Intact fibula improves fracture healing in a rat tibia osteotomy model

Journal of Orthopaedic Research

Volumn 23, Issue 2, 2005, Pages 489-493

  Shefelbine, Sandra J ^a   Augat, Peter ^a   Claes, Lutz ^a   Beck, Alexander ^a  

^a Institute for Orthopaedics and Biomechanics   (Germany)

Author keywords

Fracture; Rat; Stability; Tibia; Torsional rigidity

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MINERAL; CALLUS; CONTROLLED STUDY; FIBULA; FRACTURE HEALING; IN VITRO STUDY; IN VIVO STUDY; INTRAMEDULLARY NAIL; JOINT MOBILITY; LEG FRACTURE; MALE; NONHUMAN; OSTEOTOMY; PRIORITY JOURNAL; RAT; RIGIDITY; TIBIA FRACTURE; TIBIA TORSION;

ANIMALS; BONE DENSITY; FIBULA; FRACTURE HEALING; MALE; OSTEOTOMY; RATS; RATS, WISTAR; TIBIAL FRACTURES; TORSION;

EID: 14244254460     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.orthres.2004.08.007     Document Type: Article

References (30)

1. Y. An R.J. Friedman T. Parent R.A. Draughn Production of a standard closed fracture in the rat tibia J. Orthop. Trauma 8 1994 111-115
2. H.T. Aro H.T. Wahner E.Y. Chao Healing patterns of transverse and oblique osteotomies in the canine tibia under external fixation J. Orthop. Trauma 5 1991 351-364
3. P. Augat J. Burger S. Schorlemmer T. Henke M. Peraus L. Claes Shear movement at the fracture site delays healing in a diaphyseal fracture model J. Orthop. Res. 21 2003 1011-1017
4. P. Augat K. Margevicius J. Simon S. Wolf G. Suger L. Claes Local tissue properties in bone healing: Influence of size and stability of the osteotomy gap J. Orthop. Res. 16 1998 475-481
5. P. Augat J. Merk H.K. Genant L. Claes Quantitative assessment of experimental fracture repair by peripheral computed tomography Calcif. Tissue Int. 60 1997 194-199
6. B. Bak K.S. Jensen Standardization of tibial fractures in the rat Bone 13 1992 289-295
7. Bishop N, Tami I, van Rhijn M, Corveleijn R, Schneider E, Ito K. Effects of volumetric vs. shear deformation on tissue differentiation during secondary bone healing. In: Transactions of 49th orthopaedic research society 2003;23:114. New Orleans: Orthopaedic Research Society
8. F. Bonnarens T.A. Einhorn Production of a standard closed fracture in laboratory animal bone J. Orthop. Res. 2 1984 97-101
9. D.A. Chakkalakal J.R. Novak E.D. Fritz T.J. Mollner D.L. McVicker D.L. Lybarger et al. Chronic ethanol consumption results in deficient bone repair in rats Alcohol Alcoh. 37 2002 13-20
10. L. Claes P. Augat G. Suger H.J. Wilke Influence of size and stability of the osteotomy gap on the success of fracture healing J. Orthop. Res. 15 1997 577-584
11. R. David M. Nissan I. Cohen M. Soudry Effect of low-power He-Ne laser on fracture healing in rats Lasers Surg. Med. 19 1996 458-464
12. S.M. Day D.H. DeHeer Reversal of the detrimental effects of chronic protein malnutrition on long bone fracture healing J. Orthop. Trauma 15 2001 47-53
13. T.A. Einhorn F. Bonnarens A.H. Burstein The contributions of dietary protein and mineral to the healing of experimental fractures. A biomechanical study J. Bone Joint Surg. Am. 68 1986 1389-1395
14. A. Ekeland L.B. Engesaeter N. Langeland Mechanical properties of fractured and intact rat femora evaluated by bending, torsional and tensile tests Acta Orthop. Scand. 52 1981 605-613
15. N. Elmali K. Ertem S. Ozen M. Inan T. Baysal G. Guner et al. Fracture healing and bone mass in rats fed on liquid diet containing ethanol Alcohol Clin. Exp. Res. 26 2002 509-513
16. B.A. Evans J.T. Warner C. Elford S.L. Evans A. Laib R.K. Bains et al. Morphological determinants of femoral strength in growth hormone-deficient transgenic growth-retarded (Tgr) rats J. Bone Miner. Res. 18 2003 1308-1316
17. O. Grundnes O. Reikeras Effects of instability on bone healing. Femoral osteotomies studied in rats Acta. Orthop. Scand. 64 1993 55-58
18. S. Hankemeier S. Grassel G. Plenz H.U. Spiegel P. Bruckner A. Probst Alteration of fracture stability influences chondrogenesis, osteogenesis and immigration of macrophages J. Orthop. Res. 19 2001 531-538
19. R.W. Jackson C.A. Reed J.A. Israel F.K. Abou-Keer H. Garside Production of a standard experimental fracture Can. J. Surg. 13 1970 415-420
20. J. Kenwright A.E. Goodship Controlled mechanical stimulation in the treatment of tibial fractures Clin. Orthop. Rel. Res. 241 1989 36-47
21. J.E. Madsen M. Hukkanen A.K. Aune I. Basran J.F. Moller J.M. Polak et al. Fracture healing and callus innervation after peripheral nerve resection in rats Clin. Orthop. 1998 230-240
22. A. Molster N.R. Gjerdet T.S. Raugstad K. Hvidsten A. Alho G. Bang Effect of instability of experimental fracture healing Acta. Orthop. Scand. 53 1982 521-526
23. A.O. Molster Effects of rotational instability on healing of femoral osteotomies in the rat Acta. Orthop. Scand. 55 1984 632-636
24. A. Nakajima S. Shimizu H. Moriya M. Yamazaki Expression of fibroblast growth factor receptor-3 (FGFR3), signal transducer and activator of transcription-1, and cyclin-dependent kinase inhibitor p21 during endochondral ossification: Differential role of FGFR3 in skeletal development and fracture repair Endocrinology 144 2003 4659-4668
25. T.E. Otto P. Patka H.J. Haarman Closed fracture healing: A rat model Eur. Surg. Res. 27 1995 277-284
26. S.H. Park K. O'Connor R. Sung H. McKellop A. Sarmiento Comparison of healing process in open osteotomy model and closed fracture model J. Orthop. Trauma 13 1999 114-120
27. A. Probst H. Jansen A. Ladas H.U. Spiegel Callus formation and fixation rigidity: A fracture model in rats J. Orthop. Res. 17 1999 256-260
28. C.H. Rundle N. Miyakoshi E. Ramirez J.E. Wergedal K.H. Lau D.J. Baylink Expression of the fibroblast growth factor receptor genes in fracture repair Clin. Orthop. 2002 253-263
29. Wildemann B, Schmidmaier G, Brenner N, Huning M, Stange R, Haas NP. Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing. Calcif Tissue Int; 2004
30. B. Wildemann G. Schmidmaier S. Ordel R. Stange N.P. Haas M. Raschke Cell proliferation and differentiation during fracture healing are influenced by locally applied IGF-I and TGF-beta1: Comparison of two proliferation markers, PCNA and BrdU J. Biomed. Mater. Res. 65B 2003 150-156