Effects of astragalosides on the expression of BDNF, TrkB and p75NTR mRNA against focal cerebral ischemia-reperfusion injury

Chinese Pharmacological Bulletin

Volumn 25, Issue 5, 2009, Pages

  Yin, Yan Yan ^a   Li, Wei Ping ^a   Li, Wei Zu ^a   Gong, Hui Ling ^a   Zhu, Fen Fang ^a   Wu, Guo Cui ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Astragalosides; BDNF; Cerebral ischemia; p75NTR; Trkb

Indexed keywords

ASTRAGALOSIDE IV; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MESSENGER RNA; NEUROTROPHIN RECEPTOR P75;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 68849097514     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Liu D M, Xu D F, Liu Z J, et al. Protective effect of extract of astragalus against injury induced by amyloid peptide in hippocampal neuron[ J ]. Chin Phamacol Bull, 2007, 23(4) :543-547
2. Zhu HY, Pu L. Study the effect of extract of astragalus on antiinflammatory , analgesia, antihypoxia and antifatigue [ J ]. Lishizhen Med Mat Med Res, 2007, 18(5) :1156-1157
3. Yin Y Y, Li W P, Wang S B, et al. Effect of extract of astragalus on inflammatory factor and apoptosis after focal cerebral ischemia/ reperfusion injury in rats [ J ]. Chin Phamacol Bull, 2005, 21 (12):1486-1489 (Pubitemid 43219190)
4. Longa E Z, Weinstein P R, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats [ J ]. Stroke, 1989, 20(1) :84-91. (Pubitemid 19040218)
5. Xu S Y, Bian R L, Chen X, chief ed. Methodology of pharmacological experiment[ M ]. 3rd ed, Beijing: People's Medical Publishing House, 2002:1066-1067
6. Bederson J B, Pitts L H, Tsuji M, et al. Rat middle cerebral artery occlusion ; evaluation of the model and development of a neurologic examination [ J ]. Stroke, 1986, 17(3) :472-476 (Pubitemid 16085691)
7. Liu W, Cheng Y, Wang Q. Brain-derived neurotraphic factor and cerebral ischemic injury [ J ]. Cerebrovasc Dise Fore Med Sd, 2004, 12(6):433-436
8. Marini A M, Jiang X, Wu X, et al. Role of brain-derived neurotrophic factor and NF-kappa B in neuronal plasticity and survival : From genes to phenotype[ J ]. Restor Neurol Neurosci, 2004, 22(2) 1121-1130 (Pubitemid 38850339)
9. Kim M W, Bang MS, Han T R, et al. Exercise increased BDNF and trkB in the contralateral hemisphere of the ischemic rat brain [ J ]. Brain Res, 2005, 1052( 1 ) :16-21.
10. Lang E M, Asan E, Plesnila N, et al. Motoneuron survival after C7 nerve root avulsion and replantation in the adult rabbit : Effects of local ciliary neurotrophic factor and brain-derived neurotrophic factor application [ J ]. Plast Reconstr Surg, 2005, 115(7) : 2042-2050 (Pubitemid 40770517)
11. Kim M W, Bang M S, Han T R, et al. Exercise increased BDNF and trkB in the contralateral hemisphere of the ischemic rat brain [ J ]. Brain Res,2005, 1052(1 ):16-21.
12. Harrington A W, Leiner B, Blechschmitt C, et al. Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury[ J ]. Proc Natl Acad Sei USA, 2004, 101 ( 16) : 6226-6230 (Pubitemid 38520556)
13. Yeiser E C, Rutkoski N J, Naito A, et al. Neurotrophin signaling through the p75 receptor is deficient in traf6-/-mice[ J ]. J Neuros- ci, 2004, 24:10521-10529 (Pubitemid 39552637)
14. Becker E B, Howell J, Kodama Y, et al. Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis[ J ]. J Neurosci, 2004, 24(40) :8762-8770 (Pubitemid 39362971)
15. Schäbitz WR, Berger C, KollmarR, etal. Effect of brain-derived neurotrophic factor treatment and forced arm use on functional motor recovery after small cortical ischemia [ J ]. Stroke, 2004, 35 (4): 992-997 (Pubitemid 38419816)