Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer

BMC Cancer

Volumn 9, Issue , 2009, Pages

  Mansfield, Aaron S ^a   Heikkila, Paivi S ^a   Vaara, Ari T ^a   von Smitten, Karl A J ^a   Vakkila, Jukka M ^a   Leidenius, Marjut H K ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; INDOLEAMINE 2,3 DIOXYGENASE; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IMMUNOSUPPRESSIVE AGENT;

ADULT; AGED; ARTICLE; BREAST CANCER; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPHOCYTIC INFILTRATION; MACROPHAGE; PROTEIN EXPRESSION; SENTINEL LYMPH NODE; BIOSYNTHESIS; BREAST TUMOR; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LYMPH NODE; METABOLISM; METASTASIS; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; SENTINEL LYMPH NODE BIOPSY; TREATMENT OUTCOME;

AGED; BREAST NEOPLASMS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; LYMPH NODES; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM METASTASIS; SENTINEL LYMPH NODE BIOPSY; TREATMENT OUTCOME;

EID: 68849129604     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-9-231     Document Type: Article

References (34)

1. Shevach EM CD4+ CD25+ suppressor T cells: More questions than answers Nat Rev Immunol 2002, 2(6):389-400. 12093005
2. Curiel TJ Coukos G Zou L Alvarez X Cheng P Mottram P Evdemon-Hogan M Conejo-Garcia JR Zhang L Burow M et al Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival Nat Med 2004, 10(9):942-949. 10.1038/nm1093 15322536
3. Wolf D Wolf AM Rumpold H Fiegl H Zeimet AG Muller-Holzner E Deibl M Gastl G Gunsilius E Marth C The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer Clin Cancer Res 2005, 11(23):8326-8331. 10.1158/1078-0432.CCR-05-1244 16322292
4. Ichihara F Kono K Takahashi A Kawaida H Sugai H Fujii H Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers Clin Cancer Res 2003, 9(12):4404-4408. 14555512
5. Shimizu J Yamazaki S Sakaguchi S Induction of tumor immunity by removing CD25+CD4+ T cells: A common basis between tumor immunity and autoimmunity J Immunol 1999, 163(10):5211-5218. 10553041
6. Munn DH Sharma MD Hou D Baban B Lee JR Antonia SJ Messina JL Chandler P Koni PA Mellor AL Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes J Clin Invest 2004, 114(2):280-290. 449750 15254595
7. Munn DH Shafizadeh E Attwood JT Bondarev I Pashine A Mellor AL Inhibition of T cell proliferation by macrophage tryptophan catabolism J Exp Med 1999, 189(9):1363-1372. 2193062 10224276 10.1084/jem.189.9.1363
8. Munn DH Zhou M Attwood JT Bondarev I Conway SJ Marshall B Brown C Mellor AL Prevention of allogeneic fetal rejection by tryptophan catabolism Science 1998, 281(5380):1191-1193. 10.1126/science.281.5380.1191 9712583
9. Friberg M Jennings R Alsarraj M Dessureault S Cantor A Extermann M Mellor AL Munn DH Antonia SJ Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection Int J Cancer 2002, 101(2):151-155. 10.1002/ijc.10645 12209992
10. Sakurai K Amano S Enomoto K Kashio M Saito Y Sakamoto A Matsuo S Suzuki M Kitajima A Hirano T et al [Study of indoleamine 2,3-dioxygenase expression in patients with breast cancer] Gan To Kagaku Ryoho 2005, 32(11):1546-1549. 16315864
11. Brandacher G Perathoner A Ladurner R Schneeberger S Obrist P Winkler C Werner ER Werner-Felmayer G Weiss HG Gobel G et al Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: Effect on tumor-infiltrating T cells Clin Cancer Res 2006, 12(4):1144-1151. 10.1158/1078-0432.CCR-05-1966 16489067
12. Curti A Pandolfi S Valzasina B Aluigi M Isidori A Ferri E Salvestrini V Bonanno G Rutella S Durelli I et al Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells Blood 2007, 109(7):2871-2877. 17164341
13. Hou DY Muller AJ Sharma MD DuHadaway J Banerjee T Johnson M Mellor AL Prendergast GC Munn DH Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses Cancer Res 2007, 67(2):792-801. 10.1158/ 0008-5472.CAN-06-2925 17234791
14. Nemoto T Vana J Bedwani RN Baker HW McGregor FH Murphy GP Management and survival of female breast cancer: Results of a national survey by the American College of Surgeons Cancer 1980, 45(12):2917-2924. 10.1002/ 1097-0142(19800615)45:12<2917::AID-CNCR2820451203>3.0.CO;2-M 7388735
15. Rosen PP Groshen S Saigo PE Kinne DW Hellman S Pathological prognostic factors in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma: A study of 644 patients with median follow-up of 18 years J Clin Oncol 1989, 7(9):1239-1251. 2549203
16. Mansour EG Ravdin PM Dressler L Prognostic factors in early breast carcinoma Cancer 1994, 74(1 Suppl):381-400. 8004612
17. Leidenius MH Krogerus LA Toivonen TS von Smitten KA Sentinel node biopsy is not sensible in breast cancer patients with large primary tumours Eur J Surg Oncol 2005, 31(4):364-368. 10.1016/j.ejso.2004.11.006 15837040
18. Whiteside TL Immune suppression in cancer: Effects on immune cells, mechanisms and future therapeutic intervention Semin Cancer Biol 2006, 16(1):3-15. 10.1016/j.semcancer.2005.07.008 16153857
19. Sobin LHWC editors TNM classification of malignant tumors New York: John Wiley and Sons 6 2002
20. Leidenius MH Krogerus LA Toivonen TS Von Smitten KJ The feasibility of intraoperative diagnosis of sentinel lymph node metastases in breast cancer J Surg Oncol 2003, 84(2):68-73. 10.1002/jso.10296 14502779
21. Leikola JP Toivonen TS Krogerus LA von Smitten KA Leidenius MH Rapid immunohistochemistry enhances the intraoperative diagnosis of sentinel lymph node metastases in invasive lobular breast carcinoma Cancer 2005, 104(1):14-19. 10.1002/cncr.21133 15929120
22. Bates GJ Fox SB Han C Leek RD Garcia JF Harris AL Banham AH Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse J Clin Oncol 2006, 24(34):5373-5380. 10.1200/JCO.2006.05.9584 17135638
23. Ladoire S Arnould L Apetoh L Coudert B Martin F Chauffert B Fumoleau P Ghiringhelli F Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp3+ regulatory T cells Clin Cancer Res 2008, 14(8):2413-2420. 10.1158/1078-0432.CCR-07-4491 18413832
24. Viguier M Lemaitre F Verola O Cho MS Gorochov G Dubertret L Bachelez H Kourilsky P Ferradini L Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells J Immunol 2004, 173(2):1444-1453. 15240741
25. Matsuura K Yamaguchi Y Ueno H Osaki A Arihiro K Toge T Maturation of dendritic cells and T-cell responses in sentinel lymph nodes from patients with breast carcinoma Cancer 2006, 106(6):1227-1236. 10.1002/ cncr.21729 16475148
26. Chen W Liang X Peterson AJ Munn DH Blazar BR The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation J Immunol 2008, 181(8):5396-5404. 18832696
27. Vogel CF Goth SR Dong B Pessah IN Matsumura F Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase Biochem Biophys Res Commun 2008, 375(3):331-335. 10.1016/j.bbrc.2008.07.156 18694728
28. Yu G Dai H Chen J Duan L Gong M Liu L Xiong P Wang CY Fang M Gong F Gene delivery of indoleamine 2,3-dioxygenase prolongs cardiac allograft survival by shaping the types of T-cell responses J Gene Med 2008, 10(7):754-761. 10.1002/jgm.1201 18452241
29. Park MJ Min SY Park KS Cho YG Cho ML Jung YO Park HS Chang SH Cho SG Min JK et al. Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer's patches in an orally tolerized, collagen-induced arthritis mouse model Arthritis Res Ther 2008, 10(1):R11. 2374459 18221522 10.1186/ar2361
30. Nakamura T Shima T Saeki A Hidaka T Nakashima A Takikawa O Saito S Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer Cancer Sci 2007, 98(6):874-881. 10.1111/ j.1349-7006.2007.00470.x 17433037
31. Wobser M Voigt H Houben R Eggert AO Freiwald M Kaemmerer U Kaempgen E Schrama D Becker JC Dendritic cell based antitumor vaccination: Impact of functional indoleamine 2,3-dioxygenase expression Cancer Immunol Immunother 2007, 56(7):1017-1024. 10.1007/s00262-006-0256-1 17195079
32. Sharma MD Baban B Chandler P et al Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase J Clin Invest 2007, 117(9):2570-82. 1940240 17710230 10.1172/JCI31911
33. Polak ME Borthwick NJ Gabriel FG Johnson P Higgins B Hurren J McCormick D Jager MJ Cree IA Mechanisms of local immunosuppression in cutaneous melanoma Br J Cancer 2007, 96(12):1879-1887. 10.1038/sj.bjc.6603763 17565341
34. Lee JH Torisu-Itakara H Cochran AJ Kadison A Huynh Y Morton DL Essner R Quantitative analysis of melanoma-induced cytokine-mediated immunosuppression in melanoma sentinel nodes Clin Cancer Res 2005, 11(1):107-112. 15671534