Mice expressing a constitutively active PTH/PTHrP receptor in osteoblasts show reduced callus size but normal callus morphology during fracture healing

Acta Orthopaedica

Volumn 78, Issue 1, 2007, Pages 39-45

  Marsell, Richard ^a   Jonsson, Kenneth B ^a   Cho, Tae Joon ^e   Einhorn, Thomas A ^b   Ohlsson, Claes ^c   Schipani, Ernestina ^d  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE GROWTH; BONE MINERAL; BONE RADIOGRAPHY; CALLUS; CONTROLLED STUDY; FRACTURE HEALING; MOUSE; NONHUMAN; OSTEOBLAST; PERIOSTEUM; PHENOTYPE; PROTEIN EXPRESSION; TIBIA; TIBIA FRACTURE; TISSUE SECTION; TRABECULAR BONE; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; BONE DENSITY; BONY CALLUS; FRACTURE HEALING; GENE EXPRESSION; MICE; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOGENESIS; RECEPTOR, PARATHYROID HORMONE, TYPE 1; TIBIA; TIBIAL FRACTURES;

EID: 34147096382     PISSN: 17453674     EISSN: 17453682     Source Type: Journal    
DOI: 10.1080/17453670610013402     Document Type: Article

References (21)

1. Alkhiary Y M, Gerstenfeld L C, Krall E, Westmore M, Sato M, Mitlak B H, Einhorn T A. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J Bone Joint Surg (Am) 2005; 87 (4): 731-41.
2. Andreassen T T, Fledelius C, Ejersted C, Oxlund H. Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone. Acta Orthop Scand 2001; 72 (3): 304-7.
3. Andreassen T T, Willick G E, Morley P, Whitfield J F. Treatment with parathyroid hormone hPTH(1-34), hPTH(1-31), and monocyclic hPTH(1-31) enhances fracture strength and callus amount after withdrawal fracture strength and callus mechanical quality continue to increase. Calcif Tissue Int 2004; 74 (4): 351-6.
4. Bolander M E. Regulation of fracture repair by growth factors. Proc Soc Exp Biol Med 1992; 200 (2): 165-70.
5. Bonnarens F, Einhorn T A. Production of a standard closed fracture in laboratory animal bone. J Orthop Res 1984; 2 (1): 97-101.
6. Bourque W T, Gross M and Hall B K. A reproducible method for producing and quantifying the stages of fracture repair. Lab Anim Sci 1992; 42 (4): 369-74.
7. Buckwalter J A, ,Hunziker E B. Orthopaedics. Healing of bones, cartilages, tendons, and ligaments: a new era. Lancet 1996; 348 Suppl 2: sII18.
8. Calvi L M, Sims N A, Hunzelman J L, Knight M C, Giovannetti A, Saxton J M, Kronenberg H M, Baron R, Schipani E. Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone. J Clin Invest 2001; 107 (3): 277-86.
9. Chung U I, Lanske B, Lee K, Li E, Kronenberg H. The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc Natl Acad Sci U S A 1998; 95 (22): 13030-5.
10. Holzer G, Majeska R J, Lundy M W, Hartke J R, Einhorn T A. Parathyroid hormone enhances fracture healing. A preliminary report. Clin Orthop 1999;(366): 258-63.
11. Jansen M. Über atypische Chondrodystrofie (Achondroplasie) und über eine noch nicht beschriebene angeborene Wachstumsstörnung des Knochensystems: Metaphysäre Dysostosis 1934.
12. Juppner H, Abou-Samra A B, Freeman M, Kong X F, Schipani E, Richards J, Kolakowski L F, Jr., Hock J, Potts J T, Jr., Kronenberg H M. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 1991; 254 (5034): 1024-6.
13. Juppner H, Schipani E. Receptors for parathyroid hormone and parathyroid hormone-related peptide: from molecular cloning to definition of diseases. Curr Opin Nephrol Hypertens 1996; 5 (4): 300-6.
14. Kronenberg H M. Developmental regulation of the growth plate. Nature 2003; 423 (6937): 332-6.
15. Kronenberg H M, Lanske B, Kovacs C S, Chung U I, Lee K, Segre G V, Schipani E, Juppner H. Functional analysis of the PTH/PTHrP network of ligands and receptors. Recent Prog Horm Res 1998; 53: 283-301; discussion 301-3.
16. Kurland E S, Cosman F, McMahon D J, Rosen C J, Lindsay R, Bilezikian J P. Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers. J Clin Endocrinol Metab 2000; 85 (9): 3069-76.
17. Lanske B, Karaplis A C, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize L H, Ho C, Mulligan R C, Abou-Samra A B, Juppner H, Segre G V, Kronenberg H M. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 1996; 273 (5275): 663-6.
18. Neer R M, Arnaud C D, Zanchetta J R, Prince R, Gaich G A, Reginster J Y, Hodsman A B, Eriksen E F, Ish-Shalom S, Genant H K, Wang O, Mitlak B H. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 2001; 344 (19): 1434-41.
19. Schipani E, Kruse K, Juppner H. A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 1995; 268 (5207): 98-100.
20. Schipani E, Lanske B, Hunzelman J, Luz A, Kovacs C S, Lee K, Pirro A, Kronenberg H M, Juppner H. Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc Natl Acad Sci USA 1997; 94 (25): 13689-94.
21. Vortkamp A, Lee K, Lanske B, Segre G V, Kronenberg H M, Tabin C J. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 1996; 273 (5275): 613-22.