Con: Dexmedetomidine Should Not Be Used for Infants and Children During Cardiac Surgery

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 22, Issue 1, 2008, Pages 152-154

  Hammer, Gregory B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cardiac surgery; dexmedetomidine; pediatric patients

Indexed keywords

EID: 38749103866     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2007.10.007     Document Type: Note

References (13)

1. Bloor B.C., Ward D.S., Belleville J.P., et al. Effects of intravenous dexmedetomidine in humans, II: Hemodynamic changes. Anesthesiology 77 (1992) 1134-1142
2. Ebert T.J., Hall J.E., Barney J.A., et al. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 93 (2000) 382-394
3. 2-agonist is mediated in the locus coeruleus in rats. Anesthesiology 76 (1992) 948-952
4. Chiu T.H., Chen M.J., Yang Y.R., et al. Action of dexmedetomidine on rat locus coeruleus neurons: intracellular recording in vitro. Eur J Pharmacol 285 (1995) 261-268
5. 2-adrenergic agonists to prevent perioperative complications: A meta-analysis. Am J Med 114 (2003) 742-752
6. Mukhtar A.M., Obayah E.M., and Hassona A.M. The use of dexmedetomidine in pediatric cardiac surgery. Anesth Analg 103 (2006) 52-56
7. Blake D.W., Ludbrook J., and Van Leeuwen A.F. Dexmedetomidine and haemodynamic responses to acute central hypovolemia in conscious rabbits. Clin Exp Pharm Physiol 27 (2000) 801-809
8. Blake D.W. Dexmedetomidine and haemodynamic responses to acute central hypovolaemia in conscious rabbits. Anesth Analg 91 (2000) 1112-1117
9. Valsangiacomo E., Schmid E.R., Schupbach R.W., et al. Early postoperative arrhythmias after cardiac operation in children. Ann Thorac Surg 74 (2002) 792-796
10. Delaney J.W., Moltedo J.M., Dziura J.D., et al. Early postoperative arrhythmias after pediatric cardiac surgery. J Thorac Cardiovasc Surg 131 (2006) 1296-1300
11. Hammer GB, Cao H, Jackson E, et al: Effects of dexmedetomidine on cardiac electrophysiology in children. Anesth Analg (in press)
12. Kastner S.B.R., Kull S., Kutter A.P.N., et al. Cardiopulmonary effects of dexmedetomidine in sevoflurane-anesthetized sheep with and without nitric oxide inhalation. Am J Vet Res 66 (2005) 1496-1502
13. But A.K., Ozgul O.F., Gulhas N., et al. The effects of preoperative dexmedetomidine infusion on hemodynamics in patients with pulmonary hypertension undergoing mitral valve replacement surgery. Acta Anaesthesiol Scand 50 (2006) 1207-1212