Ex vivo analysis of rotational stiffness of different osteosynthesis techniques in mouse femur fracture

Journal of Orthopaedic Research

Volumn 27, Issue 9, 2009, Pages 1152-1156

  Histing, Tina ^a,b   Holstein, Joerg H ^a,b   Garcia, Patric ^a,b   Matthys, Romano ^c   Kristen, Alexander ^a,b   Claes, Lutz ^d   Menger, Michael D ^a,b   Pohlemann, Tim ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b AO FOUNDATION   (Switzerland)

^c AO Development Institute   (Switzerland)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

Bone healing; Femur fracture; Mice; Osteosynthesis; Torsional stiffness

Indexed keywords

ANIMAL TISSUE; ARTICLE; BONE SCREW; CONTROLLED STUDY; EX VIVO STUDY; EXTERNAL FIXATOR; FEMUR FRACTURE; FRACTURE EXTERNAL FIXATION; FRACTURE HEALING; INTERLOCKING NAIL; INTRAMEDULLARY NAILING; MECHANICAL TORSION; MOUSE; NONHUMAN; OSTEOSYNTHESIS; PRIORITY JOURNAL; RIGIDITY; ROTATION;

ANIMALS; BONE NAILS; DISEASE MODELS, ANIMAL; FEMORAL FRACTURES; FEMUR; FRACTURE FIXATION, INTERNAL; FRACTURE HEALING; MICE; MICE, INBRED STRAINS; OSTEOTOMY; TORSION, MECHANICAL;

EID: 68849096492     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20849     Document Type: Article

References (32)

1. Jacenko O, Olsen BR. 1995. Transgenic mouse models in studies of skeletal disorders. J Rheumatol 43:39-41.
2. Cho TJ, Gerstenfeld LC, Einhorn TA. 2002. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res 17:513-520.
3. Hiltunen A, Vuorio E, Aro AT. 1993. A standardized experimental fracture in the mouse tibia. J Orthop Res 11:305-312.
4. Nakase T, Nomura S, Yoshikawa H, et al. 1994. Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing. J Bone Miner Res 9:651-659.
5. Ohta S, Muramatsu H, Senda T, et al. 1999. Midkine is expressed during repair of bone fracture and promotes chondrogenesis. J Bone Miner Res 14:1132-1144.
6. Yamagiwa H, Tokunaga K, Hayami T, et al. 1999. Expression of metalloproteinase-13 (collagenase-3) is induced during fracture healing in mice. Bone 25:197-203.
7. Cheung K, Kalurachi K, Andrew G, et al. 2003. An external fixed femoral fracture model for mice. J Orthop Res 21:685-690.
8. Connolly CK, Li G, Bunn JR, et al. 2003. A reliable externally fixated murine femoral fracture model that accounts for variation in movement between animals. J Orthop Res 21:843-849.
9. Isefuku S, Joyner CJ, Reed AA, et al. 2004. Distraction osteogenesis in the Cbfa-1+/- mouse. J Orthop Res 22:1276-1282.
10. Garcia P, Holstein JH, Histing T, et al. 2008. A simple and reliable internally fixed femoral fracture model in mice. J Biomech (in press).
11. Gardner MJ, van der Meulen MC, Demetrkopoulos D, et al. 2006. In vivo cyclic axial compression affects bone healing in the mouse tibia. J Orthop Res 24:1679-1686.
12. Holstein JH, Menger MD, Meier C, et al. 2007. Development of a locking femur nail for mice. J Biomech 40:215-219.
13. Holstein JH, Becker S, Fiedler M, et al. 2008. Development of an intramedullary fixation screw for mice. J Surg Res (in press).
14. Li M, Healy Dr, Li Y, et al. 2005. Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice. Bone 37:46-54.
15. Manigrasso MB, O'Connor PJ. 2004. Characterization of closed femur fracture model in mice. J Orthop Trauma 18:687-695.
16. Marsell R, Jonsson KB, Cho TJ, et al. 2007. Mice expressing a constitutively active PTH/PTHrP receptor in osteoblasts show reduced callus size but normal callus morphology during fracture healing. Acta Orthop 78:39-45.
17. Le AX, Miclau T, Hu D, et al. 2001. Molecular aspects of healing in stabilized and non-stabilized fractures. J Orthop Res 19:78-84.
18. Bhandari M, Schemitsch EH. 2002. Bone formation following intramedullary femoral reaming is decreased by indomethaci and antibodies to insulin-like growth factors. J Orthop Trauma 16:717-722.
19. Gerstenfeld LC, Alkhiary YM, Krall EA, et al. 2006. Three-dimensional reconstruction of fracture callus morphogenesis. J Histochem Cytochem 54:1215-1228.
20. Skoglund B, Forslund C, Aspenberg P. 2002. Simvastin improves fracture healing in mice. J Bone Miner Res 17:2004-2008.
21. Colnot C, Thompson Z, Miclau T, et al. 2003. Altered fracture repair in the absence of MMP9. Development 130:4123-4133.
22. Augat P, Burger J, Schorlemmer S, et al. 2003. Shear movement at the fracture site delays healing in a diaphyseal fracture model. J Orthop Res 21:1011-1017.
23. Shefelbine SJ, Augat P, Claes L, et al. 2005. Intact fibula improves fracture healing in a rat tibia osteotomy model. J Orthop Res 23:489-493.
24. Schell H, Epari DR, Kassi JP, et al. 2005. The course of bone healing is influenced by the initial shear fixation stability. J Orthop Res 23:1002-1028.
25. Schoen M, Rotter R, Schattner S, et al. 2008. Introduction of a new interlocked intramedullary nailing device for stabilization of critically sized femoral defects in the rat: a combined biomechanical and animal experimental study. J Orthop Res 26:184-189.
26. Aro HT, Wahner HT, Chao EY. 1991. Healing patterns of transverse and oblique osteotomies in the canine tibia under external fixation. J Orthop Trauma 5:351-364.
27. Epari DR, Schell H, Bail HJ, et al. 2006. Instability prolongs the chondral phase during bone healing in sheep. Bone 38:864-870.
28. Molster AO. 1984. Effects of rotational instability on healing of femoral osteotomies in rat. Acta Orthop Scand 55:632-636.
29. Grundnes O, Reikeras O. 1993. Effects of instability on bone healing. Femoral osteotomies studied in rats. Acta Orthop Scand 64:55-58.
30. Sochen JE. 1994. Orthopaedic wounds. Am J Surg 167:52-55.
31. Thompson Z, Miclau T, Hu D, et al. 2002. A model for intramembranous ossification during fracture healing. J Orthop Res 20:1091-1098.
32. Vu TH, Shipley JM, Bergers G, et al. 1998. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93:411-422.