Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS)

AIDS Research and Therapy

Volumn 6, Issue , 2009, Pages

  Murdoch, David M ^a   Suchard, Melinda S ^b   Venter, Willem D F ^b   Mhlangu, Patrick ^c   Ottinger, Janet S ^d   Feldman, Charles ^b   Van Rie, Annelies ^e   Glencross, Deborah K ^b,c   Stevens, Wendy S ^b   Weinhold, Kent J ^d  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c University of the Witwatersrand ^*  (South Africa)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e IL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; VIRUS RNA;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNOPATHOGENESIS; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TREATMENT DURATION;

EID: 68849122256     PISSN: 17426405     EISSN: None     Source Type: Journal    
DOI: 10.1186/1742-6405-6-6     Document Type: Article

References (37)

1. Shelburne SA 3rd Hamill RJ Rodriguez-Barradas MC Greenberg SB Atmar RL Musher DW Gathe JC Jr Visnegarwala F Trautner BW Immune reconstitution inflammatory syndrome: Emergence of a unique syndrome during highly active antiretroviral therapy Medicine (Baltimore) 2002, 81:213-227. 10.1097/00005792-200205000-00005 11997718
2. French MA Lenzo N John M Mallal SA McKinnon EJ James IR Price P Flexman JP Tay-Kearney ML Immune restoration disease after the treatment of immunodeficient HIV-infected patients with highly active antiretroviral therapy HIV Med 2000, 1:107-115. 10.1046/j.1468-1293.2000.00012.x 11737333
3. Murdoch DM Venter WD Van Rie A Feldman C Immune reconstitution inflammatory syndrome (IRIS): Review of common infectious manifestations and treatment options AIDS Res Ther 2007, 4:9. 1871602 17488505 10.1186/ 1742-6405-4-9
4. Jevtovic DJ Salemovic D Ranin J Pesic I Zerjav S Djurkovic-Djakovic O The prevalence and risk of immune restoration disease in HIV-infected patients treated with highly active antiretroviral therapy HIV Med 2005, 6:140-143. 10.1111/j.1468-1293.2005.00277.x 15807721
5. Murdoch DM Venter WD Feldman C Van Rie A Incidence and risk factors for the immune reconstitution inflammatory syndrome in HIV patients in South Africa: A prospective study Aids 2008, 22:601-610. 10.1097/ QAD.0b013e3282f4a607 18317001
6. Ratnam I Chiu C Kandala NB Easterbrook PJ Incidence and risk factors for immune reconstitution inflammatory syndrome in an ethnically diverse HIV type 1-infected cohort Clin Infect Dis 2006, 42:418-427. 10.1086/499356 16392092
7. Shelburne SA Visnegarwala F Darcourt J Graviss EA Giordano TP White AC Jr Hamill RJ Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy Aids 2005, 19:399-406. 10.1097/01.aids.0000161769.06158.8a 15750393
8. Bucy RP Hockett RD Derdeyn CA Saag MS Squires K Sillers M Mitsuyasu RT Kilby JM Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues J Clin Invest 1999, 103:1391-1398. 408455 10330421 10.1172/JCI5863
9. Autran B Carcelain G Li TS Blanc C Mathez D Tubiana R Katlama C Debre P Leibowitch J Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease Science 1997, 277:112-116. 10.1126/science.277.5322.112 9204894
10. Wendland T Furrer H Vernazza PL Frutig K Christen A Matter L Malinverni R Pichler WJ HAART in HIV-infected patients: Restoration of antigen-specific CD4 T-cell responses in vitro is correlated with CD4 memory T-cell reconstitution, whereas improvement in delayed type hypersensitivity is related to a decrease in viraemia Aids 1999, 13:1857-1862. 10.1097/00002030-199910010-00007 10513643
11. Race EM Adelson-Mitty J Kriegel GR Barlam TF Reimann KA Letvin NL Japour AJ Focal mycobacterial lymphadenitis following initiation of protease-inhibitor therapy in patients with advanced HIV-1 disease Lancet 1998, 351:252-255. 10.1016/S0140-6736(97)04352-3 9457095
12. Bourgarit A Carcelain G Martinez V Lascoux C Delcey V Gicquel B Vicaut E Lagrange PH Sereni D Autran B Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients Aids 2006, 20:F1-7. 16511406
13. South African Department of Health Full Report of the Joint Health and Treasury Task Team Charged with Examining Treatment Options to Supplement Comprehensive Care for HIV/AIDS in the Public Health Sector, November 2003 http://www.gov.za/issues/hiv/careplan19nov03.htm last accessed 5 June 2007.
14. French MA Price P Stone SF Immune restoration disease after antiretroviral therapy Aids 2004, 18:1615-1627. 10.1097/ 01.aids.0000131375.21070.06 15280772
15. Lawn SD Bekker LG Miller RF Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals Lancet Infect Dis 2005, 5:361-373. 10.1016/ S1473-3099(05)70140-7 15919622
16. Shelburne SA 3rd Hamill RJ The immune reconstitution inflammatory syndrome AIDS Rev 2003, 5:67-79. 12876896
17. Glencross D Scott LE Jani IV Barnett D Janossy G CD45-assisted PanLeucogating for accurate, cost-effective dual-platform CD4+ T-cell enumeration Cytometry 2002, 50:69-77. 10.1002/cyto.10068 12116348
18. Wellons MF Ottinger JS Weinhold KJ Gryszowka V Sanders LL Edwards LJ Gooding ME Thomasch JR Bartlett JA Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy J Infect Dis 2001, 183:1522-1525. 10.1086/320193 11319689
19. Iyer SB Hultin LE Zawadzki JA Davis KA Giorgi JV Quantitation of CD38 expression using QuantiBRITE beads Cytometry 1998, 33:206-212. 10.1002/ (SICI)1097-0320(19981001)33:2<206::AID-CYTO15>3.0.CO;2-Y 9773881
20. Betts MR Nason MC West SM De Rosa SC Migueles SA Abraham J Lederman MM Benito JM Goepfert PA Connors M Roederer M Koup RA HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells Blood 2006, 107:4781-4789. 1895811 16467198 10.1182/blood-2005-12-4818
21. Casazza JP Betts MR Price DA Precopio ML Ruff LE Brenchley JM Hill BJ Roederer M Douek DC Koup RA Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation J Exp Med 2006, 203:2865-2877. 2118179 17158960 10.1084/jem.20052246
22. Glencross DK Janossy G Coetzee LM Lawrie D Scott LE Sanne I McIntyre JA Stevens W CD8/CD38 activation yields important clinical information of effective antiretroviral therapy: Findings from the first year of the CIPRA-SA cohort Cytometry B Clin Cytom 2008, 74(Suppl 1):S131-140. 18228566
23. Chun TW Justement JS Sanford C Hallahan CW Planta MA Loutfy M Kottilil S Moir S Kovacs C Fauci AS Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals Proc Natl Acad Sci USA 2004, 101:2464-2469. 356973 14983032 10.1073/pnas.0307328101
24. Ondoa P Dieye TN Vereecken C Camara M Diallo AA Fransen K Litzroth A Mboup S Kestens L Evaluation of HIV-1 p24 antigenemia and level of CD8+ CD38+ T cells as surrogate markers of HIV-1 RNA viral load in HIV-1-infected patients in Dakar, Senegal J Acquir Immune Defic Syndr 2006, 41:416-424. 10.1097/01.qai.0000209901.12750.d0 16652048
25. Eggena MP Barugahare B Okello M Mutyala S Jones N Ma Y Kityo C Mugyenyi P Cao H T cell activation in HIV-seropositive Ugandans: Differential associations with viral load, CD4+ T cell depletion, and coinfection J Infect Dis 2005, 191:694-701. 10.1086/427516 15688282
26. Hathcock KS Kaech SM Ahmed R Hodes RJ Induction of telomerase activity and maintenance of telomere length in virus-specific effector and memory CD8+ T cells J Immunol 2003, 170:147-152. 12496394
27. Kaech SM Hemby S Kersh E Ahmed R Molecular and functional profiling of memory CD8 T cell differentiation Cell 2002, 111:837-851. 10.1016/ S0092-8674(02)01139-X 12526810
28. Grayson JM Murali-Krishna K Altman JD Ahmed R Gene expression in antigen-specific CD8+ T cells during viral infection J Immunol 2001, 166:795-799. 11145652
29. Peixoto A Evaristo C Munitic I Monteiro M Charbit A Rocha B Veiga-Fernandes H CD8 single-cell gene coexpression reveals three different effector types present at distinct phases of the immune response J Exp Med 2007, 204:1193-1205. 2118592 17485515 10.1084/ jem.20062349
30. Lim A D'Orsogna L Price P French MA Imbalanced effector and regulatory cytokine responses may underlie mycobacterial immune restoration disease AIDS Res Ther 2008, 5:9. 2391156 18442415 10.1186/1742-6405-5-9
31. Lefrancois L Marzo AL Masopust D Schluns KS Vezy V Migration of primary and memory CD8 T cells Adv Exp Med Biol 2002, 512:141-146. 12405198
32. Lefrancois L Masopust D T cell immunity in lymphoid and non-lymphoid tissues Curr Opin Immunol 2002, 14:503-508. 10.1016/ S0952-7915(02)00360-6 12088686
33. Sallusto F Lenig D Forster R Lipp M Lanzavecchia A Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Nature 1999, 401:708-712. 10.1038/44385 10537110
34. Hikono H Kohlmeier JE Ely KH Scott I Roberts AD Blackman MA Woodland DL T-cell memory and recall responses to respiratory virus infections Immunol Rev 2006, 211:119-132. 10.1111/j.0105-2896.2006.00385.x 16824122
35. de Bree GJ van Leeuwen EM Out TA Jansen HM Jonkers RE van Lier RA Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung J Exp Med 2005, 202:1433-1442. 2212987 16301748 10.1084/jem.20051365
36. Domingo P Torres OH Ris J Vazquez G Herpes zoster as an immune reconstitution disease after initiation of combination antiretroviral therapy in patients with human immunodeficiency virus type-1 infection Am J Med 2001, 110:605-609. 10.1016/S0002-9343(01)00703-3 11382367
37. French MA Mallal SA Dawkins RL Zidovudine-induced restoration of cell-mediated immunity to mycobacteria in immunodeficient HIV-infected patients AIDS 1992, 6:1293-1297. 10.1097/00002030-199211000-00009 1472334