurosaki, M.4    Murakami, T.5    Yamamoto, C.6    Izumi, N.7    Marumo, F.8    Sato, C.9
  • 10
    • 0031978181 scopus 로고    scopus 로고
    • Base-calling of automated sequencer traces using phred. II. Error probabilities
    • Ewing B., and Green P. Base-calling of automated sequencer traces using phred. II. Error probabilities. Genome Res. 8 (1998) 186-194
    • (1998) Genome Res. , vol.8 , pp. 186-194
    • Ewing, B.1    Green, P.2
  • 11
    • 0031955518 scopus 로고    scopus 로고
    • Base-calling of automated sequencer traces using phred. I. Accuracy assessment
    • Ewing B., Hillier L., Wendl M.C., and Green P. Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res. 8 (1998) 175-185
    • (1998) Genome Res. , vol.8 , pp. 175-185
    • Ewing, B.1    Hillier, L.2    Wendl, M.C.3    Green, P.4
  • 12
    • 20444371955 scopus 로고    scopus 로고
    • Nonstructural 5A gene variability of hepatitis C virus (HCV) during a 10-year follow up
    • Fan W., Zhu W., Wei L., Wang Q., Yin L., Du S., and Zhuang H. Nonstructural 5A gene variability of hepatitis C virus (HCV) during a 10-year follow up. J. Gastroenterol. 40 (2005) 43-51
    • (2005) J. Gastroenterol. , vol.40 , pp. 43-51
    • Fan, W.1    Zhu, W.2    Wei, L.3    Wang, Q.4    Yin, L.5    Du, S.6    Zhuang, H.7
  • 15
    • 0033224562 scopus 로고    scopus 로고
    • The molecular biology of hepatitis C virus. Genotypes and quasispecies
    • vii
    • Forns X., and Bukh J. The molecular biology of hepatitis C virus. Genotypes and quasispecies. Clin. Liver Dis. 3 (1999) 693-716 vii
    • (1999) Clin. Liver Dis. , vol.3 , pp. 693-716
    • Forns, X.1    Bukh, J.2
  • 17
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • Gale Jr. M.J., Korth M.J., Tang N.M., Tan S.L., Hopkins D.A., Dever T.E., Polyak S.J., Gretch D.R., and Katze M.G. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 230 (1997) 217-227
    • (1997) Virology , vol.230 , pp. 217-227
    • Gale Jr., M.J.1    Korth, M.J.2    Tang, N.M.3    Tan, S.L.4    Hopkins, D.A.5    Dever, T.E.6    Polyak, S.J.7    Gretch, D.R.8    Katze, M.G.9
  • 18
    • 10744225097 scopus 로고    scopus 로고
    • Global burden of disease (GBD) for hepatitis C
    • GBD
    • GBD, 2004. Global burden of disease (GBD) for hepatitis C. J. Clin. Pharmacol. 44, 20-29.
    • (2004) J. Clin. Pharmacol , vol.44 , pp. 20-29
  • 19
    • 0031955116 scopus 로고    scopus 로고
    • Consed: a graphical tool for sequence finishing
    • Gordon D., Abajian C., and Green P. Consed: a graphical tool for sequence finishing. Genome Res. 8 (1998) 195-202
    • (1998) Genome Res. , vol.8 , pp. 195-202
    • Gordon, D.1    Abajian, C.2    Green, P.3
  • 21
    • 0002051540 scopus 로고    scopus 로고
    • BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT
    • Hall T.A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symposium Series, vol. 41 (1999) 95-98
    • (1999) Nucleic Acids Symposium Series, vol. 41 , pp. 95-98
    • Hall, T.A.1
  • 22
    • 11844280823 scopus 로고    scopus 로고
    • Hepatitis C virus-related resistance mechanisms to interferon alpha-based antiviral therapy
    • Hofmann W.P., Zeuzem S., and Sarrazin C. Hepatitis C virus-related resistance mechanisms to interferon alpha-based antiviral therapy. J. Clin. Virol. 32 (2005) 86-91
    • (2005) J. Clin. Virol. , vol.32 , pp. 86-91
    • Hofmann, W.P.1    Zeuzem, S.2    Sarrazin, C.3
  • 23
    • 0030571476 scopus 로고    scopus 로고
    • Characterization of the nuclear localization signal and subcellular distribution of hepatitis C virus nonstructural protein NS5A
    • Ide Y., Zhang L., Chen M., Inchauspe G., Bahl C., Sasaguri Y., and Padmanabhan R. Characterization of the nuclear localization signal and subcellular distribution of hepatitis C virus nonstructural protein NS5A. Gene 182 (1996) 203-211
    • (1996) Gene , vol.182 , pp. 203-211
    • Ide, Y.1    Zhang, L.2    Chen, M.3    Inchauspe, G.4    Bahl, C.5    Sasaguri, Y.6    Padmanabhan, R.7
  • 24
    • 0025787597 scopus 로고
    • Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates
    • Inchauspe G., Zebedee S., Lee D.H., Sugitani M., Nasoff M., and Prince A.M. Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 10292-10296
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 10292-10296
    • Inchauspe, G.1    Zebedee, S.2    Lee, D.H.3    Sugitani, M.4    Nasoff, M.5    Prince, A.M.6
  • 25
    • 33646180828 scopus 로고    scopus 로고
    • Mutations within protein kinase R-binding domain of NS5A protein of hepatitis C virus (HCV) and specificity of HCV antibodies in pretreatment sera of HCV-chronically infected patients and their effect on the result of treatment
    • Kmieciak D., Kruszyna L., Migdalski P., Lacinski M., Juszczyk J., and Trzeciak W.H. Mutations within protein kinase R-binding domain of NS5A protein of hepatitis C virus (HCV) and specificity of HCV antibodies in pretreatment sera of HCV-chronically infected patients and their effect on the result of treatment. Jpn. J. Infect. Dis. 59 (2006) 92-99
    • (2006) Jpn. J. Infect. Dis. , vol.59 , pp. 92-99
    • Kmieciak, D.1    Kruszyna, L.2    Migdalski, P.3    Lacinski, M.4    Juszczyk, J.5    Trzeciak, W.H.6
  • 28
    • 4544336360 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A: tales of a promiscuous protein
    • Macdonald A., and Harris M. Hepatitis C virus NS5A: tales of a promiscuous protein. J. Gen. Virol. 85 (2004) 2485-2502
    • (2004) J. Gen. Virol. , vol.85 , pp. 2485-2502
    • Macdonald, A.1    Harris, M.2
  • 29
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial
    • Manns M.P., McHutchison J.G., Gordon S.C., Rustgi V.K., Shiffman M., Reindollar R., Goodman Z.D., Koury K., Ling M., and Albrecht J.K. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358 (2001) 958-965
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3    Rustgi, V.K.4    Shiffman, M.5    Reindollar, R.6    Goodman, Z.D.7    Koury, K.8    Ling, M.9    Albrecht, J.K.10
  • 30
    • 0026538287 scopus 로고
    • Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution
    • Martell M., Esteban J.I., Quer J., Genesca J., Weiner A., Esteban R., Guardia J., and Gomez J. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution. J. Virol. 66 (1992) 3225-3229
    • (1992) J. Virol. , vol.66 , pp. 3225-3229
    • Martell, M.1    Esteban, J.I.2    Quer, J.3    Genesca, J.4    Weiner, A.5    Esteban, R.6    Guardia, J.7    Gomez, J.8
  • 32
    • 0036321652 scopus 로고    scopus 로고
    • The application of molecular phylogenetics to the analysis of viral genome diversity and evolution
    • McCormack G.P., and Clewley J.P. The application of molecular phylogenetics to the analysis of viral genome diversity and evolution. Rev. Med. Virol. 12 (2002) 221-238
    • (2002) Rev. Med. Virol. , vol.12 , pp. 221-238
    • McCormack, G.P.1    Clewley, J.P.2
  • 33
    • 33845484433 scopus 로고    scopus 로고
    • Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy
    • Medeiros-Filho J.E., Mello I.M.V.G.C., Pinho J.R.R., Neumann A.U., Malta F.F., da Silva L.C., and Carrilho F.J. Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy. World J. Gastroenterol. 12 (2006) 7271-7277
    • (2006) World J. Gastroenterol. , vol.12 , pp. 7271-7277
    • Medeiros-Filho, J.E.1    Mello, I.M.V.G.C.2    Pinho, J.R.R.3    Neumann, A.U.4    Malta, F.F.5    da Silva, L.C.6    Carrilho, F.J.7
  • 34
    • 33845423064 scopus 로고    scopus 로고
    • A mutation in the interferon sensitivity-determining region is associated with responsiveness to interferon-ribavirin combination therapy in chronic hepatitis patients infected with a Japan-specific subtype of hepatitis C virus genotype 1B
    • Murayama M., Katano Y., Nakano I., Ishigami M., Hayashi K., Honda T., Hirooka Y., Itoh A., and Goto H. A mutation in the interferon sensitivity-determining region is associated with responsiveness to interferon-ribavirin combination therapy in chronic hepatitis patients infected with a Japan-specific subtype of hepatitis C virus genotype 1B. J. Med. Virol. 79 (2007) 35-40
    • (2007) J. Med. Virol. , vol.79 , pp. 35-40
    • Murayama, M.1    Katano, Y.2    Nakano, I.3    Ishigami, M.4    Hayashi, K.5    Honda, T.6    Hirooka, Y.7    Itoh, A.8    Goto, H.9
  • 35
    • 0036277038 scopus 로고    scopus 로고
    • Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection
    • Murphy M.D., Rosen H.R., Marousek G.I., and Chou S. Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection. Dig. Dis. Sci. 47 (2002) 1195-1205
    • (2002) Dig. Dis. Sci. , vol.47 , pp. 1195-1205
    • Murphy, M.D.1    Rosen, H.R.2    Marousek, G.I.3    Chou, S.4
  • 36
    • 0033002009 scopus 로고    scopus 로고
    • Why is the interferon sensitivity-determining region (ISDR) system useful in Japan?
    • Nakano I., Fukuda Y., Katano Y., Nakano S., Kumada T., and Hayakawa T. Why is the interferon sensitivity-determining region (ISDR) system useful in Japan?. J. Hepatol. 30 (1999) 1014-1022
    • (1999) J. Hepatol. , vol.30 , pp. 1014-1022
    • Nakano, I.1    Fukuda, Y.2    Katano, Y.3    Nakano, S.4    Kumada, T.5    Hayakawa, T.6
  • 37
    • 0033807806 scopus 로고    scopus 로고
    • Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy
    • Nousbaum J., Polyak S.J., Ray S.C., Sullivan D.G., Larson A.M., Carithers Jr. R.L., and Gretch D.R. Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy. J. Virol. 74 (2000) 9028-9038
    • (2000) J. Virol. , vol.74 , pp. 9028-9038
    • Nousbaum, J.1    Polyak, S.J.2    Ray, S.C.3    Sullivan, D.G.4    Larson, A.M.5    Carithers Jr., R.L.6    Gretch, D.R.7
  • 38
    • 4344570256 scopus 로고    scopus 로고
    • Sustained virological response in hepatitis C virus type 1b infected patients is predicted by the number of mutations within the NS5A-ISDR: a meta-analysis focused on geographical differences
    • Pascu M., Martus P., Hohne M., Wiedenmann B., Hopf U., Schreier E., and Berg T. Sustained virological response in hepatitis C virus type 1b infected patients is predicted by the number of mutations within the NS5A-ISDR: a meta-analysis focused on geographical differences. Gut 53 (2004) 1345-1351
    • (2004) Gut , vol.53 , pp. 1345-1351
    • Pascu, M.1    Martus, P.2    Hohne, M.3    Wiedenmann, B.4    Hopf, U.5    Schreier, E.6    Berg, T.7
  • 39
    • 0037301154 scopus 로고    scopus 로고
    • Hepatitis C virus genetic variability: pathogenic and clinical implications
    • Pawlotsky J.M. Hepatitis C virus genetic variability: pathogenic and clinical implications. Clin. Liver Dis. 7 (2003) 45-66
    • (2003) Clin. Liver Dis. , vol.7 , pp. 45-66
    • Pawlotsky, J.M.1
  • 40
    • 0037784027 scopus 로고    scopus 로고
    • Mechanisms of antiviral treatment efficacy and failure in chronic hepatitis C
    • Pawlotsky J.M. Mechanisms of antiviral treatment efficacy and failure in chronic hepatitis C. Antiviral Res. 59 (2003) 1-11
    • (2003) Antiviral Res. , vol.59 , pp. 1-11
    • Pawlotsky, J.M.1
  • 41
    • 14644402363 scopus 로고    scopus 로고
    • Current and future concepts in hepatitis C therapy
    • Pawlotsky J.M. Current and future concepts in hepatitis C therapy. Semin. Liver Dis. 25 (2005) 72-83
    • (2005) Semin. Liver Dis. , vol.25 , pp. 72-83
    • Pawlotsky, J.M.1
  • 42
    • 0032885602 scopus 로고    scopus 로고
    • The non-structural 5A protein of hepatitis C virus
    • Pawlotsky J.M., and Germanidis G. The non-structural 5A protein of hepatitis C virus. J. Viral Hepat. 6 (1999) 343-356
    • (1999) J. Viral Hepat. , vol.6 , pp. 343-356
    • Pawlotsky, J.M.1    Germanidis, G.2
  • 43
    • 0031923838 scopus 로고    scopus 로고
    • Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations
    • Pawlotsky J.M., Germanidis G., Neumann A.U., Pellerin M., Frainais P.O., and Dhumeaux D. Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations. J. Virol. 72 (1998) 2795-2805
    • (1998) J. Virol. , vol.72 , pp. 2795-2805
    • Pawlotsky, J.M.1    Germanidis, G.2    Neumann, A.U.3    Pellerin, M.4    Frainais, P.O.5    Dhumeaux, D.6
  • 44
    • 16544372861 scopus 로고    scopus 로고
    • Hepatitis C virus quasispecies variability modulates nonstructural protein 5A transcriptional activation, pointing to cellular compartmentalization of virus-host interactions
    • Pellerin M., Lopez-Aguirre Y., Penin F., Dhumeaux D., and Pawlotsky J.M. Hepatitis C virus quasispecies variability modulates nonstructural protein 5A transcriptional activation, pointing to cellular compartmentalization of virus-host interactions. J. Virol. 78 (2004) 4617-4627
    • (2004) J. Virol. , vol.78 , pp. 4617-4627
    • Pellerin, M.1    Lopez-Aguirre, Y.2    Penin, F.3    Dhumeaux, D.4    Pawlotsky, J.M.5
  • 45
    • 0033837013 scopus 로고    scopus 로고
    • The protein kinase-interacting domain in the hepatitis C virus envelope glycoprotein-2 gene is highly conserved in genotype 1-infected patients treated with interferon
    • Polyak S.J., Nousbaum J.B., Larson A.M., Cotler S., Carithers Jr. R.L., and Gretch D.R. The protein kinase-interacting domain in the hepatitis C virus envelope glycoprotein-2 gene is highly conserved in genotype 1-infected patients treated with interferon. J. Infect. Dis. 182 (2000) 397-404
    • (2000) J. Infect. Dis. , vol.182 , pp. 397-404
    • Polyak, S.J.1    Nousbaum, J.B.2    Larson, A.M.3    Cotler, S.4    Carithers Jr., R.L.5    Gretch, D.R.6
  • 46
    • 0031773680 scopus 로고    scopus 로고
    • MODELTEST: testing the model of DNA substitution
    • Posada D., and Crandall K.A. MODELTEST: testing the model of DNA substitution. Bioinformatics 14 (1998) 817-818
    • (1998) Bioinformatics , vol.14 , pp. 817-818
    • Posada, D.1    Crandall, K.A.2
  • 47
    • 0033965331 scopus 로고    scopus 로고
    • Is an "a la carte" combination interferon alfa-2b plus ribavirin regimen possible for the first line treatment in patients with chronic hepatitis C?
    • The ALGOVIRC Project Group
    • Poynard T., McHutchison J., Goodman Z., Ling M.H., Albrecht J., and The ALGOVIRC Project Group. Is an "a la carte" combination interferon alfa-2b plus ribavirin regimen possible for the first line treatment in patients with chronic hepatitis C?. Hepatology 31 (2000) 211-218
    • (2000) Hepatology , vol.31 , pp. 211-218
    • Poynard, T.1    McHutchison, J.2    Goodman, Z.3    Ling, M.H.4    Albrecht, J.5
  • 48
    • 16844363814 scopus 로고    scopus 로고
    • Dynamics of hepatitis C virus NS5A quasispecies during interferon and ribavirin therapy in responder and non-responder patients with genotype 1b chronic hepatitis C
    • Puig-Basagoiti F., Forns X., Furcic I., Ampurdanes S., Gimenez-Barcons M., Franco S., Sanchez-Tapias J.M., and Saiz J.C. Dynamics of hepatitis C virus NS5A quasispecies during interferon and ribavirin therapy in responder and non-responder patients with genotype 1b chronic hepatitis C. J. Gen. Virol. 86 (2005) 1067-1075
    • (2005) J. Gen. Virol. , vol.86 , pp. 1067-1075
    • Puig-Basagoiti, F.1    Forns, X.2    Furcic, I.3    Ampurdanes, S.4    Gimenez-Barcons, M.5    Franco, S.6    Sanchez-Tapias, J.M.7    Saiz, J.C.8
  • 49
    • 0347513220 scopus 로고    scopus 로고
    • DnaSP, DNA polymorphism analyses by the coalescent and other methods
    • Rozas J., Sanchez-DelBarrio J.C., Messeguer X., and Rozas R. DnaSP, DNA polymorphism analyses by the coalescent and other methods. Bioinformatics 19 (2003) 2496-2497
    • (2003) Bioinformatics , vol.19 , pp. 2496-2497
    • Rozas, J.1    Sanchez-DelBarrio, J.C.2    Messeguer, X.3    Rozas, R.4
  • 51
    • 0034101768 scopus 로고    scopus 로고
    • Mutations in the protein kinase-binding domain of the NS5A protein in patients infected with hepatitis C virus type 1a are associated with treatment response
    • Sarrazin C., Berg T., Lee J.H., Ruster B., Kronenberger B., Roth W.K., and Zeuzem S. Mutations in the protein kinase-binding domain of the NS5A protein in patients infected with hepatitis C virus type 1a are associated with treatment response. J. Infect. Dis. 181 (2000) 432-441
    • (2000) J. Infect. Dis. , vol.181 , pp. 432-441
    • Sarrazin, C.1    Berg, T.2    Lee, J.H.3    Ruster, B.4    Kronenberger, B.5    Roth, W.K.6    Zeuzem, S.7
  • 52
    • 0036839175 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural 5A protein and interferon resistance: a new model for testing the reliability of mutational analyses
    • Sarrazin C., Herrmann E., Bruch K., and Zeuzem S. Hepatitis C virus nonstructural 5A protein and interferon resistance: a new model for testing the reliability of mutational analyses. J. Virol. 76 (2002) 11079-11090
    • (2002) J. Virol. , vol.76 , pp. 11079-11090
    • Sarrazin, C.1    Herrmann, E.2    Bruch, K.3    Zeuzem, S.4
  • 53
    • 0034630933 scopus 로고    scopus 로고
    • Cleavage of hepatitis C virus nonstructural protein 5A by a caspase-like protease(s) in mammalian cells
    • Satoh S., Hirota M., Noguchi T., Hijikata M., Handa H., and Shimotohno K. Cleavage of hepatitis C virus nonstructural protein 5A by a caspase-like protease(s) in mammalian cells. Virology 270 (2000) 476-487
    • (2000) Virology , vol.270 , pp. 476-487
    • Satoh, S.1    Hirota, M.2    Noguchi, T.3    Hijikata, M.4    Handa, H.5    Shimotohno, K.6
  • 55
    • 0027522145 scopus 로고
    • Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region
    • Simmonds P., Holmes E.C., Cha T.A., Chan S.W., McOmish F., Irvine B., Beall E., Yap P.L., Kolberg J., and Urdea M.S. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J. Gen. Virol. 74 Pt 11 (1993) 2391-2399
    • (1993) J. Gen. Virol. , vol.74 , Issue.PART 11 , pp. 2391-2399
    • Simmonds, P.1    Holmes, E.C.2    Cha, T.A.3    Chan, S.W.4    McOmish, F.5    Irvine, B.6    Beall, E.7    Yap, P.L.8    Kolberg, J.9    Urdea, M.S.10
  • 56
    • 0034715230 scopus 로고    scopus 로고
    • Nuclear localization and intramolecular cleavage of N-terminally deleted NS5A protein of hepatitis C virus
    • Song J., Nagano-Fujii M., Wang F., Florese R., Fujita T., Ishido S., and Hotta H. Nuclear localization and intramolecular cleavage of N-terminally deleted NS5A protein of hepatitis C virus. Virus Res. 69 (2000) 109-117
    • (2000) Virus Res. , vol.69 , pp. 109-117
    • Song, J.1    Nagano-Fujii, M.2    Wang, F.3    Florese, R.4    Fujita, T.5    Ishido, S.6    Hotta, H.7
  • 58
    • 34547781750 scopus 로고    scopus 로고
    • MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0
    • Tamura K., Dudley J., Nei M., and Kumar S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0. Mol. Biol. Evol. 24 (2007) 1596-1599
    • (2007) Mol. Biol. Evol. , vol.24 , pp. 1596-1599
    • Tamura, K.1    Dudley, J.2    Nei, M.3    Kumar, S.4
  • 59
    • 0031574072 scopus 로고    scopus 로고
    • The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools
    • Thompson J.D., Gibson T.J., Plewniak F., Jeanmougin F., and Higgins D.G. The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 25 (1997) 4876-4882
    • (1997) Nucleic Acids Res. , vol.25 , pp. 4876-4882
    • Thompson, J.D.1    Gibson, T.J.2    Plewniak, F.3    Jeanmougin, F.4    Higgins, D.G.5
  • 61
    • 33745451836 scopus 로고    scopus 로고
    • Mutations in carboxy-terminal part of E2 including PKR/eIF2alpha phosphorylation homology domain and interferon sensitivity determining region of nonstructural 5A of hepatitis C virus 1b: their correlation with response to interferon monotherapy and viral load
    • Ukai K., Ishigami M., Yoshioka K., Kawabe N., Katano Y., Hayashi K., Honda T., Yano M., and Goto H. Mutations in carboxy-terminal part of E2 including PKR/eIF2alpha phosphorylation homology domain and interferon sensitivity determining region of nonstructural 5A of hepatitis C virus 1b: their correlation with response to interferon monotherapy and viral load. World J. Gastroenterol. 12 (2006) 3722-3728
    • (2006) World J. Gastroenterol. , vol.12 , pp. 3722-3728
    • Ukai, K.1    Ishigami, M.2    Yoshioka, K.3    Kawabe, N.4    Katano, Y.5    Hayashi, K.6    Honda, T.7    Yano, M.8    Goto, H.9
  • 62
    • 34247154928 scopus 로고    scopus 로고
    • Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy
    • Veillon P., Payan C., Le Guillou-Guillemette H., Gaudy C., and Lunel F. Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy. World J. Gastroenterol. 13 (2007) 1195-1203
    • (2007) World J. Gastroenterol. , vol.13 , pp. 1195-1203
    • Veillon, P.1    Payan, C.2    Le Guillou-Guillemette, H.3    Gaudy, C.4    Lunel, F.5
  • 63
    • 33846521154 scopus 로고    scopus 로고
    • Viral determinants of resistance to treatment in patients with hepatitis C
    • Wohnsland A., Hofmann W.P., and Sarrazin C. Viral determinants of resistance to treatment in patients with hepatitis C. Clin. Microbiol. Rev. 20 (2007) 23-38
    • (2007) Clin. Microbiol. Rev. , vol.20 , pp. 23-38
    • Wohnsland, A.1    Hofmann, W.P.2    Sarrazin, C.3
  • 64
    • 0346121528 scopus 로고    scopus 로고
    • Mutations in the NS5A and E2-PePHD regions of hepatitis C virus genotype 1b and response to combination therapy of interferon plus ribavirin
    • Yang S.S., Lai M.Y., Chen D.S., Chen G.H., and Kao J.H. Mutations in the NS5A and E2-PePHD regions of hepatitis C virus genotype 1b and response to combination therapy of interferon plus ribavirin. Liver Int. 23 (2003) 426-433
    • (2003) Liver Int. , vol.23 , pp. 426-433
    • Yang, S.S.1    Lai, M.Y.2    Chen, D.S.3    Chen, G.H.4    Kao, J.H.5
  • 65
    • 33847379731 scopus 로고    scopus 로고
    • Genetic distance and heterogenecity between quasispecies is a critical predictor to IFN response in Egyptian patients with HCV genotype-4
    • Zekri A.R., El-Din H.M., Bahnassy A.A., Khaled M.M., Omar A., Fouad I., El-Hefnewi M., Thakeb F., and El-Awady M. Genetic distance and heterogenecity between quasispecies is a critical predictor to IFN response in Egyptian patients with HCV genotype-4. Virol. J. 4 (2007) 16
    • (2007) Virol. J. , vol.4 , pp. 16
    • Zekri, A.R.1    El-Din, H.M.2    Bahnassy, A.A.3    Khaled, M.M.4    Omar, A.5    Fouad, I.6    El-Hefnewi, M.7    Thakeb, F.8    El-Awady, M.9


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